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EP1128839A4 - Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd - Google Patents
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EP1128839A4 - Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd - Google Patents

Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd

Info

Publication number
EP1128839A4
EP1128839A4 EP99960378A EP99960378A EP1128839A4 EP 1128839 A4 EP1128839 A4 EP 1128839A4 EP 99960378 A EP99960378 A EP 99960378A EP 99960378 A EP99960378 A EP 99960378A EP 1128839 A4 EP1128839 A4 EP 1128839A4
Authority
EP
European Patent Office
Prior art keywords
hvgd
preventing
methods
pharmaceutical compositions
synthetic peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99960378A
Other languages
German (de)
French (fr)
Other versions
EP1128839A1 (en
Inventor
Rina Aharoni
Dvora Teitelbaum
Ruth Arnon
Michael Sela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of EP1128839A1 publication Critical patent/EP1128839A1/en
Publication of EP1128839A4 publication Critical patent/EP1128839A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP99960378A 1998-11-12 1999-11-12 Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd Withdrawn EP1128839A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10818498P 1998-11-12 1998-11-12
US108184P 1998-11-12
US14521999P 1999-07-23 1999-07-23
US145219P 1999-07-23
PCT/US1999/027107 WO2000027417A1 (en) 1998-11-12 1999-11-12 Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd

Publications (2)

Publication Number Publication Date
EP1128839A1 EP1128839A1 (en) 2001-09-05
EP1128839A4 true EP1128839A4 (en) 2002-10-09

Family

ID=26805609

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99960378A Withdrawn EP1128839A4 (en) 1998-11-12 1999-11-12 Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd

Country Status (4)

Country Link
EP (1) EP1128839A4 (en)
AU (1) AU775073C (en)
CA (1) CA2355400A1 (en)
WO (1) WO2000027417A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527760T3 (en) 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Treatment of Crohn's disease with copolymer 1 and polypeptides
IL141021A0 (en) 1998-07-23 2002-02-10 Yeda Res & Dev Treatment of autoimmune conditions with copolymer 1 and related copolymers
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7022663B2 (en) 2000-02-18 2006-04-04 Yeda Research And Development Co., Ltd. Oral, nasal and pulmonary dosage formulations of copolymer 1
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
US7429374B2 (en) 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
CA2411786C (en) 2002-11-13 2009-01-27 Brantford Chemicals Inc. A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
RU2339397C2 (en) * 2003-01-21 2008-11-27 Йеда Рисерч Энд Дивелопмент Ко.Лтд. Cop1 for treatment of inflammatory diseases of intestine
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
JP5495490B2 (en) 2004-05-07 2014-05-21 アレス トレーディング エスエイ Method of treating disease using random copolymer
ZA200702591B (en) 2004-09-09 2009-03-25 Teva Pharma Process for preparation of mixtures of polypeptides using purified hydrobromic acid
HRP20160455T1 (en) 2004-09-09 2016-07-15 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, their compositions and methods for their preparation, and their uses
AR052321A1 (en) 2004-10-29 2007-03-14 Sandoz Ag PROCESSES FOR THE PREPARATION OF A POLYPEPTIDE
US20080171070A1 (en) * 2005-01-31 2008-07-17 Pierre Schaaf Polyelectrolyte Multilayer Film, Preparation And Uses Thereof
US8378072B2 (en) 2006-04-13 2013-02-19 Declion Pharmaceuticals, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
AP3467A (en) 2007-10-16 2015-11-30 Peptimmune Inc Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
NZ598661A (en) 2009-08-20 2013-02-22 Yeda Res & Dev Low frequency glatiramer acetate therapy
HUE060304T2 (en) 2010-01-04 2023-02-28 Mapi Pharma Ltd Depot system containing glatiramer acetate
US8377885B2 (en) 2010-01-04 2013-02-19 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
CA2814500A1 (en) 2010-10-11 2012-04-19 Teva Pharmaceutical Industries Ltd Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
WO2012143924A1 (en) 2011-04-21 2012-10-26 Mapi Pharma Ltd. Random pentapolymer for treatment of autoimmune diseases
HK1200274A1 (en) 2011-10-10 2015-08-07 Teva Pharmaceutical Industries Ltd. Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
HK1213830A1 (en) 2012-10-10 2016-07-15 Teva Pharmaceutical Industries Ltd. Biomarkers predictive for clinical response for glatiramer acetate
UY35790A (en) 2013-10-21 2015-05-29 Teva Pharma GENETIC MARKERS THAT PREACH THE RESPONSE TO THE GLATIRAMER ACETATE
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (en) 2016-08-31 2019-07-05 Mapi医药公司 Depot system containing glatiramer acetate
CN110382052A (en) 2017-03-26 2019-10-25 Mapi医药公司 The copaxone store system of multiple sclerosis for therapeutic advance type form

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002543A1 (en) * 1990-08-01 1992-02-20 Cytel Corporation Novel immunosuppressant peptides
WO1994026774A1 (en) * 1993-05-19 1994-11-24 Cytel Corporation Novel treatments for allergic diseases
WO1995026980A2 (en) * 1994-04-01 1995-10-12 Immulogic Pharmaceutical Corporation Haptenated peptides and uses thereof
WO1995031997A1 (en) * 1994-05-20 1995-11-30 UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY Model for testing immunogenicity of peptides
WO1996032119A1 (en) * 1995-04-14 1996-10-17 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of gvhd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4339431A (en) * 1980-12-31 1982-07-13 Colgate-Palmolive Company Anticalculus oral composition
FR2658076B1 (en) * 1990-02-12 1992-06-12 Sanofi Sa COSMETIC COMPOSITION CONTAINING COPOLYMERS OF AMINO ACIDS, USEFUL AS A MOISTURIZING AGENT.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002543A1 (en) * 1990-08-01 1992-02-20 Cytel Corporation Novel immunosuppressant peptides
WO1994026774A1 (en) * 1993-05-19 1994-11-24 Cytel Corporation Novel treatments for allergic diseases
WO1995026980A2 (en) * 1994-04-01 1995-10-12 Immulogic Pharmaceutical Corporation Haptenated peptides and uses thereof
WO1995031997A1 (en) * 1994-05-20 1995-11-30 UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY Model for testing immunogenicity of peptides
WO1996032119A1 (en) * 1995-04-14 1996-10-17 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of gvhd

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
AHARONI RINA ET AL: "Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.", IMMUNOLOGY LETTERS, vol. 58, no. 2, 1997, pages 79 - 87, XP002205821, ISSN: 0165-2478 *
FRIDKIS-HARELI M. ET AL.: "Binding of random copolymers of three aminoacids to class II MHC molecules", INTERNATIONAL IMMUNOLOGY, vol. 11, no. 5, May 1999 (1999-05-01), pages 635 - 641, XP000893153 *
FRIDKIS-HARELI M. ET AL.: "Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility comples molecules on living antigen-presenting cells - specificity and promiscuity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, 1994, WASHINGTON US, pages 4872 - 4876, XP000891508 *
JANIS KUBY: "Immunology - 3rd Ed.", part Chapter 23 1 January 1997, W. H. FREEMAN AND COMPANY, USA, ISBN: 0-7167-2868-0, article "Transplantation Immunology", pages: 555 - 572 *
LI Q. ET AL.: "Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 342, 1998, pages 303 - 310, XP000893154 *
SCHLEGEL P G ET AL: "A SYNTHETIC RANDOM BASIC COPOLYMER WITH PROMISCUOUS BINDING TO CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES INHIBITS T-CELLPROLIFERATIVE RESPONSES TO MAJOR AND MINOR HISTOCOMPATIBILITY ANTIGENS IN VITRO AND CONFERS THE CAPACITY TO PREVENT MURINE GRAFT-VERSUS-HOST DISEASE IN VIVO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, no. 10, 14 May 1996 (1996-05-14), pages 5061 - 5066, XP000578029, ISSN: 0027-8424 *
SCHLEGEL P. G. ET AL., BLOOD, vol. 84, no. 8, 1994, pages 2802 - 2810, XP000577169 *
SCHLEGEL P. G. ET AL., PNAS, vol. 93, 1 January 1996 (1996-01-01), pages 5061 - 5066 *
See also references of WO0027417A1 *
SELA M ET AL: "SUPPRESSIVE ACTIVITY OF COP-1 IN EAE AND ITS RELEVANCE TO MULTIPLE SCLEROSIS", BULL. INST. PASTEUR, vol. 88, 1990, pages 303 - 314, XP002926272 *
SYKES M., FASEB J., vol. 10, 1 January 1996 (1996-01-01), pages 721 - 730 *
TEITELBAUM D ET AL: "COPOLYMER 1 FROM THE LABORATORY TO FDA", ISRAEL JOURNAL OF MEDICAL SCIENCES, ISRAEL MEDICAL ASSOCIATION, TEL AVIV, IL, vol. 33, no. 4, April 1997 (1997-04-01), pages 280 - 284, XP002926268, ISSN: 0021-2180 *
TEITELBAUM D ET AL: "CROSS-REACTIONS AND SPECIFICITIES OF MONOCLONAL ANTIBODIES AGAINST MYELIN BASIC PROTEIN AND AGAINST THE SYNTHETIC COPOLYMER1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, November 1991 (1991-11-01), pages 9528 - 9532, XP002949037, ISSN: 0027-8424 *
TEITELBAUM D ET AL: "SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY A SYNTHETIC POLYPEPTIDE", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 1, 1971, pages 242,244,246,248, XP002926270, ISSN: 0014-2980 *
TEITELBAUM D ET AL: "SYNTHETIC COPOLYMER 1 INHIBITS HUMAN T-CELL LINES SPECIFIC FOR MYELIN BASIC PROTEIN", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, January 1992 (1992-01-01), pages 137 - 141, XP002924839, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU775073C (en) 2007-05-03
CA2355400A1 (en) 2000-05-18
EP1128839A1 (en) 2001-09-05
AU1727000A (en) 2000-05-29
WO2000027417A1 (en) 2000-05-18
AU775073B2 (en) 2004-07-15

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Legal Events

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Owner name: YEDA RESEARCH AND DEVELOPMEMT CO., LTD.

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