CY1865A - Anti-histaminic compositions containing N-heterocyclyl-4- piperidinamines - Google Patents

Anti-histaminic compositions containing N-heterocyclyl-4- piperidinamines

Info

Publication number: CY1865A
Authority: CY; Cyprus
Prior art keywords: alkyl; substd; alkoxy; furanyl; opt
Prior art date: 1986-02-03

Application number

CY186596A

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-03

Filing date

1996-04-05

Publication date

1996-04-05

1996-04-05 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1996-04-05 Publication of CY1865A publication Critical patent/CY1865A/xx

Links

230000001387 anti-histamine Effects 0.000 title 1
239000000739 antihistaminic agent Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
-1 1-6C alkyl-furanyl Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
CLPYDQPFQYNIDH-UHFFFAOYSA-N n-piperidin-4-yl-1h-benzimidazol-2-amine Chemical compound C1CNCCC1NC1=NC2=CC=CC=C2N1 CLPYDQPFQYNIDH-UHFFFAOYSA-N 0.000 abstract 1
GJSYDLQEDRMJPU-UHFFFAOYSA-N n-piperidin-4-yl-1h-imidazo[4,5-b]pyridin-2-amine Chemical compound C1CNCCC1NC1=NC2=CC=CN=C2N1 GJSYDLQEDRMJPU-UHFFFAOYSA-N 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CY186596A 1986-02-03 1996-04-05 Anti-histaminic compositions containing N-heterocyclyl-4- piperidinamines CY1865A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US82549186A	1986-02-03	1986-02-03

Publications (1)

Publication Number	Publication Date
CY1865A true CY1865A (en)	1996-04-05

Family

ID=25244134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY186596A CY1865A (en)	1986-02-03	1996-04-05	Anti-histaminic compositions containing N-heterocyclyl-4- piperidinamines

Country Status (26)

Country	Link
EP (1)	EP0232937B1 (ja)
JP (2)	JPH0794393B2 (ja)
CN (1)	CN1018614B (ja)
AT (1)	ATE79620T1 (ja)
AU (1)	AU583706B2 (ja)
CA (1)	CA1327579C (ja)
CY (1)	CY1865A (ja)
DE (1)	DE3781173T2 (ja)
DK (1)	DK173674B1 (ja)
EG (1)	EG17993A (ja)
ES (1)	ES2052544T3 (ja)
FI (1)	FI870448A7 (ja)
GR (1)	GR3006158T3 (ja)
HK (1)	HK114695A (ja)
HU (1)	HU201067B (ja)
IE (1)	IE60885B1 (ja)
IL (1)	IL81448A (ja)
MA (1)	MA20868A1 (ja)
NO (1)	NO870407L (ja)
NZ (1)	NZ219165A (ja)
PH (1)	PH24738A (ja)
PT (1)	PT84234B (ja)
TN (1)	TNSN87015A1 (ja)
ZA (1)	ZA87744B (ja)
ZM (1)	ZM1287A1 (ja)
ZW (1)	ZW2087A1 (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ223654A (en) *	1987-03-09	1990-03-27	Janssen Pharmaceutica Nv	1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) *	1987-06-19	1990-01-30	Janssen Pharmaceutical N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) *	1987-07-01	1993-05-18	Janssen Pharmaceutica Naamloze Vennootschap	¬(bicyclic heterocyclyl)methyl and -hetero\| substituted hexahydro-1h-azepines and pyrrolidines
US4988689A (en) *	1987-07-01	1991-01-29	Janssen Pharmaceutica N.V.	((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
IT1229231B (it) *	1989-05-08	1991-07-26	Dompe Farmaceutici Spa	Aminoimidazopiridine farmacologicamente attive
CA2043564A1 (en) *	1990-07-06	1992-01-07	Alfons G. M. De Knaep	3-[(5-methyl-2-furanyl)methyl]-n-(4-piperidinyl)-3h-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate
NZ239540A (en) *	1990-09-24	1993-11-25	Neurosearch As	1-phenyl benzimidazole derivatives and medicaments
AU730229B2 (en) *	1992-09-03	2001-03-01	Sepracor, Inc.	Use of norastemizole for the treatment of allergic disorders
EP0920865B1 (en) *	1992-09-03	2004-01-14	Sepracor Inc.	Pharmaceutical compositions containing Norastemizole
KR960702445A (ko) *	1993-05-20	1996-04-27	간자와 무츠오	1-(2-벤조이미다졸일)-1, 5- 디아자시클로옥탄 유도체(1-(2-benzimidazo-lyl)-1,5-diazacyclooctane compounds)
TW429256B (en) *	1995-12-27	2001-04-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
RU2214245C2 (ru) *	1997-03-26	2003-10-20	Сепракор Инк.	Химически- и термостабильные готовые формы норастемизола
US5817823A (en) *	1997-04-17	1998-10-06	Sepracor Inc.	Method for synthesizing 2-substituted imidazoles
ES2215670T3 (es)	1999-06-28	2004-10-16	Janssen Pharmaceutica N.V.	Inhibidores de la replicacion del virus sincitial respiratorio.
SI1196408T1 (en) *	1999-06-28	2005-02-28	Janssen Pharmaceutica N.V.	Respiratory syncytial virus replication inhibitors
IL147327A0 (en)	1999-06-28	2002-08-14	Janssen Pharmaceutica Nv	Respiratory syncytial virus replication inhibitors
GB0215293D0 (en)	2002-07-03	2002-08-14	Rega Foundation	Viral inhibitors
WO2004113297A2 (en) *	2003-06-24	2004-12-29	Neurosearch A/S	Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP2161273B1 (en)	2003-12-22	2015-04-15	K.U.Leuven Research & Development	Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
NZ556624A (en)	2004-12-21	2010-06-25	Gilead Sciences Inc	5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
EP1838706A1 (en) *	2004-12-24	2007-10-03	Prosidion Limited	G-protein coupled receptor agonists
NZ556628A (en)	2005-03-08	2009-09-25	Janssen Pharmaceutica Nv	Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
KR101143596B1 (ko)	2006-07-07	2012-05-11	길리애드 사이언시즈, 인코포레이티드	신규의 피리다진 화합물 및 이의 용도
UA99466C2 (en)	2007-07-06	2012-08-27	Гилиад Сайенсиз, Инк.	Crystalline pyridazine compound
US8394969B2 (en) *	2008-09-26	2013-03-12	Merck Sharp & Dohme Corp.	Cyclic benzimidazole derivatives useful as anti-diabetic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1140119A (en) *	1978-04-03	1983-01-25	Joseph Torremans	N-heterocyclyl-4-piperidinamines
US4219559A (en) *	1979-01-10	1980-08-26	Janssen Pharmaceutica N.V.	N-Heterocyclyl-4-piperidinamines
US4556660A (en) *	1982-07-12	1985-12-03	Janssen Pharmaceutica N.V.	N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (ja) *	1982-07-12	1985-05-04	Janssen Pharmaceutica Nv
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
DE3484096D1 (de) *	1983-11-30	1991-03-14	Janssen Pharmaceutica Nv	Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4588722A (en) *	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PL144514B1 (en) *	1984-01-09	1988-06-30	Janssen Pharmaceutica Nv	Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines

1987
- 1987-01-28 CA CA000528342A patent/CA1327579C/en not_active Expired - Lifetime
- 1987-01-28 AT AT87200128T patent/ATE79620T1/de not_active IP Right Cessation
- 1987-01-28 ES ES87200128T patent/ES2052544T3/es not_active Expired - Lifetime
- 1987-01-28 DE DE8787200128T patent/DE3781173T2/de not_active Expired - Lifetime
- 1987-01-28 EP EP87200128A patent/EP0232937B1/en not_active Expired - Lifetime
- 1987-01-28 EG EG48/87A patent/EG17993A/xx active
- 1987-01-30 PH PH34794A patent/PH24738A/en unknown
- 1987-02-02 HU HU87354A patent/HU201067B/hu unknown
- 1987-02-02 IL IL81448A patent/IL81448A/xx not_active IP Right Cessation
- 1987-02-02 DK DK198700541A patent/DK173674B1/da not_active IP Right Cessation
- 1987-02-02 JP JP62020600A patent/JPH0794393B2/ja not_active Expired - Lifetime
- 1987-02-02 NO NO870407A patent/NO870407L/no unknown
- 1987-02-02 ZA ZA87744A patent/ZA87744B/xx unknown
- 1987-02-02 PT PT84234A patent/PT84234B/pt unknown
- 1987-02-02 FI FI870448A patent/FI870448A7/fi not_active Application Discontinuation
- 1987-02-02 IE IE25887A patent/IE60885B1/en not_active IP Right Cessation
- 1987-02-02 AU AU68218/87A patent/AU583706B2/en not_active Expired
- 1987-02-02 ZM ZM12/87A patent/ZM1287A1/xx unknown
- 1987-02-02 MA MA21102A patent/MA20868A1/fr unknown
- 1987-02-02 ZW ZW20/87A patent/ZW2087A1/xx unknown
- 1987-02-03 TN TNTNSN87015A patent/TNSN87015A1/fr unknown
- 1987-02-03 CN CN87100563A patent/CN1018614B/zh not_active Expired
- 1987-02-04 NZ NZ219165A patent/NZ219165A/en unknown
1992
- 1992-11-05 GR GR920402478T patent/GR3006158T3/el unknown
1994
- 1994-10-03 JP JP6260917A patent/JPH0819126B2/ja not_active Expired - Lifetime
1995
- 1995-07-13 HK HK114695A patent/HK114695A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY186596A patent/CY1865A/xx unknown

Also Published As

Publication number	Publication date
EP0232937A2 (en)	1987-08-19
PT84234B (pt)	1989-09-14
TNSN87015A1 (fr)	1990-01-01
NO870407D0 (no)	1987-02-02
AU6821887A (en)	1987-08-06
DE3781173D1 (de)	1992-09-24
DE3781173T2 (de)	1992-12-17
EP0232937A3 (en)	1988-04-06
DK173674B1 (da)	2001-06-05
ZW2087A1 (en)	1988-08-31
HUT44544A (en)	1988-03-28
JPS62215575A (ja)	1987-09-22
PT84234A (en)	1987-03-01
EG17993A (en)	1991-08-30
JPH0819126B2 (ja)	1996-02-28
FI870448A0 (fi)	1987-02-02
JPH0794393B2 (ja)	1995-10-11
CA1327579C (en)	1994-03-08
CN1018614B (zh)	1992-10-14
NO870407L (no)	1987-08-04
HU201067B (en)	1990-09-28
IL81448A (en)	1990-09-17
NZ219165A (en)	1990-04-26
JPH07179458A (ja)	1995-07-18
ATE79620T1 (de)	1992-09-15
CN87100563A (zh)	1987-08-19
DK54187A (da)	1987-08-04
MA20868A1 (fr)	1987-10-01
AU583706B2 (en)	1989-05-04
FI870448A7 (fi)	1987-08-04
HK114695A (en)	1995-07-21
PH24738A (en)	1990-10-01
DK54187D0 (da)	1987-02-02
IL81448A0 (en)	1987-09-16
IE870258L (en)	1987-08-03
ES2052544T3 (es)	1994-07-16
EP0232937B1 (en)	1992-08-19
IE60885B1 (en)	1994-08-24
GR3006158T3 (ja)	1993-06-21
ZA87744B (en)	1988-10-26
ZM1287A1 (en)	1988-08-29

Publication	Publication Date	Title
EG17993A (en)	1991-08-30	Anti-histaminic compositions containing n-heterocyclyl-4-piperidinanines
DE60123277D1 (de)	2006-11-02	Makrolidantibiotika
RU2001117519A (ru)	2003-05-20	Цефемовые производные, содержащие имидазол[4,5-l]пиридинийметил, обладающие широким спектром антибактериальной активности
UY25459A1 (es)	1999-11-17	Procedimiento para preparar una forma cristalina del acido 7 -([1a, 5a, 6a]-6-amino-3-azabiciclo [3, 1, 0] hex-3-il)-6-fl uor-1-(2,4-difluorofenil)-1, 4-dihidro-4-oxo-1, 8-naftiridin -3-carboxilico anhidro, sal del acido metanosulfonico
WO2002000166A3 (en)	2003-10-16	New compounds useful as antibacterial agents
AU1521202A (en)	2002-05-27	1-methylcarbapenem derivatives
CA2425319A1 (en)	2002-04-25	Treatment and prophylaxis of diseases and infections of pigs and poultry
FI872930A0 (fi)	1987-07-02	Analogiamenetelmä ripulinvastaisten 4-(bentsoyyliamino)piperidiinibutaaniamidijohdannaisten valmistamiseksi
HUT56549A (en)	1991-09-30	Process for producing new imidazole derivatives and pharmaceutical compositions comprising such imidazole derivatives as active ingredient
WO2023154804A3 (en)	2023-09-21	Method of treating spinal cord injury and composition for use therein
RU2021128535A (ru)	2023-03-29	Синергетическая композиция, содержащая четвертичное аммониевое соединение и карнозиновую кислоту для применения в качестве антибактериального, антигрибкового средства
JP2023075371A (ja)	2023-05-31	新型コロナウイルス感染症（ｃｏｖｉｄ－１９）の予防または治療剤および医薬組成物
BG103985A (en)	2000-07-31	Multicyclic derivatives of erythromycin
ATE30592T1 (de)	1987-11-15	Penicillinderivate.
ITRM20000199A1 (it)	2001-10-14	Formulazione.
KR890001561A (ko)	1989-03-27	세균감염 치료용 약제학적 제제