JP2551044B2 - Bone change quantification device - Google Patents
Bone change quantification deviceInfo
- Publication number
- JP2551044B2 JP2551044B2 JP27688387A JP27688387A JP2551044B2 JP 2551044 B2 JP2551044 B2 JP 2551044B2 JP 27688387 A JP27688387 A JP 27688387A JP 27688387 A JP27688387 A JP 27688387A JP 2551044 B2 JP2551044 B2 JP 2551044B2
- Authority
- JP
- Japan
- Prior art keywords
- bone
- images
- quantification device
- image
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Nuclear Medicine (AREA)
Description
この発明は、腎性骨異栄養症の診断や治療効果を判定
に用いる骨変化定量装置に関する。The present invention relates to a bone change quantification device used for diagnosing renal osteodystrophy and determining a therapeutic effect.
近年、人工透析技術の進歩によって慢性腎不全患者の
長期生存と社会復帰が可能となってきているが、反面、
それにともなって腎性骨異栄養症の合併が増加してい
る。そのため、腎性骨異栄養症による骨変化を定量的に
観察することは、甲状腺摘出術の可否等の診断や甲状腺
摘出等の治療効果の判定に重要である。 この骨変化の定量的観察については、従来では、たと
えば骨シンチSPECT（single photon emission computed
tomography）によるRI（放射性同位元素）カウント比
測定などの有用性が報告されている（岡村光英、他：腎
性骨異栄養症の診断および治療効果判定における画像診
断の有用性−骨シンチSPECT、Ｘ線CTおよび他検査との
比較−核医学24巻７号:933−946、1987）。これはRIを
静脈に注入して一定時間後に骨シンチグラフィを行い、
全身骨シンチ撮像後、頭蓋骨のSPECTを行ない、得られ
た頭部の横断断層像から前頭骨と頭蓋内のRIカウント比
を算出するというものである。In recent years, advances in artificial dialysis technology have enabled long-term survival and rehabilitation of patients with chronic renal failure.
Along with this, complications of renal osteodystrophy are increasing. Therefore, quantitatively observing bone changes due to renal osteodystrophy is important for diagnosing whether or not thyroidectomy is performed and for determining the therapeutic effect of thyroidectomy. Conventionally, for quantitative observation of this bone change, for example, bone cinch SPECT (single photon emission computed
Usefulness such as RI (radioisotope) count ratio measurement by tomography has been reported (Mitsuhide Okamura, et al .: Usefulness of diagnostic imaging for diagnosis of renal osteodystrophy and determination of therapeutic effect-bone scinti SPECT, Comparison with X-ray CT and other examinations-Nuclear Medicine, Vol. 24, No. 7, 933-946, 1987). This is an injection of RI into a vein and bone scintigraphy after a certain time.
After the whole-body bone scintigraphy, the skull SPECT is performed, and the RI count ratio between the frontal bone and the skull is calculated from the obtained cross-sectional tomographic image of the head.
しかしながら、従来では手動でROI（関心領域）を囲
む作業が必要であったり、測定値そのものに不安定性が
あった。 この発明は、安定に定量値が得られる骨変化定量装置
を提供することを目的とする。However, in the past, it was necessary to manually enclose the ROI (region of interest) or the measured values themselves were unstable. An object of the present invention is to provide a bone change quantifying device that can stably obtain a quantified value.
この発明による骨変化定量装置は、生体にRIを注入し
たときのシンチ画像を時間毎に順次多数枚撮像する手段
と、得られた画像に所定の領域を設定する手段と、上記
多数枚の全画像の上記領域内の全カウントを求める手段
と、上記多数枚の画像の上記領域に対してファクターア
ナリシスを適用して骨への寄与率を求める手段と、この
寄与率を上記全カウントに乗算してRIの骨への集積値を
算出する手段とからなる。The bone change quantification device according to the present invention comprises a means for sequentially capturing a large number of scintigraphic images when RI is injected into a living body, a means for setting a predetermined region in the obtained image, and a total of the plurality of sheets. A means for obtaining a total count in the region of the image, a means for applying a factor analysis to the region of the large number of images to obtain a contribution rate to bone, and the contribution rate is multiplied by the total count. And means for calculating the accumulated value of RI on the bone.
生体にRIを注入したときのシンチ画像を時間毎に順次
枚多数枚撮像すれば、これらの画像は、RIが骨へ集積し
ていく動的過程を示すデータということになる。このデ
ータに、統計学的手法である主成分分析法を応用したフ
ァクターアナリシスを適用すると、１画素ごとにその中
に含まれる骨のRIの固有な動態のいわゆる機能成分が主
成分分析法とそれに続く数学的処理によって抽出でき
（佐藤友彦：核医学動態機能解析“ファクターアナリシ
ス”島津評論Vol.43 No.2.3,1986.9）、ここで求められ
た骨への寄与率を、全画像の設定領域内全カウントに乗
算することにより、骨病変に対応する値であるRIの骨へ
の集積値が得られる。If a large number of scintigraphic images when RI is injected into a living body are taken sequentially at intervals, these images will be data showing the dynamic process of RI accumulating in bone. When a factor analysis is applied to this data by applying the principal component analysis method, which is a statistical method, the so-called functional component of the unique dynamics of bone RI contained in each pixel is determined by the principal component analysis method. It can be extracted by subsequent mathematical processing (Tomohiko Sato: Dynamic analysis of dynamics of nuclear medicine "Factor analysis" Shimadzu, Vol.43 No.2.3, 1986.9), and the contribution rate to bone obtained here can be calculated within the set area of all images. By multiplying all the counts, the accumulated value in the bone of RI, which is the value corresponding to the bone lesion, is obtained.
この実施例では第１図のように患者１の頭部にガンマ
カメラ２を向けて頭部のシンチ画像を撮像するようにし
ておく。そして、この患者１に、たとえば99mTc−MDP等
のRIを、肘静脈よりボーラスインジェクションする。そ
して、ガンマカメラ２から得られる信号をインターフェ
イス３を介して画像メモリ４に送り、たとえば30秒ごと
のデータ集積により１枚の画像を形成し、これをたとえ
ば20分間続けて第２図に示すように各時間ごとの合計40
枚の画像を画像メモリ４において得る。これらの画像は
表示装置５により表示される。そして、ROI（関心領
域）設定装置６がこれらの画像の頭蓋部に、たとえばレ
ベル法などによりROIを自動的に設定する（なお、表示
装置５に表示された画像を観察しながら操作者が手動で
設定することもできる）。すると、演算装置７におい
て、このROIにおける全画像の全カウントの計数が行な
われる。 他方、画像メモリ４に格納された40枚の第２図で示す
ような画像の、ROI内の画像についてデータ処理装置８
がファクターアナリシスを適用して処理する。これによ
り、骨への寄与率ａ（％）が求められる。つぎに演算装
置７によって上記の全カウントにこの寄与率を乗算して Ｂ＝（a/100）×（全カウント） の演算を行ない、RIの骨への集積値Ｂを求める。 なお、上記の画像メモリ４、ROI設定装置６、演算装
置７、データ処理装置８等の構成は、実際にはコンピュ
ータによって形成することもできる。 つぎに、実際に27人の患者について、このRIの骨への
集積値を求めてみたところ、次のような結果が得られ
た。 この表はＢの値の大きな順に並べたもので、Ｂの値によ
り骨変化の生じた患者群と正常な患者群（コントロー
ル）とを明らかに区別できる。なお、上記でPTX−kMは
甲状腺摘出術後ｋカ月を表わす。No.26、27の患者は回
復して正常になったものと思われる。 この表では、Ratioの値が併記してあるが、これは骨
の部分のファクターアナリシスにより得られたT.A.C.
（時間放射能曲線＝Time Ativity Curve）に関するもの
で、 Raio＝C2/C1 但しC2:最初の２分の値 C1:最後の20分の値 により求めている。このRatioの値も骨変化を定量的に
表わすものと考えられる。In this embodiment, the gamma camera 2 is directed to the head of the patient 1 as shown in FIG. Then, RI such as 99m Tc-MDP is bolus-injected into the patient 1 through the cubital vein. Then, the signal obtained from the gamma camera 2 is sent to the image memory 4 via the interface 3, and one image is formed, for example, by accumulating data every 30 seconds, and this is continued for 20 minutes as shown in FIG. A total of 40 for each hour
A single image is obtained in the image memory 4. These images are displayed by the display device 5. Then, the ROI (region of interest) setting device 6 automatically sets the ROI on the skull of these images by, for example, the level method (note that the operator manually observes the image displayed on the display device 5). Can also be set with). Then, the arithmetic unit 7 counts all the counts of all the images in this ROI. On the other hand, the data processing device 8 stores the ROI images of the 40 images stored in the image memory 4 as shown in FIG.
Applies and processes factor analysis. Thus, the contribution rate a (%) to the bone is obtained. Next, the above-mentioned total count is multiplied by this contribution ratio by the arithmetic unit 7 to calculate B = (a / 100) × (total count) to obtain the accumulated value B of RI on the bone. It should be noted that the configurations of the image memory 4, the ROI setting device 6, the arithmetic device 7, the data processing device 8 and the like can be actually formed by a computer. Next, when the RI accumulation values in bones were actually obtained for 27 patients, the following results were obtained. This table is arranged in descending order of B value, and the B value clearly distinguishes between a patient group in which bone changes have occurred and a normal patient group (control). In the above, PTX-kM represents k months after thyroidectomy. The patients of Nos. 26 and 27 are considered to have recovered to normal. In this table, the Ratio value is also shown, but this is the TAC obtained by factor analysis of the bone part.
(Time activity curve), Raio = C2 / C1 where C2: value for the first 2 minutes C1: value for the last 20 minutes. This Ratio value is also considered to quantitatively represent bone changes.
この発明の骨変化定量装置によれば、骨変化を定量的
に表わす値が自動的に安定に得られ、腎性骨異栄養症の
診断や、その甲状腺摘出術等の治療の効果の判定に有用
である。According to the bone change quantifying device of the present invention, a value that quantitatively represents bone change is automatically and stably obtained, and is useful for diagnosing renal osteodystrophy and determining the effect of treatment such as thyroidectomy. It is useful.
第１図はこの発明の一実施例のブロック図、第２図は得
られる画像を示す模式図である。 １……患者、２……ガンマカメラ、３……インターフェ
イス、４……画像メモリ、５……表示装置、６……ROI
設定装置、７……演算装置、８……データ処理装置。FIG. 1 is a block diagram of an embodiment of the present invention, and FIG. 2 is a schematic diagram showing an image obtained. 1 ... Patient, 2 ... Gamma camera, 3 ... Interface, 4 ... Image memory, 5 ... Display device, 6 ... ROI
Setting device, 7 ... Computing device, 8 ... Data processing device.
Claims (1)
間毎に順次多数枚撮像する手段と、得られた画像に所定
の領域を設定する手段と、上記多数枚の全画像の上記領
域内の全カウントを求める手段と、上記多数枚の画像の
上記領域に対してファクターアナリシスを適用して骨へ
の寄与率を求める手段と、この寄与率を上記全カウント
に乗算してRIの骨への集積値を算出する手段とからなる
骨変化定量装置。1. A means for sequentially capturing a large number of scintigraphic images when RI is injected into a living body at intervals of time, a means for setting a predetermined area in the obtained images, and the area for all the plurality of images. Of all the counts in the image, a means of applying a factor analysis to the area of the above-mentioned multiple images to obtain the contribution rate to the bone, and multiplying this contribution rate to the bone count of RI Change quantification device comprising means for calculating the accumulated value in the bone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27688387A JP2551044B2 (en) | 1987-10-31 | 1987-10-31 | Bone change quantification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27688387A JP2551044B2 (en) | 1987-10-31 | 1987-10-31 | Bone change quantification device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01119236A JPH01119236A (en) | 1989-05-11 |
| JP2551044B2 true JP2551044B2 (en) | 1996-11-06 |
Family
ID=17575727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27688387A Expired - Lifetime JP2551044B2 (en) | 1987-10-31 | 1987-10-31 | Bone change quantification device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2551044B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8249319B2 (en) * | 2006-03-10 | 2012-08-21 | Shimadzu Corporation | Nuclear medicine diagnosis apparatus and diagnostic system used thereto |
| CN109480889A (en) * | 2018-12-27 | 2019-03-19 | 佛山市第人民医院（中山大学附属佛山医院） | Quantitative detection method for avascular necrosis of femoral head |
-
1987
- 1987-10-31 JP JP27688387A patent/JP2551044B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01119236A (en) | 1989-05-11 |
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