CN201299646Y - System of non-invasive fixed micro device inside human esophagus - Google Patents

Abstract

Disclosed is a system of a non-invasive fixed micro device inside a human esophagus, which is characterized in that the system comprises an external magnetic field locating device and a micro device arranged inside the human body. The external magnetic field locating device comprises a permanent magnet and a locating carrier thereof; and the locating carrier is used to fix the permanent magnet and to carry and position the permanent magnet at a special part of the human body. The micro device inside the human body comprises a shell, a functional module and a permanent magnet. The external magnetic field locating device generates magnetic force through the permanent magnet thereof to attract the permanent magnet embedded in the micro device inside the human body to locate the micro device inside the human body. The shell of the micro device takes the shape of a flat capsule, a relatively flat crust is adhered at the side face of the shell, which is parallel to the embedded permanent magnet, and the other parts of the crust is streamline. The micro device is equipped with a sensor or an actuator inside to satisfy the requirements of physiological parameter monitoring and treatment inside the esophagus. The micro device is pain-free and non-invasive, and convenient to operate, and a patient can endure the micro device with little pain.

Description

A system for non-invasive fixation of microdevices in the esophagus

technical field

The utility model relates to a medical device, in particular to a medical device for diagnosing and treating esophageal diseases, in particular to a system for non-invasively fixing micro devices in the esophagus.

Background technique

With the acceleration of people's life rhythm and the continuous change of diet structure, the incidence of digestive tract functional diseases is increasing to the first place, among which common esophageal diseases include reflux esophagitis, esophageal cancer, esophageal stricture, esophageal varicose veins , indigestion, functional dysphagia, etc., have brought pain to people physically and mentally. In the process of medical diagnosis and treatment, continuous monitoring or treatment of specific three-dimensional space in the esophagus is often required, such as: identification of reflux esophagitis, whether there is acid reflux or alkali reflux, and the degree of reflux; for esophagus For diseases, continuous electrical stimulation, drug release and other treatments are carried out; especially after esophageal surgery, it is necessary to understand the effect of the surgery, whether there is rejection, whether the organ function returns to normal, and long-term monitoring is required.

Now there are many diagnosis and treatment technologies for the esophagus, such as fiber-optic gastroscopy, electronic gastroscopy, ultrasonography and other push-type upper gastrointestinal endoscopes, which can enter the esophagus to observe the image of the lesion area, and can perform sampling, resection and other treatments. Not suitable for prolonged operations due to poor tolerance. The prior art also includes catheter-type physiological parameter monitors, such as catheter-type pH meters, catheter-type manometers, catheter-type bilirubin meters and other monitoring methods. These technologies all require catheter indwelling, which makes people feel painful, embarrassed, unable to It is hard to use it for a long time without eating, too.

Recently, various radio telemetry techniques have been created and used. Patents ZL200410021933.5, ZL02137054.0, and US2003191430 describe several capsule-shaped micro-devices in the body. After being swallowed, they move with the peristalsis of the digestive tract and can monitor parameters such as images, pH, and pressure in the digestive tract. Radio frequency transmission to small receivers outside the body, however, because the position of these capsule-shaped micro-devices in the body cannot be fixed, it is also impossible to monitor a specific three-dimensional space for a long time.

The patent US6285897 describes a method for remotely monitoring physiological parameters in the human body cavity. The monitor containing the sensor of the physiological parameter is fixed to the wall of the cavity, and the fixing method adopted by the monitor on the wall is as follows: One or more items: nails, needles, hooks, barbs, clips or other items that at least partially penetrate into the mucosa of the cavity wall. Patent US6689056 mentions a method for fixing a device on the surface tissue of the human body. The housing of the device has a cavity and pins, and the device is transported to a certain position by a guiding device, so that the cavity is close to the fixed position The surface tissue of the device is drawn into the cavity, and the needle is pushed through the tissue to fix the device in place. The fixation methods mentioned above are all traumatic, poorly tolerated by patients, and prone to risk of infection.

Those skilled in the art know that the esophagus is a muscular conduit connecting the pharynx and the stomach, and the esophagus wall is composed of four layers of tissue: mucosa, submucosa, muscular layer, and adventitia. There is a lot of mucus on the esophagus wall, so the surface is smooth. In the process of swallowing saliva or food, the esophagus moves in a migratory wave-like motion in which the smooth muscle layer contracts sequentially, and the peristaltic wave produces a certain contraction force. Therefore, to fix a micro-device in the esophagus, it must be able to overcome its own gravity and the force generated by swallowing. Thrust, and considering the needs of long-term operation, the technology should preferably be painless, non-invasive, and not affect daily life, which is difficult to achieve with existing technologies.

Contents of the invention

In view of the deficiencies in the prior art, the purpose of this utility model is to provide a system for non-invasively fixing micro-device in the esophagus at a specific position. According to clinical needs, the micro-device in the body is used to monitor the physiological parameters in the esophagus, or it can also perform Electrical stimulation or drug release in the esophagus, precise positioning and safe operation.

The technical solution adopted to achieve the purpose of the utility model is as follows, that is, a system for non-invasively fixing micro-device in the esophagus, including an external magnetic field positioning device and a micro-device inside the body; the external magnetic field positioning device includes a permanent magnet and its positioning The carrier, the positioning carrier includes the fixing of the permanent magnet, and the positioning of the permanent magnet on a specific part of the human body; the micro-device in the body includes a shell, a functional module and a permanent magnet, wherein: the functional module and the permanent magnet are sealed by the shell; The external magnetic field positioning device generates magnetic attraction to the permanent magnet in the micro-device in the body through the permanent magnet, and completes the positioning of the micro-device in the body.

The external magnetic field positioning device at a specific part of the esophagus can generate a stable gradient magnetic field in the three-dimensional space of the designated area of the esophagus, and the magnetic field strength outside the external magnetic field positioning device does not exceed 100 gauss; the material of the permanent magnet can be NdFeB, AlNi One of cobalt or other permanent magnet materials with high magnetic energy product parameters, the magnetic energy product is greater than 20MGOe; the positioning carrier adopts an elastic vest-shaped fixing belt that can fix the permanent magnet on the upper half of the human torso, or an elastic Cross straps.

The material of the shell of the micro-device in the body is a medical polymer plastic compatible with the internal tissue of the human body, which has hydrophobic properties and is not easy to adhere to solution and food residue; The side of the relatively flat shell in contact with the esophageal wall is attached, the side of the shell is parallel to the embedded permanent magnet, and the other shell parts adopt a streamlined appearance; the material of the permanent magnet is NdFeB, AlNiCo or other magnetic materials with high energy product parameters Material, the magnetic energy product is greater than 20MGOe; the permanent magnet is a sheet structure, and the magnetization direction is the thickness direction.

In order to prevent the micro-device in the body from falling off into the stomach immediately after swallowing, and to facilitate accurate positioning, the shell of the micro-device in the body has a perforation that is not connected to the inside of the shell, so that the micro-device in the body can be threaded on a pull wire, according to The length of the pullwire determines where it enters the body, such as the esophagus, and after positioning, the pullwire is removed or swallowed.

In order to meet the needs of clinical applications, the functional module contains at least one physiological parameter sensor or actuator. For example, in order to realize the physiological parameter monitoring function, the functional module should contain at least one sensor, and the monitored parameters include but are not limited to the following types: image, temperature, pressure, pH value, impedance, enzyme, glucose, bilirubin, muscle Amino acid anhydride, blood urea nitrogen, urine nitrogen, renin, angiotensin, specific ions (such as sodium, potassium, calcium, carbonate, phosphate, etc.); in order to achieve therapeutic purposes, micro-device in the body should be able to complete the predetermined Actions or perform corresponding operations according to the commands of the external controller, such as: electrical stimulation, ultrasonic diagnosis, electromagnetic waves, or tissue sampling, drug release and other functions.

Based on the above structure, the utility model discloses a method for non-invasively fixing micro-device in the esophagus. As shown in Figure 1, an external magnetic field positioning device is fixed on the human trunk, and the external magnetic field positioning device can generate A stable static magnetic field with a certain magnetic field gradient; the external structure of the capsule-shaped internal micro-device 2 embedded with permanent magnets is designed in a streamlined shape, and the patient swallows the internal micro-device and enters the esophagus. When it reaches the range of the gradient magnetic field in the esophagus, Under the action of a magnetic field, the micro-device in the body will stick to the wall of the esophagus; in the process of swallowing saliva or food, mucus or liquid food will impact the micro-device in the body, and the streamlined shell design can achieve the smallest impact; After the micro-device is impacted, it will deviate from the balance point and slide towards the stomach. Since the gradient magnetic field moves in the direction of the stomach, the magnetic field strength will gradually increase, and the direction is all pointing to the balance point. The attraction of the micro-device in the body Increased size can offset the impact caused by liquid food or mucus, and gradually return to the equilibrium position after swallowing, realizing the purpose of non-invasively fixing the micro-device in the esophagus. If there is no need to continue to fix the micro-device in the body, as long as the external magnetic field positioning device is removed, the micro-device in the body will slide down from the wall of the esophagus and be naturally discharged through the digestive tract. The device has a simple structure, is convenient to operate, has no damage to the human body, and the micro-device in the body is for one-time use, thereby avoiding the risk of cross-infection.

It can be known from anatomical knowledge and radiological examination that the esophagus is basically located in the upper middle of the trunk. When the same person is fasting, full, standing, walking, sleeping and lying down in different eating states and different postures, the esophagus will have certain changes relative to the human trunk. The relative displacement of the external magnetic field positioning device and the human torso is fixed. Therefore, the relative position of the micro-device in the body and the esophagus will also have a certain relative displacement. This factor should be considered in the clinical application process. In order to ensure the safety, reliability and comfort of the system, the following key issues need to be resolved:

1. Design requirements for the micro-device in the body: the size of the shell should be appropriate to avoid incarceration, use medical materials and be firmly sealed, and be resistant to acid and alkali corrosion; when swallowing saliva or food, the impact on the micro-device in the body should be as small as possible; The contact area should not be too small to reduce the pressure on the esophagus.

2. Embedded small permanent magnets: Due to the overall structure and weight constraints of the micro-device in the body, materials with high magnetic energy product parameters need to be selected, and the shape of the magnet and the direction of magnetization should be reasonably designed to maximize the force between the magnets. The goal of reducing the overall weight of the system.

3. In vitro magnetic field positioning device: select permanent magnet materials with high magnetic energy product parameters, rationally design the permanent magnet structure and magnetic circuit, and build a gradient magnetic field along the direction of the esophagus in a three-dimensional space centered on the "fixed point" in the esophagus; for different For people with different body types, use different external magnetic field positioning devices to reduce the strength and weight of the external magnetic field positioning device as much as possible to improve comfort and safety; the external magnetic field positioning device should be fixed relative to the trunk, comfortable to wear, and does not affect sleep and basic functions. Life needs; the magnetic field outside the target area needs to be weakened to avoid attracting iron-containing items and accidents.

Description of drawings

Fig. 1 is a functional schematic diagram of the utility model.

Fig. 2 is a schematic diagram of the micro-device in the body being affected by the impact force of the fluid.

Fig. 3 is a functional schematic diagram of the pH in vivo micro-device of the embodiment.

Fig. 4 is a functional schematic diagram of the data logger of the embodiment.

Fig. 5 is a force analysis diagram of the pH micro-device in the body in three positions.

In the drawings: 1. External magnetic field positioning device; 2. In vivo micro-device; 3. Esophagus; 11. Permanent magnet; 21. Capsule shell; 22. Functional module; 23. Permanent magnet; 221. pH sensor, 222. Battery ; Data 223, processor; 224, memory; 225, A/D sampling circuit; 226, radio frequency transmitting module; 4, data recorder; 41 battery; 42, signal receiving module; 43, memory; 44, data processor; 45. Button; 46. Indicator light; 47. Buzzer; 48. Data interface; 49. Recorder shell.

Detailed ways

The technical solution of the present utility model will be further elaborated below in conjunction with the accompanying drawings and embodiments.

Fig. 1 is a functional schematic diagram of the utility model. An external magnetic field positioning device 1 is fixed on the human trunk to generate an attraction force for the internal micro-device 2 swallowed into the esophagus 3, so that the internal micro-device 2 can be fixed on the wall of the esophagus.

As shown in Figure 2 is a schematic diagram of the micro-device in the body being affected by the impact force of fluid liquid. When a person swallows saliva and liquid food, it will inevitably cause an impact force on the micro-device 2 in the body, which will seriously affect the fixing effect. Therefore, the outer shell Streamlined design of the shape, such as cars, airplanes, and bridge piers are all streamlined, usually showing a smooth and regular surface, without large undulations and sharp edges and corners. The fluid on the surface of a streamlined object is mainly laminar, with no or little turbulence, which ensures that the object is subject to less resistance. The possibility of such shocks causing the internal microdevice 2 in the esophagus 3 to fall off is minimized.

In order to better illustrate the utility model, an embodiment of "Esophageal pH Wireless Monitoring Capsule System" is now introduced, which is used for long-term monitoring of the pH value at 5 cm above the LES (lower sphincter) in the esophagus, including an in vitro magnetic field positioning device 1, pH in vivo Micro device 2 and external data recorder 4 are three parts. When the capsule-like pH in vivo micro-device 2 is swallowed and enters the esophagus, attracted by the external magnetic field positioning device 1, the pH in-vivo micro-device 2 sticks to the wall of the esophagus, monitors the pH value in the esophagus for a long time, and transmits the data through radio frequency signals The embodiment of the invention is used to realize the wireless monitoring of the pH value in the esophagus, which can be used for the diagnosis of reflux esophagitis, and can also be used for the auxiliary diagnosis of esophagus-related diseases.

The permanent magnet 11 of the present embodiment adopts NdFeB permanent magnet material, brand N50, and the magnetic energy product is 50MGOe, and elastic materials such as cotton, nylon, rubber band are made the positioning carrier 12 of short vest style, wear on the human trunk, wherein, The magnetic field generated by the special-shaped permanent magnet ensures that a stable gradient magnetic field can be formed within a specific three-dimensional space with a radius of 2 cm near the 5 cm above the LES of the esophagus.

From the perspective of life safety, the external magnetic field strength of the external magnetic field positioning device 1 of the present utility model does not exceed 100 gauss. In order to achieve this purpose, the permanent magnet 11 in the external magnetic field positioning device 1 is designed as a special-shaped structure, such as: a part adopts a U shape structure, or use a combination of magnets with multiple magnetization directions, so that the magnetic field outside the torso is in a closed magnetic circuit, and only the torso in the target area is in an open magnetic circuit. For the shielding of the static magnetic field, of course, magnetic shielding materials such as soft iron, silicon steel, and permalloy can also be used to assist. The higher the magnetic permeability of the magnetic shielding material, the thicker the cylinder wall, the more significant the shielding effect; The method of elastic material thickness protects human life safety. During the implementation process, factors such as the weight of the magnetic shielding material, human comfort, and safety should be analyzed, and the design should be based on the application.

Fig. 4 is a functional schematic diagram of the micro-device 2 in vivo as an embodiment. The micro-device 2 in the pH body consists of three parts: a shell 21, a functional module 22 and a permanent magnet 23, wherein the functional module includes a pH sensor 221, a battery 222, a data processor 223, a memory 224, an A/D sampling 225, and a radio frequency transmitting module 226 , wherein the sensing part of the pH sensor 221 is exposed on the outside of the capsule shell; the pH sensor is connected to the data processor through the A/D sampling circuit, and under the control of the data processor, the pH sensor collects the pH value through the A/D sampling The circuit converts the data into a data format, temporarily stores it in the memory in the capsule, and then transmits the data to the data recorder 4 outside the body through the signal transmitting module. The material of the permanent magnet 23 is NdFeB material, and the magnetic field direction generated by the embedded permanent magnet is perpendicular to the length direction of the shell. After the micro-device 2 in the pH body is swallowed, it slides down the esophagus, and the magnetic field direction of the embedded permanent magnet is vertical. in the esophagus. Among them, the corresponding device can be selected as follows: the battery 222 adopts a 3V silver oxide button battery, and the data processor 223 can adopt a chip modeled as MSP430f2012, which integrates 2Kflash, 128B RAM, and 10Bit AD, which can meet data storage and program requirements. For storage needs, the pH sensor 221 selects a pH sensor composed of a medical antimony measuring electrode and an Ag/AgCl reference electrode, uses a miniature three-operation amplifier, and uses a constant voltage and constant current circuit to construct the A/D sampling circuit 225 of the pH sensor. The built-in A/D of the device is used for data collection, and then the signal transmission module 226 of TH72015, FSK/ASK communication mode, and the European 433MHz ISM frequency band are used to transmit the data to the external data recorder.

FIG. 5 is a functional schematic diagram of the data recorder 4 of the embodiment. Data recorder 4 is made up of battery 41, signal receiving module-42, memory-43, data processor-44, button 45, indicator light-46, buzzer-47, data interface-48, recorder shell-49. Wherein: the signal receiving module 42 receives the data transmitted by the functional module 22 , and under the control of the data processor 44 , temporarily stores the data in the memory 43 , or sends it again through the data interface 48 . Described data logger shell 49 is made of nontoxic, harmless material to human body; Patient utilizes the button 45 on the data logger to record events such as eating, sleep, acid reflux in the operation process; Memory 43 is used to store pH data, and described pH data can carry out data transmission between data processing equipment such as computer PC through data interface 48; You can also perform operations such as display, statistics, and analysis on the test data. Wherein, described battery 41 can adopt 7#1.5 volt alkaline battery, utilize LDO step-up module to provide 3V voltage for system application, data processor 44 adopts MSP430F1232, 22 I/Os, 10 ADs, program memory is not less than 8K, with 1 serial port, 8MHZ clock, signal receiving module 22 adopts TH71101 FSK/FM/ASK 433MHz receiver, memory 43 adopts 64M BIT FALSH memory AT45DB642D of ATMEL company, data interface 48 adopts RS232 MAX3221 for two-way data transmission with PC .

Taking the micro-device 2 in the body as the force object for analysis, it mainly includes its own gravity, the elasticity of the esophagus, the downward thrust of food, the attraction of the magnetic field, the friction with the esophagus, etc. In addition to gravity, the magnitude of each force The direction and direction change with factors such as the posture of the person, the peristalsis of the digestive tract, and the sliding speed of the micro-device 2 in the body. Taking the micro-device 2 in the body as the force object for analysis, it mainly includes gravity G, magnetic attraction F, friction force f with the esophagus, elasticity N of the esophagus, and downward thrust T of food, etc. In addition to gravity, each The magnitude and direction of the force vary with factors such as the person's posture, peristalsis of the digestive tract, and the sliding speed of the pH capsule. As shown in Figure 5, the left picture shows the three positions of the pH micro-device in the esophagus, and the right picture shows the corresponding force analysis pictures. The pH in vivo micro-device 2 is embedded with a permanent magnet 23 close to the flat side of the shell 21 at different positions of the gradient magnetic field. In state ①, the micro-device 2 in the pH body has just swallowed and entered the esophagus, and the micro-device 2 in the pH body is mainly affected by the gravity G and the thrust T1 generated by swallowing, and accelerates its descent. With the progress of swallowing, the friction of the esophagus slows down the speed. Under the force of the magnetic field, it sticks to the wall of the esophagus and enters the second state. It is balanced with the frictional force f1 of the esophagus wall, and the micro-device (2) in the pH body remains stationary relative to the esophagus wall. When swallowing saliva or food, the micro-device 2 in the pH body is subjected to an instantaneous impact force, and is shifted to the stomach, the magnetic field attraction increases rapidly, and the direction points to the balance point, while the impact force T2 decreases rapidly, and the magnetic field attraction force F2 and friction force The resultant force of f2, impact force T2, and gravity G is upward, and the micro-device 2 in the pH body will return to the equilibrium point.

According to clinical trials, the driving force on the micro-module is about 0.05N during the process of eating liquid food. According to the analysis of the ultimate stress situation, the attraction between the external magnetic field positioning device 1 and the pH micro-device 2 in the body is greater than the gravity and the downward thrust of the esophagus, which can meet the fixing needs of the pH micro-device 2 in the body. Take a human as an example, the distance from the front chest to the back is 16cm, assuming that the esophagus is located in the middle of the torso, the two permanent magnets are separated by 8cm, the capsule-shaped pH micro-device 2 weighs 3g, and the pH micro-device 2 is embedded with a brand N50 NdFeB permanent magnet, the standard value of the magnetic energy product is 50MGOe, the size is 8mm×20mm×2mm, the magnetization direction is the direction of thickness 2mm, a 50mm×50mm×25mm brand N50 NdFeB magnet is placed outside the body, and the magnetization The direction is the direction of the thickness of 25mm, and the attractive force of the two can reach 0.2N, which is far greater than the resultant force of 0.07N of the gravity of the capsule and the thrust of the liquid food, which can meet the fixing requirements. In the actual application process, in order to reduce the weight of the system and meet the clinical needs, as few permanent magnets as possible are used to reduce the burden on patients and improve the comfort of use.

For people with different body types and different esophageal diseases, using the utility model to fix the micro-device in the esophagus, it is necessary to comprehensively analyze the distance between the esophagus and the body surface, the smoothness of the esophagus surface, the degree of viscous mucus, the diameter of the esophagus, and the movement of the esophagus. The accuracy of the fixed position is also related to the distribution of the gradient magnetic field, the weight of the micro-device in the body, and the material and shape of the shell.

In the utility model, if the swallowing speed of the micro-device 2 in the body is too fast, and the gradient magnetic field is too narrow, it may affect the effect of attracting the magnetic field positioning device 1 outside the body, and some auxiliary technical means or operating methods can be adopted to improve operational reliability. The shell 21 of the micro-device 2 in the body has a perforation that is not connected to the housing, so that the micro-device 2 in the body can be threaded on a pull wire, and the length of the pull wire is used to determine its entry into the body, such as the position in the esophagus. After positioning , remove the pull wire, this method can prevent the micro-device 2 from falling into the stomach soon after swallowing, and is also convenient for precise positioning. However, the withdrawal of the pull wire will cause some discomfort to the pharynx. You can also choose a medical wire that can delay melting, such as medical protein wire, medical PVA water-soluble material, etc., to ensure that after the positioning is completed, continue to swallow the remaining pull wire. After a certain period of time, the pull wire melts automatically.

At the same time, during the operation, the external magnetic field positioning device 1 can be brought close to the throat to limit the movement speed of the internal micro-device, and then slowly pull the internal micro-device to a designated position. Alternatively, the patient swallows the micro-device 2 in the body in a supine position, weakening the influence of the gravity of the micro-device 2 in the body on the acceleration, or adding a delay-melting wire to the micro-device 2 in the body, etc., all of which can reach the limit in a short time. The purpose of swallowing the micro-device in the body and improving the reliability of fixation.

In addition to the above-mentioned embodiment "wireless monitoring capsule system for esophagus pH", in order to meet the needs of clinical applications, the utility model can produce many different types of embodiments of "wireless monitoring capsule system for esophagus physiological parameters": the implementation For example, the pH sensor 221 in the functional module 22 of the micro-device 2 in the "esophagus pH wireless monitoring capsule system" can be replaced with other physiological sensors and related conversion circuits. For example: image acquisition system composed of transparent optical front cover + micro wide-angle lens + CMOS integrated imaging chip; temperature acquisition system using platinum electrodes; pressure acquisition system using MEMS silicon pressure sensor + pressure sensing film; impedance test circuit + shell Impedance acquisition system composed of conductive electrode + voltage acquisition circuit in the shell; with the development of ion-sensitive field effect transistor ISFET technology, it can detect various parameters according to the different sensitive films, such as: inorganic ion FET, its sensitive film is generally Inorganic gate, solid film or organic polymer PVC film, used to detect the concentration of sodium ions, calcium ions, ammonium ions, etc.; Enzyme FET, a layer of enzyme film is fixed on the surface of the sensitive gate, which is generated by the reaction between the substrate to be tested and the enzyme The local pH value of the enzyme membrane caused by the substance is measured; the dissolved oxygen electrode is used to test the concentration of glucose; and other sensors can be used to test bilirubin, creatinine, blood urea nitrogen, urine nitrogen, renin, angiotensin, etc. Physiological parameters in the esophagus, etc., will not be enumerated here.

The utility model provides a system for non-invasively fixing micro-device in a specific position in the esophagus. According to clinical needs, the micro-device in the body can be used to monitor various physiological parameters in the esophagus. At the same time, in order to achieve therapeutic purposes, the utility model can generate multiple A different type of embodiment of the "capsule system for wireless esophagus therapy": replace the pH sensor 221 in the functional module 22 of the micro-device 2 in the body of the "capsule system for wireless monitoring of esophageal pH" in the embodiment with other actuators And the relevant conversion circuit is enough, the micro-device in the body should be able to complete the predetermined action or perform the corresponding operation according to the command of the controller outside the body, for example: through the digital logic circuit of the data processor to drive the voltage-controlled oscillator to output current pulse, through the external shell metal electrodes to realize the therapeutic function of electric discharge stimulation; control the MEMS microfluidic integrated chip through the I/O port and D/A output of the data processor, which can be used for the sampling function of esophageal body fluid; Long-term treatment can be carried out in the way of sustained release of drugs to the designated position of the esophagus; and other therapeutic functions for ultrasonic diagnosis, electromagnetic waves, tissue sampling, etc., which will not be listed here.

In a word, the system provided by the utility model for non-invasively fixing micro-device in a specific position in the esophagus can adopt the utility model as long as the medical sensors and actuators are miniaturized and integrated by using MEMS technology and nanotechnology. Carry out implementation, manufacture the equipment that clinically needs to carry out corresponding diagnosis and treatment, the operation is safe, the patient uses without pain.

Claims (10)

1. A system for non-invasively fixing micro-device in the esophagus, characterized in that: it includes an external magnetic field positioning device (1) and a micro-device (2) in the body, and the external magnetic field positioning device includes a permanent magnet (11) and its positioning carrier (12), the positioning carrier (12) includes fixing to the permanent magnet (11), and carries the positioning of the permanent magnet on a specific part of the human body; the micro-device (2) in the body includes a shell (21), a functional module ( 22) and a permanent magnet (23), wherein: the functional module (22) and the permanent magnet (23) are sealed by the casing (21); The magnetic attraction of the permanent magnet (23) in the body completes the positioning of the micro-device (2) in the specific part of the esophagus; the shell (21) of the micro-device (2) is in the shape of a flat capsule, with a relatively flat shell attachment side A permanent magnet (23) is embedded parallel to the inner wall of the attached side of the shell, and the other surfaces of the shell are streamlined. 2. The system for non-invasively fixing micro-device in the esophagus according to claim 1, characterized in that: the permanent magnet (23) is a sheet structure, and the magnetization direction is the thickness direction. 3. The system for non-invasively fixing micro-device in the esophagus according to claim 2, characterized in that: the outer shell (21) has a perforation that is not connected with the inside of the shell. 4. The system for non-invasively fixing micro-device in the esophagus according to claim 1, characterized in that: the permanent magnet in the external magnetic field positioning device (1) is NdFeB, AlNiCo or other high magnetic energy product One of the permanent magnet materials with a magnetic energy product greater than 20MGOe; the permanent magnet in the micro-device (2) is one of NdFeB, AlNiCo or other high magnetic energy product permanent magnetic materials with a magnetic energy product greater than 20MGOe. 5. The system for non-invasively fixing micro-device in the esophagus according to claim 1, characterized in that: said functional module (22) contains at least one physiological parameter sensor or actuator. 6. The system for non-invasively fixing micro-device in the esophagus according to claim 5, characterized in that: said functional module (22) has a signal transmitting module, and said system has a data recorder ( 4). 7. The system for non-invasively fixing micro-device in the esophagus according to claim 5, characterized in that: the physiological parameter sensors are image, temperature, pressure, pH value, impedance, enzyme, glucose, bilirubin, creatinine Anhydride, blood urea nitrogen, urine nitrogen, renin, angiotensin or ion sensors. 8. The system for non-invasively fixing micro-device in the esophagus according to claim 1, characterized in that: the positioning carrier adopts an elastic vest-shaped fixing belt capable of fixing the permanent magnet on the upper half of the human body, or Elastic criss-cross straps. 9. The system for non-invasively fixing micro-device in the esophagus according to claim 6, characterized in that: the functional module (22) includes a pH sensor (221), an A/D sampling circuit (225), a data processor ( 223), memory (224) and signal transmission module (226), described parts are sealed in the capsule casing (21), and wherein the sensing part of pH sensor (221) is exposed to the outside of capsule casing; Described pH sensor passes through The A/D sampling circuit is connected to the data processor. Under the control of the data processor, the pH sensor converts the collected pH value into a data format through the A/D sampling circuit, temporarily stores it in the memory in the capsule, and then transmits the data through the signal transmitting module. A data logger (4) transmitted outside the body. 10. The system for non-invasively fixing micro-device in the esophagus according to claim 6, characterized in that: the data recorder (4) includes a signal receiving module (42), a memory (43), a data processor (44) and a data interface (48), wherein: the signal receiving module (42) receives the data transmitted by the functional module (22), and temporarily stores the data in the memory (43) under the control of the data processor (44), or passes the data Interface (48) for retransmission.

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