GB2256271B - Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D) - Google Patents

Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D)

Info

Publication number: GB2256271B
Authority: GB; United Kingdom
Prior art keywords: cyp2d; debrisoquine; bufuralol; hydroxylase; cytochrome
Prior art date: 1990-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB9213523A

Other versions

GB9213523D0 (en

GB2256271A (en

Inventor

Charles R Wolf

John S Miles

Nigel K Spurr

Alan C Gough

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cancer Research Horizons Ltd

Original Assignee

Imperial Cancer Research Technology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-18

Filing date

1992-06-25

Publication date

1993-10-27

1990-01-18 Priority claimed from GB909001181A external-priority patent/GB9001181D0/en

1992-06-25 Application filed by Imperial Cancer Research Technology Ltd filed Critical Imperial Cancer Research Technology Ltd

1992-06-25 Priority to GB9213523A priority Critical patent/GB2256271B/en

1992-09-23 Publication of GB9213523D0 publication Critical patent/GB9213523D0/en

1992-12-02 Publication of GB2256271A publication Critical patent/GB2256271A/en

1993-10-27 Application granted granted Critical

1993-10-27 Publication of GB2256271B publication Critical patent/GB2256271B/en

2012-06-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

SSEBTPPFLLCUMN-CYBMUJFWSA-N (1r)-2-(tert-butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol Chemical compound CCC1=CC=CC2=C1OC([C@H](O)CNC(C)(C)C)=C2 SSEBTPPFLLCUMN-CYBMUJFWSA-N 0.000 title 1
108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title 1
102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 title 1
101000896586 Homo sapiens Cytochrome P450 2D6 Proteins 0.000 title 1
101000896576 Homo sapiens Putative cytochrome P450 2D7 Proteins 0.000 title 1
108010074633 Mixed Function Oxygenases Proteins 0.000 title 1
102000008109 Mixed Function Oxygenases Human genes 0.000 title 1
102100021702 Putative cytochrome P450 2D7 Human genes 0.000 title 1
238000003556 assay Methods 0.000 title 1
229950006886 bufuralol Drugs 0.000 title 1
JWPGJSVJDAJRLW-UHFFFAOYSA-N debrisoquin Chemical compound C1=CC=C2CN(C(=N)N)CCC2=C1 JWPGJSVJDAJRLW-UHFFFAOYSA-N 0.000 title 1
229960004096 debrisoquine Drugs 0.000 title 1
230000035772 mutation Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

GB9213523A 1990-01-18 1992-06-25 Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D) Expired - Lifetime GB2256271B (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
GB9213523A GB2256271B (en)	1990-01-18	1992-06-25	Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB909001181A GB9001181D0 (en)	1990-01-18	1990-01-18	Genetic assay
PCT/GB1991/000066 WO1991010745A1 (en)	1990-01-18	1991-01-17	Genetic assay for cytochrome p450
GB9213523A GB2256271B (en)	1990-01-18	1992-06-25	Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D)

Publications (3)

Publication Number	Publication Date
GB9213523D0 GB9213523D0 (en)	1992-09-23
GB2256271A GB2256271A (en)	1992-12-02
GB2256271B true GB2256271B (en)	1993-10-27

Family

ID=26296520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB9213523A Expired - Lifetime GB2256271B (en)	1990-01-18	1992-06-25	Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D)

Country Status (1)

Country	Link
GB (1)	GB2256271B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9509321D0 (en) *	1995-05-09	1995-06-28	Zylepsis Ltd	Methods of and substances for inhibiting oxidative enzymes

1992
- 1992-06-25 GB GB9213523A patent/GB2256271B/en not_active Expired - Lifetime

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Am.J.Hum.Genet.1989,45,889-904 *
Genomics 1988,2, 174-179 *
J.Clin.Invest.1989,83,1066-1072 *
Nature 1988,331,442-446 *
Proc.Natl.Acad.Sci.USA 1988,85,5240-5243 *
Science 1988,293,487-491 *
The Lancet 1990,336,529-532 *
US Pat.Appl.US292815 *

Also Published As

Publication number	Publication date
GB9213523D0 (en)	1992-09-23
GB2256271A (en)	1992-12-02

Legal Events

Date	Code	Title	Description
2000-12-20	727	Application made for amendment of specification (sect. 27/1977)
2001-02-28	727A	Application for amendment of specification now open to opposition (sect. 27/1977)
2001-06-13	727B	Case decided by the comptroller ** specification amended (sect. 27/1977)
2002-11-20	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2006-12-13	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2007-03-14	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2011-02-09	PE20	Patent expired after termination of 20 years	Expiry date: 20110116

Publication	Publication Date	Title
USD397744S (en)	1998-09-01	Dinosaur design
AU8856391A (en)	1992-03-30	Improvements in tiltable lift seat devices
AU5362794A (en)	1994-05-09	Ergonomic keyboard and operator's chair
AU6275894A (en)	1994-09-26	Unitary seat support with integrated electronics
AU2748592A (en)	1993-05-06	Methods and reagents for hla class 1 dna typing
AU1403392A (en)	1992-10-15	Track ball mounted on keyboard
AU3787697A (en)	1998-03-06	Child's seat
AU1799692A (en)	1993-01-08	Keyboard
AU4139889A (en)	1990-03-29	Secure keyboard
AU2832995A (en)	1996-02-29	Seat for baby carriage
AU2977295A (en)	1996-02-16	Keyboard for one hand typing
AU3811795A (en)	1996-05-31	Mutant mono-oxygenase cytochrome p-450cam
AU6533294A (en)	1994-11-21	Seating arrangements for cycles, exercice cycles, other pedal-powered contrivances and the like contrivances
AU3697395A (en)	1996-05-06	Sitting and training surface
GB2256271B (en)	1993-10-27	Assay for mutation in the DNA if cytochrome p450 debrisoquine/bufuralol hydroxylase(CYP2D)
GB2285047B (en)	1998-04-15	Polypeptides which inhibit the NADPH oxidase complex
AU3589189A (en)	1990-01-04	Seat for children's pushchairs
GB2289071A (en)	1995-11-08	Dual child and adult toilet seat
AU6387890A (en)	1991-04-26	Tiltable child's seat
AU1209392A (en)	1992-09-15	Arrangement in pivots
AU4357493A (en)	1994-01-24	Vitamin d hydroxylase gene
AU6743290A (en)	1991-05-31	Auxiliary toilet seat for physically-impaired users
EP0647420A3 (en)	1996-05-22	Furniture for sitting and/or lying.
GB2283165B (en)	1998-04-29	Docking chair
AU1546295A (en)	1995-08-01	Arrangement in a chair, especially a chair for children