JP2619841B2 - Oral composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oral composition,
More specifically, the present invention relates to a composition for oral cavity which is excellent in anti-inflammatory effect on gingiva and comprises a tea leaf extract preserved under anaerobic conditions.

[0002]

2. Description of the Related Art Conventionally, the cause of dental caries, that is, tooth decay, is generally caused by the overlapping of three conditions of sucrose, oral bacteria, and tooth quality existing in the mouth. It is said that the mechanism is considered as follows.

[0003] That is, sucrose contained in food and drink is subjected to the action of glucosyltransferase, an enzyme secreted by certain kinds of oral bacteria adhered to the tooth surface, and is a glucan which is a sticky and insoluble polysaccharide. In addition to the formation of plaque, which is a nest of bacteria, bacteria break down sugars in plaque to produce an acid, which demineralizes the enamel surface of the tooth and promotes caries. In addition, the disease rate of so-called periodontal disease has increased due to the rapid evolution toward an aging society in recent years, and prevention of such diseases is an urgent need at present.

[0004] Periodontal disease refers to all diseases that occur in tissues around teeth. If care is not properly made such as by brushing teeth, inflammation becomes chronic, tissue supporting teeth is destroyed, and finally, Will lose teeth. There are various types of disease that appear depending on the stage of the condition and the age of the patient. That is, at the very beginning of periodontal disease, plaque and tartar adhere to the surface of the tooth hairline, and the gums surrounding the teeth are swollen and inflamed. If this inflammation lasts for a long time, there is a gap between the teeth and the gums, so-called periodontal pockets. And as it goes further, the alveolar bone at the bottom will gradually disappear. Periodontal disease is chronic inflammation that progresses without subjective symptoms without pain, but often involves bleeding from the gums, swelling of the gums, bad breath and the like.

Heretofore, as an effective anti-inflammatory agent, anti-inflammatory agents such as glycyrrhizin, ε-aminocaproic acid, vitamin Es, allantoin, hinokitiol, etc. have been blended into dentifrices as oral compositions. However, the anti-inflammatory effect is insufficient, and the above problem has not been solved.

In view of such circumstances, the present inventors have conducted intensive studies on an oral composition having an excellent anti-inflammatory effect for suppressing gum inflammation such as periodontal disease. after saving, and steam heating treatment and / or drying process, it
It has been found that the addition of a tea leaf extract obtained by extraction is effective for anti-inflammatory action, and the present invention has been completed.

[0007] That is, an object of the present invention is to provide an oral composition which suppresses and improves gingival inflammation and has an excellent effect of preventing alveolar pyorrhea and gingivitis.

[0008]

SUMMARY OF THE INVENTION The present invention provides a tea leaf extract obtained by storing fresh tea leaves under anaerobic conditions, subjecting them to steam heating treatment and / or drying treatment , and extracting them. An oral composition characterized by being incorporated in an amount of 0.01% by weight or more as a solid content.

Hereinafter, the configuration of the present invention will be described. Tea is not only a favorite beverage, but is also widely consumed as a health drink due to the physiological effects of vitamin C, caffeine, amino acids and the like contained in the tea. The method of making tea leaves is
Various methods have been adopted by various countries since ancient times,
Generally, it can be classified into non-fermentation methods such as gyokuro, matcha, sencha and bancha, semi-fermentation methods such as oolong tea, and fermentation methods such as black tea. All the operations during the manufacturing process of any of these teas are performed in the presence of oxygen.

[0010] However, recently, a method for producing tea with enhanced blood pressure lowering action has attracted attention. This method is generally used in non-fermentation methods such as green tea and matcha in the process of producing tea leaves.
As a pretreatment for steaming tea leaves, sealed and stored for 5 to 30 hours in a closed container in which air has been completely replaced with nitrogen or carbon dioxide. Similarly, it is a method of sealing and storing in a sealed container replaced with nitrogen or carbon dioxide. The content of γ-aminobutyric acid in the tea leaf extract subjected to this treatment is up to 300 m.
g / 100 g, whereas 30 mg / 100 g for a tea leaf extract not subjected to such treatment is about 1/10.
Only included. Therefore, the tea leaf extract treated by the conventional production method hardly exhibits a blood pressure lowering effect, but the tea leaf extract preserved under anaerobic conditions has an advantage of exhibiting an excellent blood pressure lowering effect.

The present inventors have sufficiently replaced the air in a container containing freshly picked tea leaves with an inert gas such as carbon dioxide gas or nitrogen gas, and then sealed the container. As a result of intensive research focusing on the phenomenon that the content of γ-aminobutyric acid is significantly increased by leaving the tea leaves for more than 3 hours (preserving the tea leaves under anaerobic conditions), the tea leaves preserved under anaerobic conditions were found. For example, after steam heating for 10 to 30 minutes, air-dry, or put into a dryer at 80 ° C. or more for 5 hours or more, and dry the dried tea leaves with water, a water-miscible organic liquid, and water and a water-miscible organic liquid. It has been found that extraction should be performed at a boiling point of a solvent such as a mixture of the above for 30 to 60 minutes. The extract is concentrated by a usual method, or, if necessary, purified by activated clay, chromatography, etc., and then concentrated under reduced pressure to obtain a solid (active ingredient). Things.

The extract (solid matter) thus obtained
Has a high content of γ-aminobutyric acid, and the oral composition of the present invention containing the γ-aminobutyric acid, combined with the action of promoting blood circulation of gums, has a peripheral vasodilatory action contained in the extract, Caffeine having a nerve stimulating action, flavonoids having a peripheral blood vessel strengthening and an anti-inflammatory action act synergistically to activate periodontal tissue in the oral cavity, and exhibit a rapid and effective blood circulation promoting and anti-inflammatory action. Furthermore, the moisturizing action of amino acids such as aspartic acid, glutamic acid, alanine, serine, glutamine, arginine and the like has a mild action in the oral cavity.

The storage time of tea leaves under anaerobic conditions is usually at least 3 hours at room temperature, preferably at least 5 hours.
More preferably, it is 8 hours or more. Short storage time γ
-Production of aminobutyric acid and the like is not sufficient, and it is difficult to sufficiently achieve the above-mentioned effects of promoting blood circulation in the oral cavity and anti-inflammatory effects.

The water-miscible organic liquid (hydrophilic organic liquid) in the above solvent includes, for example, glycols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and diethylene glycol, glycerin, maltitol and the like. Polyhydric alcohols, lower monohydric alcohols such as ethyl alcohol, propyl alcohol and butyl alcohol, water-miscible ketones such as acetone and methyl ethyl ketone, and tetrohydrfuran.

The fresh leaves of tea used in the present invention are:
Any varieties such as alley and fuji can be applied, and the time of plucking is not particularly limited.

The amount of the tea leaf extract obtained by performing the above-mentioned treatment in the present invention is 0.01% by weight based on the total amount of the oral composition as a solid component.
(Hereinafter abbreviated as wt%), preferably 1 to
10 wt%. That is, if it is less than 10 wt%, the anti-inflammatory effect in the oral cavity intended by the present invention will not be exhibited as expected, and if it exceeds 10 wt%, the effect corresponding to the increase cannot be expected, so that it is economically desirable. Absent.

The composition for oral cavity according to the present invention is applied to dentifrices such as toothpaste, powdered toothpaste, water dentifrice, mouthwash, mouth freshener, troche, pasta, paint and the like. In addition, chewing gum, candy, gummy candy,
Also include candy and the like.

The content of the extract in the composition for oral cavity of the present invention may be determined in consideration of factors such as the effective concentration and the like.
It is preferably set to 10% to 10%, particularly preferably 0.05% to 5%.

The other components of the present invention are appropriately selected according to the type of the oral composition. For example, for toothpaste,
Calcium carbonate, magnesium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, magnesium phosphate, silica, zeolite, which are generally used as abrasives,
Examples include sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, calcium pyrophosphate, red iron oxide, calcium sulfate, and silicic anhydride.

Also, a binder such as carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, methylcellulose, magnesium oxide, alumina sol, calcium silicate, pectin, guar gum, kaolin and the like, lauryl sulfate Sodium, sodium dodecylbenzene sulfonate, sodium lauroyl sulfoacetate, sodium N-lauryl sulfonate, sodium N-lauroyl sarcosinate,
A foaming agent such as sucrose fatty acid ester, polyoxyethylene sorbitan, or alkylolamide is used.

Further, sweeteners such as sodium saccharin, steviosite, glycyrrhizin, chalcone, dihydrochalcone, humectants such as glycerin, sorbitol, propylene glycol, polyethylene glycol, chylesitol, dipropylene glycol, sodium lactate, maltitol, paraoxybenzoate Preservatives such as acids, peppermint, spearmint essential oil, fragrances such as menthol, other aluminum lactate, edetates, pigments, BHT, etc. are used, and if necessary, lysozyme chloride, dextranase, lytic enzyme as other active ingredients. , Mutanase, sorbic acid, alexidine, cetylpyridinium chloride, alkylglycine, sodium chloride, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, sodium fluoride, Fluorides such fluoro sodium phosphate, isopropyl methyl phenol, polyethylene glycol, polyvinyl pyrrolidone, glycyrrhizin, glycyrrhizic acid, hinokitiol, vitamin E
Etc. can also be used. Then, these components and water are mixed and manufactured according to a conventional method.

In addition, components such as mouthwash, troche, chewing gum and the like depending on the properties of the product are appropriately blended.

[0023]

The present invention will be described in detail below based on examples and comparative examples. [Production method of tea leaf extract treated under anaerobic conditions] 500 g of freshly picked tea leaves are placed in a vacuum desiccator containing 2 liters, a porcelain porous plate is placed thereon, and the edges are sealed with a lid coated with grease. After that, the vessel was evacuated and connected to a nitrogen cylinder to allow nitrogen to flow into the vessel. When the pressure in the vessel reached 0.8 atm, the flow of nitrogen was stopped. Leave for a time. Thereafter, the tea leaves treated under anaerobic conditions are taken out of the container and put in a steaming basket for 30 minutes.
After steaming for a minute, spread on a dried towel and leave it in a room at 25 ° C for 2 days and night to dry naturally.

100 g of the tea leaf thus obtained is
In a beaker containing 00 ml, 300 ml of 25 ° C. water or a 10% aqueous solution of ethyl alcohol was injected, heated for 30 minutes, and filtered to obtain 300 ml of an extract to be dropped. Next, the extract was concentrated by a conventional concentration method under reduced pressure or the like, and 4.6 g of a solid substance was mixed with toothpaste or the like to prepare each test sample.

The results of analysis of the extract obtained by the present production method are shown in Table 1 together with the component contents of the tea leaves (converted from the extract content).

[0026]

[Table 1]

Further, the composition for oral cavity of the present invention promotes blood circulation,
For the anti-inflammatory effect, a continuous test was carried out using prototypes, and improvement in inflammatory changes in the gingiva was observed.

(1) Twenty subjects with periodontal disease in the upper and lower front teeth of the upper and lower mandibular teeth were subjected to a continuous test for 4 weeks with the compositions shown in Table 2. About 1 g of Example 1 (Sample A) was applied to a toothbrush twice a day for 10 persons, and Comparative Example 1 (Sample B) was similarly used for the remaining 10 persons.
At the time of use, the same toothbrush was used by 20 people, the brushing method was also explained, and the same conditions were used as much as possible. Gingival redness, gingival swelling, and gingival bleeding before and after the test were observed.

[0029]

[Table 2]

The preparation method was in accordance with the usual toothpaste method.

As can be seen from Table 3, the composition of the present invention is superior in all of the properties as compared with those of the comparative examples.

[0032]

[Table 3]

Example 2 Toothpaste Dibasic calcium phosphate dihydrate 45 (wt%) Silicic anhydride 10 Glycerin 15 Titanium oxide 5 Sodium carboxymethylcellulose 1 Sodium lauryl sulfate 0.5 Fragrance 0.7 Sodium saccharin 0.1 Tea leaf extraction Thing 0.1 water remaining

Example 3 Mouthwash Ethanol 8 (wt%) Glycerin 5 Polyoxyethylene hydrogenated castor oil 0.7 Sodium benzoate 0.1 Fragrance 0.5 Tea leaf extract 0.2 Sodium lauryl sulfate 0.3 Water remaining

Example 4: Mouth freshener ethanol 15 (wt%) glycerin 3 polyoxyethylene hydrogenated castor oil 0.5 saccharin sodium 0.1 flavor 0.2 tea leaf extract 2.0 water remaining

Example 5: Toothpaste Dibasic calcium phosphate 45 (wt%) Calcium carbonate 35 Glycerin 5 Dextrin 1 Methylcellulose 1 Saccharin sodium 0.05 Fragrance 0.2 Sodium lauryl sulfate 0.5 Tea leaf extract 1.5 Water Remaining

Example 6 Chewing gum Gum base 45 (wt%) Powdered sugar 25 Mannit 20 Sorbitol 5 Flavor 0.5 Tea leaf extract 3 Water Remaining

[0038] As a result of the use of the oral composition prepared by blending the extracts of Examples 2 to 6 with 10 subjects each for one month, the composition was effective against gingival redness, gingival swelling, gingival bleeding and the like. An improvement effect was observed. No discomfort such as bitterness was felt during use.

[0039]

As described above, the oral composition of the present invention has an effect of improving gingival redness, swelling, bleeding, etc., and is also useful in preventing alveolar pyorrhea, gingivitis and the like. It is clear that this is a composition for use.

Claims (1)

(57) [Claims] Claims 1. After storing fresh tea leaves under anaerobic conditions,
Steam heating and / or drying and extracting
The extracted tea leaf extract as a solid content of 0.01% by weight
An oral composition characterized by being blended as described above.