GB896940A - Healing agent for wounds of the body surface - Google Patents
Healing agent for wounds of the body surfaceInfo
- Publication number
- GB896940A GB896940A GB5280/60A GB528060A GB896940A GB 896940 A GB896940 A GB 896940A GB 5280/60 A GB5280/60 A GB 5280/60A GB 528060 A GB528060 A GB 528060A GB 896940 A GB896940 A GB 896940A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glucosamine
- glucosamines
- phosphate
- derivatives
- body surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010052428 Wound Diseases 0.000 title abstract 2
- 208000027418 Wounds and injury Diseases 0.000 title abstract 2
- 239000013003 healing agent Substances 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 150000002302 glucosamines Chemical class 0.000 abstract 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 2
- 229960002442 glucosamine Drugs 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- DPZHKLJPVMYFCU-UHFFFAOYSA-N 2-(5-bromopyridin-2-yl)acetonitrile Chemical compound BrC1=CC=C(CC#N)N=C1 DPZHKLJPVMYFCU-UHFFFAOYSA-N 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- BRGMHAYQAZFZDJ-PVFLNQBWSA-N N-Acetylglucosamine 6-phosphate Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BRGMHAYQAZFZDJ-PVFLNQBWSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- -1 adenosine phosphates Chemical class 0.000 abstract 1
- XHMJOUIAFHJHBW-UKFBFLRUSA-N alpha-D-glucosamine 6-phosphate Chemical compound N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O XHMJOUIAFHJHBW-UKFBFLRUSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000174 gluconic acid Substances 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229950006780 n-acetylglucosamine Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960004441 tyrosine Drugs 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 235000002374 tyrosine Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical composition for healing wounds of the body surface, in dosage unit form comprises glucosamine and/or one or more derivatives of glucosamine and a pharmaceutically acceptable carrier. Specified derivatives of glucosamine are the lower N-alkanoyl glucosamines, e.g. N-acetyl glucosamine; phosphorylated glucosamines, e.g. N-acetyl glucosamine - 6 - phosphate or glucosamine - 6 -phosphate; and salts of glucosamine with pharmaceutically-acceptable acids, e.g. hydrochloric, phosphoric, citric, gluconic, acetic or malic acid. Additional therapeutic agents specified are sources of high energy phosphorus, e.g. phosphoenolpyrivic acid and adenosine phosphates such as the mono and dephorphates; tetracycline, oxytetracycline, ascorbic acid and tyrosine. The compositions may be administered locally, orally in the form of suspensions, inaqueous glycols or sugar solutions, tablets or capsules and in particular parenterally in the form of an intravenous injection employing isotonic saline solution as carrier. Specification 819,122 is referred to. Reference has been directed by the Comptroller to Specification 856,493.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US896940XA | 1959-02-26 | 1959-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB896940A true GB896940A (en) | 1962-05-23 |
Family
ID=22219092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5280/60A Expired GB896940A (en) | 1959-02-26 | 1960-02-15 | Healing agent for wounds of the body surface |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB896940A (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328258A (en) * | 1962-09-10 | 1967-06-27 | Lipha | Anti-microbial therapeutics consisting of nitrofurantoin, tetracycline, and d-glucosamine |
| FR2473887A1 (en) * | 1980-01-22 | 1981-07-24 | Curri Sergio | NOVEL USE OF GLUCOSAMINO-GLYCAN BIOCHEMICAL PRECURSORS AND RESPECTIVE PHARMACEUTICAL AND COSMETIC COMPOSITIONS |
| US4870061A (en) * | 1986-01-29 | 1989-09-26 | Ulrich Speck | Use of N-acetylglucosamine for the therapy of degenerative joint disease and related diseases |
| US5804594A (en) * | 1997-01-22 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
| US6358539B1 (en) | 1999-08-20 | 2002-03-19 | Howard Murad | Pharmaceutical compositions for reducing the appearance of cellulite |
| US6645948B2 (en) | 1998-03-24 | 2003-11-11 | George D. Petito | Nutritional composition for the treatment of connective tissue |
| US6693188B2 (en) | 2001-08-08 | 2004-02-17 | Cargill Incorporated | N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine |
| US7049433B2 (en) | 2001-02-16 | 2006-05-23 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| ES2255829A1 (en) * | 2004-08-06 | 2006-07-01 | Bioiberica, S.A. | Use of organic glucosamine salts |
| US7691829B2 (en) | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US7923437B2 (en) | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| EP1734821A4 (en) * | 2004-04-14 | 2011-07-06 | Uab Research Foundation | ACTIVATORS OF THE BIOSYNTHESIS OF HEXOSAMINE AS INHIBITORS OF LESION INDUCED BY ISCHEMIA OR SHOCK HAEMORRHAGIC |
| WO2011121250A2 (en) | 2010-04-02 | 2011-10-06 | Libragen | Cosmetic and pharmaceutical composition comprising n-acetylglucosamine-6-phosphate |
| US8222232B2 (en) | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
-
1960
- 1960-02-15 GB GB5280/60A patent/GB896940A/en not_active Expired
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328258A (en) * | 1962-09-10 | 1967-06-27 | Lipha | Anti-microbial therapeutics consisting of nitrofurantoin, tetracycline, and d-glucosamine |
| FR2473887A1 (en) * | 1980-01-22 | 1981-07-24 | Curri Sergio | NOVEL USE OF GLUCOSAMINO-GLYCAN BIOCHEMICAL PRECURSORS AND RESPECTIVE PHARMACEUTICAL AND COSMETIC COMPOSITIONS |
| US4870061A (en) * | 1986-01-29 | 1989-09-26 | Ulrich Speck | Use of N-acetylglucosamine for the therapy of degenerative joint disease and related diseases |
| US5804594A (en) * | 1997-01-22 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
| US5972999A (en) * | 1997-01-22 | 1999-10-26 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
| US7691829B2 (en) | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US8168599B2 (en) | 1998-03-24 | 2012-05-01 | Petito George D | Composition and method for healing tissues |
| US6645948B2 (en) | 1998-03-24 | 2003-11-11 | George D. Petito | Nutritional composition for the treatment of connective tissue |
| US6358539B1 (en) | 1999-08-20 | 2002-03-19 | Howard Murad | Pharmaceutical compositions for reducing the appearance of cellulite |
| US6676977B2 (en) | 1999-08-20 | 2004-01-13 | Howard Murad | Pharmaceutical compositions and methods for reducing the appearance of cellulite |
| US8034925B2 (en) | 2001-02-16 | 2011-10-11 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US7049433B2 (en) | 2001-02-16 | 2006-05-23 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US8222232B2 (en) | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US7923437B2 (en) | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| US6693188B2 (en) | 2001-08-08 | 2004-02-17 | Cargill Incorporated | N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine |
| EP1734821A4 (en) * | 2004-04-14 | 2011-07-06 | Uab Research Foundation | ACTIVATORS OF THE BIOSYNTHESIS OF HEXOSAMINE AS INHIBITORS OF LESION INDUCED BY ISCHEMIA OR SHOCK HAEMORRHAGIC |
| ES2255829B1 (en) * | 2004-08-06 | 2007-08-16 | Bioiberica, S.A. | NEW USE OF GLUCOSAMINE SALTS. |
| ES2255829A1 (en) * | 2004-08-06 | 2006-07-01 | Bioiberica, S.A. | Use of organic glucosamine salts |
| WO2011121250A2 (en) | 2010-04-02 | 2011-10-06 | Libragen | Cosmetic and pharmaceutical composition comprising n-acetylglucosamine-6-phosphate |
| FR2958157A1 (en) * | 2010-04-02 | 2011-10-07 | Libragen | COSMETIC AND PHARMACEUTICAL COMPOSITION COMPRISING N-ACETYL-GLUCOSAMINE-6-PHOSPHATE |
| WO2011121250A3 (en) * | 2010-04-02 | 2011-11-17 | Libragen | Cosmetic and pharmaceutical composition comprising n-acetylglucosamine-6-phosphate |
| CN102905680A (en) * | 2010-04-02 | 2013-01-30 | 莱博睿金公司 | Cosmetic and pharmaceutical composition comprising n-acetylglucosamine-6-phosphate |
| US9907760B2 (en) | 2010-04-02 | 2018-03-06 | Libragen | Cosmetic and pharmaceutical composition comprising N-acetylglucosamine-6-phosphate |
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