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GB2256183A - Diagnostic aid - Google Patents
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GB2256183A - Diagnostic aid - Google Patents

Diagnostic aid

Info

Publication number
GB2256183A
GB2256183A GB9214210A GB9214210A GB2256183A GB 2256183 A GB2256183 A GB 2256183A GB 9214210 A GB9214210 A GB 9214210A GB 9214210 A GB9214210 A GB 9214210A GB 2256183 A GB2256183 A GB 2256183A
Authority
GB
United Kingdom
Prior art keywords
microcapsules
core
oil
water
double emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9214210A
Other versions
GB2256183B (en
GB9214210D0 (en
Inventor
Lisbeth Illum
Clive Washington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909003821A external-priority patent/GB9003821D0/en
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Priority to GB9214210A priority Critical patent/GB2256183B/en
Publication of GB9214210D0 publication Critical patent/GB9214210D0/en
Publication of GB2256183A publication Critical patent/GB2256183A/en
Application granted granted Critical
Publication of GB2256183B publication Critical patent/GB2256183B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Hollow (i.e. gas- or vapour-filled) microcapsules, for example of albumin, are prepared by forming a shell around a solid or liquid core and subsequently removing the core. The core may be a volatile oil such as perfluorohexane. The shell may be made by simple or complex coacervation, oil/water/oil double emulsion, or MSIEP (minimisation of solubility at isoelectric point) methods, followed by chemical or heat hardening to render it water-insoluble. When the double emulsion method is used, the microcapsules have a honeycomb appearance with multiple gas-filled chambers. The microcapsules can be used for echocardiography.
GB9214210A 1990-02-20 1992-07-03 Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use Expired - Fee Related GB2256183B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9214210A GB2256183B (en) 1990-02-20 1992-07-03 Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909003821A GB9003821D0 (en) 1990-02-20 1990-02-20 Diagnostic aid
PCT/GB1991/000247 WO1991012823A1 (en) 1990-02-20 1991-02-19 Diagnostic aid
GB9214210A GB2256183B (en) 1990-02-20 1992-07-03 Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use

Publications (3)

Publication Number Publication Date
GB9214210D0 GB9214210D0 (en) 1992-09-16
GB2256183A true GB2256183A (en) 1992-12-02
GB2256183B GB2256183B (en) 1994-03-09

Family

ID=26296693

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9214210A Expired - Fee Related GB2256183B (en) 1990-02-20 1992-07-03 Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use

Country Status (1)

Country Link
GB (1) GB2256183B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6193951B1 (en) 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
US8486444B2 (en) 1999-08-13 2013-07-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781230A (en) * 1968-12-23 1973-12-25 Champion Int Corp Microcapsular opacifier system
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
US4173488A (en) * 1968-12-23 1979-11-06 Champion International Corporation Oil-in-water emulsions containing hydropholeic starch
EP0327490A1 (en) * 1988-02-05 1989-08-09 Schering Aktiengesellschaft Ultrasonic imaging agents, process for their preparation and their diagnostic and therapeutical use
US4968562A (en) * 1990-02-27 1990-11-06 Minnesota Mining And Manufacturing Company Hollow acid-free acrylate polymeric microspheres having multiple small voids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781230A (en) * 1968-12-23 1973-12-25 Champion Int Corp Microcapsular opacifier system
US4173488A (en) * 1968-12-23 1979-11-06 Champion International Corporation Oil-in-water emulsions containing hydropholeic starch
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
EP0327490A1 (en) * 1988-02-05 1989-08-09 Schering Aktiengesellschaft Ultrasonic imaging agents, process for their preparation and their diagnostic and therapeutical use
US4968562A (en) * 1990-02-27 1990-11-06 Minnesota Mining And Manufacturing Company Hollow acid-free acrylate polymeric microspheres having multiple small voids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Microcapsule Processing and Technology 1979 A Kondo p18-20 p61, 68, 70,90-92,106-109,118-119 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6193951B1 (en) 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
US8486444B2 (en) 1999-08-13 2013-07-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system

Also Published As

Publication number Publication date
GB2256183B (en) 1994-03-09
GB9214210D0 (en) 1992-09-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19960219