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FR2578542B2 - Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase - Google Patents
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FR2578542B2 - Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase - Google Patents

Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase

Info

Publication number
FR2578542B2
FR2578542B2 FR8503236A FR8503236A FR2578542B2 FR 2578542 B2 FR2578542 B2 FR 2578542B2 FR 8503236 A FR8503236 A FR 8503236A FR 8503236 A FR8503236 A FR 8503236A FR 2578542 B2 FR2578542 B2 FR 2578542B2
Authority
FR
France
Prior art keywords
inhibitors
useful
processes
preparation
aldose reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8503236A
Other languages
English (en)
Other versions
FR2578542A2 (fr
Inventor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carpibem SA
Original Assignee
Carpibem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carpibem SA filed Critical Carpibem SA
Priority to FR8503236A priority Critical patent/FR2578542B2/fr
Priority to IE112685A priority patent/IE58312B1/en
Priority to PH32246A priority patent/PH21118A/en
Priority to GR851159A priority patent/GR851159B/el
Priority to DE8585400927T priority patent/DE3569529D1/de
Priority to EP85400927A priority patent/EP0162776B1/fr
Priority to AT85400927T priority patent/ATE42297T1/de
Priority to NZ212060A priority patent/NZ212060A/xx
Priority to CA000481503A priority patent/CA1306747C/fr
Priority to US06/733,685 priority patent/US4755509A/en
Priority to AU42518/85A priority patent/AU586972B2/en
Priority to KR1019850003306A priority patent/KR900004320B1/ko
Priority to JP60102788A priority patent/JPH0692371B2/ja
Priority to ES543266A priority patent/ES8607263A1/es
Priority to DK219685A priority patent/DK219685A/da
Priority to PT80489A priority patent/PT80489B/fr
Publication of FR2578542A2 publication Critical patent/FR2578542A2/fr
Application granted granted Critical
Publication of FR2578542B2 publication Critical patent/FR2578542B2/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8503236A 1984-05-18 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase Expired FR2578542B2 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR8503236A FR2578542B2 (fr) 1985-03-05 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
IE112685A IE58312B1 (en) 1984-05-18 1985-05-06 Heterocyclic derivatives, processes for their preparation and drugs in which they are present, which are useful especially as aldose reductase inhibitors
PH32246A PH21118A (en) 1984-05-18 1985-05-09 Heterocyclic derivatives, a process for their preparation the pharmaceutical composition containing them
DE8585400927T DE3569529D1 (en) 1984-05-18 1985-05-13 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them
EP85400927A EP0162776B1 (fr) 1984-05-18 1985-05-13 Dérivés hétérocycliques, leurs procédés de préparation,médicaments les contenant, utiles notamment comme inhibiteurs de l'aldose réductase
AT85400927T ATE42297T1 (de) 1984-05-18 1985-05-13 Heterozyklische derivate, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel brauchbar als aldosereduktaseinhibitoren.
NZ212060A NZ212060A (en) 1984-05-18 1985-05-13 Bicyclic hetrocycles and pharmaceutical derivatives
GR851159A GR851159B (fr) 1984-05-18 1985-05-13
CA000481503A CA1306747C (fr) 1984-05-18 1985-05-14 Procede pour la preparation de derives heterocycliques pouvant etre utilises comme inhibiteurs de l'aldose reductase
US06/733,685 US4755509A (en) 1984-05-18 1985-05-14 Heterocyclic aldose reductase inhibitors and methods of using them
AU42518/85A AU586972B2 (en) 1984-05-18 1985-05-15 New heterocyclic derivatives, the processes for their preparation and drugs in which they are present, which are useful especially as aldose reductase inhibitors
KR1019850003306A KR900004320B1 (ko) 1984-05-18 1985-05-15 헤테로 사이클릭 유도체의 제조방법
JP60102788A JPH0692371B2 (ja) 1984-05-18 1985-05-16 新規複素環誘導体、その製法およびこれらを含有し、アルド−ス還元酵素抑制剤として特に有用な医薬の製法
ES543266A ES8607263A1 (es) 1984-05-18 1985-05-17 Un procedimiento de preparacion de compuestos heterociclicos
DK219685A DK219685A (da) 1984-05-18 1985-05-17 Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
PT80489A PT80489B (fr) 1984-05-18 1985-05-17 Procede de preparation de nouveaux derives heterocycliques utilisables notamment comme innibiteurs de l'aldose reductase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8503236A FR2578542B2 (fr) 1985-03-05 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase

Publications (2)

Publication Number Publication Date
FR2578542A2 FR2578542A2 (fr) 1986-09-12
FR2578542B2 true FR2578542B2 (fr) 1987-08-28

Family

ID=9316883

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8503236A Expired FR2578542B2 (fr) 1984-05-18 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase

Country Status (1)

Country Link
FR (1) FR2578542B2 (fr)

Also Published As

Publication number Publication date
FR2578542A2 (fr) 1986-09-12

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