CN120419949A

CN120419949A - Applicator and analyte monitoring system

Info

Publication number: CN120419949A
Application number: CN202410151895.2A
Authority: CN
Inventors: 李运峰
Original assignee: Shenzhen Guiji Sensing Technology Co ltd
Current assignee: Shenzhen Guiji Sensing Technology Co ltd
Priority date: 2024-02-02
Filing date: 2024-02-02
Publication date: 2025-08-05
Also published as: WO2025161989A1

Abstract

The present disclosure describes an application device and analyte monitoring system, the application device comprising a first housing, a second housing, a drive mechanism, a moving body, a piercing member disposed on the moving body, and a proximal end operatively proximal to the host and a distal end distal from the host, the first housing and the second housing being relatively movable in close proximity to each other to release retention of the moving body, the moving body being released for movement with the piercing member together toward the proximal end under the influence of the drive mechanism to apply the monitoring device to the host and at least partially beneath the skin of the host. According to the present disclosure, an application device and an analyte monitoring system that are convenient to operate and that can accurately apply a monitoring device to a host can be provided.

Description

Applicator and analyte monitoring system

Technical Field

The present disclosure relates generally to the field of medical devices, and more particularly to an applicator and analyte monitoring system.

Background

Current methods for self-blood glucose monitoring in diabetics mainly include traditional finger blood testing (Blood Glucose Monitoring, BGM) and continuous blood glucose monitoring systems (Continuous Glucose Monitoring System, CGMS). Wherein, CGMS can detect the blood sugar level of a patient in real time, has the capability of finding hidden hyperglycemia and hypoglycemia which are not easy to be detected by the traditional finger blood detection method, and becomes a new trend of blood sugar monitoring.

CGMS is typically the monitoring of glucose concentration in tissue fluids using a glucose sensor that can be inserted under the skin and that can react with glucose in the tissue fluid, and an electronic device that is applied to the skin and connected to the glucose sensor. In order to insert the glucose sensor under the skin and apply the electronic device to the skin, it is often necessary to resort to an insertion device. In particular, the insertion device may comprise a needle capable of penetrating the skin, through which the glucose sensor is inserted under the skin, and then separated from the glucose sensor and removed from the skin.

However, in the above prior art, the process of inserting or removing the needle into or from the skin generally requires driving by means of manpower. In this case, it may be difficult to obtain a relatively accurate control due to the force of driving the needle, the position of the needle to pierce the skin, the depth of the needle to pierce the skin, the timing of taking the needle out of the skin, or the like, which may affect the user's experience when the glucose sensor is inserted, on the one hand, and may cause a low accuracy in the obtained glucose concentration due to the glucose sensor not being inserted to the desired position, on the other hand.

Disclosure of Invention

The present disclosure has been made in view of the above-described state of the art, and an object thereof is to provide an application device and an analyte monitoring system that are easy to operate and capable of accurately applying a monitoring device to a host.

To this end, the present disclosure provides an application device for applying a monitoring device to a host, the application device comprising a first housing comprising a first holding portion releasably holding the moving body, a second housing having a proximal surface operatively in contact with the skin of the host, a drive mechanism, a moving body, a piercing member disposed on the moving body, the moving body comprising a receiving portion for receiving the monitoring device, the piercing member being configured to at least partially introduce the monitoring device into the subcutaneous of the host, the first housing and the second housing being relatively movable in close proximity to each other to release the holding of the moving body by the first holding portion, the moving body being movable together with the piercing member toward the proximal end under the influence of the drive mechanism to apply the monitoring device to the host and being at least partially located under the subcutaneous of the host after release.

In the present disclosure, the applying device includes a moving body for accommodating the monitoring device, a puncture member subcutaneously that can introduce the monitoring device at least partially into the host, a first housing that releasably holds the moving body, and a second housing that can be engaged with the first housing to release the lock of the moving body by the first housing (even if the first holding portion releases the moving body, this action may be simply referred to as unlocking), the moving body and the puncture member being movable toward a proximal end near the host after unlocking by a driving mechanism to apply the monitoring device to a body surface of the host, and the puncture member being capable of introducing the monitoring device at least partially subcutaneously into the host. In this case, by placing the proximal end surface of the second housing on the skin of the host, on the one hand, the application of force to move the two housings (first housing and second housing) relative to each other to unlock the moving body can be facilitated, and on the other hand, the position of application can be further facilitated, and the driving action can be provided relatively accurately by the driving mechanism, so that the penetration force and penetration depth of the penetrating member during application can be controlled more accurately, whereby accurate application of the monitoring device to the host can be facilitated.

Further, according to the application device to which the present disclosure relates, optionally, the moving body includes a first locking portion configured to be releasably interlocked with the first holding portion, and the second housing includes a first triggering portion that can separate the first holding portion from the first locking portion to release the moving body. Thereby, the moving body can be releasably held to the first holding portion by the engagement of the first locking portion with the first holding portion, and the moving body can be released by the relative movement of the two housings by the first triggering portion.

In addition, according to the application device related to the present disclosure, optionally, when the first housing and the second housing are relatively moved in a direction along a central axis of the application device, the first triggering portion acts on the first locking portion to separate the first locking portion from the first holding portion. In this case, the first locking portion and the first holding portion can be separated by the first triggering portion by relatively moving the two housings in the direction of the central axis, which can be convenient for the operator to use.

In addition, according to the application device related to the present disclosure, optionally, the first holding portion is a convex structure formed on an inner wall of the first housing, the first locking portion is engaged with the convex structure when the moving body is held to the first holding portion, and the first triggering portion deflects the first locking portion in a direction away from the first holding portion to separate the first locking portion from the first holding portion. In this case, the provision of the first holding portion in the convex structure formed on the inner wall of the first housing can reduce the space required for providing the first holding portion while reducing the difficulty of the manufacturing process of the first housing, as compared with the provision of the first holding portion having a certain length and being capable of being displaced inside the first housing, thereby contributing to the miniaturization of the application device and facilitating the use of the operator.

Further, according to the application device related to the present disclosure, optionally, the first housing includes a first restriction configured to inhibit detachment of the second housing from the first housing, the second housing includes a first restriction coupled to the first restriction. In this case, the second housing can be restricted to the first housing by the engagement of the first restricting portion with the first restricting portion, and suppressing the detachment of the second housing from the first housing can contribute to improvement in reliability of the application device.

Further, according to the application device related to the present disclosure, optionally, the first housing includes a second restriction configured to restrain movement of the second housing toward the proximal end, and the second housing is restricted by the second restriction after the movement body is released by the relative movement of the first housing and the second housing. In this case, the second restriction portion restricts the movement of the second housing toward the proximal end, thereby suppressing the operator from repeatedly using the applicator, and reducing the risk of the used piercing member not subjected to secondary sterilization coming into contact with the host again.

Further, according to the application device related to the present disclosure, optionally, the first restricting portion and the second restricting portion are provided adjacently in a direction along a central axis of the application device, and the first restricting portion is configured to be engageable with the second restricting portion to hold the second housing. This can help simplify the structure of the applicator.

Further, according to the application device related to the present disclosure, optionally, the driving mechanism includes a first driving portion and a second driving portion, the moving body includes a second holding portion that releasably holds the puncture member, the moving body and the puncture member move together toward the proximal end to a predetermined position under the action of the first driving portion, and the second holding portion releases the puncture member, and the puncture member moves toward the distal end under the action of the second driving portion. In this case, the piercing force, the piercing depth, and the timing of leaving the host of the piercing member can be controlled more accurately by performing the two operations of application and retraction by the first driving portion and the second driving portion, respectively.

In addition, according to the application device related to the present disclosure, optionally, the first driving portion is an elastic element, and both ends of the first driving portion are respectively abutted against the first housing and the moving body, and when the moving body is held in the first holding portion, the first driving portion is in a compressed state. In this case, when the moving body is released, the first driving part in a compressed state can automatically apply a force to the moving body to thereby achieve automatic pushing, which is convenient for an operator to use.

In addition, according to the applying device related to the present disclosure, optionally, the second driving portion is an elastic element, and both ends of the second driving portion are respectively abutted against the moving body and the piercing member, and when the piercing member is held in the second holding portion, the second driving portion is in a compressed state. In this case, when the puncture member is released, the second driving section in a compressed state can automatically apply a force to the puncture member to thereby achieve automatic retraction of the puncture member, facilitating use by an operator.

Further, according to the application device related to the present disclosure, optionally, the application device includes an applicator cover detachably assembled to the first housing, and the second housing is located in a sealed accommodation space formed by the applicator cover and the first housing when the applicator cover is assembled to the first housing. In this case, a sealed space can be formed by the cooperation of the applicator cover and the first housing to protect the internal structure, and the second housing is located in the sealed space, which can suppress occurrence of unexpected false touch, improving reliability of the applicator.

Additionally, in accordance with the application device contemplated by the present disclosure, optionally, the monitoring device includes a sensor that is partially subcutaneously positionable in the host, an electronics assembly coupled to the sensor, and a sealing assembly that seals the sensor, the applicator cap being coupled to the sealing assembly, the sealing assembly being jointly removed with the applicator cap upon removal of the applicator cap from the first housing to form the application device into an applicable state. In this case, the aseptic state of the sensor can be maintained for a long time by sealing the sealing assembly of the sensor, and the sealing assembly can be simultaneously removed by coupling the applicator cover with the sealing assembly and removing the applicator cover, thereby facilitating the use of the operator.

Additionally, in accordance with the application device of the present disclosure, optionally, the seal assembly has a first engagement feature, the applicator cap includes a second engagement feature, the first engagement feature cooperates with the second engagement feature to cause the seal assembly to follow the rotation of the applicator cap when the applicator cap is rotated in a first direction, and the seal assembly to be stationary when the applicator cap is rotated in a second direction opposite the first direction. In this case, the sealing member can be removed while the applicator cap is rotated in a first direction to remove the applicator cap, thereby facilitating the use, and the sealing state of the sealing member is not affected during the assembly of the applicator cap to the first housing by rotating the applicator cap in a second direction opposite to the first direction, thereby facilitating the assembly of the applicator and the monitoring device by the factory.

A second aspect of the present disclosure provides an analyte monitoring system comprising an applicator as described in the first aspect of the present disclosure, and a monitoring device. Thus, an analyte monitoring system that is easy to operate and that can accurately apply a monitoring device to a host can be provided.

According to the present disclosure, an application device and an analyte monitoring system that are convenient to operate and that can accurately apply a monitoring device to a host can be provided.

Drawings

Embodiments of the present disclosure will now be explained in further detail by way of example only with reference to the accompanying drawings.

Fig. 1 is a schematic diagram illustrating an application scenario of a monitoring apparatus according to an example of the present disclosure.

Fig. 2 is a schematic diagram illustrating a monitoring apparatus according to an example of the present disclosure.

Fig. 3 is a schematic diagram illustrating a sensor to which examples of the present disclosure relate.

Fig. 4 is a schematic diagram illustrating a sterilization assembly according to an example of the present disclosure.

Fig. 5 is an exploded view illustrating a sterilization assembly according to an example of the present disclosure.

Fig. 6A is a schematic diagram illustrating a sterilization assembly prior to assembly with an electronic assembly in accordance with examples of the present disclosure.

Fig. 6B is a schematic diagram illustrating an assembled sterilization assembly with an electronic assembly in accordance with examples of the present disclosure.

Fig. 7 is a schematic view showing the overall appearance of the application device according to the example of the present disclosure.

Fig. 8 is a cross-sectional view showing an application device according to an example of the present disclosure.

Fig. 9 is an exploded view showing an application device to which an example of the present disclosure relates.

Fig. 10 is a schematic diagram showing a first housing to which examples of the present disclosure relate.

Fig. 11 is a schematic diagram showing a second housing to which the examples of the present disclosure relate.

Fig. 12 is a schematic diagram showing a moving body to which examples of the present disclosure relate.

Fig. 13 is a schematic sectional view showing an assembled first housing, second housing, and moving body according to an example of the present disclosure.

Fig. 14 is a schematic cross-sectional view showing the first locking portion according to the example of the present disclosure before being triggered by the first trigger portion.

Fig. 15 is a schematic cross-sectional view showing the first locking portion according to the example of the present disclosure after being triggered by the first trigger portion.

Fig. 16 is a schematic cross-sectional view showing that the first restriction portion is not engaged with the second restriction portion according to the example of the present disclosure.

Fig. 17 is a schematic cross-sectional view showing engagement of a first restriction portion and a second restriction portion according to an example of the present disclosure.

Fig. 18 is an exploded schematic view showing a first perspective of a moving body and a piercing member according to an example of the present disclosure.

Fig. 19 is an exploded schematic view showing a second perspective of the moving body and the piercing member according to an example of the present disclosure.

Fig. 20 is a schematic cross-sectional view showing a state where a puncture member according to an example of the present disclosure is held.

Fig. 21 is a schematic diagram illustrating a seal assembly and an applicator cap in accordance with examples of the present disclosure.

Fig. 22 is a schematic diagram showing the structure of an inclined groove according to an example of the present disclosure.

Detailed Description

Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same members are denoted by the same reference numerals, and overlapping description thereof is omitted. In addition, the drawings are schematic, and the ratio of the sizes of the components to each other, the shapes of the components, and the like may be different from actual ones.

It should be noted that the terms "comprises" and "comprising," and any variations thereof, in this disclosure, such as a process, method, system, article, or apparatus that comprises or has a list of steps or elements is not necessarily limited to those steps or elements expressly listed or inherent to such process, method, article, or apparatus, but may include or have other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

The present disclosure relates to an applicator that may be used to apply a monitoring device to a host, such as by applying the monitoring device to a body surface of the host, or by placing the monitoring device wholly or partially subcutaneously in the host, etc. The application device according to the present embodiment can facilitate application of the monitoring device to a desired position. In the present disclosure, the monitoring device may be used to monitor a physiological parameter of the host. The monitoring device may also be other medical devices that need to be applied to the host.

The applicator according to the present embodiment may be referred to as an insertion device, a pushing device, a boosting device, a delivery device, an implantation device, an application device, an auxiliary device, or the like. The names are used to indicate the device for applying the monitoring device to the host according to the present embodiment, and should not be construed as limiting.

In addition, the present disclosure also provides an analyte monitoring system that may include a monitoring device, and an application device. The monitoring device may be used to obtain physiological parameter information of the host. The monitoring device may be applied to the host by the application device, by which the physiological parameter information of the host may be monitored. In this disclosure, an analyte monitoring system may also be referred to as an analyte monitoring kit, an analyte combination kit, or a monitoring system, among others.

The application device and analyte monitoring system according to the present disclosure are described below with reference to the accompanying drawings.

Fig. 1 is an application scenario diagram illustrating a monitoring apparatus 800 according to an example of the present disclosure.

In some examples, the monitoring device 800 may be applied to a host via the application device 100 and to a desired location, and the host may obtain physiological parameter information (which may be referred to as physiological information) by the monitoring device 800 being applied to itself.

In some examples, analyte monitoring system 1000 may include monitoring device 800, and application device 100 (see fig. 1). The monitoring device 800 may be used to obtain physiological parameter information of a host. The monitoring device 800 may be applied to the host by the application device 100, and physiological parameter information of the host may be monitored by the monitoring device 800.

In some examples, analyte monitoring system 1000 may also include a reading device 900 (see fig. 1) that may be communicatively coupled to monitoring apparatus 800. The monitoring device 800 applied to the host may transmit the acquired physiological parameter information to the reading apparatus 900, for example, wirelessly, thereby enabling the host to conveniently read and monitor the physiological parameter information itself.

In some examples, the monitoring device 800 may be an analyte sensor device that may generate information of a particular analyte in a bodily fluid based on the bodily fluid, etc., such as reacting with the analyte in the bodily fluid and generating analyte information. In this case, the reaction with the analyte in the body fluid by the sensor 8, whereby the acquisition of analyte information in the body fluid can be facilitated.

In some examples, the analyte may be one or more of glucose, acetylcholine, amylase, bilirubin, cholesterol, chorionic gonadotrophin, creatine kinase, creatine, DNA, fructosamine, glucose, glutamine, growth hormone, ketone bodies, lactate, oxygen, peroxide, prostate specific antigen, prothrombin, RNA, thyroid stimulating hormone, or troponin.

For ease of understanding, the monitoring device 800 of the present disclosure will be described first. The monitoring device 800 according to the present embodiment will be described below with reference to glucose as an analyte. It should be noted that, for other analytes, those skilled in the art can analyze other analytes with a slight modification of the monitoring device 800 used for glucose.

Fig. 2 is a schematic diagram illustrating a monitoring device 800 according to an example of the present disclosure. Fig. 3 is a schematic diagram showing a sensor 8 to which an example of the present disclosure relates.

In some examples, the monitoring device 800 may include a sensor 8 and an electronic assembly 9 (see fig. 2). The sensor 8 may be mounted to an electronic assembly 9. The sensor 8 may be placed partially or fully subcutaneously in the host for the purpose of facilitating reaction with interstitial fluid, such as body fluids. The sensor 8, when placed subcutaneously, may react with glucose in the subcutaneous tissue fluid to generate glucose information of the host. The electronic assembly 9 may be applied to the body surface of the host. The electronic assembly 9 may be electrically connected to the sensor 8 and receive glucose information generated by the sensor 8. In addition, the electronics 9 may also provide the sensor 8 with the electrical energy needed to obtain physiological information. Thus, continuous monitoring of the sensor 8 subcutaneously in the host can be facilitated.

In some examples, the sensor 8 may include an implant portion 81 and a connection portion 82 (see fig. 3). The implanted portion 81 may be placed subcutaneously in the host and connected to the electronic component 9 by the connecting portion 82. In this case, by placing the implanted portion 81 under the skin of the host and connecting the implanted portion 81 with the electronic component 9 through the connecting portion 82, it is possible to facilitate temporary fixation of the sensor 8 at a specific site of the host.

In some examples, the implanted portion 81 may include a working electrode and a counter electrode. In this embodiment, a sensing layer including a glucose enzyme may be provided on the working electrode, and the sensor 8 placed under the skin may generate a current signal by causing a redox reaction between the glucose enzyme on the working electrode and glucose in tissue fluid or blood, and forming a circuit with the counter electrode, and analyze the current signal to obtain glucose concentration information. The current signal generated by the sensor 8 may be transmitted to the electronic assembly 9.

In some examples, the implanted portion 81 may also include a reference electrode. The reference electrode may be at a known and fixed potential difference with the interstitial fluid or blood. In this case, the potential difference between the working electrode and the tissue fluid or blood can be measured based on the potential difference formed between the reference electrode and the working electrode. Thus, the voltage generated by the working electrode can be obtained more accurately. In addition, in this case, the electronic component 9 can automatically adjust and maintain the stability of the voltage at the working electrode according to the preset voltage value, so that the measured current signal can more accurately reflect the glucose concentration information in the tissue fluid or blood. In some examples, the number of reference electrodes may be one or more, such as two.

In some examples, the electronic assembly 9 may include a housing 91 (see fig. 2). In some examples, the electronic assembly 9 may include electronics disposed inside the housing 91. In some examples, the electronic device may include a power module, a switch module, and a processing module. The power module may supply power to the sensor 8 and/or the processing module, the switching module may control on/off of the power module with the sensor 8 and/or the processing module, and the processing module may process signals (e.g., glucose information) generated by the sensor 8.

In some examples, the electronic device may have an initial mode configured as an open circuit and an operating mode configured as a closed circuit. In this case, the electronic device is configured as an open circuit when in the initial mode, whereby power consumption can be saved before the electronic device enters the operating state. In some examples, the switch module may be in an open state when the electronic device is configured in the initial mode and in a closed state when the electronic device is configured in the operational mode. That is, the electronic device can be switched from the initial mode to the operation mode by the switching module. In this case, the switching of the electronic device from the initial mode to the operation mode is controlled by the switching module, whereby the power consumption before the operation of the electronic device can be effectively reduced.

In some examples, the electronic assembly 9 may be configured to be magnetically or optically activated to be activated from an initial mode to an operational mode. In this case, the electronic component 9 is excited from the initial mode to the operation mode by a noncontact member such as a magnetic action or a light action, and thus the miniaturization of the electronic component 9 can be facilitated.

In some examples, the application device 100 (described later) may include a magnet. In some examples, when the monitoring device 800 has not been applied to the host, the switch module of the electronic assembly 9 may be in an off state as the electronic assembly 9 of the monitoring device 800 is now close to the magnet. In some examples, when the monitoring device 800 is applied to a host, the switch module of the electronic assembly 9 may be activated to a closed state as the electronic assembly 9 of the monitoring device 800 is now away from the magnet. In this case, in a standby state before the analyte monitoring system 1000 is not yet used after shipment, the monitoring device 800 is located in the application device 100, and at this time, the monitoring device 800 may be in an initial mode with low power consumption or zero power consumption, which helps to prolong the standby life (may also be referred to as shelf life) of the monitoring device 800.

In some examples, when the monitoring device 800 is applied to the host and the application device 100 has not yet left the host, the switch module of the electronic assembly 9 may be in an off state as the electronic assembly 9 of the monitoring device 800 is now close to the magnet. In some examples, after the monitoring device 800 is applied to the host and the application device 100 has been moved away from the host, the switch module of the electronic assembly 9 may be activated to a closed state as the electronic assembly 9 of the monitoring device 800 is now moved away from the magnet.

Fig. 4 is a schematic diagram illustrating sterilization assembly 92 in accordance with examples of the present disclosure. Fig. 5 is an exploded view illustrating sterilization assembly 92 in accordance with examples of the present disclosure. Fig. 6A is a schematic diagram illustrating a sterilization assembly 92 prior to assembly with an electronic assembly 9 in accordance with examples of the present disclosure. Fig. 6B is a schematic diagram illustrating the assembly of sterilization assembly 92 with electronic assembly 9 in accordance with examples of the present disclosure. In fig. 5 and 6A, line JK schematically represents the central axis of sterilization assembly 92.

In some examples, sensor 8 may be sealed, sterilization assembly 92 including sensor 8 may be sterilized, and sterilization assembly 92 may be assembled to electronic assembly 9 and then assembled with applicator 100. In this case, compared to the case where the sensor 8 needs to be sterilized separately from the electronic component 9 in the prior art, the operator needs to pick up and assemble the sensor 8 located in another container with the application device 100 including the electronic component 9 before using the application device, so as to form the complete monitoring device 800, and the application device 100 of the present disclosure can accommodate the complete monitoring device 800, and the operator does not need to perform any additional pick up and assembly operation before using the device. Can be used by operators conveniently.

In the present disclosure, sealing the sensor 8 includes various embodiments, and hereinafter, one example of sealing the sensor 8 is described, but the specific structure is not limited thereto.

In some examples, the monitoring device 800 may include a seal assembly 93 (see fig. 4). The sealing assembly 93 may be used to seal the sensor 8. Specifically, the seal assembly 93 may seal the implanted portion 81 of the sensor 8. In this case, the sealing unit 93 sealing the sensor 8 can help maintain the sterile state of the sensor 8 for a long period of time, and thus the standby life of the monitoring device 800 can be increased (the standby life refers to the period of time from when the sterilization assembly of the monitoring device 800 is completed to when the monitoring device is used by an operator, and may be referred to as shelf life).

In some examples, the sensor 8 may be sterilized, the sensor 8 held in the seal assembly 93, the sensor 8 and seal assembly 93 assembled to the electronics assembly 9 to form the monitoring device 800, and the monitoring device 800 installed into the applicator 100. That is, the seal assembly 93 may be included as part of the sterilization assembly 92. Before the monitoring device 800 is applied to the host using the application device 100, the seal assembly 93 may be removed to allow the monitoring device 800 to be brought into an applicable state. In this case, compared to the case where the sensor 8 and the electronic component 9 need to be packaged separately for sterilization in the prior art, the operator needs to pick up the sensor 8 located in another container before using and assemble the sensor and the electronic component 9 into the complete monitoring device 800, the application device 100 of the present disclosure can accommodate the complete monitoring device 800, and the operator does not need to additionally perform the pick-up assembly before using. Can be used by operators conveniently.

In some examples, the monitoring device 800 may include a mount 94 (see fig. 4). The sensor 8 may be assembled with the electronic assembly 9 by means of the mounting 94. In some examples, the mount 94 may have a first through hole 941 (see fig. 5). The first through hole 941 may serve as a channel through which the sensor 8 extends outwardly. In some examples, one end of the sensor 8 may protrude through a sidewall of the mount 94. Specifically, the connection portion 82 of the sensor 8 may pass out through a sidewall of the mount 94. In some examples, the electronic component 9 may include an electrical connection socket. After the sensor 8 is assembled with the electronic assembly 9 via the mounting base 94, the sensor 8 may be electrically connected to the electronics inside the electronic assembly 9 via the electrical connection base.

In some examples, the seal assembly 93 may cooperate with the mount 94 to seal the sensor 8. Specifically, the implanted portion 81 of the sensor 8 may extend beyond the mounting seat 94, and the seal assembly 93 may abut the mounting seat 94 and surround the outer periphery of the implanted portion 81 of the sensor 8 extending beyond the mounting seat 94. That is, the sealing member 93 may seal one end of the first through hole 941.

In some examples, the applicator 100 may include a piercing member 40 (see fig. 4 and 5). The piercing member 40 may be configured to at least partially introduce the monitoring device 800 subcutaneously into a host. For example, piercing member 40 may introduce implanted portion 81 of sensor 8 subcutaneously into a host. In some examples, piercing member 40 may include a needle 41 and a carrier 42 connected to needle 41 (see fig. 5). The needle 41 can house the sensor 8. In some examples, the seal assembly 93, mount 94, and piercing member 40 may cooperate to seal the sensor 8 (the specific structure of the piercing member 40 will be described in detail later, and the disclosure herein will be directed to sealing the sensor 8). Specifically, the first through hole 941 of the mounting seat 94 may be used as a channel through which the puncture member 40 passes downward, the bearing portion 42 of the puncture member 40 abuts against the upper surface of the mounting seat 94, the upper end of the first through hole 941 is sealed, the needle portion 41 passes through the first through hole 941 and passes downward to penetrate and accommodate the implanted portion 81 of the sensor 8, the sealing assembly 93 surrounds the needle portion 41 and the portion of the sensor 8 penetrating the mounting seat 94, and at this time, the puncture member 40 and the sealing assembly 93 respectively seal two ends of the first through hole 941, so that the sensor 8 is sealed in a sealed space formed by the mating connection of the puncture member 40, the mounting seat 94 and the sealing assembly 93. In some examples, the carrier 42 may also pass downwardly out of the first through hole 941, and the seal assembly 93 may be detachably connected to the carrier 42.

In some examples, sterilization assembly 92 may also include a seal. For example, sterilization assembly 92 may include a first seal 951 and a second seal 952 (see fig. 5). Wherein the first seal 951 may be located between the carrier 42 and an upper surface of the mount 94. This can facilitate improved sealing of sterilization assembly 92. A second seal 952 may be located between the seal assembly 93 and the lower surface of the mount 94. This can facilitate improved sealing of sterilization assembly 92.

In some examples, sterilization assembly 92, including mount 94, seal assembly 93, piercing member 40, and sensor 8, may be sterilized and then assembled with applicator 100 after sterilization assembly 92 is assembled to electronic assembly 9. Referring to fig. 6A, sterilization assembly 92 may be assembled to electronic assembly 9 along direction D1, forming an assembly including monitoring device 800 that is mountable to applicator 100 as shown in fig. 6B.

In the present disclosure, sealing the sensor 8 may also include other variations. For example, in some examples, the housing 91 of the electronic assembly 9 may include an upper housing 911 and a lower housing 912 (see fig. 2). The electronic device may be disposed in the receiving space formed by the upper case 911 and the lower case 912. In some examples, mount 94 may be an upper housing 911 or a lower housing 912 of electronic assembly 9 and may cooperate with seal assembly 93 and lancing member 40 to seal sensor 8. The specific structure can be obtained by slightly modifying the above-mentioned mounting base 94, and will not be described herein.

In some examples, the electronic component 9 may be adhered to a body surface of the host. For example, the monitoring device 800 may further include an adhesive sheet having adhesive properties provided at the bottom of the case 91 of the electronic component 9. The electronic component 9 may be adhered to the host body surface by an adhesive sheet.

In some examples, the electronic component 9 may be configured to communicate with an external device via wireless communication or wired communication. In this case, by configuring the electronic component 9 to be communicable with an external device, the analyte information acquired by the sensor 8 can be read in real time or at a fixed timing. The external device may be the reading device 900.

In some examples, the monitoring apparatus 800 may be communicatively connected with the reading device 900. In some examples, the reading device 900 may be a display with communication capabilities. In some examples, the communication functionality of the reading device 900 may be implemented by wireless communication or wired communication. The wireless communication mode can be Bluetooth, NFC, wifi and the like. The wired communication mode can be USB, optical fiber, etc. In addition, the reading apparatus 900 may be an intelligent terminal installed with an application program matched with the monitoring device 800. The intelligent terminal can be a notebook computer, a tablet computer, a smart phone and the like.

As described above, the monitoring device 800 according to the present disclosure may be applied to a host by the application device 100. The applicator 100 according to the present disclosure will be described in detail below with reference to the accompanying drawings.

Fig. 7 is a schematic view showing the overall appearance of the application device 100 according to the example of the present disclosure. Fig. 8 is a cross-sectional view showing an application device 100 according to an example of the present disclosure. Fig. 9 is an exploded view showing the application device 100 according to the example of the present disclosure. In fig. 8 and 9, a line CA schematically represents the central axis CA of the applicator 100. The subsequent occurrence of the "central axis CA" refers to the central axis CA of the applicator 100.

In some examples, the application device 100 may include a first housing 10 that may provide a moving space, and a moving body 20 (see fig. 7, 8, and 9 in combination). The moving body 20 may house the monitoring device 800 and be configured to be movable within a movement space of the first housing 10. In some examples, the applicator 100 may have a proximal end 101 that is operatively proximal to the host and a distal end 102 that is distal to the host (see fig. 8). It is to be understood that in this context, the "proximal end 101" may be understood as the end that is operatively proximal to the host, and the "distal end 102" may be understood as the end that is operatively distal to the host.

In some examples, the moving body 20 may be releasably held to the first housing 10. The moving body 20 can move within the movement space of the first housing 10 when released.

In some examples, the applicator 100 may include a second housing 30 (see fig. 8 or 9). The second housing 30 is movable relative to the first housing 10. In some examples, the second housing 30 may be at least partially located within the receiving space of the first housing 10. In some examples, a moving space may be formed after the first housing 10 is assembled with the second housing 30. The moving body 20 can move in a moving space formed after the first housing 10 and the second housing 30 are assembled and combined.

In some examples, the second housing 30 may limit the movement path of the moving body 20. That is, the moving body 20 may move along a movement path defined by the second housing 30 when released. In some examples, the axis of the first housing 10 and the axis of the second housing 30 may be substantially parallel to the central axis CA of the applicator 100. In some examples, the first housing 10 and the second housing 30 may be coaxially disposed. For example, in fig. 8, the axes of the first housing 10 and the second housing 30 may overlap with the central axis CA of the application device 100.

In some examples, the second housing 30 and the first housing 10 may be relatively movable to release the moving body 20. In this case, the lock on the moving body 20 can be released by the engagement of the two housings, and the operator can use it conveniently. In some examples, the second housing 30 may define the application location of the monitoring device 800 to the body surface of the host. In some examples, the second housing 30 may have a proximal surface 31 that is in contact with the skin of the host when in operation (see fig. 9). In this case, by placing the proximal surface 31 of the second housing 30 on the skin of the host, it is possible to facilitate, on the one hand, the application of force to move the first housing 10 and the second housing 30 relative to each other (hereinafter simply referred to as the two housings being moved relative to each other) to unlock the moving body 20, and, on the other hand, to define the application position, to facilitate the accurate application of the monitoring device 800 to the host. Moreover, the application device 100 of the present disclosure can place the proximal end surface 31 of the second housing 30 on the skin of the host for application of force, which can have a larger area of force than an application device with a trigger button provided on the housing, and can be more conveniently used by an operator through the coordinated triggering of the two housings.

In some examples, the moving body 20 may include a receiving portion 21 (see fig. 9). The housing 21 may be used to house the monitoring device 800. In some examples, the monitoring device 800 may be releasably retained to the receptacle 21. In this case, the monitoring device 800 can be moved together by driving the moving body 20, and the monitoring device 800 can be left in the host for monitoring by detaching the monitoring device 800 from the housing portion 21 after the monitoring device 800 is applied to the host.

In some examples, the monitoring device 800 applied to the host may stay on the host off the hold of the moving body 20. Thus, the monitoring device 800 applied to the host may monitor the physiological parameter of the host. In some examples, the monitoring device 800 applied to the host may adhere to the body surface of the host. When the operator removes the applicator 100 from the body surface of the host, the monitoring device 800 may adhere to the body surface of the host and be detached from the housing portion 21.

In some examples, as previously described, the applicator 100 may include a piercing member 40 (see fig. 8 or 9). The piercing member 40 may introduce the monitoring device 800 partially subcutaneously into the host. In some examples, piercing member 40 may be provided to moving body 20. When the moving body 20 is movable toward the proximal end 101 after being released, the penetrating member 40 and the receiving portion 21 provided to the moving body 20 are also moved toward the proximal end 101 to apply the monitoring device 800 received in the receiving portion 21 to the host, and the penetrating member 40 may place the monitoring device 800 at least partially under the skin of the host.

In some examples, piercing member 40 may be releasably disposed to moving body 20. The penetrating member 40 is movable relative to the moving body 20 when released. For example, the penetrating member 40 may be moved in a direction away from the host relative to the moving body 20 when released. Thereby, the puncture member 40 can be separated from the host.

In some examples, the applicator 100 may include a drive mechanism 50 (see fig. 8). The moving body 20, when released, can move with the piercing member 40 toward the proximal end 101 under the influence of the drive mechanism 50 to apply the monitoring device 800 to the host and at least partially subcutaneously in the host. In this case, the driving action can be provided relatively precisely by the driving mechanism 50, so that the penetration force and penetration depth of the penetration member 40 during the application can be controlled more precisely, whereby the monitoring device 800 can be advantageously applied to the host accurately.

In some examples, the drive mechanism 50 may include a first drive portion 51 (see fig. 9). The first driving part 51 may be configured to drive the moving body 20. In some examples, the first drive portion 51 may apply an effect to the moving body 20 in a manner toward the proximal end 101. When the moving body 20 is released, the moving body 20 may be driven toward the proximal end 101 by the first driving portion 51 to push the monitoring device 800 accommodated in the accommodating portion 21 toward the host.

In other examples, the applicator 100 may not include the first drive portion 51. In this case, when the moving body 20 is released, the moving body 20 may also be manually driven to move toward the proximal end 101.

In some examples, the drive mechanism 50 may include a second drive portion 52 (see fig. 9). The second drive portion 52 may be configured to drive the piercing member 40. In some examples, the second driver 52 may apply an action to the penetrating member 40 in a manner toward the distal end 102. When the piercing member 40 is released, the piercing member 40 may be moved toward the distal end 102 by the second drive 52 to unseat the piercing member 40 from the host. In this case, the timing at which the puncture member 40 leaves the host can be controlled more accurately by the retracting operation of the puncture member 40 by the second driving section 52.

In other examples, the applicator 100 may not include the second drive portion 52. In this case, the penetrating member 40 may be manually driven away from the host. For example, in some examples, piercing member 40 may also be integrally connected with moving body 20, with piercing member 40 being moved away from the host by manually moving body 20 in a direction away from the host.

In some examples, the applicator 100 may include a drive mechanism 7 (see fig. 8). In some examples, the transmission mechanism 7 may abut against one end of the moving body 20 toward the distal end 102, and both ends of the first driving part 51 may abut against the transmission mechanism 7 and the first housing 10, respectively. In this case, the first driving portion 51 can exert an action toward the proximal end 101 on the moving body 20 through the transmission mechanism 7. In some examples, the transmission mechanism 7 may house the piercing member 40 that moves toward the distal end 102 after being released. In this case, the puncture member 40 after being moved toward the distal end 102 can be facilitated to be stably held inside the first housing 10 by the transmission mechanism 7.

Fig. 10 is a schematic diagram showing the first housing 10 to which the examples of the present disclosure relate. Fig. 11 is a schematic diagram showing the second housing 30 according to the example of the present disclosure. Fig. 12 is a schematic diagram showing the moving body 20 to which the examples of the present disclosure relate. Fig. 13 is a schematic sectional view showing an assembled first housing 10, second housing 30, and moving body 20 according to an example of the present disclosure.

In some examples, one or more rib-like projections 11 (see fig. 10) extending substantially in the direction of the central axis CA may be provided on the inner wall of the first housing 10. In some examples, the rib-like protrusions 11 may act as reinforcing ribs to effectively enhance the deformation resistance of the first housing 10. In some examples, the rib-like protrusions 11 may also serve as guide ribs to facilitate assembly of the first housing 10 with the second housing 30. Wherein the guide ribs also help to inhibit undesired rotation of the second housing 30 within the first housing 10.

In some examples, male and female mechanical mating structures may be provided on the inner wall of the first housing 10 and the outer wall of the second housing 30. In some examples, the male and female mechanical mating structures may be male and female mating structures. For example, in some examples, one or more rib-like protrusions 11 may be provided on an inner wall of the first housing 10, and one or more rib-like grooves 32 may be provided on an outer wall of the second housing 30 (see fig. 10 and 11). In some examples, when the second housing 30 is assembled to the first housing 10, the one or more rib-like protrusions 11 of the first housing 10 may be respectively embedded in the one or more rib-like grooves 32 of the second housing 30. In this case, the fitting of the first housing 10 and the second housing 30 can be facilitated by the fitting of the rib-like projections 11 and the rib-like grooves 32, on the one hand, the direction of the relative movement of the first housing 10 and the second housing 30 can be guided by the rib-like projections 11 and the rib-like grooves 32, on the other hand, and further, the undesired rotation of the second housing 30 can be suppressed by the fitting of the rib-like projections 11 and the rib-like grooves 32. In some examples, the plurality of rib-like protrusions 11 provided on the inner wall of the first housing 10 may be uniformly or symmetrically distributed on the inner wall of the first housing 10.

In some examples, the rib-like protrusions 11 provided on the inner wall of the first housing 10 may be formed with a concave structure, and the rib-like grooves 32 provided on the outer wall of the second housing 30 may be formed with a convex structure. When the second housing 30 is assembled to the first housing 10, the rib-like protrusions 11 of the first housing 10 may be located in the rib-like grooves 32 of the second housing 30, and the protrusion structures in the rib-like grooves 32 may be located in the recess structures in the rib-like protrusions 11. This can further improve the stability of the assembly of the first housing 10 and the second housing 30, and can further define the guide path, thereby facilitating more accurate direction guidance when the first housing 10 and the second housing 30 move relative to each other.

In some examples, as described above, the moving body 20 may be releasably held to the first housing 10. In some examples, the first housing 10 may include a first retention portion 12 (see fig. 10). The first retaining portion 12 may be configured to releasably retain the moving body 20. In some examples, the first retaining portion 12 may be provided to an inner wall of the first housing 10. For example, in some examples, the first holding portion 12 may be a convex structure formed on an inner wall of the first housing 10.

In some examples, the moving body 20 may include a first locking portion 23 (see fig. 12). Wherein the first locking portion 23 may be configured to be releasably interlocked with the first holding portion 12. Thereby, the moving body 20 can be releasably held to the first holding portion 12 by the engagement of the first locking portion 23 with the first holding portion 12. In some examples, the motion body 20 may include a sidewall 22. In some examples, the first locking portion 23 may be provided to the side wall 22 of the moving body 20.

In some examples, the interlock between the first retaining portion 12 and the retained member may be achieved by at least one of a snap, hook, latch, or pin arrangement. For example, in some examples, the interlock between the first retaining portion 12 and the first locking portion 23 may be achieved by at least one of a snap, hook, latch, or pin arrangement. In this case, the first holding portion 12 and the first locking portion 23 are releasably interlocked by at least one of a snap, a hook, a latch, or a pin, whereby an interlocking manner that facilitates release can be provided.

In some examples, as previously described, the first holding portion 12 may be a convex structure formed on an inner wall of the first housing 10 (see fig. 10). In some examples, the first locking portion 23 engages with the convex structure when the moving body 20 is held to the first holding portion 12. The first locking portion 23 may be separated from the first holding portion 12 by deflecting the first locking portion 23 in a direction away from the first holding portion 12. Since the target member is generally manufactured by adjusting a material or an adjusting structure in order to allow the target member to be offset, for example, using a soft material or by providing a target member having a certain length, such a target member can be offset by an external force, in the present disclosure, in order to allow the first housing 10 to protect an internal structure, the first housing 10 is generally manufactured using a harder material, in which case the first holding portion 12 is provided as a convex structure formed on an inner wall of the first housing 10 as compared with the first holding portion 12 having a certain length provided inside the first housing 10, which can reduce a space required for providing the first holding portion 12 while reducing difficulty of the manufacturing process of the first housing 10, thereby contributing to miniaturization of the applying apparatus 100 and facilitating use by an operator.

In some examples, the first retaining portion 12 may have a surface facing the distal end 102, and the first locking portion 23 may have a surface facing the proximal end 101, and the surface of the first retaining portion 12 facing the distal end 102 and the surface of the first locking portion 23 facing the proximal end 101 may engage with each other when the moving body 20 is retained. In some examples, the surface of the first retaining portion 12 facing the distal end 102 and the surface of the first locking portion 23 facing the proximal end 101 may be separated from each other when the moving body 20 is released.

In some examples, the first locking portion 23 may include an arm 230 extending substantially in the direction of the central axis CA (for convenience of reading, the arm will be hereinafter referred to as a first arm 230), and a protrusion 231 (for convenience of reading, the protrusion 231 will be hereinafter referred to as a first protrusion 231) that is coupled with the first arm 230 and protrudes away from the central axis CA in a direction substantially orthogonal to the central axis CA (for convenience of reading). In some examples, the first arm 230 may be formed on the sidewall 22 of the moving body 20. In this case, when the first protrusion 231 of the first locking portion 23 overlaps the first holding portion 12, by actuating the first protrusion 231 to move toward the central axis CA, the first protrusion 231 no longer overlaps the first holding portion 12 (i.e., the first locking portion 23 is separated from the first holding portion 12), thereby enabling the first locking portion 23 to be released from the first holding portion 12 conveniently.

In some examples, the first arm 230 may have elasticity. In some examples, the first arm 230 may have elasticity in a direction substantially orthogonal to the central axis CA. In some examples, the first arm 230 may tend to expand away from the central axis CA in a direction from the proximal end 101 to the distal end 102. That is, in a natural state (i.e., in a state in which no external force is applied), the end of the first arm 230 near the proximal end 101 is closer to the central axis CA than the end of the first arm 230 near the distal end 102. In other examples, the first arm 230 may also be substantially parallel to the central axis CA. In some examples, the first arm 230 may pivot when the first arm 230 is acted upon in a direction generally orthogonal to the central axis CA. For example, when first arm 230 is acted upon in a direction generally orthogonal to central axis CA in a direction toward central axis CA, first arm 230 may deflect such that an end of first arm 230 proximate distal end 102 moves toward central axis CA. Thereby, the moving body 20 can be released with ease.

In some examples, the first arm 230 may expand in a direction away from the central axis CA in a direction from the proximal end 101 to the distal end 102, and the first protrusion 231 of the first locking portion 23 may protrude in a direction away from the central axis CA. In this case, interlocking with the first holding portion 12 can be formed on the outside (away from the central axis CA) by expanding the first locking portion 23 as a whole outward, and the first locking portion 23 can be disengaged from the first holding portion 12 by actuating the first locking portion 23 toward the inside (close to the central axis CA) to be released.

In some examples, the first protrusion 231 may have a surface facing the proximal end 101. In some examples, the surface of the first projection 231 facing the proximal end 101 may be substantially orthogonal to the central axis CA. The first locking portion 23 may be held by overlapping/abutting against the surface of the first holding portion 12 facing the distal end 102. Thereby, the movement of the moving body 20 toward the proximal end 101 can be facilitated to be suppressed. The first locking portion 23 is released when the first locking portion 23 is actuated such that the proximally 101 facing surface of the first protrusion 231 is out of position, i.e. no longer overlapping the distally 102 facing surface of the first holding portion 12. That is, the first locking portion 23 may be a catch, a hook, a latch, or a pin formed on the moving body 20. For example, the first locking portion 23 may be formed in a structure that is at least split into two parts, such as a finger, a straight, an L-shape, a J-shape, or a Z-shape, and at least one part thereof (for example, the first arm 230 connected to the side wall 22 of the moving body 20) may pivot, and the other part thereof (for example, a convex structure protruding outward from the first arm 230 and abutting the first holding portion 12) may be separated from the initial position along with the pivot, thereby releasing the hook, the catch, the latch, the roof, the support, and the like of the held member.

In some examples, the number of first retainers 12 may be one or more. For example, the number of first holding parts 12 may be 1,2,3, or 4. Correspondingly, the number of the first locking portions 23 may be identical to the number of the first holding portions 12. In the embodiment shown in fig. 12, the number of the first locking parts 23 is 2, and two first locking parts 23 may be symmetrically distributed at opposite sides of the moving body 20. This can help to stably hold the moving body 20 and improve the reliability of the applicator 100.

In some examples, as described above, the first housing 10 and the second housing 30 may be relatively moved to release the moving body 20. In some examples, the second housing 30 may include a first trigger 33. The first triggering portion 33 may be configured to separate the first holding portion 12 from the first locking portion 23 to release the moving body 20. Thereby, the release of the moving body 20 by the relative movement of the two housings can be facilitated by the first triggering part 33.

In some examples, the second housing 30 and the first housing 10 may be relatively moved in a manner to approach each other to release the holding of the moving body 20 by the first holding portion 12. In some examples, the first housing 10 and the second housing 30 may be relatively moved in the direction of the central axis CA to release the holding of the moving body 20 by the first holding portion 12. In this case, the first locking portion 23 and the first holding portion 12 can be separated by the first triggering portion 33 by relatively moving the two housings in the direction of the central axis CA, which can be convenient for the operator to use. In the example shown in fig. 13, the relative movement of the first housing 10 and the second housing 30 in a manner approaching each other may include the first housing 10 moving in the direction F1 (i.e., moving in a direction approaching the proximal end 101), the second housing 30 moving in the direction F2 (i.e., moving in a direction approaching the distal end 102), or the first housing 10 moving in the direction F1 while the second housing 30 moves in the direction F2.

In some examples, the first triggering part 33 may be formed on a sidewall of the second housing 30. In some examples, the first trigger 33 may include a trigger arm 330 (see fig. 11) extending generally along the direction of the central axis CA. When the first housing 10 and the second housing 30 are relatively moved, the trigger arm 330 may act on the first locking portion 23 to separate the first locking portion 23 from the first holding portion 12.

In some examples, the first locking portion 23 may include a protrusion 232 protruding away from the central axis CA in a direction substantially orthogonal to the central axis CA (for convenience of reading, the protrusion 232 will be hereinafter referred to as a second protrusion 232) (see fig. 12). The second protrusion 232 may be provided on the first arm 230. In some examples, the first trigger 33 may apply an action to the second protrusion 232 to offset the first arm 230.

In some examples, the second protrusion 232 may have a surface facing the proximal end 101. In some examples, the trigger arm 330 may have a surface facing the distal end 102. When the first casing 10 and the second casing 30 are relatively moved in a manner approaching each other, the first trigger portion 33 is moved to abut against the second protrusion 232 so that the distal end 102-facing surface of the trigger arm 330 is brought into contact with the proximal end 101-facing surface of the second protrusion 232, and the second protrusion 232 is pressed to gradually deflect the first arm 230 in a direction approaching the central axis CA during the continued movement, and when the first arm 230 is deflected to leave the first holding portion 12, the moving body 20 is in a released state. Thereby, unlocking the moving body 20 by the relative movement of the first and second housings 10 and 30 can be facilitated, thereby facilitating the use of the operator.

In some examples, the surface of the second protrusion 232 facing the proximal end 101 and/or the surface of the trigger arm 330 facing the distal end 102 may be an inclined or curved surface. In this case, the second protrusion 232 can be moved by the trigger arm 330 when abutting against the trigger arm 330.

In some examples, when the moving body 20 is held to the first holding portion 12, the second protrusion 232 is closer to the first trigger portion 33 than both the first protrusion 231 and the second protrusion 232. That is, when the moving body 20 is held to the first holding portion 12, the second protrusion 232 is closer to the proximal end 101 than the first protrusion 231 is to the second protrusion 232 in the direction from the proximal end 101 to the distal end 102. In this case, unlocking of the moving body 20 by the relative movement of the first and second housings 10 and 30 in a manner approaching each other can be facilitated.

In some examples, the first protrusion 231 and the second protrusion 232 may be disposed offset in a vertical direction and/or a horizontal direction. The staggered arrangement of the first protrusion 231 and the second protrusion 232 in the vertical direction may mean that the axes of the first protrusion 231 and the second protrusion 232 in the vertical direction do not overlap, or that the first protrusion 231 and the second protrusion 232 do not overlap each other when projected along the vertical direction, and the staggered arrangement in the horizontal direction is the same as the staggered arrangement in the vertical direction. In this case, since the first protrusion 231, the second protrusion 232, the first holding portion 12 of the first housing 10, and the trigger arm 330 of the second housing 30 are associated with each other, it is necessary to consider the positional relationship of the respective components with each other in design, and also consider the utilization rate of the internal space of the first housing 10, in this embodiment, the first protrusion 231 and the second protrusion 232 are arranged to be offset in the vertical direction and/or the horizontal direction, and compared with the case where the two protrusions are arranged on the same axis, it is possible to save space, improve the integration of the internal structure of the application device 100, and contribute to the miniaturization of the application device 100.

In some examples, the first protrusion 231 and the second protrusion 232 may be disposed to be offset in both the vertical direction and the horizontal direction, and when the moving body 20 is held to the first holding portion 12, the first holding portion 12 may be horizontally adjacent to the second protrusion 232 and in contact with the first protrusion 231, and at this time, the first holding portion 12 may overlap with the first protrusion 231 in the vertical direction. In this case, when the first protrusion 231 is actuated to disengage from the first holding portion 12, the second protrusion 232 and the trigger arm 330 are not in the path of the first protrusion 231 moving toward the proximal end 101, facilitating the smooth actuation of the moving body 20 to the host.

In some examples, the number of second protrusions 232 in one first locking portion 23 may be one or more. For example, the number of the second protrusions 232 may be 1,2,3, or 4. In the embodiment shown in fig. 12, the number of the second protrusions 232 is 4 (one of the second protrusions 232 is not shown because of a viewing angle problem), and the 4 second protrusions 232 are disposed on the first locking portion 23 two by two. Correspondingly, the number of the first triggering parts 33 may be identical to the number of the second protrusions 232. In the embodiment shown in fig. 11, the number of the first triggering parts 33 is 4, and the 4 first triggering parts 33 correspond to the positions of the 4 second protrusions 232. In this case, it is possible to facilitate separation of the first locking portion 23 and the first holding portion 12 by the first triggering portion 33 exerting an action on the second protrusion 232 when the two housings are relatively moved.

Fig. 14 is a schematic cross-sectional view showing the first locking portion 23 according to the example of the present disclosure before being triggered by the first trigger portion 33. Fig. 15 is a schematic cross-sectional view showing the first locking portion 23 according to the example of the present disclosure after being triggered by the first trigger portion 33. Fig. 14 and 15 are enlarged views of the region a in fig. 13, and fig. 14 and 15 mainly show the triggering of the first locking portion 23 by the first triggering portion 33, so that lines which may cause shielding are omitted for more clear illustration, and gaps between the respective members are enlarged, and fig. 15 shows only the first holding portion 12, the first locking portion 23, and the first triggering portion 33 for more clear illustration, and specific structural details of these members can be seen in fig. 14.

Hereinafter, the triggering of the first locking portion 23 by the first triggering portion 33 will be described in detail with reference to fig. 14 and 15. As described above, before the first triggering portion 33 actuates the first locking portion 23, the first locking portion 23 contacts the first holding portion 12, the first holding portion 12 can restrict the movement of the first locking portion 23 toward the proximal end 101 to hold the moving body 20 (see fig. 14), when the first triggering portion 33 actuates the first locking portion 23 (for example, when the two housings relatively move toward each other), the first arm 230 and the first protrusion 231 gradually retract inward (i.e., move toward the central axis CA) under the action of the first triggering portion 33, and when the first protrusion 231 is moved to be separated from the first holding portion 12, the moving body 20 can be released (see fig. 15).

In some examples, moving body 20 may move toward proximal end 101 after being released. In some examples, when the moving body 20 applies the monitoring device 800 to the host, the end of the moving body 20 near the proximal end 101 may be flush with the proximal end 101 of the application device 100. Thereby, it is possible to facilitate application of the monitoring device 800 located in the housing portion 21 to the host.

In some examples, the first retaining portion 12 has a surface facing the proximal end 101. In some examples, the first trigger portion 33 has a first surface 331 and a second surface 332 (see fig. 14) facing the distal end 102. Wherein the first surface 331 may face the first locking portion 23 and the second surface 332 may face the first holding portion 12. When the first housing 10 and the second housing 30 are relatively moved in a manner approaching each other, the first surface 331 may be brought into contact with the first locking portion 23 during travel to exert an effect on the first locking portion 23, and the second surface 332 may be brought into contact with the surface of the first holding portion 12 facing the proximal end 101 during continued travel. Thereby, it is possible to facilitate the application of an action toward the center axis CA to the first locking portion 23 to separate the first locking portion 23 from the first holding portion 12.

In some examples, the first triggering portion 33 may act on the first locking portion 23 to separate the first locking portion 23 from the first holding portion 12 when the first housing 10 and the second housing 30 are relatively moved in the direction of the central axis CA. In this case, the first locking portion 23 and the first holding portion 12 can be separated by the first triggering portion 33 by relatively moving the two housings in the direction of the central axis CA, which can be convenient for the operator to use.

In some examples, the proximal surface 31 of the second housing 30 may be placed on the skin of the host, an action directed toward the host may be applied to the first housing 10 (e.g., an operator presses the first housing 10 toward the host), the first housing 10 and the second housing 30 may be moved relatively toward each other, thereby releasing the moving body 20, the moving body 20 may be moved toward the proximal end 101 with the piercing member 40 after being released to apply the monitoring device 800 to the body surface of the host, and at least a portion of the monitoring device 800 may be introduced subcutaneously into the host via the piercing member 40. Thereby, the host one-handed operation of the applicator 100 can be facilitated.

In some examples, the second housing 30 may include one or more protruding structures 391 (see fig. 11). In some examples, the protruding structure 391 may protrude from the inner wall of the second housing 30 in a direction substantially orthogonal to the central axis CA toward a direction away from the central axis CA. In some examples, the protruding structure 391 may be a clearance fit with an inner wall of the first housing 10. In this case, the protrusion structure 391 can help to suppress the occurrence of undesired shaking and/or rotation of the second housing 30 inside the first housing 10, thereby improving the reliability of the applying apparatus 100. In some examples, the plurality of protruding structures 391 may be disposed dispersedly at the outer circumference of the second housing 30.

In some examples, the first housing 10 may include a first restriction 13 (see fig. 10). The first restriction portion 13 may restrict the second housing 30 to prevent the second housing 30 from being separated from the first housing 10. This can help to improve the reliability of the applicator 100. That is, in some examples, the first housing 10 may include a first restraining portion 13 configured to restrain the second housing 30 from being detached from the first housing 10.

In some examples, the first limiting portion 13 may be a convex structure formed on an inner wall of the first housing 10 (see fig. 10).

In some examples, the second housing 30 may include a first restriction 34 (see fig. 11). The first restriction 34 may be coupled to the first restriction 13. In some examples, the first restriction 34 may be provided on a side wall of the second housing 30. In some examples, the interlock between the first restriction 13 and the first restriction 34 may be achieved by at least one of a snap, a hook, a latch, or a pin structure.

In some examples, the first restricted portion 34 may be coupled with the first restricted portion 13 when the moving body 20 is held to the first holding portion 12. Accordingly, the second housing 30 can be restricted in the standby state in which the moving body 20 is held by the first holding portion 12, and the second housing 30 can be prevented from being separated from the first housing 10.

In some examples, the first limiter 13 may have a surface facing the distal end 102. In some examples, the first constrained portion 34 may have a surface facing the proximal end 101. When the moving body 20 is held to the first holding portion 12, the surface of the first restriction portion 13 facing the distal end 102 may be engaged with the surface of the first restriction portion 34 facing the proximal end 101. In some examples, when moving body 20 is held to first holding portion 12, first constrained portion 34 is closer to distal end 102 than first constrained portion 13.

In some examples, the first restricted portion 34 may include an extension portion 340 extending generally along the direction of the central axis CA, and a snap-fit portion 341 (see fig. 11) that is in linkage with the extension portion 340. When the engagement portion 341 engages with the first limiting portion 13, the second housing 30 may be limited by the first housing 10.

In some examples, the first housing 10 may include a second restriction 14 (see fig. 10). The second restriction portion 14 may impose restriction on the second housing 30. Specifically, the second restriction portion 14 may be configured to inhibit movement of the second housing 30 toward the proximal end 101, and the second housing 30 may be restricted by the second restriction portion 14 after the first housing 10 and the second housing 30 are relatively moved to release the moving body 20. In this case, the movement of the second housing 30 toward the proximal end 101 can be restricted by the second restriction portion 14, so that the operator can be restrained from re-using the application device 100, and the risk of the used piercing member 40 not subjected to secondary sterilization coming into contact with the host again can be reduced. In some examples, the second restriction portion 14 may be a convex structure formed on an inner wall of the first housing 10.

In some examples, the second housing 30 may include a second restriction 35 (see fig. 11). The second restriction 35 may be configured to interlock with the second restriction 14. Thereby, the second housing 30 can be held by the first holding portion 12 by the engagement of the second restriction portion 35 with the second restriction portion 14. Specifically, after the relative movement of the first casing 10 and the second casing 30 releases the holding of the moving body 20 by the first holding portion 12, the second restriction portion 35 may be engaged with the second restriction portion 14.

In some examples, the second constrained portion 35 is closer to the proximal end 101 than the second constrained portion 14 when the moving body 20 is held to the first holding portion 12, and the second constrained portion 35 is closer to the distal end 102 than the second constrained portion 14 when the moving body 20 is in the released state. In some examples, the interlock between the second restriction 14 and the second restriction 35 may be achieved by at least one of a snap, a hook, a latch, or a pin structure.

In some examples, the second limiter 14 may have a surface facing the distal end 102. In some examples, the second restriction 35 may have a surface facing the proximal end 101. When the second housing 30 is held, the surface of the second restriction portion 14 facing the distal end 102 and the surface of the second restriction portion 35 facing the proximal end 101 may be engaged with each other.

In some examples, the structure of the second restricted portion 35 may be identical to the structure of the first restricted portion 34. That is, the second restricted portion 35 may also include an extension portion 340 and a clamping portion 341. In some examples, the first restriction 34 and the second restriction 35 may be the same structure. That is, the first restriction portion 34 may cooperate with the second restriction portion 14 in addition to the first restriction portion 13 to hold the second housing 30. In other words, in some examples, the first limiter 34 may be configured to cooperate with the second limiter 14 to retain the second housing 30. This can help simplify the structure of the applicator 100.

In some examples, the first restrictions 34 may form a similar H-shaped structure or arch-shaped structure (see fig. 11). In this case, the second housing 30 is restricted by the first restriction portion 13 or the second restriction portion 14 by overlapping the cross bar structure in the first restriction portion 34 with the first restriction portion 13 or the second restriction portion 14. In some examples, the extension 340 and the clip 341 may cooperate to form a structure similar to an H-shape or arch. The extending portion 340 may form an H-shaped structure or a vertical structure in an arch-shaped structure, and the clamping portion 341 may form a cross bar structure in the H-shaped structure. In this case, on the one hand, the engagement of the vertical structure helps to suppress the undesired rotation of the second housing in the first housing, and on the other hand, the structure formed by the extending portion 340 and the engaging portion 341 is a single-layer structure in the same thickness direction as the structure formed by the extending portion 340 and the engaging portion 341 in the L-shaped structure, and the L-shaped structure is a double-layer structure, so that the provision of the single-layer structure helps to reduce the space required in the same width direction of the application device 100 as compared to the provision of the double-layer structure, thereby facilitating the engagement with other members to form a compact structure, and improving the utilization rate of the space inside the first housing. In other examples, the extension portion 340 and the engagement portion 341 may cooperate to form an L-shaped, J-shaped, or Z-shaped structure.

In other examples, the extension 340 may be an arm (for convenience of reading, the arm will be referred to as a second arm hereinafter) extending in the direction of the central axis CA (see fig. 11). In some examples, the clip 341 may be provided to the extension 340 (see fig. 11). In this case, the extension 340 and the engagement portion 341 can be facilitated to cooperate to form a structure that can be coupled with the first restriction portion 13 and the second restriction portion 14. In some examples, the clip 341 and the extension 340 may be integrally formed.

In some examples, the second arm may have elasticity. In some examples, the second arm may have elasticity in a direction substantially orthogonal to the central axis CA. In some examples, the second arm may tend to expand away from the central axis CA in a direction from the proximal end 101 to the distal end 102. That is, in a natural state (i.e., in a state in which no external force is applied), the end of the second arm near the proximal end 101 is closer to the central axis CA than the end of the second arm near the distal end 102. In other examples, the second arm may also be substantially parallel to the central axis CA.

In some examples, the second arm may pivot when acted upon in a direction generally orthogonal to the central axis CA. For example, when the second arm is acted upon in a direction generally orthogonal to the central axis CA in a direction toward the central axis CA, the second arm may deflect such that an end of the second arm proximal to the distal end 102 moves in a direction toward the central axis CA. In this case, when the first housing 10 and the second housing 30 move relatively toward each other, the second arm can be deflected so that the engagement portion 341 straddles the second restriction portion 14 and overlaps the second restriction portion 14.

In some examples, the second arm may be formed on a sidewall of the second housing 30. In some examples, the second arm may also be provided as part of a side wall of the second housing 30. The second housing 30 can be held when the engagement portion 341 of the second restriction portion 35 overlaps the second restriction portion 14.

In some examples, the second arm may expand in a direction away from the central axis CA in a direction from the proximal end 101 to the distal end 102, and the clip portion 341 may protrude in a direction away from the central axis CA. In this case, interlocking with the second restriction portion 14 can be formed on the outside (away from the central axis CA) by expanding the second restriction portion 35 integrally outward.

In some examples, the second limiter 14 may have a surface facing the proximal end 101. In some examples, the clip 341 may have a surface facing the distal end 102. When the first housing 10 and the second housing 30 relatively move in a manner of approaching each other, the surface of the clamping portion 341 facing the distal end 102 is first in contact with the surface of the second limiting portion 14 facing the proximal end 101, and during the continued movement, the clamping portion 341 is pressed by the second limiting portion 14 to be deflected in a direction approaching the central axis CA as a whole, and when the surface of the clamping portion 341 facing the proximal end 101 is moved closer to the distal end 102 than the surface of the second limiting portion 14 facing the distal end 102, the clamping portion 341 is expanded outward by being pressed by the second limiting portion 14, so that the surface of the second limiting portion 14 facing the distal end 102 and the surface of the clamping portion 341 facing the proximal end 101 are engaged with each other to hold the second housing 30.

In some examples, the surface of the second limiter 14 facing the proximal end 101 and/or the surface of the clip 341 facing the distal end 102 may be an inclined or curved surface. In this case, when the two housings are moved relatively, the engagement portion 341 can smoothly ride over the surface of the second restriction portion 14 facing the proximal end 101 and overlap the second restriction portion 14 when pressed by the second restriction portion 14.

In some examples, the first restriction 34 may be separated from the first restriction 13 after the moving body 20 is released. In some examples, the second housing 30 may be held to the second restriction 14 via the second restriction 35 after the moving body 20 is released.

In some examples, the first restriction 13 may be configured to conform to the second restriction 14. In some examples, the first restriction portion 13 may be disposed adjacent to the second restriction portion 14 in a direction along the central axis CA. In some examples, the first restriction 13 is closer to the proximal end 101 than the second restriction 14. In this case, the second housing 30 can be restricted to the first housing 10 via the engagement of the first restriction portion 34 with the first restriction portion 13 before the moving body 20 is released, and the second housing 30 can be restricted to the first housing 10 via the engagement of the first restriction portion 34 with the second restriction portion 14 after the moving body 20 is released by the relative movement of the first housing 10 and the second housing 30 in such a manner as to approach each other.

In some examples, the number of first restrictions 13 may be one or more. For example, the number of the first limiting portions 13 may be 1, 2, 3, or 4. The number of the first restricted portion 34 and the first restricted portion 13 may be identical. In some examples, the number of second restrictions 14 may be one or more. For example, the number of the second limiting portions 14 may be 1, 2, 3, or 4.

Fig. 16 is a schematic cross-sectional view showing that the first restriction portion 34 according to the example of the present disclosure is not engaged with the second restriction portion 14. Fig. 17 is a schematic cross-sectional view showing engagement of the first restriction portion 34 with the second restriction portion 14 in accordance with an example of the present disclosure. Note that, in fig. 16 and 17, the cooperation of the first limiting portion 34, the first limiting portion 13, and the second limiting portion 14 is mainly illustrated, and some lines that may cause shielding or misunderstanding are omitted.

Hereinafter, referring to fig. 16 and 17, the engagement of the first restriction portion 34, the first restriction portion 13, and the second restriction portion 14 will be described in detail. As described above, before the first trigger portion 33 actuates the first locking portion 23 (i.e., in a standby state in which the moving body 20 is held by the first holding portion 12), the first restricted portion 34 may be engaged with the first restricting portion 13, movement of the second housing 30 toward the proximal end 101 may be restricted by the first restricting portion 13 (see fig. 16), when the two housings are relatively moved in a direction approaching each other along the central axis CA, the first restricted portion 34 is pressed inward by the second restricting portion 14, the second arm and the engaging portion 341 are gradually retracted inward (i.e., moved in a direction approaching the central axis CA), and when the surface of the engaging portion 341 facing the proximal end 101 is moved higher than the surface of the second restricting portion 14 facing the distal end 102, the engaging portion 341 is released from the pressing of the second restricting portion 14 to expand, so that the surface of the second restricting portion 14 facing the distal end 102 and the surface of the engaging portion 341 facing the proximal end 101 are mutually engaged to hold the second housing 30 (see fig. 17).

In some examples, the second restriction portion 14 may not be provided. In this case, after the action of relatively moving the first casing 10 and the second casing 30 is stopped, the second casing 30 and the first casing 10 can be automatically restored to the standby position for the next use. In the example of reusable applicator 100, needle 41 and abutment 43 in piercing member 40 may be configured to be removably engaged, and after one application action is completed, needle 41 may be removed from abutment 43, replaced with a new sterilized needle 41, and new monitoring device 800 assembled to applicator 100 for the next use.

In some examples, male and female mechanical mating structures may be provided on the side walls of the second housing 30 and the side walls 22 of the moving body 20. In some examples, the second housing 30 may include a third engagement feature 38 and the moving body 20 may include a fourth engagement feature 28 (see fig. 11 and 12). The mating of the third engagement feature 38 with the fourth engagement feature 28 may form a male-female mechanical mating structure. In some examples, the male and female mechanical mating structures may be male and female mating structures. In some examples, the third engagement feature 38 may be one or more rib-like protrusions provided on the side wall of the second housing 30 and the fourth engagement feature 28 may be one or more rib-like grooves provided on the side wall 22 of the moving body 20 (see fig. 11 and 12). In some examples, when the moving body 20 is assembled to the second housing 30, the one or more rib-like protrusions of the second housing 30 may be respectively inserted into the one or more rib-like grooves of the moving body 20. In this case, on the one hand, the fitting of the second housing 30 with the moving body 20 can be facilitated by the fitting of the rib-like projections with the rib-like grooves, on the other hand, the moving direction of the moving body 20 can also be guided by the rib-like projections with the rib-like grooves, and furthermore, the undesired rotation of the moving body 20 can also be suppressed by the fitting of the rib-like projections with the rib-like grooves.

In some examples, the plurality of rib-like protrusions provided on the sidewall of the second housing 30 may be uniformly or symmetrically distributed on the sidewall of the second housing 30.

In some examples, the second housing 30 may include a third restriction 36 (see fig. 11). The third restriction portion 36 may impose restriction on the moving body 20. In some examples, third limiter 36 may be located at least partially on a travel track of movement of motion body 20 toward proximal end 101. In this case, when the movement body 20 moves to the proximal end 101 to the third restricting portion 36, the movement body 20 can be stopped by restricting the movement body 20 by the third restricting portion 36, and the monitoring device 800 can be applied to a predetermined position, and the detachment of the movement body 20 from the second housing 30 can be suppressed. Thereby, the reliability of the applying device 100 can be improved.

In some examples, the motion body 20 may include a third restriction 24 (see fig. 12). The third restriction portion 24 may be coupled with the third restriction portion 36 to restrict the moving body 20 to the second housing 30. In some examples, the interlock between the third restriction 36 and the third restriction 24 may be achieved by at least one of a snap, a hook, a latch, or a pin structure. In some examples, the third restriction 36 may be provided on a side wall of the second housing 30. In some examples, the third restriction 24 may be provided on the side wall 22 of the moving body 20.

In some examples, the third limiter 24 is closer to the distal end 102 than the third limiter 36 when the moving body 20 is held to the first holder 12. In some examples, the third limiter 36 may have a surface facing the distal end 102. In some examples, the third restriction 24 may have a surface facing the proximal end 101. When the motion body 20 moves toward the proximal end 101 until the third constrained portion 24 contacts the third constrained portion 36, a surface of the third constrained portion 36 facing the distal end 102 may engage a surface of the third constrained portion 24 facing the proximal end 101.

In some examples, the third restriction 24 may include an arm 240 extending generally along the direction of the central axis CA (for ease of reading, the arm 240 will be referred to hereinafter as the third arm 240), and a protrusion 241 coupled with the third arm 240 and protruding away from the central axis CA in a direction generally orthogonal to the central axis CA) (for ease of reading, the protrusion 241 will be referred to hereinafter as the third protrusion 241). In this case, the movement body 20 can be restrained when the third protrusion 241 of the third restraining portion 24 overlaps the third restraining portion 36.

In some examples, the third arm 240 may have elasticity. In some examples, the third arm 240 may have elasticity in a direction substantially orthogonal to the central axis CA. In some examples, the third arm 240 may pivot when the third arm 240 is acted upon in a direction generally orthogonal to the central axis CA. In this case, the moving body 20 can be easily assembled to the second housing 30. In some examples, the third arm 240 may tend to expand away from the central axis CA in a direction from the proximal end 101 to the distal end 102. In this case, after the moving body 20 and the second housing 30 are assembled in place, the third protrusion 241 can be facilitated to be positioned above the third restriction portion 36, so that the third protrusion 241 can overlap the third restriction portion 36 when the subsequent moving body 20 moves toward the proximal end 101.

In some examples, the axis of the second housing 30 and the axis of the moving body 20 may be substantially parallel to the central axis CA. In some examples, the second housing 30 and the moving body 20 may be coaxially disposed. For example, in fig. 8, the axis of the second housing 30 and the axis of the moving body 20 may overlap with the central axis CA. In some examples, the second housing 30 and the moving body 20 may be disposed to overlap. Specifically, a hollowed-out portion 39 (see fig. 11) may be provided on the second housing 30, and a part of the member (e.g., the first locking portion 23) of the moving body 20 may be inserted from the hollowed-out portion 39. In this case, the internal space utilization of the first housing 10 can be improved, contributing to downsizing of the applicator 100. In some examples, the moving body 20 may be movably embedded in the second housing 30.

In some examples, the number of third restrictions 36 may be one or more. For example, the number of the third restrictions 36 may be 1,2, 3, or 4. The number of third restrictions 24 and 36 may be identical.

In some examples, the motion body 20 may include a sidewall and a first bottom 25 facing the proximal end 101 (see fig. 12). In some examples, the first driving part 51 may be located between the first housing 10 and the moving body 20. Thereby, the first driving portion 51 can be facilitated to apply an action to the moving body 20. For example, in some examples, the first driving part 51 may be located between the first housing 10 and the first bottom 25 of the moving body 20. For another example, in some examples, the first driving part 51 may be located between the first housing 10 and the top of the moving body 20.

In some examples, a first positioning portion 251 for positioning the first driving portion 51 may be provided on the first bottom portion 25. In this case, the position where the first driving part 51 acts on the moving body 20 can be more stably defined by the first positioning part 251.

In some examples, the first positioning portion 251 of the first bottom 25 may be a stepped structure protruding from the first bottom 25 along the central axis CA toward the distal end 102. The first driving part 51 may be located in a groove-shaped space formed by the stepped structure in cooperation with the sidewall of the second housing 30. In some examples, the first driving part 51 may be sleeved on the outer circumference of the sidewall 22 of the moving body 20 and abut against the first positioning part 251.

In some examples, the first positioning part 251 may have a cylindrical shape. In some examples, the first positioning portion 251 may have a solid cylindrical shape, and the first driving portion 51 may be sleeved on the outer circumference of the first positioning portion 251. In other examples, the first positioning portion 251 may have a hollow cylindrical shape, and the first driving portion 51 may be fitted around the outer periphery of the first positioning portion 251 or may be fitted around the inner periphery of the first positioning portion 251.

In some examples, the first driving part 51 may have an energy storage state and an energy release state. When the first driving portion 51 is switched from the energy storage state to the energy release state, the first driving portion 51 may release energy and exert an effect on the moving body 20 in a manner toward the proximal end 101. The first driving part 51 may exist between the moving body 20 and the first housing 10 in an energy storage state when the moving body 20 is held, and the first driving part 51 may be switched from the energy storage state to the energy release state when the moving body 20 is released and exert an effect on the moving body 20 in a manner toward the proximal end 101.

In some examples, the first drive portion 51 may have a compressed state and an extended state, and the first drive portion 51 may release energy when the first drive portion 51 is switched from the compressed state to the extended state. In some examples, the first driving part 51 may be an elastic element. In some examples, both ends of the first driving part 51 may abut against the first housing 10 and the first bottom 25, respectively. The first driving part 51 may be in a compressed state when the moving body 20 is held at the first holding part 12. In this case, when the moving body 20 is released, the first driving part 51 in a compressed state can automatically apply a force to the moving body 20 to thereby achieve automatic pushing of the moving body 20, facilitating use by an operator. In some examples, the first drive portion 51 may be a spring.

In some examples, one end of the first driving part 51 may be sleeved on the first positioning part 251 of the first bottom part 25. In some examples, the first housing 10 may have a second positioning portion 15 (see fig. 10). In some examples, the second positioning portion 15 may have a cylindrical shape. In this case, the other end of the first driving part 51 may be fitted over the second positioning part 15. In some examples, the second positioning portion 15 may have a hollow cylindrical shape. In this case, the other end of the first driving portion 51 may be fitted or embedded in the second positioning portion 15. In some examples, the second positioning portion 15 may be composed of at least two arcuate posts. In this case, the other end of the first driving part 51 may be embedded between the arc-shaped columns.

The applicator 100 of the present embodiment is not limited to this. In some examples, the applicator 100 may not include the first drive portion 51. In this case, when the moving body 20 is released, the moving body 20 may also be moved toward the proximal end 101 by manually applying an action to the moving body 20.

Fig. 18 is an exploded view showing a first perspective of the moving body 20 and the penetration member 40 according to the example of the present disclosure, fig. 19 is an exploded view showing a second perspective of the moving body 20 and the penetration member 40 according to the example of the present disclosure, and fig. 20 is a cross-sectional view showing the penetration member 40 according to the example of the present disclosure when held.

In some examples, the moving body 20 and the piercing member 40 may be fixedly connected as one piece. In other examples, the moving body 20 and the piercing member 40 may be detachably assembled. In some examples, piercing member 40 may be releasably retained by moving body 20.

In some examples, the motion body 20 may include a hollow 26 (see fig. 18). Specifically, the sidewall 22 of the motion body 20 and the first bottom 25 of the motion body 20 facing the proximal end 101 may cooperate to form the hollow 26. In some examples, piercing member 40 may be releasably disposed within hollow portion 26 of moving body 20. In some examples, the piercing member 40 is movable along the hollow 26 of the moving body 20 when released. In this case, the hollow portion 26 is formed by the first bottom portion 25 and the side wall, and the storage portion 21 is provided at the first bottom portion 25, and the puncture member 40 is provided at the hollow portion 26, so that the puncture member 40 can be easily moved relative to the storage portion 21 when released. Thus, when the monitoring device 800 is applied to the host, the puncture member 40 is released and moves relative to the housing 21, so that the puncture member 40 can be moved away from the host.

In some examples, the moving body 20 may include a second through hole 260 (see fig. 19) that communicates the receiving portion 21 and the hollow portion 26. In some examples, the piercing member 40 may be in contact with the monitoring device 800 via the second through hole 260. Thereby, it can be facilitated to introduce the monitoring device 800 at least partially subcutaneously into the host during application via the piercing member 40.

In other examples, piercing member 40 may also be fixedly disposed to moving body 20. In this case, after the monitoring device 800 is applied to the host, the moving body 20 may be entirely separated from the host by means of manpower, whereby the penetration member 40 can also be separated from the host.

In some examples, the second drive portion 52 may be located between the moving body 20 and the piercing member 40. In some examples, the second drive portion 52 may be located between the first base portion 25 and the piercing member 40. The second drive portion 52 may be configured to apply an action to the piercing member 40 toward the distal end 102. When the penetrating member 40 is released, the second driver 52 may apply an action to the penetrating member 40 toward the distal end 102 to unseat the penetrating member 40 from the host. This can help to control the timing of the puncture member 40 from the host more accurately.

In some examples, the second drive portion 52 may have an energy storage state and an energy release state, and when the second drive portion 52 is switched from the energy storage state to the energy release state, the second drive portion 52 may release energy and apply an action to the penetrating member 40 in a manner toward the distal end 102. The second driving part 52 may exist between the moving body 20 and the penetrating member 40 in an energy storage state when the penetrating member 40 is held, and the second driving part 52 may be switched from the energy storage state to the energy release state when the penetrating member 40 is released and apply an action to the penetrating member 40 toward the distal end 102.

In some examples, the second drive portion 52 may have a compressed state and an extended state, and the second drive portion 52 may release energy when the second drive portion 52 is switched from the compressed state to the extended state. In some examples, the second drive portion 52 may be a resilient element. In some examples, both ends of the second driving part 52 may abut against the first bottom 25 and the penetration member 40, respectively. That is, both ends of the second driving part 52 may be respectively abutted against the moving body 20 and the penetration member 40. The second drive portion 52 may be in a compressed state when the piercing member 40 is held. In this case, when the penetration member 40 is released, the second driving part 52 in a compressed state can automatically apply a force to the penetration member 40 to achieve automatic retraction of the penetration member 40, thereby facilitating the use of an operator. In some examples, the second drive 52 may be a spring.

In some examples, as previously described, piercing member 40 may include needle 41 and carrier 42 connected to needle 41 (see fig. 18). In some examples, grooves may be provided on the needle 41 that extend along the length of the needle 41. The sensor 8 may be at least partially disposed within the recess of the needle 41. In this case, the sensor 8 can be received in the groove so as to allow the sensor 8 to follow the needle 41 and be placed under the skin of the host.

In some examples, piercing member 40 may include a bearing seat 43 (see fig. 18) that supports needle 41. The support seat 43 can support the needle 41 via the bearing 42.

In some examples, bearing 43 may be disposed within hollow 26 of moving body 20 and bearing 42 and/or needle 41 may pass through second throughbore 260. In this case, by disposing the bearing portion 42 and/or the needle portion 41 through the second through hole 260, the bearing portion 42 and/or the needle portion 41 can be engaged with the monitoring device 800 housed in the housing portion 21, and it can be facilitated to place the monitoring device 800 at least partially under the skin of the host by the puncture member 40.

In some examples, the moving body 20 may include a third positioning portion 252 (see fig. 18). The third positioning portion 252 may be used to position the second driving portion 52. In this case, the position where the second driving portion 52 acts on the puncture member 40 can be more stably defined by the third positioning portion 252. In some examples, the third positioning portion 252 may be disposed on the first bottom portion 25.

In some examples, one end of the second driving portion 52 may be sleeved on the third positioning portion 252 of the first bottom portion 25. In some examples, the third positioning portion 252 may be cylindrical. In this case, one end of the first driving portion 51 can be fitted over the third positioning portion 252. In some examples, the piercing member 40 may have a fourth location 44 (see fig. 19). In some examples, the fourth positioning portion 44 may be a hollow cylindrical protrusion formed on the support seat 43. In this case, the end of the second driving portion 52 that contacts the puncture member 40 can be fitted over or fitted into the fourth positioning portion 44. In some examples, the third positioning portion 252 and/or the fourth positioning portion 44 may be comprised of at least two arcuate posts. In this case, the end of the first driving part 51 can be embedded between the arc-shaped columns.

In some examples, needle 41 and bearing 43 may be integrally formed. In other examples, needle 41 and bearing 43 may be configured to be removably assembled. This can facilitate the additional sterilization of needle 41.

In some examples, male and female mechanical mating structures may be provided on the inner wall of the moving body 20 and the outer wall of the piercing member 40. In some examples, the moving body 20 may include a fifth engagement feature 29 and the piercing member 40 may include a sixth engagement feature 46 (see fig. 18 and 19). The male and female mechanical mating structures may be formed by the fifth engagement feature 29 mating with the sixth engagement feature 46. In some examples, the male and female mechanical mating structures may be male and female mating structures. In some examples, fifth engagement feature 29 may be one or more rib-like protrusions disposed on an inner wall of moving body 20 and sixth engagement feature 46 may be one or more rib-like grooves disposed on an outer wall of piercing member 40 (see fig. 18 and 19). In some examples, when piercing member 40 is assembled to moving body 20, one or more rib-like projections of moving body 20 may respectively engage one or more rib-like grooves of piercing member 40. In this case, on the one hand, the fitting of the moving body 20 and the puncture member 40 can be facilitated by the fitting of the rib-like projections and the rib-like grooves, on the other hand, the direction in which the puncture member 40 and the moving body 20 move relative to each other can be guided by the rib-like projections and the rib-like grooves, and furthermore, the undesired rotation of the puncture member 40 can be suppressed by the fitting of the rib-like projections and the rib-like grooves. In some examples, the plurality of rib-like protrusions provided on the inner wall of the moving body 20 may be uniformly or symmetrically distributed on the inner wall of the moving body 20.

In some examples, as described above, piercing member 40 may be releasably retained to moving body 20. In some examples, the moving body 20 may include a second holding portion 27 (see fig. 18). The second retaining portion 27 may be configured to releasably retain the piercing member 40. In some examples, the second holding portion 27 may be formed on the side wall 22 of the moving body 20. In some examples, the second holding portion 27 may be a cutout formed on the side wall 22 of the moving body 20 (see fig. 18).

In some examples, the piercing member 40 may include a second locking portion 45. The second locking portion 45 may be configured to be releasably interlocked with the second holding portion 27. Thereby, the puncture member 40 can be releasably held by the second holding portion 27 by the engagement of the second locking portion 45 with the second holding portion 27. In some examples, the second locking portion 45 may be provided on the support seat 43 of the piercing member 40.

In some examples, the second locking portion 45 may include an arm 450 (hereinafter, this arm will be referred to as a fourth arm 450) extending substantially in the direction of the central axis CA, and a protrusion 451 (hereinafter, this protrusion 451 will be referred to as a fourth protrusion 451) that is interlocked with the fourth arm 450 and protrudes away from the central axis CA substantially in the direction orthogonal to the central axis CA. In this case, when the puncture member 40 is placed in the hollow portion 26 of the moving body 20, the second locking portion 45 overlaps the cutout of the moving body 20, whereby the puncture member 40 can be held with a simplified structure.

In some examples, the fourth arm 450 may be resilient in a direction that is generally orthogonal to the central axis CA. In some examples, the fourth projection 451 can pass through the incision when the piercing member 40 is held. In this case, by overlapping the fourth projection 451 with the cutout of the moving body 20, the second locking portion 45 can be held with a simplified structure.

In some examples, the second holding portion 27 may include a first cutout 271 and a second cutout 272 (see fig. 18) extending substantially along the central axis CA and communicating with each other. The first incision 271 may be proximal to the proximal end 101 and the second incision 272 may be proximal to the distal end 102. In some examples, the widths of the first and second cutouts 271, 272 may be different. In some examples, the width of the first cutout 271 may be greater than the width of the second cutout 272.

In some examples, the first incision 271 can have a surface facing the proximal end 101. In some examples, the fourth protrusion 451 may have a surface facing the distal end 102. When the puncture member 40 is held to the second holding portion 27, the surface of the fourth projection 451 facing the distal end 102 overlaps the surface of the first cutout 271 facing the proximal end 101.

In some examples, the fourth arm 450 may pivot when applied in a direction generally orthogonal to the central axis CA to the fourth arm 450. For example, when the fourth arm 450 is acted upon in a direction generally orthogonal to the central axis CA in a direction toward the central axis CA, the fourth arm 450 may deflect such that an end of the fourth arm 450 proximate the distal end 102 moves in a direction toward the central axis CA. When the fourth arm 450 is deflected toward the central axis CA until the second locking portion 45 is separated from the second holding portion 27, the puncture member 40 can be released. This allows easy operation of releasing the puncture member 40.

In some examples, the arms of the second latch 45 may be pressed toward the central axis CA when the piercing member 40 is released. This allows the second locking portion 45 to be released easily. In some examples, the second retaining portion 27 and the second locking portion 45 may be configured to releasably interlock by at least one of a snap, a hook, a latch, or a pin. Thus, an interlocking means for facilitating release can be provided.

In some examples, the second locking portion 45 of the piercing member 40 may be formed in a shoulder structure (see fig. 18, 19, and 20 in combination). In some examples, the fourth arm 450 may gradually move away from the central axis CA along the central axis CA and in a direction toward the distal end 102. In some examples, the projection is performed along the direction of the central axis CA, and the projection surface of the fourth protrusion 451 and the projection surface of the first cutout 271 may be wholly or partially overlapped. In some examples, the number of second latches 45 may be one or more, such as 1,2, 3, or 4. In some examples, the number of second locking portions 45 may be identical to the number of second holding portions 27. In some examples, the width of the surface of the fourth protrusion 451 facing the distal end 102 may be less than the width of the first cutout 271 and may be greater than the width of the second cutout 272.

In some examples, the second housing 30 may include a second trigger 37 (see fig. 11, 16, and 20). The second trigger portion 37 may be configured to separate the second holding portion 27 from the second locking portion 45 to release the puncture member 40. Thereby, the release of the moving body 20 can be facilitated by the second triggering portion 37. In some examples, the second trigger portion 37 may apply an action toward the central axis CA to the second locking portion 45 to press the second locking portion 45 inward, thereby separating the second locking portion 45 from the second holding portion 27. In some examples, the second locking portion 45 may disengage the second retaining portion 27 after the moving body 20 and the piercing member 40 are moved to a predetermined position toward the proximal end 101, thereby allowing the piercing member 40 to be released. Thus, the puncture member 40 can be automatically triggered to be released after the moving body 20 and the puncture member 40 are moved to a predetermined position, which contributes to more precise control of the timing at which the puncture member 40 leaves the host. The predetermined location may be a location where the monitoring device 800 has been applied to a host body surface. In some examples, the predetermined location may also be a location where the penetrating member 40 has introduced the implanted portion 81 of the sensor 8 to a predetermined depth beneath the skin of the host. That is, in some examples, the piercing member 40 may be configured to be releasable after being moved a predetermined distance relative to the second housing 30.

In some examples, the second triggering portion 37 may be formed on an inner wall of the second housing 30. In some examples, the second triggering portion 37 may be a protrusion (hereinafter referred to as a fifth protrusion) formed on the inner wall of the second housing 30 to protrude near the central axis CA in a direction substantially orthogonal to the central axis CA. When the moving body 20 and the penetrating member 40 move relative to the second housing 30 (i.e., when the moving body 20 and the penetrating member 40 move toward the proximal end 101), the second locking portion 45 moves first to a position contacting the second triggering portion 37, and during continued movement of the moving body 20 and the penetrating member 40 toward the proximal end 101, the fifth protrusion may abut against the fourth protrusion 451 and continuously exert an action toward the central axis CA on the fourth protrusion 451, and when the moving body 20 and the penetrating member 40 move to a predetermined position, the fourth arm 450 is folded inward to separate the fourth protrusion 451 from the second holding portion 27, thereby releasing the penetrating member 40.

The engagement of the second holding portion 27, the second locking portion 45, and the second triggering portion 37 will be described again below. When the penetrating member 40 is held in the second holding portion 27, the second locking portion 45 is in contact with the second holding portion 27, and the second holding portion 27 can restrict the movement of the second locking portion 45 toward the distal end 102 to hold the penetrating member 40 (see fig. 20). The second locking portion 45 may be moved to a position contacting the second triggering portion 37 when the moving body 20 and the penetrating member 40 are moved toward the proximal end 101, and the fifth protrusion may abut against the fourth protrusion 451 and continuously exert an action toward the central axis CA on the fourth protrusion 451 during the continuous movement of the moving body 20 and the penetrating member 40 toward the proximal end 101, and the fourth arm 450 is folded inward to separate the fourth protrusion 451 from the second holding portion 27 when the moving body 20 and the penetrating member 40 are moved to a predetermined position, thereby releasing the penetrating member 40.

In some examples, when piercing member 40 is released by moving body 20, second drive 52 drives piercing member 40 toward distal end 102 to unseat piercing member 40 from the host. In some examples, the retracted piercing member 40 may be entirely located in the interior space of the first housing 10. In this case, the sharp needle-like portion 41 can be prevented from being exposed to the outside of the applicator 100, and the safety of the applicator 100 can be improved.

In some examples, as previously described, the moving body 20 may include a receiving portion 21. In some examples, the receiving portion 21 may be provided at an end of the moving body 20 facing the proximal end 101, and an inlet of the receiving portion 21 may be directed toward the proximal end 101 (see fig. 19). In this case, the monitoring device 800 can be easily mounted to the housing portion 21.

In some examples, the receiving portion 21 may include a restraining portion 210 (see fig. 19) that restrains the monitoring device 800. In this case, the monitoring device 800 accommodated in the accommodating portion 21 is restrained by the restraining portion 210, so that the monitoring device 800 can be accommodated more firmly.

In some examples, the constraint 210 may include a constraint arm 211, and a protrusion 212 proximate the central axis CA in a direction generally orthogonal to the central axis CA (see fig. 19). Wherein the constraint arm 211 may extend in the direction of the central axis CA. In some examples, the constraint arm 211 may have elasticity. In some examples, the constraint arms 211 may be drawn toward the central axis CA. In this case, the restraint portion 210 can restrain the monitoring device 800 having a smaller outline size than the housing portion 21, for example, the electronic component 9 of the monitoring device 800 may be embedded inside the housing portion 21, and an interference fit is formed between the restraint portion 210 and the case 91 of the electronic component 9. In some examples, the number of constraints 210 may be one or more, such as 1,2,3, or 4. In some examples, the restrictions 210 may be evenly distributed along the outer circumference of the receiving portion 21.

Fig. 21 is a schematic diagram illustrating a seal assembly 93 and an applicator cap 6 in accordance with examples of the present disclosure.

In some examples, the applicator 100 may include an applicator cap 6 (see fig. 9). In some examples, the applicator cap 6 may be removably mounted to the first housing 10. The second housing 30 may be located in a sealed receiving space formed by the applicator cover 6 and the first housing 10 when the applicator cover 6 is assembled to the first housing 10. In this case, a sealed space can be formed by the cooperation of the applicator cover 6 and the first housing 10 to protect the internal structure, and the second housing 30 is located in the sealed space, which can suppress occurrence of an unexpected false touch, improving the reliability of the applicator 100.

In some examples, the applicator cap 6 may be removed from the first housing 10 to form the applicator 100 into an applicable state. In some examples, as previously described, the monitoring device 800 may include a seal assembly 93 that seals the sensor 8. In some examples, the applicator cap 6 may be removed from the first housing 10 and the seal assembly 93 removed from the monitoring device 800 to form the applicator 100 into an applicable state.

In some examples, the applicator cap 6 and the first housing 10 may be threadably connected. Specifically, the outer circumference of the first housing 10 near one end of the host may be provided with external threads, and the inner wall of the applicator cap 6 may be provided with internal threads that match the external threads. Thereby, the attachment and detachment of the applicator cover 6 to and from the first housing 10 can be facilitated. In some examples, the applicator cap 6 may be rotated in a predetermined direction to be detached from the first housing 10, and may be rotated in a direction opposite to the predetermined direction to be assembled to the first housing 10. In some examples, the predetermined direction may be a clockwise direction or a counter-clockwise direction.

In some examples, the seal assembly 93 may include a first engagement feature 930 and the applicator cap 6 may include a second engagement feature 61 (see fig. 21). The first engagement feature 930 cooperating with the second engagement feature 61 may cause the seal assembly 93 to follow the rotation of the applicator cap 6 when the applicator cap 6 is rotated in a first direction and the seal assembly 93 to be immobilized when the applicator cap 6 is rotated in a second direction opposite the first direction. In this case, the sealing assembly 93 can be removed simultaneously with the removal of the applicator cap 6 by rotating the applicator cap 6 in the first direction, thereby facilitating the use, and the sealing state of the sealing assembly 93 is not affected during the assembly of the applicator cap 6 to assemble the applicator cap 6 to the first housing 10 by rotating the applicator cap 6 in the second direction, thereby facilitating the assembly of the applicator 100 and the monitoring device 800 by a factory.

Fig. 22 is a schematic diagram showing the structure of an inclined groove according to an example of the present disclosure. Wherein fig. 22 is a schematic view projected in the direction of the central axis CA of the applicator 100, components and lines that may cause shielding and misunderstanding have been omitted in order to more clearly illustrate the cooperation of the seal assembly 93 with the applicator cap 6.

In some examples, the first engagement feature 930 may be an angled groove formed in a sidewall of the seal assembly 93 (see fig. 22). Wherein the angled slot may have a stop surface 931, an angled surface 932 that transitions with a sidewall of the seal assembly 93, and the second engagement feature 61 may be a protrusion 62 (which may be referred to as a sixth protrusion 62) that mates with the angled slot (see fig. 21 and 22). The sixth protrusion 62 may abut against the limit surface 931 to cause the seal assembly 93 to follow the rotation of the applicator cap 6 when the applicator cap 6 is rotated in a first direction, and the sixth protrusion 62 may slide along the inclined surface 932 and the outer circumference of the sidewall of the seal assembly 93 when the applicator cap 6 is rotated in a second direction opposite to the first direction. Thus, the cooperation of the first engagement feature 930 with the second engagement feature 61 enables the aforementioned predetermined function.

Referring to fig. 22, in the example of fig. 22, the direction C1 schematically represents a clockwise direction, the direction C2 schematically represents a counterclockwise direction (i.e., a direction opposite to the direction C1), the sixth protrusion 62 of the applicator cap 6 may abut against the stop surface 931 when the applicator cap 6 is rotated in the direction C1, and the sixth protrusion 62 of the applicator cap 6 may slide along the inclined surface 932 and the outer circumference of the side wall of the seal assembly 93 when the applicator cap 6 is rotated in the direction C2.

In some examples, the applicator cap 6 may include a fourth limiter 63 (see fig. 21). The fourth restriction 63 may restrict the position of the seal assembly 93. In some examples, the fourth limiter 63 may limit the seal assembly 93 in a manner that surrounds the outer circumference of the seal assembly 93. Thereby, it is possible to help suppress the seal assembly 93 and the monitoring device 800 from undesirably shaking within the first housing 10. In some examples, the seal assembly 93 may also be referred to as a sensor cap.

In some examples, the fourth restriction 63 may include an arm (may be referred to as a fifth arm) extending in the direction of the central axis CA. In some examples, the second engagement feature 61 may be formed on the fourth limiter 63. Thus, it can be convenient to engage the second engagement feature 61 with the first engagement feature 930 when the seal assembly 93 is restrained by the fourth restraining portion 63.

In some examples, the monitoring device 800 may be conveniently applied to the host by means of the application device 100 after removal of the applicator cap 6. In some examples, a desiccant may be disposed in the sealed receiving space formed by the applicator cap 6 and the first housing 10. This can help create a dry environment within the applicator 100, thereby facilitating the preservation of the monitoring device 800.

Now, the application process of the application device 100 will be described again, i.e., the application of the monitoring device 800 to the host by the application device 100 may include an application phase and a withdrawal phase. The applicator 100 may be applied to the host during the application phase and the piercing member 40 may exit the host during the withdrawal phase.

First, the applicator cap 6 is removed from the first housing 10, and the applicator 100 is brought into an applicable state.

In the application phase, by placing the application device 100 on the body surface of the host, bringing the proximal end surface 31 of the second housing 30 into contact with the body surface of the host, and then pressing the first housing 10 toward the host, when the first trigger portion 33 moves to the first locking portion 23, the first trigger portion 33 actuates the first locking portion 23 to pivot in a direction approaching the central axis CA, so that the first locking portion 23 is separated from the first holding portion 12, thereby releasing the moving body 20, and then the first driving portion 51 (or by means of a human force) applies an action to the moving body 20 in a manner toward the proximal end 101, so that the moving body 20 moves together with the puncture member 40 toward the proximal end 101, the monitoring device 800 located at the receiving portion 21 can be pushed toward the body surface of the host, and the sensor 8 is placed at least partially under the skin of the host by the puncture member 40.

In the withdrawal stage, as the moving body 20 and the penetrating member 40 move toward the proximal end 101, the second triggering part 37 provided on the inner wall of the second housing 30 contacts the second locking part 45 of the penetrating member 40, the second triggering part 37 actuates the second locking part 45 to deflect toward a direction approaching the central axis CA to separate the second locking part 45 from the second holding part 27, thereby releasing the penetrating member 40, and then the second driving part 52 (or by a human force) applies an action to the penetrating member 40 toward the distal end 102 to move the penetrating member 40 toward the distal end 102 and away from the host.

In addition, during the retraction phase, the first driving portion 51 (or by means of manpower) may still exert an effect on the moving body 20 towards the proximal end 101. In other words, with the first driving portion 51 configured as an elastic member (e.g., a spring), when the moving body 20 is driven toward the host and the monitoring device 800 accommodated in the accommodating portion 21 has been applied to the body surface of the host, the first driving portion 51 may still be in the energy storage state. In this case, the monitoring device 800 is brought into close contact with the body surface of the host by the first driving portion 51 in the retraction stage, and thus the possibility that the monitoring device 800 is separated from the host by the influence of separation of the puncture member 40 from the sensor 8 in the retraction stage can be effectively reduced.

In summary, according to the present disclosure, an application device 100 and an analyte monitoring system 1000 that are easy to operate and capable of accurately applying a monitoring device 800 to a host may be provided.

While the disclosure has been described in detail in connection with the drawings and embodiments, it should be understood that the foregoing description is not intended to limit the disclosure in any way. Modifications and variations of the present disclosure may be made as desired by those skilled in the art without departing from the true spirit and scope of the disclosure, and such modifications and variations fall within the scope of the disclosure.

Claims

1. An application device for applying a monitoring device to a host, characterized in that,

The application device comprises a first shell, a second shell, a driving mechanism, a moving body, a puncture member arranged on the moving body, a proximal end which is close to a host when in operation and a distal end which is far away from the host,

The first housing including a first retaining portion releasably retaining the moving body, the second housing having a proximal surface that is in operative contact with the skin of the host,

The moving body including a receiving portion for receiving the monitoring device, the piercing member being configured to at least partially introduce the monitoring device subcutaneously into a host,

The first housing and the second housing are relatively moved in a manner approaching each other to release the holding of the moving body by the first holding portion, and the moving body is moved toward the proximal end together with the piercing member under the action of the driving mechanism to apply the monitoring device to the host and is at least partially positioned subcutaneously in the host after being released.

2. The application device according to claim 1, wherein,

The moving body includes a first locking portion configured to releasably interlock with the first holding portion, and the second housing includes a first triggering portion that can disengage the first holding portion from the first locking portion to release the moving body.

3. The application device according to claim 2, wherein the applicator comprises a pump,

When the first housing and the second housing are relatively moved in the direction along the central axis of the applying device, the first triggering part acts on the first locking part to separate the first locking part from the first holding part.

4. The application device of claim 3, wherein the applicator comprises a dispensing means,

The first holding portion is a convex structure formed on an inner wall of the first housing, the first locking portion is engaged with the convex structure when the moving body is held on the first holding portion, and the first triggering portion deflects the first locking portion in a direction away from the first holding portion to separate the first locking portion from the first holding portion.

5. The application device according to claim 1 or 2, wherein,

The first housing includes a first restraining portion configured to restrain the second housing from being disengaged from the first housing, the second housing includes a first restraining portion coupled to the first restraining portion.

6. The application device of claim 5, wherein the applicator comprises a dispensing means,

The first housing includes a second restriction configured to inhibit movement of the second housing toward the proximal end, the second housing being restricted by the second restriction upon relative movement of the first housing and the second housing to release the moving body.

7. The application device of claim 6, wherein the applicator comprises a dispensing means,

The first restriction portion and the second restriction portion are disposed adjacently in a direction along a central axis of the applying device, and the first restriction portion is configured to be engageable with the second restriction portion to hold the second housing.

8. The application device according to claim 1 or 2, wherein,

The driving mechanism comprises a first driving part and a second driving part, the moving body comprises a second holding part which can hold the puncture member in a releasable way, the second holding part releases the puncture member after the moving body and the puncture member move towards the proximal end to a preset position together under the action of the first driving part, and the puncture member moves towards the distal end under the action of the second driving part.

9. The application device of claim 8, wherein the applicator comprises a dispensing means,

The first driving part is an elastic element, two ends of the first driving part are respectively abutted against the first shell and the moving body, and when the moving body is held by the first holding part, the first driving part is in a compressed state.

10. The application device of claim 8, wherein the applicator comprises a dispensing means,

The second driving part is an elastic element, two ends of the second driving part are respectively abutted against the moving body and the puncture member, and when the puncture member is held in the second holding part, the second driving part is in a compressed state.

11. The application device according to claim 1, wherein,

The applicator includes an applicator cap removably mounted to the first housing, the second housing being positioned in a sealed receiving space formed by the applicator cap and the first housing when the applicator cap is mounted to the first housing.

12. The application device of claim 11, wherein the applicator comprises a dispensing means,

The monitoring device includes a sensor that is partially subcutaneously positionable in a host, an electronics assembly coupled to the sensor, and a sealing assembly that seals the sensor, the applicator cap being coupled to the sealing assembly, the sealing assembly being jointly removed with the applicator cap when the applicator cap is removed from the first housing to cause the applicator device to assume an applicable state.

13. The application device of claim 12, wherein the applicator comprises a dispensing means,

The seal assembly has a first engagement feature, the applicator cap includes a second engagement feature, the first engagement feature cooperates with the second engagement feature to cause the seal assembly to follow rotation of the applicator cap when the applicator cap is rotated in a first direction, and the seal assembly to be stationary when the applicator cap is rotated in a second direction opposite the first direction.

14. An analyte monitoring system comprising the application device of any one of claims 1 to 13, and a monitoring device.