GB2198642A - Hydrogen peroxide emulsion - Google Patents
Hydrogen peroxide emulsion Download PDFInfo
- Publication number
- GB2198642A GB2198642A GB08728875A GB8728875A GB2198642A GB 2198642 A GB2198642 A GB 2198642A GB 08728875 A GB08728875 A GB 08728875A GB 8728875 A GB8728875 A GB 8728875A GB 2198642 A GB2198642 A GB 2198642A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- emulsion
- anesthetic
- hydrogen peroxide
- anaesthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims description 22
- 239000000839 emulsion Substances 0.000 title claims description 22
- 239000000203 mixture Substances 0.000 claims description 27
- 230000003444 anaesthetic effect Effects 0.000 claims description 13
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 10
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
- 150000002576 ketones Chemical class 0.000 claims description 6
- 229960003920 cocaine Drugs 0.000 claims description 5
- 230000000249 desinfective effect Effects 0.000 claims description 5
- 150000002170 ethers Chemical class 0.000 claims description 5
- 150000003840 hydrochlorides Chemical class 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 229960004194 lidocaine Drugs 0.000 claims description 5
- 229960004919 procaine Drugs 0.000 claims description 5
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 5
- YUGZHQHSNYIFLG-UHFFFAOYSA-N N-phenylcarbamic acid [2-[anilino(oxo)methoxy]-3-(1-piperidinyl)propyl] ester Chemical compound C1CCCCN1CC(OC(=O)NC=1C=CC=CC=1)COC(=O)NC1=CC=CC=C1 YUGZHQHSNYIFLG-UHFFFAOYSA-N 0.000 claims description 4
- 229960001747 cinchocaine Drugs 0.000 claims description 4
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims description 4
- 229960002228 diperodon Drugs 0.000 claims description 4
- BZEWSEKUUPWQDQ-UHFFFAOYSA-N dyclonine Chemical compound C1=CC(OCCCC)=CC=C1C(=O)CCN1CCCCC1 BZEWSEKUUPWQDQ-UHFFFAOYSA-N 0.000 claims description 4
- 229960000385 dyclonine Drugs 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000008595 infiltration Effects 0.000 claims description 4
- 238000001764 infiltration Methods 0.000 claims description 4
- 239000003589 local anesthetic agent Substances 0.000 claims description 4
- 229960001896 pramocaine Drugs 0.000 claims description 4
- DQKXQSGTHWVTAD-UHFFFAOYSA-N pramocaine Chemical compound C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 DQKXQSGTHWVTAD-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 3
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 claims description 3
- 150000003931 anilides Chemical class 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 150000003673 urethanes Chemical class 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229940072358 xylocaine Drugs 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010006802 Burns second degree Diseases 0.000 description 1
- 206010006803 Burns third degree Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- -1 hexachlorophene Chemical class 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000004045 organic chlorine compounds Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
2198642 W f Disinfecting composition for human or veterinary use
SUMMARY OF THE INVENTION
The invention relates to a disinfecting composition for human or veterinary use, based on an aqueous emulsion of hydrogen peroxide. It is intended essentially for external use, especially for the treatment of sores o f various types or skin complaints.
BACKGROUND OF THE INVENTION
In the treatment of sore's or certain skin complaints1which cause open wounds, or in the case of burns such as second or third degree burns, it is necessary to resort to the use of disinfectants. Doctors currently have a large number of products at their disposal, for example mercury derivatives, organochlorine compounds like hexachlorophene, and aqueous solutions or emulsions of hydrogen peroxide.
Aqueous solutions and emulsions of hydrogen peroxide, in particular some emulsions of the oil-inwater type, are of great value for the disinfection of serious burns because no toxic active compounds are present. By virtue of their high content of active oxygen,-such emulsions favor reconstitution of the destroyed tissues, enabling the patients to be cured more quickly. However, it has been observed, without a satisfactory explanation having been found for this phenomenon, that the pain characteristic of burns reappears apprecia,bly sooner than in the case of treatment with other disinfectants. This pain is most generally reduced internally (by injections) using appropriate anesthetics, a local external treatment being excluded on the grounds that conditions of sterility cannot be respected.
1 2 THE INVENTION The present invention makes it possible advantageously to overcome these drawbacks by proposing a disinfecting composition for human or veterinary use, based on an aqueous emulsion of hydrogen peroxide, the said composition containing a local anesthetic which does not affect the stability of the emulsion.
PREFERRED EMBODIMENTS OF THE INVENTION According to the invention, the emulsion can be of the oil-in-water type or water-in-oil type. A stable oil-in-water emulsion which is particularly suitable for the preparation of the composition of the invention is described in US Patent 3.954.974.
According to the invention, the local anesthetic is advantageously selected from the following class of compounds: benzoic or paraaminobenzoic acid esters, amides, especially aromatic acid amides, anilides, urethanes, ketones and ethers, especially alkylaromatic ketones and ethers (in this connection, see Arbeitstechniken der pharmazeutischen Industrie (Working techniques in the pharmaceutical industry), volume 4, pages 217 et seq., Georg THIEME Verlag, 1982).
An anesthetic of this type can equally well be administered by injection, infiltration or surface application provided that it is suitable for the preparation of the composition according to the invention and develops its effect once in contact with the tissues. The said anesthetic will preferably be selected from the group comprising cocaine, procaine, cinchocaine, lidocaine, diperodon, dyclonine, pramocaine or some of their water-soluble salts, especially their hydrochlorides. Hydrochlorides which may be mentioned in particular are those of cocaine, procaine, tetracaine or lidocaine (XYLOCAINE, Registered Trademark), the 1e,'.p j r, i i latter being of particular value.
The concentration of local anesthetic can vary within wide limits according to the desired effect and the type of tissue_to be treated. For treatment of the mucosa, for 'example, the concentration of anesthetic will be relatively low and of the order of about 0.5 to 1.5% by weight. Concentrations of the order of about 3 to 12% by weight are suitable for most purposes, but they can be greater, for example up to about 25% by weight, without detracting from the stability of the emulsion.
The usual techniques are employed to prepare the composition according to the invention. The anesthetic is generally added in the form of an aqueous solution, together wAth the other water-soluble constituents of the emulsion, to the substances forming the oily phase.
This gives a composition based on an aqueous emulsion of hydrogen peroxide which offers all the- stability and sterility guarantees required for its use. This type of composition can be presented in the form of an ointment of greater or lesser consistency or in the form of a relatively liquid emulsion. Reserved for external use, it affords an effective treatment for open wounds-such as ulcers, disorders due to hemorrhoids and, in particular, burns.
A composition of this kind is given in detail below by way of a nonlimiting example. Example A first composition of the oil type is prepared using the following ingredients:
Petrolatum 570.0 g Liquid paraffin 412.5 g Cetyl alcohol 382.5 g Monostearine 330.0 g Total 1695.0 g The following water-soluble ingredients are mixed in a separate operation:
30% H 2 0 2 "TWEEN 8C Salicylic acid 100% XYLOCAINE Distilled water Total 825 89 10 440 7941 g 9305 g 9 9 9 9 The XYLOCAINE is introduced into the aqueous mixture at 38% with stirring. The "oil" and "water" phases are then mixed in an appropriate apparatus at 8CC until a homogeneous emulsion is obtained. This gives 11 kg of a composition containing 2% (by weight) of hydrogen peroxide and 4% of XYLOCAINE.
- A IV
Claims (4)
- WHAT WE CLAIM IS: 1. A disinfecting composition for human or veterinaryuse, based on an aqueous emulsion of hydrogen peroxide, the said composition containing a local anestheticwhich does not affect the stabi lity of the emulsion. 2. The composition as claimed in claim 1, wherein the anesthetic is an agent administered by injection, infiltration or surface application. 3. The composition as claimed in claim I or 2, wherein the anesthetic -is selected from the class comprising benzoic or paraaminobenzoic acid esters, amides, especially aromatic acid amides, anilides, urethanes, ketones and ethers, especially alkylaromatic ketones and ethers. 4. The composition as claimed in one of claims 1 to 3, wherein the anesthetic is selected from the group comprising cocaine, procaine, cinchoc aine, lidocaine, diperodon, dyclonine, pramocaine or some of their water-soluble salts, especially their hydrochlorides. 5. The composition as claimed in one of claims 1 to 4 which contains the anesthetic in an amount of about 0.5 to about 25% by weight. 6. A disinfecting composition, comprising an aqueous emulsion of hydrogen peroxide, the said composition containing a local anaesthetic which does not effect the.stability of the emulsion.Amendments to the claims have been filed as follows CLAIMS 1. A composition suitable for the treatment of burns, for human or veterinary use, and based on an aqueous emulsion of hydrogen peroxide, the composition containing a local anaesthetic which does not affect the stability of the emulsion, is an agent administered by injection, infiltration or surface application, and is selected from benzoic or paraaminobenzoic acid esters, amides, anilides, urethanes, ketones and ethers.
- 2. A composition according to claim 1. wherein the anaesthetic is selected from cocaine, procaine, cinchocaine, lidocaine, diperodon, dyclonine, pramocaine or suitable water-soluble salts thereof, especially their hydrochlorides.
- 3. A composition according to claim 1 or 2, wherein the local anaesthetic is an aromatic acid amide or an alkylaromatic ketone or ether.
- 4. A composition according to claim 1, 2 or 3, which contains the anaesthetic in an amount of 0.5 to 25% by weight.S. A composition, suitable for the treatment of burns, for human or veterinary use, comprising an aqueous emulsion of hydrogen peroxide, and a local anesthetic which does not effect the stability of the emulsion, is an agent administered by injection, infiltration or surface application, and is selected from cocaine, procaine, cinchocaine, lidocaine, diperodon, dyclonine, pramocaine or suitable water- soluble salts therefore, especially their hydrochlorides.Published 1988 P. 'be Patent Office, State Hcuse. 66'71 1-Lgh Holborn. London WC1R 4TP. Further copies may be obtained from The Patent Office, Sales Branch, St Mary Cray, Orpington, Kent BAE 31RD. Pruted by Multiplex techniques ltd, St Maxy Cray, Kent. Con. 1/87.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH495386A CH668912A5 (en) | 1986-12-12 | 1986-12-12 | DISINFECTANT COMPOSITION FOR HUMAN OR VETERINARY USE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8728875D0 GB8728875D0 (en) | 1988-01-27 |
| GB2198642A true GB2198642A (en) | 1988-06-22 |
Family
ID=4285394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08728875A Pending GB2198642A (en) | 1986-12-12 | 1987-12-10 | Hydrogen peroxide emulsion |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH668912A5 (en) |
| DE (1) | DE3741561A1 (en) |
| FR (1) | FR2608048A1 (en) |
| GB (1) | GB2198642A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8822416B2 (en) | 2005-03-15 | 2014-09-02 | Animal Ethics Pty Ltd. | Topical analgesic composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954974A (en) * | 1972-06-09 | 1976-05-04 | Paul Herzog | Disinfectant for the surface of human body parts containing hydrogen peroxide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1539771A (en) * | 1976-09-01 | 1979-02-07 | Quinoderm Ltd | Dermatological compositions |
-
1986
- 1986-12-12 CH CH495386A patent/CH668912A5/en not_active IP Right Cessation
-
1987
- 1987-12-08 DE DE19873741561 patent/DE3741561A1/en not_active Withdrawn
- 1987-12-10 GB GB08728875A patent/GB2198642A/en active Pending
- 1987-12-10 FR FR8717235A patent/FR2608048A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954974A (en) * | 1972-06-09 | 1976-05-04 | Paul Herzog | Disinfectant for the surface of human body parts containing hydrogen peroxide |
Non-Patent Citations (1)
| Title |
|---|
| MARTINDALE, THE EXTRA PHARMACOPOLIA 28TH EDITION (1982)PAGE 899, PAGE 901, PAGE 908 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8822416B2 (en) | 2005-03-15 | 2014-09-02 | Animal Ethics Pty Ltd. | Topical analgesic composition |
| US8960128B2 (en) | 2005-03-15 | 2015-02-24 | Animal Ethics Pty Ltd | Topical anesthetic composition |
| US9592318B2 (en) | 2005-03-15 | 2017-03-14 | Animal Ethics Pty Ltd | Topical analgesic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8728875D0 (en) | 1988-01-27 |
| FR2608048A1 (en) | 1988-06-17 |
| CH668912A5 (en) | 1989-02-15 |
| DE3741561A1 (en) | 1988-06-23 |
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