JP2544148B2 - Hair growth and hair growth promotion charges - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial field of application) The present invention relates to a hair growth / hair growth promoting agent.

(Problems to be Solved by Prior Art and Invention) Conventionally, various compounds, extracts such as herbal medicines, etc. have been applied to hair growth / hair growth promoters, but there are almost no remarkable effects. In addition, those having a certain degree of effect have a drawback that they are so irritating that they cause dermatitis and that continuous use is difficult.

(Means for Solving Problems) As a result of various experimental studies in view of such a current situation, the present inventors have Or Ji or It was found that the above-mentioned conditions to be solved are satisfied by containing a crude drug extract extracted from the above crude drug, and the present invention has been completed.

That is, the present invention Or Ji or The present invention relates to a hair-growth / hair-growth-promoting agent comprising at least one crude drug extract obtained by extracting the crude drug with a water-soluble organic solvent or a water-containing water-soluble organic solvent.

 The present invention will be described in detail below.

As a method for obtaining a hair growth / hair growth promoter applied to the present invention, Or Ji or 100 g of herbal medicine, for example, primary alcohol such as methanol, ethanol, propanol, butanol, or acetone, tetrahydrofuran, organic solvent alone of dioxane,
Alternatively, the above-mentioned primary alcohol or acetone, tetrahydrofuran, dioxane is added to the water-containing organic solvent 11 containing 50% by weight or more, and the mixture is subjected to digestion extraction 3 times for 2 hours each. These extracts are combined, filtered with suction, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained herbal medicine extract is dissolved or dispersed and diluted with an appropriate solvent or the like into a base to obtain the hair growth and hair growth-promoting agent of the present invention.

Here, it is contained as an active ingredient of the hair-growth and hair-growth promoting agent according to the present invention. Ji, The content of one or more herbal extracts is 0.1-10.0% by weight,
It is preferably 0.5 to 5.0% by weight.

Applied to the present invention Ji, The hair growth and hair growth promoting agent containing one or more of the following herbal extracts is a method for measuring the density of hair growth of mice shown in Table 1 below, that is, other hair growth and hair growth promoting agents in Test Method I. Significant effects were shown in comparison with the so-called substance. This is a result of the fact that the components of the crude drug extract extracted from the above crude drugs stimulated the hair roots, increased blood circulation around the hair roots, and improved metabolism.

Brief Description of Test Method I Using 9-week-old C3H mice, one group has 10 mice,
Make 4 groups and apply 0.02g of the sample on the next day after removing hair to the area where the hair was removed to an area of 2.0 cm × 2.0 cm on the 9th day, 1
On the 1st and 14th days, the density of hair growth at the site was grasped as a degree of increase in blackness by using a color difference meter, and compared with conventional vitamin E as a comparative substance and 99.5% ethanol solution as a control.

In each sample applied in Table-1, A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparative substance, and B, C and D are respectively Ji, 5% by weight of crude drug extract obtained by methanol extraction of
The contained 99.5% ethanol solution, E is 99.5% ethanol as a control.

Production example 1. Purchased from Osaka crude drug market Was weighed and made into a coarse powder of about 20 mesh with a pulverizer, and then digested with 1 liter of 70 wt% methanol for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined, and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 12.6 g of a viscous dark brown crude drug extract having a characteristic odor.

Production example 2. Purchased from Osaka crude drug market 100 g was weighed and made into a coarse powder of about 20 mesh with a crusher, and then digested with 1 liter of 50 wt% ethanol for 2 hours, and then the extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 10.3 g of a viscous dark brown crude drug extract having a peculiar odor.

Production Example 3. Extract from crude herb extract 100 g of crude oil from Osaka crude drug market, weigh it with a crusher to a coarse powder of about 20 mesh, and then digest with 1 l of methanol for 2 hours, and then The extract was filtered. The extraction filtrates obtained by repeating this extraction operation three times were combined and the solvent was distilled off at 60 ° C. under reduced pressure to obtain 9.6 g of a viscous dark brown crude drug extract having a peculiar odor.

 Next, examples of clinical trials will be shown.

Example 1 As a sample, A 99.5% ethanol solution containing 2% by weight of was used.

A sample of alopecia areata, a 44-year-old female with a 3 cm diameter bald area on the occipital region, was applied once a day with 3 to 5 g of the sample, and short vellus hair was produced at the bald area after about 3 months. After 6 months, the hair became bristles and the hair loss site disappeared.

Example 2 As a sample of Production Example 2 Then, a 99.5% ethanol solution containing 2% by weight of a mixture obtained by mixing the Chinese herbal extract crude drug extract of Production Example 3 in a ratio of 1: 1 was used.

One sample per day for alopecia areata male, 36 years old, having hair loss parts 2.5 cm in diameter on the parietal region and the temporal region.
When 3 to 5 g was applied once per time, vellus hair was produced at the hair loss site of the crown and temporal region after 3 months, and vellus hair was produced after 6 months, but it was not completely cured.

In both Examples 1 and 2, no skin damage due to continuous application for 6 months was observed.

 Next, prescription examples are shown. The mixing ratio is parts by weight.

Example 1 Hair tonic Manufacturing method 99.5% ethanol It was prepared by dissolving menthol and then adding purified water.

Example 2 Hair cream Chives extract crude drug extract (Production Example 3) 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified water 41.5 Method Mixtures Chisaku extract crude drug extract, Vaseline, Beeswax, Cristol and emulsifier 80 It was dissolved at 0 ° C, and then purified water at 80 ° C was gradually added to the oil phase to form a cream.

Example 3 Ointment Manufacturing method Ground and Isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, emulsifier is melted by heating,
Separately, purified water heated to 70 ° C. or higher was added and stirred, and cooled to 40 ° C. with stirring.

Claims (1)

(57) [Claims] 1. Or Ji or A hair-growth and hair-growth promoting agent, which comprises at least one crude drug extract obtained by extracting the crude drug according to claim 1 with a water-soluble organic solvent or a water-containing water-soluble organic solvent.