AU8217787A - Process for the preparation of quinoline carboxylic acids - Google Patents
Process for the preparation of quinoline carboxylic acidsInfo
- Publication number
- AU8217787A AU8217787A AU82177/87A AU8217787A AU8217787A AU 8217787 A AU8217787 A AU 8217787A AU 82177/87 A AU82177/87 A AU 82177/87A AU 8217787 A AU8217787 A AU 8217787A AU 8217787 A AU8217787 A AU 8217787A
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- carboxylic acids
- quinoline carboxylic
- agents
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Abstract
A process for the preparation of quinolinecarboxylic acids of the formula (I) <IMAGE> in which R<1>, R<2> and R<3>, X and A have the meaning given in the description, which are used as such or in the form of their esters, salts, prodrugs etc. as antibacterial agents in human and veterinary medicine and as agents stimulating the immune defence.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3641312 | 1986-12-03 | ||
| DE19863641312 DE3641312A1 (en) | 1986-12-03 | 1986-12-03 | METHOD FOR PRODUCING CHINOLINE CARBONIC ACIDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8217787A true AU8217787A (en) | 1988-06-09 |
| AU593961B2 AU593961B2 (en) | 1990-02-22 |
Family
ID=6315377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU82177/87A Expired AU593961B2 (en) | 1986-12-03 | 1987-12-03 | Process for the preparation of quinoline carboxylic acids |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0274033B1 (en) |
| JP (1) | JPS63145268A (en) |
| KR (1) | KR970005191B1 (en) |
| CN (1) | CN87107230A (en) |
| AT (1) | ATE73446T1 (en) |
| AU (1) | AU593961B2 (en) |
| CS (1) | CS270577B2 (en) |
| DD (1) | DD270904A5 (en) |
| DE (2) | DE3641312A1 (en) |
| DK (1) | DK174929B1 (en) |
| ES (1) | ES2038156T3 (en) |
| FI (1) | FI875289A7 (en) |
| GR (1) | GR3004301T3 (en) |
| HU (1) | HU199823B (en) |
| IE (1) | IE64261B1 (en) |
| IL (1) | IL84627A (en) |
| NO (1) | NO174199C (en) |
| NZ (1) | NZ222736A (en) |
| PH (1) | PH24489A (en) |
| PL (1) | PL158614B1 (en) |
| PT (1) | PT86252B (en) |
| SU (1) | SU1482526A3 (en) |
| UA (1) | UA8017A1 (en) |
| YU (1) | YU45049B (en) |
| ZA (1) | ZA879040B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU603352B2 (en) * | 1986-02-25 | 1990-11-15 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN166416B (en) * | 1985-09-18 | 1990-05-05 | Pfizer | |
| AU5449590A (en) * | 1989-04-28 | 1990-11-29 | Daiichi Pharmaceutical Co., Ltd. | Anti-hiv drug |
| FI921475L (en) * | 1989-10-06 | 1992-04-03 | Pfizer | 1,4-DIHYDRO-4-OXO-3-QUINOLINE DERIVATIVES ARE SELECTIVELY TOXIC WITH ANTIBACTERIAL AEMENN HOS DAEGGDJUR. |
| US5385913A (en) * | 1989-10-06 | 1995-01-31 | Pfizer Inc. | 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents |
| JP2613139B2 (en) * | 1990-07-19 | 1997-05-21 | エスエス製薬 株式会社 | Quinolonecarboxylic acid derivatives |
| ES2050613B1 (en) * | 1992-10-16 | 1996-03-16 | Iteve S A | NEW PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THE ACID 1-CICLOPROPIL-3-QUINOLINCARBOXILICO. |
| US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| AU6421898A (en) * | 1997-03-25 | 1998-10-20 | Sankyo Company Limited | Anti-fiv agent |
| KR100454750B1 (en) * | 2002-06-20 | 2004-11-03 | 삼성에스디아이 주식회사 | Blue light-emitting compound for organic electroluminescent device and organic electroluminescent device using the same |
| WO2005026147A1 (en) | 2003-09-10 | 2005-03-24 | Kyorin Pharmaceutical Co., Ltd. | 7-(4-substituted 3- cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative |
| JP5322927B2 (en) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | A mutilin derivative having a heteroaromatic carboxylic acid structure at the 14-position substituent. |
| CN101671302B (en) * | 2008-12-30 | 2011-03-30 | 广东海康兽药有限公司 | Production process of enrofloxacin antibacterial drug for fowl and livestock |
| CN101899044B (en) * | 2010-08-16 | 2012-07-18 | 常州市勇毅生物药业有限公司 | Method for synthesizing Gemifloxacin main ring compound |
| CN113912540A (en) * | 2021-12-15 | 2022-01-11 | 山东国邦药业有限公司 | Synthesis method of 1-cyclopropyl-6, 7-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5365887A (en) * | 1976-11-22 | 1978-06-12 | Kyorin Seiyaku Kk | Substituted quinoline*arboxylate and process for preparing same |
| DE2656574A1 (en) * | 1976-12-10 | 1978-06-15 | Schering Ag | 1-Alkyl-4-oxo-1,4-di:hydro-1,6-naphthyridine-3-carboxylic acid derivs. - with antibacterial activity esp. effective in the urinary tract |
| JPS53141286A (en) * | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
| JPS5845426B2 (en) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | Substituted quinoline carboxylic acid derivatives |
| DE3142854A1 (en) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
| DE3318145A1 (en) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
| AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
| IL74244A (en) * | 1984-02-17 | 1988-06-30 | Warner Lambert Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
| DE3420743A1 (en) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-6,8-DIHALOGEN-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
| JPS61205258A (en) * | 1985-03-08 | 1986-09-11 | Kyorin Pharmaceut Co Ltd | Quinolonecarboxylic acid derivative and production thereof |
-
1986
- 1986-12-03 DE DE19863641312 patent/DE3641312A1/en not_active Withdrawn
-
1987
- 1987-11-17 NO NO874788A patent/NO174199C/en not_active IP Right Cessation
- 1987-11-20 ES ES198787117130T patent/ES2038156T3/en not_active Expired - Lifetime
- 1987-11-20 AT AT87117130T patent/ATE73446T1/en not_active IP Right Cessation
- 1987-11-20 EP EP87117130A patent/EP0274033B1/en not_active Expired - Lifetime
- 1987-11-20 DE DE8787117130T patent/DE3777370D1/en not_active Expired - Lifetime
- 1987-11-26 YU YU2156/87A patent/YU45049B/en unknown
- 1987-11-27 IL IL84627A patent/IL84627A/en not_active IP Right Cessation
- 1987-11-30 CS CS878688A patent/CS270577B2/en not_active IP Right Cessation
- 1987-11-30 NZ NZ222736A patent/NZ222736A/en unknown
- 1987-12-01 JP JP62301624A patent/JPS63145268A/en active Pending
- 1987-12-01 DD DD87309727A patent/DD270904A5/en not_active IP Right Cessation
- 1987-12-01 FI FI875289A patent/FI875289A7/en not_active Application Discontinuation
- 1987-12-02 ZA ZA879040A patent/ZA879040B/en unknown
- 1987-12-02 UA UA4203762A patent/UA8017A1/en unknown
- 1987-12-02 CN CN198787107230A patent/CN87107230A/en active Pending
- 1987-12-02 PT PT86252A patent/PT86252B/en unknown
- 1987-12-02 PL PL1987269185A patent/PL158614B1/en unknown
- 1987-12-02 DK DK198706331A patent/DK174929B1/en not_active IP Right Cessation
- 1987-12-02 PH PH36159A patent/PH24489A/en unknown
- 1987-12-02 KR KR1019870013716A patent/KR970005191B1/en not_active Expired - Fee Related
- 1987-12-02 IE IE327987A patent/IE64261B1/en not_active IP Right Cessation
- 1987-12-02 HU HU875424A patent/HU199823B/en unknown
- 1987-12-02 SU SU87A patent/SU1482526A3/en active
- 1987-12-03 AU AU82177/87A patent/AU593961B2/en not_active Expired
-
1992
- 1992-04-08 GR GR920400663T patent/GR3004301T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU603352B2 (en) * | 1986-02-25 | 1990-11-15 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Assignment registered |
Owner name: BAYER HEALTHCARE AG Free format text: FORMER OWNER WAS: BAYER AKTIENGESELLSCHAFT |