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GB2158443B - 1a,25-dihydroxylated vitamin d2 intermediates - Google Patents
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GB2158443B - 1a,25-dihydroxylated vitamin d2 intermediates - Google Patents

1a,25-dihydroxylated vitamin d2 intermediates

Info

Publication number
GB2158443B
GB2158443B GB08507475A GB8507475A GB2158443B GB 2158443 B GB2158443 B GB 2158443B GB 08507475 A GB08507475 A GB 08507475A GB 8507475 A GB8507475 A GB 8507475A GB 2158443 B GB2158443 B GB 2158443B
Authority
GB
United Kingdom
Prior art keywords
intermediates
dihydroxylated vitamin
dihydroxylated
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08507475A
Other versions
GB8507475D0 (en
GB2158443A (en
Inventor
Hector F Deluca
Heinrich K Schnoes
Rafal R Sicinski
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of GB8507475D0 publication Critical patent/GB8507475D0/en
Publication of GB2158443A publication Critical patent/GB2158443A/en
Application granted granted Critical
Publication of GB2158443B publication Critical patent/GB2158443B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dram (AREA)
GB08507475A 1983-05-09 1985-03-22 1a,25-dihydroxylated vitamin d2 intermediates Expired GB2158443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09

Publications (3)

Publication Number Publication Date
GB8507475D0 GB8507475D0 (en) 1985-05-01
GB2158443A GB2158443A (en) 1985-11-13
GB2158443B true GB2158443B (en) 1987-02-04

Family

ID=23957917

Family Applications (3)

Application Number Title Priority Date Filing Date
GB08411794A Expired GB2139627B (en) 1983-05-09 1984-05-09 1 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof
GB08507474A Expired GB2158442B (en) 1983-05-09 1985-03-22 Cyclovitamin d compounds
GB08507475A Expired GB2158443B (en) 1983-05-09 1985-03-22 1a,25-dihydroxylated vitamin d2 intermediates

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB08411794A Expired GB2139627B (en) 1983-05-09 1984-05-09 1 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof
GB08507474A Expired GB2158442B (en) 1983-05-09 1985-03-22 Cyclovitamin d compounds

Country Status (5)

Country Link
JP (1) JPS60501261A (en)
BE (1) BE899612A (en)
FR (1) FR2545824B1 (en)
GB (3) GB2139627B (en)
IE (1) IE58277B1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
JP2608322B2 (en) * 1988-04-11 1997-05-07 日清製粉株式会社 Method for producing 1α, 25-dihydroxyvitamin D
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
BR9405735A (en) * 1993-02-19 1995-12-05 Wisconsin Alumni Res Found Use of 26,26,26,27,27,27-hexafluoro-1-alpha 25-dihydroxy cholecalciferol for the treatment of disorders of calcium metabolism
AU743514B2 (en) 1997-05-16 2002-01-24 Women & Infants Hospital Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof
ATE322477T1 (en) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-EPI-VITAMIN D2 COMPOUNDS AND THEIR APPLICATIONS
AU2001291239A1 (en) * 2000-10-06 2002-04-22 Abbott Laboratories Use of vitamin d2 compounds for alopecia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
NL188286C (en) * 1978-01-16 1992-05-18 Wisconsin Alumni Res Found PROCESS FOR PREPARING A 1-ALFA-HYDROXYVITAMINE D COMPOUND
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

Also Published As

Publication number Publication date
GB2158442A (en) 1985-11-13
GB2158442B (en) 1987-02-04
IE58277B1 (en) 1993-08-25
GB8507475D0 (en) 1985-05-01
BE899612A (en) 1984-08-31
GB2139627A (en) 1984-11-14
JPH0364498B2 (en) 1991-10-07
IE841149L (en) 1984-11-09
GB8507474D0 (en) 1985-05-01
GB2158443A (en) 1985-11-13
FR2545824A1 (en) 1984-11-16
FR2545824B1 (en) 1987-11-20
GB2139627B (en) 1987-02-04
JPS60501261A (en) 1985-08-08
GB8411794D0 (en) 1984-06-13

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20030509