CR7091A - RECOMBINANT ANTIBODIES ASSOCIATED WITH GANGLIOSIDS, THEIR USE IN DIAGNOSIS AND TUMORS TREATMENT - Google Patents
RECOMBINANT ANTIBODIES ASSOCIATED WITH GANGLIOSIDS, THEIR USE IN DIAGNOSIS AND TUMORS TREATMENTInfo
- Publication number
- CR7091A CR7091A CR7091A CR7091A CR7091A CR 7091 A CR7091 A CR 7091A CR 7091 A CR7091 A CR 7091A CR 7091 A CR7091 A CR 7091A CR 7091 A CR7091 A CR 7091A
- Authority
- CR
- Costa Rica
- Prior art keywords
- antibodies
- murine
- diagnosis
- frs
- produced
- Prior art date
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se relaciona con la obtención de anticuerpos modificados por ingeniería genética a partir del anticuerpo monoclonal murino P3 (AcM P3), producido por el hibridoma depositado según el tratado de Budapest bajo el número ECACC 94113026 y de su anti-idiotipo 1E10 (AcMai 1E10) producido por el hibridoma ECACC 97112901, con el objetivo de lograr anticuerpos con las mismas propiedades de reconocimiento de los originales pero que sean menos inmunogénicos que éstos. Los anticuerpos quiméricos, contienen los dominios variables de la inmunoglobulina murina y las regiones constantes de la inmunoglobulina humana; y los humanizados, además de contener las regiones constantes de la inmunoglobulina humana, son modificados en la región de los marcos (FRs) murinos y en particular en aquellas zonas que pudieran resultar en un sitio antigénico para las células T, por lo que algunas posiciones de los FRS son humanas. Estos anticuerpos pueden ser utilizados en el diagnóstico y la terapia de diferentes tipos de tumores.The present invention relates to obtaining genetically engineered antibodies from the murine monoclonal antibody P3 (AcM P3), produced by the hybridoma deposited according to the Budapest treaty under ECACC number 94113026 and its anti-idiotype 1E10 (AcMai 1E10) produced by the hybridoma ECACC 97112901, with the aim of achieving antibodies with the same recognition properties of the originals but that are less immunogenic than these. The chimeric antibodies contain the variable domains of the murine immunoglobulin and the constant regions of the human immunoglobulin; and the humanized ones, in addition to containing the constant regions of the human immunoglobulin, are modified in the region of the murine frames (FRs) and in particular in those areas that could result in an antigenic site for the T cells, so that some positions of the FRS are human. These antibodies can be used in the diagnosis and therapy of different types of tumors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20040084 | 2001-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR7091A true CR7091A (en) | 2004-05-03 |
Family
ID=51359494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR7091A CR7091A (en) | 2001-04-06 | 2003-10-01 | RECOMBINANT ANTIBODIES ASSOCIATED WITH GANGLIOSIDS, THEIR USE IN DIAGNOSIS AND TUMORS TREATMENT |
Country Status (1)
| Country | Link |
|---|---|
| CR (1) | CR7091A (en) |
-
2003
- 2003-10-01 CR CR7091A patent/CR7091A/en unknown
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