IL281196B2 - תהליך להכנה של מתיל 6–(4,2–דיכלורופניל)–5–[4–[(s3)–1–(3–פלואורופרופיל)פירולידין–3–איל]אוקסיפניל]–9,8–דיהידרו–h7–בנזו[7]אנולן–2–קרבוקסילט - Google Patents
תהליך להכנה של מתיל 6–(4,2–דיכלורופניל)–5–[4–[(s3)–1–(3–פלואורופרופיל)פירולידין–3–איל]אוקסיפניל]–9,8–דיהידרו–h7–בנזו[7]אנולן–2–קרבוקסילטInfo
- Publication number
- IL281196B2 IL281196B2 IL281196A IL28119621A IL281196B2 IL 281196 B2 IL281196 B2 IL 281196B2 IL 281196 A IL281196 A IL 281196A IL 28119621 A IL28119621 A IL 28119621A IL 281196 B2 IL281196 B2 IL 281196B2
- Authority
- IL
- Israel
- Prior art keywords
- compound
- process according
- reagent
- group
- palladium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306177 | 2018-09-07 | ||
| PCT/EP2019/073827 WO2020049153A1 (en) | 2018-09-07 | 2019-09-06 | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL281196A IL281196A (he) | 2021-04-29 |
| IL281196B IL281196B (he) | 2022-10-01 |
| IL281196B2 true IL281196B2 (he) | 2023-02-01 |
Family
ID=63637829
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281191A IL281191B (he) | 2018-09-07 | 2019-09-06 | מלחים של מתיל 6–(4,2–דיכלורופניל)–5–[4–[(s3)–1–(3–פלואורופרופיל)פירולידין–3–איל]אוקסיפניל]–9,8–דיהידרו–h7–בנזו[7]אנולן–2–קרבוקסילט ותהליכים להכנתם |
| IL281196A IL281196B2 (he) | 2018-09-07 | 2021-03-02 | תהליך להכנה של מתיל 6–(4,2–דיכלורופניל)–5–[4–[(s3)–1–(3–פלואורופרופיל)פירולידין–3–איל]אוקסיפניל]–9,8–דיהידרו–h7–בנזו[7]אנולן–2–קרבוקסילט |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281191A IL281191B (he) | 2018-09-07 | 2019-09-06 | מלחים של מתיל 6–(4,2–דיכלורופניל)–5–[4–[(s3)–1–(3–פלואורופרופיל)פירולידין–3–איל]אוקסיפניל]–9,8–דיהידרו–h7–בנזו[7]אנולן–2–קרבוקסילט ותהליכים להכנתם |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US12157721B2 (he) |
| EP (2) | EP3847156B1 (he) |
| JP (2) | JP7398436B2 (he) |
| KR (2) | KR20210057031A (he) |
| CN (2) | CN112638869B (he) |
| AR (2) | AR116300A1 (he) |
| AU (2) | AU2019335542A1 (he) |
| BR (2) | BR112021003440A2 (he) |
| CA (2) | CA3111466A1 (he) |
| CY (2) | CY1125418T1 (he) |
| DK (2) | DK3847157T3 (he) |
| ES (2) | ES2923412T3 (he) |
| HU (2) | HUE059362T2 (he) |
| IL (2) | IL281191B (he) |
| MX (2) | MX2021002665A (he) |
| SG (2) | SG11202102059YA (he) |
| TW (2) | TWI803692B (he) |
| WO (2) | WO2020049150A1 (he) |
| ZA (2) | ZA202101006B (he) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| BR112021003440A2 (pt) | 2018-09-07 | 2021-05-18 | Sanofi | sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação |
| EP4037768B1 (en) | 2019-10-01 | 2023-10-11 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| AU2020399168A1 (en) | 2019-12-09 | 2022-07-28 | Sanofi | Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| CN115916769B (zh) | 2020-06-28 | 2024-09-10 | 深圳扬厉医药技术有限公司 | 并环吲唑类化合物 |
| CN116615414A (zh) * | 2020-10-19 | 2023-08-18 | 赛诺菲 | 经取代的6,7-二氢-5h-苯并[7]轮烯化合物及其衍生物、其制备方法及其治疗用途 |
| TW202233572A (zh) * | 2020-10-19 | 2022-09-01 | 法商賽諾菲公司 | 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途 |
| WO2022084280A1 (en) | 2020-10-19 | 2022-04-28 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
| JP7805677B2 (ja) | 2021-12-28 | 2026-01-26 | 浙江揚歴医薬技術有限公司 | テトラヒドロシクロヘプタインダゾール化合物の結晶 |
| WO2023187086A1 (en) | 2022-03-31 | 2023-10-05 | Sanofi | Amorphous solid form of amcenestrant |
| JP2025512050A (ja) | 2022-04-15 | 2025-04-16 | サノフイ | 新規の置換された４－アミノ－４－オキソ－ブト－２－エニル誘導体、それらの調製のためのプロセス及びその治療的使用 |
| WO2023198905A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted fluorinated vinyl-n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| WO2023198879A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted fluorinated n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| JP2025513853A (ja) | 2022-04-15 | 2025-04-30 | サノフイ | 新規の置換フッ化ｎ－プロピル－ピロリジン及びｎ－プロピル－アゼチジン化合物、それらの調製のためのプロセス及びその治療的使用 |
| US20250255848A1 (en) * | 2022-04-15 | 2025-08-14 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene derivatives, processes for their preparation and therapeutic uses thereof |
| TW202543650A (zh) | 2024-03-08 | 2025-11-16 | 美商海爾達醫療運營公司 | 異雙官能化合物及其在治療疾病中之用途 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1752792A (en) | 1991-03-08 | 1992-10-06 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
| DE19833786A1 (de) | 1998-07-18 | 2000-01-20 | Schering Ag | Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| EP1229036B1 (en) | 2001-01-24 | 2005-01-12 | CHIESI FARMACEUTICI S.p.A. | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
| PL374215A1 (en) | 2001-08-11 | 2005-10-03 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
| DK1501819T3 (da) | 2002-04-24 | 2011-01-10 | Merck Sharp & Dohme | Østrogenreceptormodulatorer |
| CA2512000C (en) | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
| WO2006012135A1 (en) | 2004-06-24 | 2006-02-02 | Janssen Pharmaceutica, N. V. | Quaternary salt ccr2 antagonists |
| ES2551086T3 (es) | 2005-06-14 | 2015-11-16 | Baylor University | Análogos de combretastatina con actividad de unión a tubulina |
| BRPI0810330A2 (pt) * | 2007-05-03 | 2014-10-14 | Cephalon Inc | "processo para preparar l-tartarato de (r)-2-metil pirrolidina, processo para preparar 6-{4-[3-((r)-2-metil-pirrolidin-1-il)-propoxi] - fenil}-2h-piridazin-3-ona, processo para preparar d-tartarato de (s)-2-metil pirrolidina" |
| US8127618B1 (en) | 2007-05-18 | 2012-03-06 | Pacesetter, Inc. | Implantable micro-electromechanical system sensor |
| EP2048126A1 (de) | 2007-10-11 | 2009-04-15 | Bayer Schering Pharma AG | Benzocycloheptanderivate als selektiv wirksame Estrogene |
| WO2009101634A2 (en) | 2008-02-13 | 2009-08-20 | Lupin Limited | A novel process for the preparation of eszopiclone |
| DE102010030538A1 (de) | 2010-06-25 | 2011-12-29 | Bayer Schering Pharma Aktiengesellschaft | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| WO2012068284A2 (en) | 2010-11-16 | 2012-05-24 | Baylor University | Efficient method for preparing functionalized benzosuberenes |
| CA2819299A1 (en) | 2010-12-24 | 2012-06-28 | Merck Sharp & Dohme B.V. | N-substituted azetidine derivatives |
| DE102011087987A1 (de) | 2011-12-08 | 2013-06-13 | Bayer Intellectual Property Gmbh | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2013097773A1 (en) | 2011-12-30 | 2013-07-04 | Centaurus Biopharma Co., Ltd. | Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators |
| CN102584687A (zh) | 2011-12-30 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 作为选择性雌激素受体调节剂的乙烯衍生物 |
| CN105828822B (zh) | 2013-08-14 | 2019-10-18 | 诺华股份有限公司 | 用于治疗癌症的组合疗法 |
| WO2015028409A1 (de) | 2013-08-27 | 2015-03-05 | Bayer Pharma Aktiengesellschaft | 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| EP3089747A1 (en) | 2013-12-06 | 2016-11-09 | F. Hoffmann-La Roche AG | Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer |
| KR102598782B1 (ko) | 2014-10-03 | 2023-11-07 | 노파르티스 아게 | 알펠리십을 포함하는 제약 조성물 |
| TWI874834B (zh) | 2014-12-18 | 2025-03-01 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| WO2016097071A1 (en) | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Estrogen receptor modulators and uses thereof |
| KR20250152679A (ko) | 2015-04-29 | 2025-10-23 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| CN106924210A (zh) | 2015-12-29 | 2017-07-07 | 北京新领先医药科技发展有限公司 | 一种含有帕布昔利布的胶囊剂及其制备方法 |
| EA034994B1 (ru) | 2016-02-15 | 2020-04-15 | Санофи | 6,7-дигидро-5h-бензо[7]аннуленовые производные в качестве модуляторов эстрогеновых рецепторов |
| ES3039455T3 (en) * | 2016-11-17 | 2025-10-21 | Sanofi Sa | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| EP3434272A1 (en) * | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| CN111386113A (zh) | 2017-12-01 | 2020-07-07 | 诺华股份有限公司 | 包含lsz102和阿培利司的药物组合 |
| CN109896991B (zh) | 2017-12-08 | 2020-11-20 | 苏州远智医药科技有限公司 | 一种δ阿片受体拮抗剂及其用途和药物组合物 |
| BR112021003440A2 (pt) | 2018-09-07 | 2021-05-18 | Sanofi | sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação |
| AU2019379179A1 (en) | 2018-11-16 | 2021-06-10 | Arqule, Inc. | Pharmaceutical combination for treatment of cancer |
| MX2021005876A (es) | 2018-11-30 | 2021-07-16 | Radius Pharmaceuticals Inc | Elacestrant en combinacion con abemaciclib en mujeres con cancer de mama. |
| CA3146346A1 (en) | 2019-05-09 | 2020-11-12 | Sanofi | 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid for use in metastatic or advanced breast cancer patients |
| KR20220046586A (ko) * | 2019-07-22 | 2022-04-14 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 선택적 에스트로겐 수용체 분해제 |
| EP4037768B1 (en) | 2019-10-01 | 2023-10-11 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| AU2020380211A1 (en) * | 2019-11-04 | 2022-05-19 | Recurium Ip Holdings, Llc | Salts and forms of an estrogen receptor modulator |
| AU2020399168A1 (en) * | 2019-12-09 | 2022-07-28 | Sanofi | Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| CA3169679A1 (en) | 2020-03-06 | 2021-09-10 | Olema Pharmaceuticals, Inc. | Methods of treating estrogen receptor-associated diseases |
| TW202233572A (zh) | 2020-10-19 | 2022-09-01 | 法商賽諾菲公司 | 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途 |
| WO2022084280A1 (en) | 2020-10-19 | 2022-04-28 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
| WO2022106711A1 (en) | 2020-11-23 | 2022-05-27 | Sanofi | Combination comprising abemaciclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| TW202304424A (zh) | 2021-04-12 | 2023-02-01 | 法商賽諾菲公司 | 包含依維莫司和安森司群的組合 |
| TW202304425A (zh) | 2021-04-12 | 2023-02-01 | 法商賽諾菲公司 | 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合 |
-
2019
- 2019-09-06 BR BR112021003440-4A patent/BR112021003440A2/pt not_active IP Right Cessation
- 2019-09-06 ES ES19765710T patent/ES2923412T3/es active Active
- 2019-09-06 AU AU2019335542A patent/AU2019335542A1/en not_active Abandoned
- 2019-09-06 AU AU2019336532A patent/AU2019336532A1/en not_active Abandoned
- 2019-09-06 EP EP19765710.9A patent/EP3847156B1/en active Active
- 2019-09-06 TW TW108132201A patent/TWI803692B/zh not_active IP Right Cessation
- 2019-09-06 WO PCT/EP2019/073823 patent/WO2020049150A1/en not_active Ceased
- 2019-09-06 SG SG11202102059YA patent/SG11202102059YA/en unknown
- 2019-09-06 WO PCT/EP2019/073827 patent/WO2020049153A1/en not_active Ceased
- 2019-09-06 IL IL281191A patent/IL281191B/he unknown
- 2019-09-06 CN CN201980058342.XA patent/CN112638869B/zh active Active
- 2019-09-06 DK DK19765711.7T patent/DK3847157T3/da active
- 2019-09-06 JP JP2021512678A patent/JP7398436B2/ja active Active
- 2019-09-06 BR BR112021003061-1A patent/BR112021003061A2/pt not_active IP Right Cessation
- 2019-09-06 DK DK19765710.9T patent/DK3847156T3/da active
- 2019-09-06 MX MX2021002665A patent/MX2021002665A/es unknown
- 2019-09-06 ES ES19765711T patent/ES2924738T3/es active Active
- 2019-09-06 HU HUE19765710A patent/HUE059362T2/hu unknown
- 2019-09-06 AR ARP190102550A patent/AR116300A1/es unknown
- 2019-09-06 TW TW108132203A patent/TW202026280A/zh unknown
- 2019-09-06 AR ARP190102549A patent/AR116299A1/es not_active Application Discontinuation
- 2019-09-06 EP EP19765711.7A patent/EP3847157B1/en active Active
- 2019-09-06 KR KR1020217006751A patent/KR20210057031A/ko not_active Ceased
- 2019-09-06 SG SG11202102057SA patent/SG11202102057SA/en unknown
- 2019-09-06 CN CN201980058412.1A patent/CN112638870B/zh active Active
- 2019-09-06 CA CA3111466A patent/CA3111466A1/en active Pending
- 2019-09-06 CA CA3111359A patent/CA3111359A1/en active Pending
- 2019-09-06 KR KR1020217006752A patent/KR20210057032A/ko not_active Ceased
- 2019-09-06 JP JP2021512672A patent/JP7413363B2/ja active Active
- 2019-09-06 HU HUE19765711A patent/HUE059527T2/hu unknown
- 2019-09-06 MX MX2021002666A patent/MX2021002666A/es unknown
-
2021
- 2021-02-15 ZA ZA2021/01006A patent/ZA202101006B/en unknown
- 2021-02-17 ZA ZA2021/01079A patent/ZA202101079B/en unknown
- 2021-03-02 IL IL281196A patent/IL281196B2/he unknown
- 2021-03-05 US US17/193,706 patent/US12157721B2/en active Active
- 2021-03-05 US US17/193,776 patent/US11713296B2/en active Active
-
2022
- 2022-07-26 CY CY20221100508T patent/CY1125418T1/el unknown
- 2022-08-18 CY CY20221100558T patent/CY1125486T1/el unknown
-
2024
- 2024-10-23 US US18/924,400 patent/US20250042849A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3847157B1 (en) | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and a salt thereof | |
| EP3765452B1 (en) | Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives | |
| JP2024508105A (ja) | ３，４位に７員複素環が縮合されたオキシインドレン化合物、及びその合成方法と使用 | |
| HK40052408B (en) | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and a salt thereof | |
| HK40052408A (en) | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and a salt thereof | |
| HK40046965B (en) | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof | |
| HK40046965A (en) | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof | |
| US10544177B2 (en) | Chiral dihydrobenzooxaphosphole ligands and synthesis thereof | |
| KR20220048950A (ko) | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법 | |
| JP4509327B2 (ja) | Ｎ，ｎ−ジ置換−４−アミノクロトン酸エステルの製造方法 | |
| JP4725760B2 (ja) | 光学活性リン酸エステル誘導体及びその用途 | |
| KR101299720B1 (ko) | 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법 | |
| JP2011526257A (ja) | Ｎ−フェニル−ｎ−（４−ピペリジニル）アミド塩の製造方法 |