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GB2178189A - Chemically cleaning contact lenses - Google Patents
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GB2178189A - Chemically cleaning contact lenses - Google Patents

Chemically cleaning contact lenses Download PDF

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Publication number
GB2178189A
GB2178189A GB08617294A GB8617294A GB2178189A GB 2178189 A GB2178189 A GB 2178189A GB 08617294 A GB08617294 A GB 08617294A GB 8617294 A GB8617294 A GB 8617294A GB 2178189 A GB2178189 A GB 2178189A
Authority
GB
United Kingdom
Prior art keywords
treating
contact lens
composition
monoperoxyphthalate
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08617294A
Other versions
GB8617294D0 (en
Inventor
John Cannell
Andrew Hopkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CooperVision Lens Care Ltd
Original Assignee
Sauflon Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sauflon Pharmaceuticals Ltd filed Critical Sauflon Pharmaceuticals Ltd
Publication of GB8617294D0 publication Critical patent/GB8617294D0/en
Publication of GB2178189A publication Critical patent/GB2178189A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0078Compositions for cleaning contact lenses, spectacles or lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124Hydrogen peroxide; Peroxy compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39Organic or inorganic per-compounds
    • C11D3/3945Organic per-compounds

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eyeglasses (AREA)
  • Detergent Compositions (AREA)

Abstract

A method of treating a contact lens which comprises treating a said lens with an aqueous solution containing an effective amount of monoperoxyphthalate salt, wherein the said aqueous solution may also contain a non-ionic detergent, a buffer, saline, at least one effervescing agent, and optionally, other lens- cleaning ingredients. Contact lens treating compositions are disclosed as is a two part pack for preparing such a composition.

Description

SPECIFICATION Contact lens treating composition This invention relates to a novel contact lens treating composition and to a method of treating contact lenses.
A known composition for treating contact lenses includes as an active ingredient sodium perborate. The known composition is in the form of a powder which is not readily soluble.
Moreover the method of use of the known composition requires that in treating lenses a solution of the composition be held at a controlled elevated temperature for 2 hours.
Additionally sodium perborate causes ocular irritation and is used at high pH. Both these factors mean that every trace of the treating solution must be removed from the lenses after treatment. This removal process is laborious and involves repeated heat treatments and pH measurements.
Finally, the sodium perborate-containing solution cannot be used to treat lenses made from hydroxyethylmethacrylate (HEMA).
It is an object of the present invention to provide a composition and method which alleviates some or all of the disadvantages of the known compositions.
According to a first aspect of the present invention there is provided a method of treating a contact lens which comprises treating a said lens with an aqueous solution containing an effective amount of a monoperoxyphthalate salt.
Very preferably the solution contains a nonionic detergent, such as, for example, a polyethylene oxide to improve wettability and cleaning effectiveness. Preferably the solution also contains saline and buffer and may be made by dissolving a mixture of detergent and monoperoxyphthalate in isotonic buffered saline solution.
Very preferably magnesium monoperoxyphthalate hexahydrate is employed in the method of the present invention since this is commercially available (as Interox H48 from Interox Chemicals Ltd. of Warrington, Cheshire), is freely soluble and is effective at room temperature. Other salts such as, for example, sodium or potassium salts can be employed.
The monoperoxyphthalate is preferably used in an amount of from 1% to 20% by weight in a said aqueous solution, more preferably from 1% to 5% by weight in such a solution.
The present invention can be used to clean both hard lenses, e.g. of glass or methyl methacrylate or soft lenses such as those made of HEMA or from cross-linked copolymers of methyl methacrylate with hydrophilic comonomers e.g. polyvinyl pyrrolidone.
Generally speaking the solution will be made up shortly before by dissolving a tablet or powder in buffered saline. In a preferred formulation a powder for dissolution contains 30% by weight of magnesium monoperoxyphthalate hexahydrate and 70% by weight of detergent. In general the powder may contain from 10% to 80% by weight of the monoperoxyphthalate salt and from 90% to 20% of detergent. Inert fillers, effervescing agents etc.
may be added if desired together with other lens-cleaning ingredients.
According to a second aspect of the present invention there is provided a contact lens treating composition comprising an effective quantity of a monoperoxyphthalate salt and a non-ionic detergent. The composition may be in the form of a solution or in the form of a two part pack, the one part consisting of a predetermined quantity of a solid composition as aforesaid and the other part consisting of a predetermined quantity of an aqueous vehicle in which the solid composition is to be dissolved to form the said contact lens treating composition.
Examples of suitable detergents include polyethylene oxide formulations such as are available under the trade names PLURIOL PE6800 and PLURONIC.
The present invention will now be further described by way of example only by reference to the following illustrative examples.
EXAMPLE 1 A solution was prepared containing magnesium monoperoxyphthalate hexahydrate in an amount of 1gm/10mls water. It was found that 10 mls of this solution adequately cleaned one soft HEMA contact lens after treatment thereof at 60"C for approx. 2 hours.
EXAMPLE 2 A solution was prepared containing magnesium monoperoxyphthalate hexahydrate and PLURIOL PE6800 (non-ionic detergent) respectively in amounts of 1 gm each per 10 mls water. It was found that 10 mls of this solution adequately cleaned one soft contact lens (a cross-linked copolymer of methyl methacrylate and polyvinyl pyrrolidone) after treatment thereof at 60"C for approx. 2 hours.
The present invention provides a method of and composition for treating contact lenses which obviates or alleviates the disadvantages of known methods and compositions.
It will be apparent to one skilled in the art that the invention can be performed otherwise than as has been particularly described and the invention includes within its scope all such changes or modifications to the invention as would be apparent to one skilled in the art.
1. A method of treating a contact lens which comprises treating a said lens with an aqueous solution containing an effective amount of a monoperoxyphthalate salt.
2. A method of treating a contact lens according to claim 1, wherein said aqueous solu
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (20)

**WARNING** start of CLMS field may overlap end of DESC **. SPECIFICATION Contact lens treating composition This invention relates to a novel contact lens treating composition and to a method of treating contact lenses. A known composition for treating contact lenses includes as an active ingredient sodium perborate. The known composition is in the form of a powder which is not readily soluble. Moreover the method of use of the known composition requires that in treating lenses a solution of the composition be held at a controlled elevated temperature for 2 hours. Additionally sodium perborate causes ocular irritation and is used at high pH. Both these factors mean that every trace of the treating solution must be removed from the lenses after treatment. This removal process is laborious and involves repeated heat treatments and pH measurements. Finally, the sodium perborate-containing solution cannot be used to treat lenses made from hydroxyethylmethacrylate (HEMA). It is an object of the present invention to provide a composition and method which alleviates some or all of the disadvantages of the known compositions. According to a first aspect of the present invention there is provided a method of treating a contact lens which comprises treating a said lens with an aqueous solution containing an effective amount of a monoperoxyphthalate salt. Very preferably the solution contains a nonionic detergent, such as, for example, a polyethylene oxide to improve wettability and cleaning effectiveness. Preferably the solution also contains saline and buffer and may be made by dissolving a mixture of detergent and monoperoxyphthalate in isotonic buffered saline solution. Very preferably magnesium monoperoxyphthalate hexahydrate is employed in the method of the present invention since this is commercially available (as Interox H48 from Interox Chemicals Ltd. of Warrington, Cheshire), is freely soluble and is effective at room temperature. Other salts such as, for example, sodium or potassium salts can be employed. The monoperoxyphthalate is preferably used in an amount of from 1% to 20% by weight in a said aqueous solution, more preferably from 1% to 5% by weight in such a solution. The present invention can be used to clean both hard lenses, e.g. of glass or methyl methacrylate or soft lenses such as those made of HEMA or from cross-linked copolymers of methyl methacrylate with hydrophilic comonomers e.g. polyvinyl pyrrolidone. Generally speaking the solution will be made up shortly before by dissolving a tablet or powder in buffered saline. In a preferred formulation a powder for dissolution contains 30% by weight of magnesium monoperoxyphthalate hexahydrate and 70% by weight of detergent. In general the powder may contain from 10% to 80% by weight of the monoperoxyphthalate salt and from 90% to 20% of detergent. Inert fillers, effervescing agents etc. may be added if desired together with other lens-cleaning ingredients. According to a second aspect of the present invention there is provided a contact lens treating composition comprising an effective quantity of a monoperoxyphthalate salt and a non-ionic detergent. The composition may be in the form of a solution or in the form of a two part pack, the one part consisting of a predetermined quantity of a solid composition as aforesaid and the other part consisting of a predetermined quantity of an aqueous vehicle in which the solid composition is to be dissolved to form the said contact lens treating composition. Examples of suitable detergents include polyethylene oxide formulations such as are available under the trade names PLURIOL PE6800 and PLURONIC. The present invention will now be further described by way of example only by reference to the following illustrative examples. EXAMPLE 1 A solution was prepared containing magnesium monoperoxyphthalate hexahydrate in an amount of 1gm/10mls water. It was found that 10 mls of this solution adequately cleaned one soft HEMA contact lens after treatment thereof at 60"C for approx. 2 hours. EXAMPLE 2 A solution was prepared containing magnesium monoperoxyphthalate hexahydrate and PLURIOL PE6800 (non-ionic detergent) respectively in amounts of 1 gm each per 10 mls water. It was found that 10 mls of this solution adequately cleaned one soft contact lens (a cross-linked copolymer of methyl methacrylate and polyvinyl pyrrolidone) after treatment thereof at 60"C for approx. 2 hours. The present invention provides a method of and composition for treating contact lenses which obviates or alleviates the disadvantages of known methods and compositions. It will be apparent to one skilled in the art that the invention can be performed otherwise than as has been particularly described and the invention includes within its scope all such changes or modifications to the invention as would be apparent to one skilled in the art. CLAIMS
1. A method of treating a contact lens which comprises treating a said lens with an aqueous solution containing an effective amount of a monoperoxyphthalate salt.
2. A method of treating a contact lens according to claim 1, wherein said aqueous solu tion contains a non-ionic detergent.
3. A method of treating a contact lens according to claim 2, wherein said non-ionic detergent comprises polyethylene oxide.
4. A method of treating a contact lens according to any preceding claim, wherein said aqueous solution contains a buffer.
5. A method of treating a contact lens according to any preceding claim, wherein said aqueous solution contains saline.
6. A method of treating a contact lens according to any preceding claim, wherein said monoperoxyphthalate salt comprises a sodium salt.
7. A method of treating a contact lens according to claims 1 to 5, wherein said monoperoxyphthalate salt comprises a potassium sait.
8. A method of treating a contact lens according to claims 1 to 5, wherein said monoperoxyphthalate salt comprises a magnesium salt
9. A method of treating a contact lens according to claim 8, wherein said monoperoxyphthalate salt comprises magnesium monoperoxyphthalate hexahydrate.
10. A method of treating a contact lens according to any preceding claim, wherein said monoperoxyphthalate salt is used in an amount of from 1% to 20% by weight in a said aqueous solution.
11. A method of treating a contact lens according to claims 1 to 9, wherein said monoperoxyphthalate salt is used in an amount of from 1% to 5% by weight in a said aqueous solution.
12. A method of treating a contact lens according to any preceding claim, wherein said aqueous solution is provided by dissolving a tablet or powder in aqueous liquid.
13. A method of treating a contact lens according to claim 12, wherein said tablet or powder contains from 10% to 80% by weight of a said monoperoxyphthalate salt and from 90% to 20% by weight of detergent.
14. A method of treating a contact lens according to claim 13, wherein said tablet or powder contains 30% by weight of magnesium monoperoxyphthalate hexahydrate and 70% by weight of detergent.
15. A contact lens treating composition comprising an effective quantity of a monoper oxyphthajate salt and a non-ionic detergent.
16. A contact lens treating composition according to claim 15, wherein said composition is in the form of an aqueous solution.
17. A contact lens treating composition according to claim 16, wherein said composition includes at least one effervescing agent.
18. A two part pack for producing a contact lens treating composition, said two part pack comprising one part consisting of a predetermined quantity of a tablet or powder containing a monoperoxyphthalate salt and a non-ionic detergent, and another part consisting of a pedetermined quantity of an aqueous vehicle.
19. A method of treating a contact lens, substantially as hereinbefore described.
20. The features hereinbefore disclosed, or their equivalents, in any novel selection.
GB08617294A 1985-07-17 1986-07-16 Chemically cleaning contact lenses Withdrawn GB2178189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517987A GB8517987D0 (en) 1985-07-17 1985-07-17 Contact lens treating composition

Publications (2)

Publication Number Publication Date
GB8617294D0 GB8617294D0 (en) 1986-08-20
GB2178189A true GB2178189A (en) 1987-02-04

Family

ID=10582391

Family Applications (2)

Application Number Title Priority Date Filing Date
GB858517987A Pending GB8517987D0 (en) 1985-07-17 1985-07-17 Contact lens treating composition
GB08617294A Withdrawn GB2178189A (en) 1985-07-17 1986-07-16 Chemically cleaning contact lenses

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB858517987A Pending GB8517987D0 (en) 1985-07-17 1985-07-17 Contact lens treating composition

Country Status (1)

Country Link
GB (2) GB8517987D0 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0645235A3 (en) * 1990-04-17 1996-04-24 Johnson & Johnson Vision Prod Process for the hydration of soft contact lenses.
DE19835064A1 (en) * 1998-07-23 2000-02-10 Bode Chemie Gmbh & Co Stable combinations of active ingredients for the disinfection and cleaning of contact lenses, as well as packaging and methods for producing the same
WO2001060421A1 (en) * 2000-02-16 2001-08-23 Novartis Ag Contact lens treating method and composition
EP0974368A3 (en) * 1998-07-23 2003-02-05 Bode Chemie GmbH & Co. Stable combinations of active agents for disinfecting and cleaning contact lenses
US6569824B2 (en) 2000-02-16 2003-05-27 Novartis Ag Contact lens treating method and composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0645235A3 (en) * 1990-04-17 1996-04-24 Johnson & Johnson Vision Prod Process for the hydration of soft contact lenses.
DE19835064A1 (en) * 1998-07-23 2000-02-10 Bode Chemie Gmbh & Co Stable combinations of active ingredients for the disinfection and cleaning of contact lenses, as well as packaging and methods for producing the same
DE19835064C2 (en) * 1998-07-23 2001-01-18 Bode Chemie Gmbh & Co Contact lens disinfectant and process for its manufacture
EP0974368A3 (en) * 1998-07-23 2003-02-05 Bode Chemie GmbH & Co. Stable combinations of active agents for disinfecting and cleaning contact lenses
WO2001060421A1 (en) * 2000-02-16 2001-08-23 Novartis Ag Contact lens treating method and composition
US6569824B2 (en) 2000-02-16 2003-05-27 Novartis Ag Contact lens treating method and composition

Also Published As

Publication number Publication date
GB8617294D0 (en) 1986-08-20
GB8517987D0 (en) 1985-08-21

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)