HRP20080052T3 - Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala - Google Patents

Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala

Info

Publication number: HRP20080052T3
Authority: HR; Croatia
Prior art keywords: santagonistic; imidazopyridine; hiv; inflammation; action
Prior art date: 2003-10-03

Application number

HR20080052T

Other languages

English (en)

Croatian (hr)

Inventor

Anthony Stupple Paul

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-28

Publication date

2008-02-29

2003-10-03 Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en

2003-10-27 Priority claimed from GB0325020A external-priority patent/GB0325020D0/en

2004-08-19 Priority claimed from GB0418566A external-priority patent/GB0418566D0/en

2004-09-28 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2008-02-29 Publication of HRP20080052T3 publication Critical patent/HRP20080052T3/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)

HR20080052T 2003-10-03 2004-09-28 Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala HRP20080052T3 (hr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0323236.0A GB0323236D0 (en)	2003-10-03	2003-10-03	Chemical compounds
GB0325020A GB0325020D0 (en)	2003-10-27	2003-10-27	Chemical compounds
GB0418566A GB0418566D0 (en)	2004-08-19	2004-08-19	Tropane derivatives
PCT/IB2004/003153 WO2005033107A1 (en)	2003-10-03	2004-09-28	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number	Publication Date
HRP20080052T3 true HRP20080052T3 (hr)	2008-02-29

Family

ID=34426592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080052T HRP20080052T3 (hr)	2003-10-03	2004-09-28	Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala

Country Status (35)

Country	Link
US (2)	US7309790B2 (sr)
EP (1)	EP1682545B1 (sr)
JP (1)	JP4874107B2 (sr)
KR (1)	KR100777885B1 (sr)
AP (1)	AP2174A (sr)
AR (1)	AR045856A1 (sr)
AT (1)	ATE380813T1 (sr)
AU (1)	AU2004278158B2 (sr)
BR (1)	BRPI0414862A (sr)
CA (1)	CA2540834C (sr)
CY (1)	CY1107281T1 (sr)
DE (1)	DE602004010708T2 (sr)
DK (1)	DK1682545T3 (sr)
EA (1)	EA009941B1 (sr)
EC (1)	ECSP066475A (sr)
ES (1)	ES2295924T3 (sr)
GE (1)	GEP20084417B (sr)
HN (1)	HN2004000383A (sr)
HR (1)	HRP20080052T3 (sr)
IL (1)	IL174208A0 (sr)
MA (1)	MA28080A1 (sr)
MX (1)	MXPA06003749A (sr)
MY (1)	MY137609A (sr)
NO (1)	NO20061978L (sr)
NZ (1)	NZ545837A (sr)
OA (1)	OA13266A (sr)
PA (1)	PA8614301A1 (sr)
PE (1)	PE20050961A1 (sr)
PL (1)	PL1682545T3 (sr)
PT (1)	PT1682545E (sr)
RS (1)	RS20060198A (sr)
SI (1)	SI1682545T1 (sr)
TW (1)	TWI280244B (sr)
UY (1)	UY28546A1 (sr)
WO (1)	WO2005033107A1 (sr)

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PE20030762A1 (es)	2001-12-18	2003-09-05	Schering Corp	Compuestos heterociclicos como antagonistas nk1
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
WO2005012294A1 (en)	2003-07-30	2005-02-10	Rigel Pharmaceuticals, Inc.	2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
BRPI0610876B8 (pt)	2005-06-08	2021-05-25	Rigel Pharmaceuticals Inc	composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
ES2622493T3 (es)	2006-02-24	2017-07-06	Rigel Pharmaceuticals, Inc.	Composiciones y métodos para la inhibición de la ruta de JAK
CN103751186B (zh) *	2006-04-05	2016-08-24	欧科生医股份有限公司	药物制剂：8-[{1-(3,5-双-(三氟甲基)苯基)-乙氧基}-甲基]-8-苯基-1,7-二氮杂-螺[4.5]癸-2-酮的盐及用其治疗的方法
WO2008030853A2 (en) *	2006-09-06	2008-03-13	Incyte Corporation	Combination therapy for human immunodeficiency virus infection
JP5161233B2 (ja)	2006-10-19	2013-03-13	ライジェルファーマシューティカルズ，インコーポレイテッド	自己免疫疾患の処置のためのｊａｋキナーゼの阻害剤としての２，４−ピリミジンアミン誘導体
WO2008085302A1 (en) *	2006-12-20	2008-07-17	Merck & Co., Inc.	Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
AR065802A1 (es) *	2007-03-22	2009-07-01	Schering Corp	Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
SG2012079653A (en) *	2007-10-25	2014-05-29	Exelixis Inc	Tropane compounds
HUE030912T2 (en)	2008-02-15	2017-06-28	Rigel Pharmaceuticals Inc	Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases
US8063058B2 (en)	2008-04-16	2011-11-22	Portola Pharmaceuticals, Inc.	Inhibitors of syk and JAK protein kinases
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
AU2009238590A1 (en)	2008-04-22	2009-10-29	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
SG157299A1 (en)	2008-05-09	2009-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
CN102573475B (zh)	2009-08-14	2016-01-20	欧科生医股份有限公司	神经激肽-1拮抗剂的静脉内制剂
MA34215B1 (fr)	2010-04-02	2013-05-02	Phivco 1 Llc	Traitement d'association comprenant un antagoniste du récepteur ccr5, un inhibiteur de la protéase du vih-1 et un accélérateur pharmacocinétique
EP2975027A1 (en)	2010-11-01	2016-01-20	Portola Pharmaceuticals, Inc.	Nicotinamides as jak kinase modulators
WO2013024022A1 (en)	2011-08-12	2013-02-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
MX363551B (es)	2011-11-23	2019-03-27	Portola Pharmaceuticals Inc Star	Compuestos derivados de pirazina como inhibidores de cinasa.
WO2014058921A2 (en)	2012-10-08	2014-04-17	Portola Pharmaceuticals, Inc.	Substituted pyrimidinyl kinase inhibitors
CA2922723C (en) *	2013-09-25	2022-04-19	Mallinckrodt Llc	Improved process for the preparation of radioiodinated 3-fluoropropyl-nor-b-cit
GB201321748D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US20250205220A1 (en) *	2022-03-31	2025-06-26	Bruce K. Patterson	Methods of Treating a Subject for Post-Treatment Lyme Disease (PTLD) and Compositions for Use in the Same
WO2023192361A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for fibromyalgia and compositions for use in the same

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2004
- 2004-09-28 KR KR1020067006293A patent/KR100777885B1/ko not_active Expired - Fee Related
- 2004-09-28 NZ NZ545837A patent/NZ545837A/en not_active IP Right Cessation
- 2004-09-28 HR HR20080052T patent/HRP20080052T3/xx unknown
- 2004-09-28 OA OA1200600114A patent/OA13266A/en unknown
- 2004-09-28 AT AT04769496T patent/ATE380813T1/de active
- 2004-09-28 DK DK04769496T patent/DK1682545T3/da active
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- 2004-09-28 JP JP2006530737A patent/JP4874107B2/ja not_active Expired - Fee Related
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- 2004-09-28 DE DE602004010708T patent/DE602004010708T2/de not_active Expired - Lifetime
- 2004-09-28 RS YUP-2006/0198A patent/RS20060198A/sr unknown
- 2004-09-28 EA EA200600480A patent/EA009941B1/ru not_active IP Right Cessation
- 2004-09-28 EP EP04769496A patent/EP1682545B1/en not_active Expired - Lifetime
- 2004-09-28 MX MXPA06003749A patent/MXPA06003749A/es active IP Right Grant
- 2004-09-28 PL PL04769496T patent/PL1682545T3/pl unknown
- 2004-09-28 ES ES04769496T patent/ES2295924T3/es not_active Expired - Lifetime
- 2004-09-28 AU AU2004278158A patent/AU2004278158B2/en not_active Ceased
- 2004-09-28 WO PCT/IB2004/003153 patent/WO2005033107A1/en not_active Ceased
- 2004-09-28 BR BRPI0414862-2A patent/BRPI0414862A/pt not_active IP Right Cessation
- 2004-09-29 TW TW093129475A patent/TWI280244B/zh not_active IP Right Cessation
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2006
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- 2006-04-03 MA MA28906A patent/MA28080A1/fr unknown
- 2006-05-03 NO NO20061978A patent/NO20061978L/no not_active Application Discontinuation
2007
- 2007-08-27 US US11/845,500 patent/US7790740B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
HN2004000383A (es)	2008-10-14
AU2004278158B2 (en)	2009-08-13
RS20060198A (sr)	2008-09-29
NO20061978L (no)	2006-07-03
US7309790B2 (en)	2007-12-18
GEP20084417B (en)	2008-07-10
US7790740B2 (en)	2010-09-07
SI1682545T1 (sl)	2008-04-30
MY137609A (en)	2009-02-27
DE602004010708D1 (de)	2008-01-24
EP1682545A1 (en)	2006-07-26
PE20050961A1 (es)	2005-11-29
PT1682545E (pt)	2008-02-11
PL1682545T3 (pl)	2008-04-30
AU2004278158A1 (en)	2005-04-14
WO2005033107A1 (en)	2005-04-14
IL174208A0 (en)	2006-08-01
TW200519112A (en)	2005-06-16
CA2540834A1 (en)	2005-04-14
DK1682545T3 (da)	2008-03-17
BRPI0414862A (pt)	2006-11-28
US20050131011A1 (en)	2005-06-16
ATE380813T1 (de)	2007-12-15
AP2174A (en)	2010-11-20
KR20060070571A (ko)	2006-06-23
AR045856A1 (es)	2005-11-16
EA009941B1 (ru)	2008-04-28
JP4874107B2 (ja)	2012-02-15
JP2007507483A (ja)	2007-03-29
DE602004010708T2 (de)	2008-12-04
KR100777885B1 (ko)	2007-11-28
MXPA06003749A (es)	2006-06-14
US20080045563A1 (en)	2008-02-21
CA2540834C (en)	2010-06-22
EA200600480A1 (ru)	2006-08-25
EP1682545B1 (en)	2007-12-12
ES2295924T3 (es)	2008-04-16
OA13266A (en)	2007-01-31
MA28080A1 (fr)	2006-08-01
ECSP066475A (es)	2006-10-10
TWI280244B (en)	2007-05-01
UY28546A1 (es)	2005-05-31
PA8614301A1 (es)	2005-05-10
NZ545837A (en)	2009-12-24
AP2006003580A0 (en)	2006-04-30
CY1107281T1 (el)	2012-11-21

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