JP2609564B2 - Cream for allergic dermatitis and method for producing the same - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an allergic skin dermatitis <br/> cream and its preparation, allergies, and in particular metal, cosmetics, effective contact dermatitis such as lacquer allergy
Dermatitis cream.

[0002]

2. Description of the Related Art Cell-mediated allergic reactions in which antibodies are not found in serum and are called type IV allergic reactions include reactions associated with infections such as bacteria and viral mold,
Contact dermatitis such as metals, cosmetics, and urushi belong to this category.

[0003] In the case of a reaction associated with infection by bacteria or the like, there is a countermeasure by removing the bacteria or the like. However, no appropriate treatment other than steroid hormones has been proposed for allergy and contact dermatitis.

However, licorice root has long been known as a medicinal herb having an anti-inflammatory effect, and its active ingredient glycyrrhizic acid has an anti-inflammatory, anti-allergic, anti-peptic ulcer effect, etc., so that acute and chronic dermatitis Others have been added to basic cosmetics and dentifrice as being effective for aphthous stomatitis and the like.

[0005] Oubak is a crude drug containing berberine as a main component together with spinach and ogon, but its usage in Chinese medicine is often different from spinach and ogon. There are many uses of oak for estimating bactericidal effects such as digestive effects and eye diseases. Also, the efficacy of oubaku is characterized by its use as an external preparation, and berberine is reported as a topical bactericide to have a wound healing promoting action that cannot be explained by mere bactericidal action.

[0006] Clara is mainly made of matrine and is used for skin diseases such as eczema and athlete's foot, stomatitis and the like.

[0007]

[Problems to be Solved by the Invention] However, these are conventionally used as traditional Chinese medicines, only used as so-called decoctions, and their general pharmacology is almost an experimental stage, and a combination thereof produces a synergistic effect. The method of use has not been performed at all.

[0008]

[Means for Solving the Problems] Accordingly, in the present invention, 6 to 14% of a tripenoite glycoside having a skin disorder healing action and an antiallergic action is contained, and its representative components, glycyrrhizin and glallicaci, are contained.
It is a herbal medicine containing berberine as a main component, provided with licorice that can utilize many sapogenins such as d and gabrolide, many flavonoids, and flavones. A licorice extract mainly composed of glycyrrhizic acid, which makes use of its ingredients, which are often used differently, as a cream for allergic dermatitis, which is especially effective for contact dermatitis. From 0.05 to 0.
A cream for allergic dermatitis comprising 5%, 0.1-10% of an oak extract, and 0.1-10% of a Clara extract, and squalane as a base material;
Vaseline, miscible dissolved by heating liquid paraffin, this was emulsified by adding hot purified water containing preservatives, Gurichi thereto
A method for producing a cream for allergic dermatitis characterized by adding a licorice extract mainly composed of luritic acid, an oak extract and, if necessary, a Clara extract and then cooling while stirring. It is.

[0009]

Hereinafter, the present invention will be described in detail with reference to examples. First, glyceryl monostearate as an emulsifier,
Polyoxyethylene hydrogenated castor oil and butyl parahydroxybenzoate as a preservative are mixed and dissolved by heating. To this is added hot purified water in which a preservative, methyl parahydroxybenzoate, is dissolved to emulsify. This is licorice extract, but glycy
glycyrrheti of rrhizin and its genin
C acid has many pharmacological effects such as water electrolyte and carbohydrate hormone-like action of the adrenal cortex, estrogen action, antitussive action, anti-inflammatory action, anti-allergic action, and the like. To be contained. In addition, a suitable amount of tocopherol acetate-dl-α-tocopherol acetate is added as an antioxidant.

As described above, oak has a bactericidal action, but a growth inhibitory action against staphylococci was observed at 5%.
B. pneumoniae has the strongest antibacterial activity, berberine 0.62
5% and oak powder showed an inhibitory effect up to a concentration of 0.015%.

[0011] Although the efficacy of bark is the wound healing effects can not be explained by the strength of mere bactericidal action, for example, rabbits healing of fresh wounds 2 cm ² was reached muscle created dorsal skin compared to Acrinol berberine The solution treatment group was clearly faster. Since the bactericidal efficacy in test tubes is clearly weaker than synthetic bactericides, it is likely that astringent anti-inflammatory effects are involved in promoting healing. In addition, esters of linoleic acid, palmitic acid and phytosterin have been identified as components other than oak alkaloids.

Since ancient times, powdered oak powder has been used for burns and soaking, and in recent years, a strong resistance inflammatory effect has been detected in screening studies of anti-inflammatory effects using fertilized eggs. That is, when the activity was examined using the filter paper disc in which the specimen was immersed in the embryo of the fertilized chicken egg to inhibit the formation of granulation, the 50% methanol-extracted extract of oak was 53% in the capacity of 500 μg / dise. Has a granulation inhibitory effect. Berberine hydrochloride is 6 at a volume of 50 μg / dise.
8.8% inhibition was shown. The components involved in oak inflammation are unclear. Berberine was converted to berberine chloride in a 1.3-butylene glycol extract of Oubaku Japan Pharmaceutical Co., Ltd.
Use those containing 15 to 0.25 w / v%,
Contains 10%.

Clara is a sophora fla
vecens Aiton root as it is 50v / v%
A mixture of 1.3-butylene glycol and purified water added to an ethanol-extracted solution, containing (+)-matrine, the main component of alkaloids, and (+)-oxynatrine, a minor component, and Xanthoumol, isolanthoh as flavonos
amol etc. They are used for skin diseases, skin infections, hot flashes, sores, genital pruritus and the like. or,
When combined with snakebed, itching effect is enhanced. The Clara liquor contains 1 to 10% of the whole.

The above-mentioned emulsifiers include licorice extract, especially dipotassium glycyrrhizinate, antioxidant dl-α-tocopherol acetate, oak extract and Clara extract, each having 1 to 1 part.
After adding 0%, the mixture is cooled with stirring to obtain a product.

[Practical example 1]

[Practical example 2]

[Practical example 3] The above cream was found to have an excellent antipruritic effect.

[0018] In each practical example, many hairdressers who are in daily contact with hair shampoos, rinses, etc. and have skin irritation have used it. Even within a few weeks, itching disappeared, and the inflammation healed or diminished. There are few cases of differences between the practical examples, and it takes time to find out.

The effects of the practical example 3 will be described below. Effective Rate for Hand Dermatitis by Practical Example 3

The effects of the usage example of practical example 1 will be described below. Effective Rate for Hand Dermatitis by Practical Example 1

It was also found that each of the practical examples was highly effective against atopic dermatitis. Allegern is not a single substance but a complex substance, so the combined use of this product provides a symptomatic effect. In addition, clophenylamine maleate was added as an antihistamine to these practical examples, but it was found that the stimulation of itching was neutralized and effective.

2 shows the effective rate of atopic dermatitis according to Example 2 against the lichenicus form of eczema. The lower part shows a usage example of the antihistamine compound.

[0023]

According to the present invention as described above, a licorice extract mainly containing glycyrrhizic acid is used in an amount of 0.05 to 0.5.
%, Oak extract 1 to 10%, and Clara extract 1 to 10% as needed. The cream for allergic dermatitis is mixed and dissolved by heating squalane, petrolatum and liquid paraffin as base materials. Then, hot purified water containing a preservative is added to the mixture to emulsify the mixture, and glycyrrhizic acid-based licorice extract and oak extract, and Clara extract as needed, are added thereto , and then stirred. Since it is made to be manufactured by cooling, the anti-inflammatory effect of licorice extract, berberine of oak extract, a promotion of wound healing based on the convergent anti-inflammatory effect of alkaloids, etc., anti-inflammatory effect, Clara extract The major alkaloids possessed by Matrine combine their abilities to prevent ulcer occurrence and the ability to respond to skin infections. It is possible to provide a cream for over dermatitis.

Claims (3)

(57) [Claims] 1. A licorice extract mainly composed of glycyrrhizic acid in an amount of 0.05 to 0.5% and an oak extract in an amount of 1 to 10%.
And a cream for allergic dermatitis . 2. The allergic dermatitis according to claim 1, wherein the Clara extract contains 1 to 10%.
For cream. 3. Squalane, petrolatum and liquid paraffin as base materials are mixed and dissolved by heating, and hot purified water containing a preservative is added to the mixture for emulsification, and glycyrrhizic acid is mainly contained in the mixture .
A method for producing a cream for allergic dermatitis, characterized in that a licorice extract and oak extract are further added, if necessary, to a Clara extract and then cooled while stirring.