AU747373B2 - Tetrakis-pentafluorophenyl borates from pentafluorophenyl grignard reagents - Google Patents
Tetrakis-pentafluorophenyl borates from pentafluorophenyl grignard reagents Download PDFInfo
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- AU747373B2 AU747373B2 AU15003/01A AU1500301A AU747373B2 AU 747373 B2 AU747373 B2 AU 747373B2 AU 15003/01 A AU15003/01 A AU 15003/01A AU 1500301 A AU1500301 A AU 1500301A AU 747373 B2 AU747373 B2 AU 747373B2
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- pentafluorophenyl
- tetrakis
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- -1 pentafluorophenyl grignard reagents Chemical class 0.000 title description 25
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 81
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 47
- 239000002904 solvent Substances 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 16
- 229910052796 boron Inorganic materials 0.000 claims description 15
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 14
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 13
- 229910001623 magnesium bromide Inorganic materials 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 11
- AMQDBUIQKQUCKY-UHFFFAOYSA-M magnesium;1,2,3,4,5-pentafluorobenzene-6-ide;bromide Chemical compound [Mg+2].[Br-].FC1=[C-]C(F)=C(F)C(F)=C1F AMQDBUIQKQUCKY-UHFFFAOYSA-M 0.000 claims description 9
- 150000001450 anions Chemical class 0.000 claims description 5
- 238000005341 cation exchange Methods 0.000 claims description 5
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 5
- 239000002685 polymerization catalyst Substances 0.000 claims description 5
- 150000001336 alkenes Chemical class 0.000 claims description 4
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 4
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 claims description 2
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- ANEFWEBMQHRDLH-UHFFFAOYSA-N tris(2,3,4,5,6-pentafluorophenyl) borate Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1OB(OC=1C(=C(F)C(F)=C(F)C=1F)F)OC1=C(F)C(F)=C(F)C(F)=C1F ANEFWEBMQHRDLH-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 46
- 150000004795 grignard reagents Chemical class 0.000 description 19
- 239000007818 Grignard reagent Substances 0.000 description 15
- 239000004215 Carbon black (E152) Substances 0.000 description 10
- 150000001768 cations Chemical class 0.000 description 10
- 229930195733 hydrocarbon Natural products 0.000 description 10
- 150000002430 hydrocarbons Chemical class 0.000 description 10
- 239000011777 magnesium Substances 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 6
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 6
- 239000011877 solvent mixture Substances 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 5
- 150000004820 halides Chemical class 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 150000002170 ethers Chemical class 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical group 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical group CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000002221 trityl group Chemical class [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 150000001721 carbon Chemical group 0.000 description 3
- URSLCTBXQMKCFE-UHFFFAOYSA-N dihydrogenborate Chemical compound OB(O)[O-] URSLCTBXQMKCFE-UHFFFAOYSA-N 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- OJJVPGJEBAZOIF-UHFFFAOYSA-N (2,3,4,5-tetrafluorophenoxy)boronic acid Chemical compound OB(O)OC1=CC(F)=C(F)C(F)=C1F OJJVPGJEBAZOIF-UHFFFAOYSA-N 0.000 description 2
- SZNYYWIUQFZLLT-UHFFFAOYSA-N 2-methyl-1-(2-methylpropoxy)propane Chemical compound CC(C)COCC(C)C SZNYYWIUQFZLLT-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- FPPYBBOIFQGHHZ-UHFFFAOYSA-M Fc1c(F)c(F)c([Mg]Cl)c(F)c1F Chemical compound Fc1c(F)c(F)c([Mg]Cl)c(F)c1F FPPYBBOIFQGHHZ-UHFFFAOYSA-M 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 239000002879 Lewis base Substances 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 125000002015 acyclic group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 150000001642 boronic acid derivatives Chemical class 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 125000001207 fluorophenyl group Chemical group 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- 150000007527 lewis bases Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012968 metallocene catalyst Substances 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical group CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- 238000004293 19F NMR spectroscopy Methods 0.000 description 1
- ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 238000003747 Grignard reaction Methods 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- JOXNNISDIMLBKW-UHFFFAOYSA-M [Br-].[Mg+2].B(OC1=C(C(=C(C(=C1F)F)F)F)F)([O-])O Chemical compound [Br-].[Mg+2].B(OC1=C(C(=C(C(=C1F)F)F)F)F)([O-])O JOXNNISDIMLBKW-UHFFFAOYSA-M 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- WOAZEKPXTXCPFZ-UHFFFAOYSA-N dimethyl(phenyl)azanium;chloride Chemical compound Cl.CN(C)C1=CC=CC=C1 WOAZEKPXTXCPFZ-UHFFFAOYSA-N 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 description 1
Description
AUSTRALIA
Patents Act COMPLETE SPECIFICATION
(ORIGINAL)
Class Int. Class Application Number: Lodged: Complete Specification Lodged: Accepted: Published: Priority Related Art: Name of Applicant: Boulder Scientific Company Actual Inventor(s): Fredric Askham Address for Service: PHILLIPS ORMONDE FITZPATRICK Patent and Trade Mark Attorneys 367 Collins Street Melbourne 3000 AUSTRALIA Invention Title: TETRAKIS-PENTAFLUOROPHENYL BORATES FROM PENTAFLUOROPHENYL GRIGNARD
REAGENTS
Our Ref: 634761 POF Code: 93796/123527 The following statement is a full description of this invention, including the best method of performing it known to applicant(s): -1- 6006q 2 TETRAKIS-PENTAFLUOROPHENYL BORATES FROM PENTAFLUOROPHENYL GRIGNARD REAGENTS This application is a divisional application of Australian Patent Application No. 54493/98, the entire disclosure of which is incorporated herein by reference.
FIELD OF THE INVENTION The invention relates to novel Grignard reagents for the production of tetrakis-pentafluorophenyl borate magnesium halides and to the conversion of such halides to different tetrakis-pentafluorophenyl salts having borate anions useful in metallocene olefin polymerization catalysts.
BACKGROUND OF THE INVENTION The discussion of the background to the invention herein is included to explain the context of the invention. This is not to be taken as an admission that any of the material referred to was published, known or part of the common general knowledge in Australia as at the priority date of any of the claims.
Combinations of an activating cation and a weakly coordinating borate S' anion are used as components of metallocene olefin polymerization catalysts.
Procedures for preparation of the borate anion portion of such combinations are described in the prior art. See European patent applications Nos. 505,972 and 505,997, Japanese published patent application No. 63-238057, and PCT International Application WO 94/00459.
o Grignard reactions are conventionally conducted in an ether solvent.
United States patent 5,473,036 describes the reaction of a fluorophenyl Grignard with a boron trihalide in an ether solvent to produce a magnesium halide salt of a tetrakis-fluorophenyl borate. The patent states: "The ether is needed to solubilize the Grignard reagent, fluorophenyl magnesium bromide" (Col. 2, II. The magnesium halide is converted by cation exchange to a S 30 different tetrakis-fluorophenyl borate salt to provide a borate anion useful in a metallocene catalyst synthesis.
SUMMARY OF THE INVENTION According to the present invention there is provided a method which includes: 2a reacting a boron trihalide with a solution in a solvent which contains no free ether of a pentafluorophenyl magnesium bromide or chloride, wherein said solution is prepared according to the method of claim 1, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or chloride is produced.
The present invention also provides a method which includes: reacting a boron trihalide with a solution of a pentafluorophenyl magnesium bromide or chloride in a solvent that contains no free ethyl ether, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or chloride is produced.
Also disclosed herein is a method for preparing a non-ethereal hydrocarbon solvent solution of a Grignard reagent which includes: providing a first solution of said Grignard reagent in an ether, (ii) adding a hydrocarbon solvent to said first solution to provide a second solution of said Grignard reagent in a solvent mixture of said ether and said hydrocarbon solvent, and (iii) removing said ether from said step (ii) second solution, wherein a solution of said Grignard reagent in said non-ethereal S: hydrocarbon solvent is produced.
o 20 Also disclosed herein is a methyl cyclohexane or toluene solution of a Grignard reagent wherein said solution contains no free ether.
Further disclosed herein is a toluene solution of pentafluorophenyl magnesium bromide or chloride wherein said solution contains no free ethyl ether.
Still further disclosed herein is a method which includes: reacting a boron trihalide with a solution in a solvent which contains no free ether of a pentafluorophenyl magnesium bromide or chloride, wherein said solution is prepared according to the method defined above, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or 30 chloride is produced.
Still further disclosed is a method which includes providing a first solution of C 6
F
5 MgBr in ethyl ether; (ii) adding toluene to provide a second solution of said C 6
F
5 MgBr in a mixture of said ethyl ether and toluene; 2b (iii) removing the ether from said second solution wherein a third, non-ethereal solution of C 6
F
5 MgBr in toluene is formed; and (iv) optionally isolating said C 6
F
5 MgBr from said third solution.
Still further disclosed is a method which includes providing a first solution of C 6
F
5 MgBr in ethyl ether; (ii) adding toluene to provide a second solution of said C 6
F
5 MgBr in a mixture of said ethyl ether and toluene; (iii) removing the ether from said second solution wherein a third non-ethereal solution of C 6
F
5 MgBr in toluene is formed; and (iv) reacting BF 3 with said C 6
F
5 MgBr in said third solution to produce tetrakis (C6F 5 )B MgBr; and subjecting said tetrakis (C 6
F
5 )B MgBr to a cation exchange reaction to produce a different tetrakis pentafluorophenyl borate salt which has an anion useful as a metallocene polymerization catalyst component.
Still further disclosed is a pentafluorophenyl magnesium bromide or chloride in solution in a solvent wherein said solvent contains no free ethyl ether.
Still further disclosed is a method which includes: reacting a boron trihalide with a solution of a pentafluorophenyl 20 magnesium bromide or chloride in solution in a solvent that contains no free ethyl ether, wherein said solution is prepared according to the method defined above, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or chloride is produced.
Accordingly, there are provided solutions of Grignard reagents in solvents which are not an ether, in particular, hydrocarbon solvents.
Pursuant to another aspect of the invention, a pentafluorophenyl magnesium halide is reacted with a boron trihalide in a solvent which is not an ether to produce a tetrakis-pentafluorophenyl magnesium halide. The 30 magnesium halide may be converted by reaction with a suitable cation, such as substituted ammonium, trityl or onium cation, to a compound comprising a weakly coordinating borate anion and an activating cation.
2c
DEFINITIONS
Ether A compound having the formula ROR, Ar-O-Ar or R-O-Ar in which R is alkyl and Ar is aryl.
Non-ethereal solvent A solvent which is not an ether.
Isolated, crystalline Grignard reagents are typically compounds coordinated with a Lewis base, usually the ether solvent in which the reagent is prepared. Such coordinated ethers are an integral part of the Grignard and do not function as solvents.
Similarly, ethers coordinated with boron halide,
BX
3 -OEt 2 in which X is a halide, do not function as solvents in the methodology of this invention.
Although such boron trihalide ether complexes are useful as a matter of convenience in the laboratory practice of the invention, boron halides 2= se are to be used commercially.
Non-interfering solvent-A solvent which does not interfere with the reaction between a pentafluorophenyl Grignard reagent, pentafluorophenyl magnesium chloride or bromide, and a boron trihalide.
Grignard reaqent-Any art recognized compound which functions as a Grignard reagent. For the purposes of this invention, Grignard reagents have the formula RMgX (excluding any coordinated Lewis base such as an ether) in which X is a halogen, preferably chlorine or bromine and R is a straight or branched chain acyclic or cyclic two to eight carbon atom aliphatic hydrocarbon or a two to eight carbon atom 25 aromatic hydrocarbon group which may be substituted with, inter alia, a halogen. Representative aliphatic hydrocarbons include methyl, propyl, isopropyl, pentyl, isopentyl, hexyl, isohexyl, cyclohexyl and methyl cyclohexyl groups. Representative aromatic groups include phenyl, tolyl, xylenyl groups which may be halogen or otherwise substituted.
Preferred Grignard reagents for one embodiment of this invention are fluorophenyl, in particular, pentafluorophenyl magnesium halides. A particularly preferred Grignard reagent is pentafluorophenyl magnesium bromide.
DESCRIPTION OF THE PREFERRED EMBODIMENTS An important aspect of this invention provides solutions of Grignard reagents in non-ethereal S. solvents. A first solution of the Grignard in an 15 ether, usually ethyl ether, is prepared. A non- .ethereal solvent, preferably a hydrocarbon solvent, is then added, and ether is removed to provide a second solution of the Grignard reagent in the non-ethereal solvent.
The relative proportions of the ethereal and nonethereal solvents are chosen to maintain the Grignard reagent in solution not only in the mixed solvent but also in the non-ethereal solvent after the ether component of the mixed solvent is removed. In general, S 25 both of the ethereal and non-ethereal components may constitute 30% to 70% by volume of the initial solvent mixture.
The ether component of the solvent mixture may have the formula.R-O-R', in which R and R' are the same or different two to five or more carbon atom alkyl groups. Diethyl ether is preferred. Dipropyl, diisopropyl, dibutyl and diisobutyl ether solvents are also appropriate.
The non-interfering, non-ethereal solvent component is preferably a five to eight carbon atom, acyclic or cyclic, aliphatic, or six to nine carbon atom aromatic hydrocarbon. Representative hydrocarbon solvents include normal or iso pentane, hexane, heptane, octane, cyclohexane, methyl cyclohexane, 15 benzene, toluene and xylene.
A preferred embodiment provides a method for producing a solution in a hydrocarbon solvent, e.g., toluene, of the Grignard reagent (C 6 Fs) MgX in which X is a halogen, preferably chlorine or bromine.
20 Pursuant to that embodiment, a solution of pentafluorophenyl magnesium halide in a solvent mixture including an ether and a non-interfering, non-ethereal, preferably hydrocarbon, solvent is provided. The ether component of the solvent mixture is then removed to provide a solution of pentafluorophenyl magnesium halide Grignard in the non-ethereal solvent. The Grignard is then reacted with a boron trihalide to produce a tetrakis-pentafluorophenyl magnesium halide in solution in the non-ethereal solvent.
Typically, an ethyl ether solution of from about 0.5 to 2.0 molar in pentafluorophenyl magnesium bromide Grignard reagent is utilized in the first step of the method. The non-interfering, non-ethereal solvent is combined with the solution of the Grignard reagent in an amount sufficient to maintain the pentafluorophenyl borate magnesium halide produced in subsequent steps in solution.
Preferably, the ether component of the original solvent mixture is removed under vacuum, about Torr, until the pot temperature rises to from 20 0 C to 15 40 0 C, preferably 30 0 C. Ether removal provides a nonethereal solution of the Grignard. Boron trihalide, i: which for laboratory purposes, may be in the form of an ether complex, BF3-OEt 2 is added, preferably by injection, to the non-ethereal solution of the Grignard. A spontaneous temperature rise to about to 60 0 C typically occurs, whereupon external heat is applied and a reaction temperature of 50 0 C to 100 0
C,
preferably 85 0 C to 90 0 C, is established and maintained for a time period, usually of one to four hours, appropriate to substantially complete the production of the desired tetrakis-pentafluorophenyl borate magnesium halide. In a typical reaction, this halide may comprise more than 95% of the fluorine containing reaction products.
The tetrakis borate reaction product may optionally be isolated and reacted with a salt, such as chloride, containing an appropriate cation, such as ammonium, trityl or onium, to provide by cation exchange a compound comprising a weakly coordinating borate and an activating cation useful in the preparation of metallocene olefin polymerization catalysts. Representative ammonium salts contain, as the 'cation portion, R 3 NH where R can be phenyl (Ph) which is either unsubstituted or substituted with such alkyl groups as lower alkyl, namely, ethyl S 15 and/or ethyl). Such ammonium salts may be exemplified by triethyl ammonium chloride or phenyldimethyl ammonium chloride. The corresponding trityl salts have a cation of the formula PH 3 C whereas the onium salts can contain a cation of the formula PH 2
I*.
20 The route for forming the ammonium and oniumcontaining products involves the reaction of the intermediate in water with the selected salt to precipitate the desired combination of weakly coordinating boron-containing anion and activating 25 cation. The route for forming the trityl-containing products uses a hydrocarbon solvent medium -8toluene) in which the byproduct salt is insoluble but the borate anion-cation is soluble.
EXAMPLE I Pentafluorophenyl magnesium bromide (250 ml, 1.025 M in Et2O) and dry, deoxygenated toluene (500 ml) were combined in a 1 1. flask which had previously been purged with nitrogen. Diethyl ether was removed under vacuum 30 Torr) until the pot temperature rose to 32 0 C. At this point, 3 ml of the solution was withdrawn by syringe and hydrolyzed by addition to aqueous HC1 at 0 C in a closed test tube to insure that volatile materials are not lost.
Analysis by gas chromatography showed about a 1:3 ratio of Et 2
O:C
6
F
s H which indicates a 1:3 ratio of o 15 Et 2 O:CsFsMgBr in solution before hydrolysis.
e The solvent stripping was continued until an additional 100 ml of .toluene had been removed. Another 3 ml aliquot was hydrolyzed and analyzed by gas chromatography as above with the same result (1:3 S• 20 EtO2:C 6
F
5 These results indicate that at this point, no free Et 2 O remained in solution Et 2 O is no longer a component of the solvent system). All Et20 is tightly bound to the magnesium of the Grignard reagent.
BF
3 *OEt 2 (7.0 ml) was then injected causing a 25 spontaneous temperature rise to 50 0 C. External heat was applied and the reaction temperature was maintained -9at 85-90°C. for a time sufficient to drive the reaction to completion. After cooling to room temperature, an aliquot was withdrawn and analyzed by 19F NMR. This showed tetrakis pentafluorophenyl borate magnesium bromide to comprise >95% of the fluorine containing products.
This magnesium salt, optionally after isolation, may be reacted in known manner by cation exchange to provide a compound having an anion useful in a metallocene catalyst. Use of pentafluorophenyl magnesium chloride yields a similar result.
EXAMPLE II Example I is repeated with the exception that **pentafluorophenyl magnesium bromide is added to a 15 preformed mixture of ethyl ether and toluene containing about 30% to 70% toluene.
EXAMPLE III Example I is repeated with the exception that methyl cyclohexane is substituted for toluene.
*49* Iooo
Claims (4)
1. A method which includes: reacting a boron trihalide with a solution in a solvent which contains no free ether of a pentafluorophenyl magnesium bromide or chloride, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or chloride is produced.
2. The method of claim 1, further including: (ii) isolating said tetrakis-pentafluorophenyl borate magnesium bromide or chloride produced in step and (iii) subjecting said tetrakis-pentafluorophenyl borate magnesium bromide isolated in step (ii) to a cation exchange reaction to produce a tetrakis pentafluorophenyl borate which has an anion useful as a metallocene olefin polymerization catalyst component.
3. The claim 1 or claim 2 method in which said solvent is toluene.
4. A method which includes: 6o* 20 reacting a boron trihalide with a solution of a pentafluorophenyl S magnesium bromide or chloride in a solvent that contains no free ethyl ether, wherein a tetrakis-pentafluorophenyl borate magnesium bromide or chloride is produced. o 25 DATED: 11 January 2001 00oo0o S" PHILLIPS ORMONDE FITZPATRICK Patent Attorneys for: BOULDER SCIENTIFIC COMPANY see
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| Application Number | Priority Date | Filing Date | Title |
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| AU15003/01A AU747373B2 (en) | 1996-11-19 | 2001-01-15 | Tetrakis-pentafluorophenyl borates from pentafluorophenyl grignard reagents |
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| Application Number | Priority Date | Filing Date | Title |
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| US08/751985 | 1996-11-19 | ||
| AU15003/01A AU747373B2 (en) | 1996-11-19 | 2001-01-15 | Tetrakis-pentafluorophenyl borates from pentafluorophenyl grignard reagents |
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| AU54493/98A Division AU740905B2 (en) | 1996-11-19 | 1997-11-19 | Tetrakis-pentafluorophenyl borates from pentafluorophenyl grignard reagents |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362423A (en) * | 1992-12-28 | 1994-11-08 | Tosoh Akzo Corporation | Method of producing pentafluorophenylmagnesium derivatives using pentafluorobenzene |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362423A (en) * | 1992-12-28 | 1994-11-08 | Tosoh Akzo Corporation | Method of producing pentafluorophenylmagnesium derivatives using pentafluorobenzene |
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