GB2159052A - Artificial mucus material - Google Patents
Artificial mucus material Download PDFInfo
- Publication number
- GB2159052A GB2159052A GB08412676A GB8412676A GB2159052A GB 2159052 A GB2159052 A GB 2159052A GB 08412676 A GB08412676 A GB 08412676A GB 8412676 A GB8412676 A GB 8412676A GB 2159052 A GB2159052 A GB 2159052A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sheet
- film
- polyethylene oxide
- artificial mucus
- artificial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000463 material Substances 0.000 title claims abstract description 60
- 210000003097 mucus Anatomy 0.000 title claims abstract description 26
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 19
- 230000003444 anaesthetic effect Effects 0.000 claims abstract description 7
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 7
- 206010013781 dry mouth Diseases 0.000 claims abstract description 5
- 239000000314 lubricant Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 150000003431 steroids Chemical class 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 206010028034 Mouth ulceration Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 239000000935 antidepressant agent Substances 0.000 claims description 2
- 229940005513 antidepressants Drugs 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229940126701 oral medication Drugs 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Artificial mucus material which can be used orally for patients suffering with dry mouths or for applying a specified treatment e.g. an anaesthetic or an antiseptic comprises a sheet or film of polyethylene oxide.
Description
SPECIFICATION
Artificial mucus material
This invention relates to an artificial mucus material which can be used orally for patients suffering with very dry mouths or for applying a specified treatment, for example an anaesthetic or an antiseptic.
Polyethylene oxide is a substance having a very high molecularweightand acts as an intra-oral lubricant. It is usually in the form of a white powder which has been dissolved in water and which, when placed in the mouth produces a film where there is a sore spot or will leach a mucus-like lubricant where the mouth is dry. A drawback with the material however is that it is visco-elastic and does not lend itself readily to production in conventional containers, for example tubes. It has been produced in a 1% and 2% gel form in a tube and it has also been produced in tablet form.
According to the present invention an artificial mucus material comprises a sheet or film of polyethylene oxide.
Preferably the sheet of material is large enough to be cut or broken into individual dosages. Thus, the sheet can be large enough so that a small section can be cut or broken by the practitioner to apply to the mouth not only for dry mouthed patients but also for oral ulceration generally.
If desired the sheet of film can also incorporate a treatment material and thus it can be used to apply a steroid or steroids, an anaesthetic or an antiseptic for local application.
The material is particularly useful for use with patients with very dry mouths who suffer the problem as a result of X-ray therapy for tumors, various rare conditions causing drying of the eyes and mouth, or, increasingly nowadays, as a result of certain drugs particularly antidepressants.
The material is easily handled in sheet or film form and can be easily stored.
A sheet or film of material can be made in any convenient manner and one preferred method includes evaporating a solution of polyethylene oxide in a container and removing the residue as a sheet. This produces a sheet of material rather similar to rice paper which can be easily cut or broken by the practitioner as required.
An alternative method includes pressing a powder of polyethylene oxide into a sheet or film.
The aim of the invention is to provide dental practitioners with an oral lubricant base which has the advantage of having longevity in the mouth either as a lubricant or as a vehicle for oral medication and which is provided in a convenient and easily handled form.
The invention can be performed in many ways but one sample and a method of producing it will now be described by way of example.
The material is produced as a sheet and this is made by mixing a 2% aqueous solution of polyethylene oxide using either a magnetic stirrer or by placing the material in a container which is then secured between rollers, until the solution becomes homogeneous. This can take between three or four hours.
The solution is then placed in an open container at room temperature and the water allowed to evaporate over night on a smooth surface, such as glass, until a thin homogeneous sheet of material is obtained.
This can be easily handled and the size of the sheet will obviously depend upon the size of the open container.
The sheet can be used as set forth above.
Yet another method of producing this sort of material is by taking a powdered form and compressing it between moving rollers to produce a thin sheet.
As mentioned above the sheet orfilm of polyethylene oxide has many advantages and can incorporate other treatment material. It is in a convenient form and can be produced as a sheet which can be cut or broken to size or as conveniently sized "labels". The material could also be produced as a "tape", that is an elongated sheet which can be cut or broken to size as required.
1. Artificial mucus material comprising a sheet or film of polyethylene oxide.
2. Artificial mucus material as claimed in claim 1 in which the sheet of material is large enough to be cut or broken into individual dosages.
3. Artificial mucus material as claimed in claim 2 in which the sheet of material is elongated in the form of a tape.
4. Artificial mucus material as claimed in claim 1, claim 2 or claim 3 in which the sheet or film also incorporates a treatment material.
5. Artificial mucus material as claimed in claim 4 in which the treatment material is a steroid or steroids, anaesthetic, or antiseptic.
6. A method of making a sheet of artificial mucus material as claimed in any one of the preceding claims which includes evaporating a solution of polyethylene oxide in a container and removing the residue as a sheet.
7. A method of making a sheet of artificual mucus material as claimed in any one of the preceding claims 1 to 5 which includes pressing a poweder of polyethylene oxide into a sheet or film.
8. Artificial mucus material substantially as described herein.
9. A method of making an artificial mucus material substantially as described herein.
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (9)
1. Artificial mucus material comprising a sheet or film of polyethylene oxide.
2. Artificial mucus material as claimed in claim 1 in which the sheet of material is large enough to be cut or broken into individual dosages.
3. Artificial mucus material as claimed in claim 2 in which the sheet of material is elongated in the form of a tape.
4. Artificial mucus material as claimed in claim 1, claim 2 or claim 3 in which the sheet or film also incorporates a treatment material.
5. Artificial mucus material as claimed in claim 4 in which the treatment material is a steroid or steroids, anaesthetic, or antiseptic.
6. A method of making a sheet of artificial mucus material as claimed in any one of the preceding claims which includes evaporating a solution of polyethylene oxide in a container and removing the residue as a sheet.
7. A method of making a sheet of artificual mucus material as claimed in any one of the preceding claims 1 to 5 which includes pressing a poweder of polyethylene oxide into a sheet or film.
8. Artificial mucus material substantially as described herein.
9. A method of making an artificial mucus material substantially as described herein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08412676A GB2159052A (en) | 1984-05-18 | 1984-05-18 | Artificial mucus material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08412676A GB2159052A (en) | 1984-05-18 | 1984-05-18 | Artificial mucus material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8412676D0 GB8412676D0 (en) | 1984-06-27 |
| GB2159052A true GB2159052A (en) | 1985-11-27 |
Family
ID=10561136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08412676A Withdrawn GB2159052A (en) | 1984-05-18 | 1984-05-18 | Artificial mucus material |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2159052A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0613684A1 (en) * | 1993-03-02 | 1994-09-07 | Block Drug Company Inc. | Solid form xerostomia product |
| US6884426B2 (en) | 1997-06-06 | 2005-04-26 | The Procter & Gamble Co. | Methods for whitening teeth |
| US6949240B2 (en) | 2002-05-23 | 2005-09-27 | The Procter & Gamble Company | Tooth whitening products |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB484600A (en) * | 1935-11-09 | 1938-05-09 | Ig Farbenindustrie Ag | Manufacture of shaped medicinal preparations |
-
1984
- 1984-05-18 GB GB08412676A patent/GB2159052A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB484600A (en) * | 1935-11-09 | 1938-05-09 | Ig Farbenindustrie Ag | Manufacture of shaped medicinal preparations |
Non-Patent Citations (2)
| Title |
|---|
| ENCYCLOPEDIA OF POLYMER SCIENCE AND TECHNOLOGY, 1967, INTERSCIENCE, VOLUME 6 PAGE 103 PAGES 139 TO 141 * |
| HIGH POLYMERS VOLUME XII, POLYETHERS, PART 1 1963 INTERSCIENCE PAGES 213 TO 214 AND 271 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07101856A (en) * | 1993-03-02 | 1995-04-18 | Block Drug Co Inc | Solid tablet form product to reduce oral cavity exrosis symptom |
| US5496558A (en) * | 1993-03-02 | 1996-03-05 | Block Drug Company Inc. | Solid form xerostomia product |
| AU670481B2 (en) * | 1993-03-02 | 1996-07-18 | Block Drug Company Inc., The | Solid form xerostomia product |
| JP2794388B2 (en) | 1993-03-02 | 1998-09-03 | ブロック・ドラッグ・カンパニー・インコーポレイテッド | Solid dosage form product for alleviating dry mouth symptoms |
| EP0613684A1 (en) * | 1993-03-02 | 1994-09-07 | Block Drug Company Inc. | Solid form xerostomia product |
| US6884426B2 (en) | 1997-06-06 | 2005-04-26 | The Procter & Gamble Co. | Methods for whitening teeth |
| US7122199B2 (en) | 1997-06-06 | 2006-10-17 | The Procter & Gamble Company | Methods for whitening teeth |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| US6949240B2 (en) | 2002-05-23 | 2005-09-27 | The Procter & Gamble Company | Tooth whitening products |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10493016B2 (en) | 2002-09-11 | 2019-12-03 | The Procter & Gamble Company | Tooth whitening product |
| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8412676D0 (en) | 1984-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |