JP2575417B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP2575417B2 JP2575417B2 JP62256736A JP25673687A JP2575417B2 JP 2575417 B2 JP2575417 B2 JP 2575417B2 JP 62256736 A JP62256736 A JP 62256736A JP 25673687 A JP25673687 A JP 25673687A JP 2575417 B2 JP2575417 B2 JP 2575417B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- kojic acid
- external preparation
- protein
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 8
- 239000007857 degradation product Substances 0.000 claims description 6
- 108010014258 Elastin Proteins 0.000 claims description 4
- 102000016942 Elastin Human genes 0.000 claims description 4
- 229920002549 elastin Polymers 0.000 claims description 4
- 108010068370 Glutens Proteins 0.000 claims description 3
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 2
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 108060003199 Glucagon Proteins 0.000 claims description 2
- 102000051325 Glucagon Human genes 0.000 claims description 2
- 108010070551 Meat Proteins Proteins 0.000 claims description 2
- 102000016943 Muramidase Human genes 0.000 claims description 2
- 108010014251 Muramidase Proteins 0.000 claims description 2
- 102000003505 Myosin Human genes 0.000 claims description 2
- 108060008487 Myosin Proteins 0.000 claims description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
- 108010073771 Soybean Proteins Proteins 0.000 claims description 2
- 241000209140 Triticum Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- 235000014103 egg white Nutrition 0.000 claims description 2
- 210000000969 egg white Anatomy 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 2
- 229960004666 glucagon Drugs 0.000 claims description 2
- 239000004325 lysozyme Substances 0.000 claims description 2
- 229960000274 lysozyme Drugs 0.000 claims description 2
- 235000010335 lysozyme Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229940001941 soy protein Drugs 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 21
- 229960004705 kojic acid Drugs 0.000 description 21
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 21
- 239000006210 lotion Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- -1 Polyoxyethylene Polymers 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- 241001237745 Salamis Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical group OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000015175 salami Nutrition 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は美白作用を有すると共に使用感がよく、肌に
なじみ、肌になめらかなつやを与える皮膚外用剤に関す
る。Description: TECHNICAL FIELD The present invention relates to an external preparation for skin which has a whitening effect, has a good feeling in use, adapts to the skin, and gives the skin a smooth luster.
［従来の技術］ 皮膚外用剤はローション、乳液、クリーム、パウダー
などの形で化粧料や乳剤、リニメント剤、軟膏剤などに
使用されている。これらの皮膚外用剤は直接皮膚に塗布
されるので、皮膚との親和性や使用感が重要な性質とさ
れている。[Prior Art] Skin external preparations are used in cosmetics, emulsions, liniments, ointments and the like in the form of lotions, emulsions, creams, powders and the like. Since these external preparations for skin are applied directly to the skin, affinity with the skin and feeling of use are considered to be important properties.
一方、コウジ酸またはそのエステルが安全で強い美白
作用を有していることも知られている。On the other hand, it is also known that kojic acid or its ester has a safe and strong whitening effect.
［発明が解決しようとする問題点］ 本発明は、コウジ酸またはそのエステルを用いた皮膚
外用剤が、従来の通常の処方では使用感や肌の状態にお
いて必ずしも良好ではない点に鑑みなされたものであ
り、塗布時のベタツキがなく、肌によくなじみ、肌をな
めらかにし、かつつやを与える皮膚外用剤を提供するこ
とを目的とするものである。[Problems to be Solved by the Invention] The present invention has been made in view of the fact that an external preparation for skin using kojic acid or an ester thereof is not always good in a feeling of use or skin condition by a conventional usual formulation. It is an object of the present invention to provide an external preparation for skin which has no stickiness at the time of application, adapts well to the skin, smoothes the skin, and gives a shine.
［問題点を解決するための手段］ かかる目的は、特定のタンパク質またはその分解物の
１種または２種以上とコウジ酸またはそのエステルの１
種または１種以上とを含有させることにより達成され
る。[Means for Solving the Problems] The object of the present invention is to provide one or more of a specific protein or its degradation product and one or more of kojic acid or its ester.
It is achieved by including one or more species.
［作用および実施例］ 本発明における一方の成分であるコウジ酸またはその
エステルとしては、一般式： （式中、R1およびR2は同じかまたは異なり、水素原子ま
たは炭素数３〜20個のアシル基である）で示されるもの
が好ましい。[Action and Examples] Kojic acid or an ester thereof, which is one of the components in the present invention, has the general formula: (Wherein, R 1 and R 2 are the same or different and are a hydrogen atom or an acyl group having 3 to 20 carbon atoms).
エステルとしては、コウジ酸モノブチレート、コウジ
酸モノカプレート、コウジ酸モノパルミテート、コウジ
酸モノステアレート、コウジ酸モノシンナモエートまた
はコウジ酸モノベンゾエートなどのモノエステル、コウ
ジ酸ジブチレート、コウジ酸ジパルミテート、コウジ酸
ジステアレートまたはコウジ酸ジオレエートなどのジエ
ステルが好ましい。モノエステルはコウジ酸の５位の水
酸基がエステル化されているものが好ましい。エステル
化するとメラニン生成抑制作用はコウジ酸と同等である
が、pHや光に対する安定性が向上する。これらは、単独
で使用しても併用してもよい。As the ester, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamoate or kojic acid monobenzoate monoester, kojic acid dibutyrate, kojic acid dipalmitate, Diesters such as kojic acid distearate or kojic acid dioleate are preferred. The monoester is preferably one in which the hydroxyl group at the 5-position of kojic acid is esterified. When esterified, the action of inhibiting melanin production is equivalent to that of kojic acid, but the stability to pH and light is improved. These may be used alone or in combination.
他の成分であるタンパク質またはその分解物を皮膚外
用剤の配合成分として用いることも知られているが、所
望の効果をうるためには多量に配合する必要があり、多
量に用いると塗布時にベタツキが生じたり肌へのなじみ
がわるくなることがある。しかし、このようなタンパク
質またはその分解物であってもコウジ酸またはそのエス
テルと配合するときは塗布時のベタツキが抑えられ、肌
へのすぐれた親和性と使用感を長期間保持することがで
きる。It is also known to use a protein or a hydrolyzate thereof as another component as a component of a skin external preparation, but it is necessary to mix it in a large amount in order to obtain a desired effect. It may cause discomfort or make the skin less familiar. However, even when such a protein or its degradation product is blended with kojic acid or its ester, stickiness at the time of application is suppressed, and excellent affinity to the skin and feeling of use can be maintained for a long time. .
本発明において用いられるタンパク質またはその分解
物とは、大豆タンパク、小麦タンパク、グルテリン、グ
ルカゴン、エラスチン、卵白リゾチーム、フィブリノー
ゲン、ミオシン、魚肉タンパクおよびそれらの塩からな
る群より選ばれた少なくとも１種を意味し、これらのタ
ンパク質またはその分解物は単独で使用しても併用して
もよい。コウジ酸またはそのエステルの配合量は外用剤
中、通常0.01〜20％（重量％、以下同様）好ましくは0.
1〜２％であり、上記タンパク質またはその分解物の配
合量は通常0.01〜20％、好ましくは0.1〜10％である。The protein or its degradation product used in the present invention means at least one selected from the group consisting of soy protein, wheat protein, glutelin, glucagon, elastin, egg white lysozyme, fibrinogen, myosin, fish meat protein and salts thereof. However, these proteins or their degradation products may be used alone or in combination. The amount of kojic acid or its ester in the external preparation is usually 0.01 to 20% (% by weight, the same applies hereinafter), preferably 0.1%.
The amount of the protein or its degradation product is usually 0.01 to 20%, preferably 0.1 to 10%.
本発明の外用剤としては、たとえばクリーム、化粧
料、パック、パウダーなどの化粧料のほかに乳剤、ロー
ション剤、リニメント剤、軟膏剤などの医薬部外品など
の種々の外用形態に製剤でき、それぞれの製剤において
常用されている基剤、賦形剤、安定剤、顔料、香料、紫
外線吸収剤、酸化防止剤、防腐剤、金属封印剤、有機酸
などを適宜配合してもよい。As the external preparation of the present invention, for example, creams, cosmetics, packs, in addition to cosmetics such as powders, emulsions, lotions, liniments, can be formulated into various external forms such as quasi-drugs such as ointments, Bases, excipients, stabilizers, pigments, fragrances, ultraviolet absorbers, antioxidants, preservatives, metal sealants, organic acids, and the like commonly used in each preparation may be appropriately compounded.
つぎに実施例をあげて本発明の皮膚外用剤を説明する
が、本発明はかかる実施例のみに限定されるものではな
い。Next, the skin external preparation of the present invention will be described with reference to examples, but the present invention is not limited to only these examples.
実施例１（ローション） 重量部 ポリオキシエチレン硬化ヒマシ油（60E.O.） 1.00 エタノール 15.00 クエン酸 0.10 クエン酸ナトリウム 0.30 1,3−ブチレングリコール 4.00 コウジ酸 1.00 エラスチン加水分解物 0.10 防腐剤 適量 香 料 微量 精製水 残余 （製法） 各成分を均一に撹拌、混合、溶解し、ローションをえ
た。Example 1 (Lotion) parts by weight Polyoxyethylene hydrogenated castor oil (60E.O.) 1.00 ethanol 15.00 citric acid 0.10 sodium citrate 0.30 1,3-butylene glycol 4.00 kojic acid 1.00 elastin hydrolyzate 0.10 preservative appropriate amount flavor Trace amount of purified water Residue (Preparation method) Each component was uniformly stirred, mixed and dissolved to give a lotion.
実施例２（軟膏剤） 重量部 （Ａ）モノステアリン酸ポリオキシエチレンソルビタン
（60E.O.） 1.00 テトラオレイン酸ポリオキシエチレンソルビット（60E.
O.） 1.50 自己乳化型モノステアリン酸グリセリン 1.50 サラシミツロウ 2.00 パラフィン 2.00 ステアリン酸 3.00 ベヘニルアルコール 3.00 シアバター 12.00 流動パラフィン 5.00 天然ビタミンＥ 0.04 メチルポリシロキサン 0.01 コウジ酸モノベンゾエート 3.00 防腐剤 適量 香 料 微量 （Ｂ）1,3−ブチレングリコール 5.00 クエン酸 0.30 グルテリン 6.00 精製水 残余 （製法） （Ａ）に属する成分を加熱溶解する（油相）。別に、
（Ｂ）に属する成分を加熱溶解する（水相）。油相に水
相を添加して撹拌乳化後、冷却して軟膏剤をえた。Example 2 (Ointment) parts by weight (A) Polyoxyethylene sorbitan monostearate (60E.O.) 1.00 Polyoxyethylene sorbit tetraoleate (60E.O.)
O.) 1.50 Self-emulsifying glycerin monostearate 1.50 Salami beeswax 2.00 Paraffin 2.00 Stearic acid 3.00 Behenyl alcohol 3.00 Shea butter 12.00 Liquid paraffin 5.00 Natural vitamin E 0.04 Methylpolysiloxane 0.01 Kojic acid monobenzoate 3.00 Preservatives Suitable amount Perfume Minutes (B) 1,3-butylene glycol 5.00 citric acid 0.30 glutelin 6.00 purified water residue (Production method) Heat and dissolve the components belonging to (A) (oil phase). Separately,
The components belonging to (B) are dissolved by heating (aqueous phase). The aqueous phase was added to the oil phase, and the mixture was emulsified with stirring, and then cooled to obtain an ointment.
実施例３（美白パウダー） 重量部 ミリスチン酸オクチルドデシル 1.0 コウジ酸 2.0 エラスチン 0.5 香 料 微量 マルチトール 残余 （製法） 各成分を均一に撹拌、混合して美白パウダーをえた。Example 3 (whitening powder) parts by weight octyldodecyl myristate 1.0 kojic acid 2.0 elastin 0.5 flavor trace amount maltitol residue (production method) Each component was uniformly stirred and mixed to obtain a whitening powder.
実施例４（パネルテスト） 本発明の外用剤の効果をパネルテストにより確認し
た。Example 4 (panel test) The effect of the external preparation of the present invention was confirmed by a panel test.
女性20名のパネラーの上腕内側部に本発明の外用剤を
右腕に、対照外用剤を左腕に、１日２回（朝、夜）、30
日間にわたって単純塗布した。Twenty times a day (morning and night), the external preparation of the present invention was applied to the right arm of the panel of 20 women and the left arm of the control external preparation.
Simple application over a period of days.
試験には、実施例１のローションを用い、対照品には
該ローションからコウジ酸を除いたものを用いた。In the test, the lotion of Example 1 was used, and as a control, a lotion obtained by removing kojic acid from the lotion was used.
試験終了後、ぞれの試験部位における塗布時のベタツ
キ、肌のなめらかさ、肌へのなじみ、および肌のつやに
ついて最も優れたものを５、最もわるいものを１とした
５段階で評価し、その平均値をとって比較した。結果を
第１表に示す。After the test was completed, the following items were evaluated on a 5-point scale with 5 being the best for stickiness, smoothness of the skin, conformity to the skin, and 1 being the worst for the skin, and The average value was compared. The results are shown in Table 1.
本発明の皮膚外用剤は、第１表の結果からも明らかな
ように、塗布時のベタツキをなくし、肌のなめらかさ、
肌へのなじみおよび肌のつやなどに優れ、とくにベタツ
キおよび肌のなじみにおいては、従来の皮膚外用剤には
見られない使用感を示すものである。なお、実施例２お
よび実施例３の皮膚外用剤においても同様の効果が認め
られた。 As is clear from the results in Table 1, the skin external preparation of the present invention eliminates stickiness at the time of application, makes the skin smooth,
It is excellent in skin familiarity and skin luster, and especially in stickiness and skin familiarity, shows a feeling of use that is not seen in conventional skin external preparations. The same effects were also observed with the skin external preparations of Examples 2 and 3.
Claims (1)
ン、グルカゴン、エラスチン、卵白リゾチーム、フィブ
リノーゲン、ミオシン、魚肉タンパクおよびそれらの塩
からなる群より選ばれた、タンパク質またはその分解物
の少なくとも１種と、コウジ酸またはそのエステルの少
なくとも１種とを含有する皮膚外用剤。1. A protein or a degradation product thereof selected from the group consisting of soy protein, wheat protein, glutelin, glucagon, elastin, egg white lysozyme, fibrinogen, myosin, fish meat protein and salts thereof, and koji An external preparation for skin containing at least one acid or ester thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62256736A JP2575417B2 (en) | 1987-10-12 | 1987-10-12 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62256736A JP2575417B2 (en) | 1987-10-12 | 1987-10-12 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01100113A JPH01100113A (en) | 1989-04-18 |
| JP2575417B2 true JP2575417B2 (en) | 1997-01-22 |
Family
ID=17296729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62256736A Expired - Lifetime JP2575417B2 (en) | 1987-10-12 | 1987-10-12 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2575417B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3195683B2 (en) * | 1993-03-01 | 2001-08-06 | 丸善製薬株式会社 | Skin cosmetics |
| JP2002293738A (en) * | 2001-03-30 | 2002-10-09 | Sansho Seiyaku Co Ltd | Cosmetic for improving photoaged skin |
| JP5414137B2 (en) * | 2001-03-30 | 2014-02-12 | 三省製薬株式会社 | Hyaluronidase activity inhibitor |
| JP2002293739A (en) * | 2001-03-30 | 2002-10-09 | Sansho Seiyaku Co Ltd | Skin function-improving agent |
| CN100358884C (en) * | 2005-01-25 | 2008-01-02 | 上海奥利实业有限公司 | Synthetic method of kojic acid diester |
| CN111936120A (en) * | 2018-03-08 | 2020-11-13 | 西姆莱斯股份公司 | Mixtures containing protein extracts for the treatment of human skin and/or hair |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0696509B2 (en) * | 1985-11-06 | 1994-11-30 | ポーラ化成工業株式会社 | Cosmetics |
-
1987
- 1987-10-12 JP JP62256736A patent/JP2575417B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01100113A (en) | 1989-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2565513B2 (en) | Topical drug for suppressing melanin production | |
| US5556970A (en) | Lanolin fatty acids, a method for their fractionation, cosmetics and drugs for external use | |
| JP2002504098A (en) | Tocopherol esters and their use in cosmetics and pharmaceuticals | |
| JP2929304B2 (en) | Skin whitening preparation for external use | |
| KR101308871B1 (en) | Skin-whitening agent for external application to the skin, and method for whitening the skin | |
| JP2903412B2 (en) | Cosmetics | |
| JP2575417B2 (en) | External preparation for skin | |
| JP2844103B2 (en) | External preparation for skin | |
| JPS632534B2 (en) | ||
| JP2549127B2 (en) | Topical drug for suppressing melanin production | |
| JP2822093B2 (en) | W / O / W type emulsified cosmetic | |
| JPH03275613A (en) | Skin external agent | |
| JP2949442B2 (en) | Emulsified cosmetic | |
| JPH09315960A (en) | Maillard reaction inhibitor, cosmetics, food additives and foods | |
| JP2634607B2 (en) | External preparation for skin | |
| JP2565516B2 (en) | Topical skin | |
| JPS60116618A (en) | Cosmetic | |
| JP3170700B2 (en) | Cosmetic for preventing skin aging | |
| JP2780803B2 (en) | External preparation for skin | |
| JPH03200708A (en) | Dermal external agent | |
| JPWO1995019160A1 (en) | Blood flow improver and cosmetic | |
| JP2753639B2 (en) | Cosmetics | |
| JP3083110B2 (en) | Cosmetics | |
| JP2911191B2 (en) | Topical melanin production inhibitor | |
| JP2001039826A (en) | Inorganic salt-containing oil-in-water type emulsion composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |