JP2676155B2 - Hair restoration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention provides a novel and safe herbal drug extract or a herbal drug extract and a surfactant,
The present invention relates to a hair nourishing material excellent in the effects of preventing hair loss, promoting hair growth, hair growth and the like.

[Prior Art] Conventionally, hair tonics containing various agents have been known. For example, vitamins such as vitamin B, amine acids such as methionine, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormone agents such as estradiol, and skin function-enhancing agents such as cepharanthin are mixed, It is used for the prevention and treatment of alopecia.

However, conventional hair nourishing agents are said to be effective in preventing and improving dandruff, itchiness, hair loss, etc., and promote hair growth and hair growth, but none have yet achieved satisfactory effects.

[Problems to be Solved by the Invention] The present inventors have conducted intensive studies on hair restorations that are effective in preventing hair loss, hair growth, and the like, and have excellent safety. As a result, one or two or more specific crude drug extracts are obtained. Or found that this problem can be solved by containing one or more of these specific crude drug extracts and a specific surfactant,
The present invention has been completed.

[Means for Solving the Problems] That is, the invention according to claim 1 provides a time, a sage,
A hair nourishing agent containing one or two or more herbal extracts selected from the group consisting of lavender, juniper, cedarwood, lemon, geranium, spirulina, black soybeans, and black soybean.

The invention according to claim 2 is one or more kinds of the extract of crude drug according to claim 1, one or more kinds of anionic surfactant, and a nitrogen atom in the molecule other than the anionic surfactant. A hair nourishing agent comprising one or more kinds of surfactants.

The invention according to claim 3 has one or more kinds of the crude drug extract according to claim 1, one or more kinds of an amphoteric surfactant and a semipolar surfactant, and a nitrogen atom in the molecule. A hair nourishing agent containing one or more nonionic surfactants.

The invention according to claim 4 is a hair nourishing agent characterized by containing one or more kinds of the herbal medicine extract according to claim 1 and an amine oxide.

 Hereinafter, the configuration of the present invention will be described in detail.

The crude drug extract used in the present invention includes a crude drug as a solvent, for example, hot water, lower alcohols such as methanol and ethanol, hydrous lower alcohols or polyhydric alcohols such as propylene glycol, 1-3 butylene glycol and hydrous polyhydric alcohols. Examples of the extract include extracts obtained by extraction with hydrous alcohol and the like, and extracts obtained by concentrating and drying the extracts. The compounding amount of the crude drug extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to 5% by weight, as a dried product, based on the total amount of the hair restorer. If the amount is less than 0.005% by weight, the effects of the present invention are not sufficiently exhibited, which is not preferable.

The anionic surfactant according to claim 2 includes an anionic surfactant having one or more carboxylic acid groups, sulfonic acid groups, sulfuric acid ester groups, and phosphoric acid ester groups in the molecule. As those having a carboxylic acid group, fatty acid soap, ether carboxylic acid and salts thereof, carboxylic acid salts such as condensates of amino acids and fatty acids,
Further, those having a sulfonate include alkyl sulfonate, sulfosuccinic acid, ester sulfonate, alkylallyl and alkylnaphthalene sulfonate, N
-Acyl sulfonates, formalin condensed sulfonates and the like having a sulfate ester group include sulfated oils, ester sulfates, alkyl sulfates, ether sulfates, alkylallyl ether sulfates, amide sulfates, etc. Examples of compounds having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, and alkylallyl ether phosphates. One or more of these are arbitrarily selected.

As the surfactant having a nitrogen atom in the molecule other than the anionic surfactant according to claim 2, an amphoteric surfactant having a nitrogen atom in the molecule, a semipolar surfactant, a nonionic surfactant, Examples thereof include cationic surfactants. As the amphoteric surfactant, N, N-dimethyl-
Carboxybetaines such as N-lauryl-N-carboxymethylammonium betaine, N, N-dimethyl-N-oleyl-N-carboxymethylammonium betaine,
2-lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-
Imidazoline derivatives such as carboxymethyl-N-hydroxyethylimidazolinium betaine, N-cocoalkyl-β-aminopropionic acid sodium salt, N-cocoalkyl-β-iminodipropionic acid-di-soda salt and other aminocarboxylic acid salts, Examples include sulfobetaine and aminobetaine. By semipolar surfactant is meant herein dimethyllaurylamine oxide, bis- (2-hydroxyethyl) laurylamine oxide. Examples of the nonionic surfactant include fatty acid alkanolamides, polyoxyethylene fatty acid amides, esters of alkanolamines, and polyoxyethylene alkylamines. Examples of the cationic surfactant include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, imidazolium salts and the like. One or more of these are arbitrarily selected.

As the amphoteric surfactant according to claim 3, carboxybetaines such as N, N-dimethyl-N-lauryl-N-carboxymethylammonium betaine and N, N-dimethyl-N-oleyl-N-carboxymethylammonium betaine, 2-lauryl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine and other imidazoline derivatives, N-cocoalkyl-β-aminopropionate sodium Examples thereof include salts, aminocarboxylic acid salts such as N-coconut alkyl-β-iminodipropionic acid-di-soda salt, sulfobetaines, aminobetaines and the like.

Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamides, polyoxyethylene fatty acid amides, alkanolamine esters, and polyoxyethylene alkylamines.

Examples of the amine oxide according to claim 4 include those of the following general formulas (A) to (C).

(In the formula, R ₁ , R ₂ and R ₃ represent a linear or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, R ₁ ,
At least one of R ₂ and R ₃ represents a linear or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms. ) Specific examples of the amine oxide represented by the general formula (A) include dimethyllaurylamine oxide, dimethylmyristylamine oxide, dimethylcetylamine oxide, dimethylstearylamine oxide, dimethyloleylamine oxide, dimethylbehenylamine oxide, and methyldilaurylamine. Examples thereof include oxides.

(In the formula, R ₄ represents a linear or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms.) (In the formula, R ₅ represents a linear or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, and n represents an integer of 1 to 5.) In the present invention, these amine oxides are One kind or two kinds or more are arbitrarily selected and used.

The total compounding amount of the anionic surfactant according to claim 2 and the surfactant having a nitrogen atom in the molecule other than the anionic surfactant is preferably 0.001 to 10% by weight, and more preferably the total amount of the hair nourishing agent. It is 0.01 to 5% by weight. Also,
The ratio of the anionic surfactant and the surfactant having a nitrogen atom in the molecule other than the anionic surfactant is preferably 20: 1 to 1:20 in a molecular ratio, more preferably 10: 1 to 1 :
It is 10.

The total blending amount of one or more of the amphoteric surfactant and the semipolar surfactant according to claim 3 and one or more of the nonionic surfactant having a nitrogen atom in the molecule is a hair restorer. The total amount is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight. Further, the ratio of one or more amphoteric surfactants and semipolar surfactants and one or more nonionic surfactants having a nitrogen atom in the molecule is 20: 1 in terms of molecular ratio. ~ 1: 20 is preferred,
More preferably, it is 10: 1 to 1:10.

The compounding amount of the amine oxide according to claim 4 is preferably 0.0001 to 20% by weight based on the total amount of the hair nourishing agent. If the blending amount is less than 0.0001% by weight, a sufficient hair nourishing effect cannot be obtained, and if the blending amount exceeds 20% by weight, it is not preferable in terms of preparation or skin irritation.

In addition to the above essential ingredients, the hair nourishment according to the present invention includes general-purpose ingredients usually used in hair nourishments, such as vitamin B ₆ , vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid. And derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cepharanthin, oxendron, diazoxide, minoxidil, hair growth aids such as ethinyl estradiol, hinokitiol, hexachlorophene, phenol, Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol,
Drugs such as salicylic acid, zinc and derivatives thereof, lactic acid and alkyl esters thereof, organic acids such as citric acid, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols, and glycerin , Polyhydric alcohols such as propylene glycol, fragrances, antioxidants, ultraviolet absorbers, pigments, alcohols such as ethanol, benzyl alcohol, isopropyl alcohol, water, humectants, thickeners and the like do not impair the effects of the present invention. It can be appropriately compounded within the range.

The hair restorer of the present invention may be any liquid form, emulsion, ointment, cream, gel, aerosol or any other dosage form applicable to the outer skin, and is used in the form of a tonic, conditioner, scalp treatment, shampoo, rinse, etc. .

[Examples] Next, the present invention will be described in detail with reference to examples.
The present invention is not limited to these. The compounding amount is% by weight.

Trichogram Test and End Hair Conversion Test In order to investigate the hair nourishing action of the hair nourishing agent according to the present invention, a trichogram test and an end hair conversion test were carried out.

In both tests, 30 male subjects were divided into 3 groups of 10 subjects, and 3 different test solutions were given to the subjects in each group for comparison.

 Table 1 shows the three test solutions.

(I) Trichogram The hair roots of extracted hair before and after the use of each test solution are observed under a microscope, the number of resting hair roots is calculated from the morphology of the hair roots, and the hair growth of each test solution is calculated by increasing or decreasing the ratio. The effects were compared.

Here, the resting hair root is a hair root of which hair has stopped growing.

Since those who complain of hair loss have more hair-resting hair roots than those of normal hair-removing hair roots, the hair nourishing effect was evaluated based on the reduction of hair-resting hair roots. The application of each test solution to the scalp was continued for 3 months, and the hair roots removed immediately before and immediately after the application were started for each subject.
I checked 60 each.

 The results are shown in Table 2 below.

(Ii) Hair loss conversion rate test The conversion rates of downy hairs to terminal hairs were compared before and after the application of each test solution at 3 locations on each head hairy hair site of 30 subjects with male baldness. Here, the terminal hair refers to hair other than downy hair, that is, hair having a length of 14 mm or more, and the conversion from downy hair to terminal hair means a hair nourishing effect. Immediately before the start of application of each test solution and immediately after the end of application for 4 months, the conversion of the above-mentioned head follicles was taken by taking a direct close-up photograph. The conversion rate to terminal hairs was shown as a percentage for an average of 3 months.

 Table 3 shows the results.

From the results shown in Tables 2 and 3, it is understood that the herbicide cedarwood of the present invention has a sufficient hair nourishing effect at 0.01% to 0.001%.

Using the measurement method of the hair-growth effect (hair growth effects measured in mice) Male C ₃ H mice (60 days old), the method of Ogawa et al. [(Normal and Abnormal Epidermal Differentiatio
n) Edited by M. Seiji and IA Bernstein]. That is, about 2 × the back hair of a mouse
After shaving to a size of 4 cm, sample application was performed once a day from the next day, and the change in the area ratio of the part where hair regeneration started was determined and the speed of hair regeneration was compared. The sample was prepared by dissolving a dried product of each crude drug extract in 75% ethanol with stirring, adding a surfactant to the solution and dissolving it. The test used 75% ethanol as a control. For each sample, 10 mice were used, and the average value of the rate of change was determined. The results of the area of hair regeneration after 20 days are shown in Table 4 in percentage.

Comparative Example 2 (1) 75% ethanol 100 Comparative Example 3 (1) 50% ethanol extract of dried sea bream (dried product) 0.2 (2) 75% ethanol Residual Comparative Example 4 (1) 70% ethanol extract of Touki (dried) Material) 0.2 (2) 75% ethanol residue Comparative Example 5 (1) Kujin 50% ethanol extract (dry matter) 0.2 (2) 75% ethanol residue Example 3 (1) Thyme 50% ethanol extract (dry matter) 0.2 (2) 75% ethanol residue Example 4 (1) Sage methanol extract (dry matter) 0.1 (2) 75% ethanol residue Example 5 (1) Dimethyllaurylamine oxide 0.1 (2) Thyme 50% ethanol extraction Dry matter 0.1 (3) 75% ethanol residual Example 6 (1) Dimethylstearylamine oxide 0.1 (2) Sage methanol extract (dry matter) 0.1 (3) 75% ethanol residual Example 7 (1) Dodecylbenzenesulfonate 0.05 (2) Lauryldimethylamine oxide 0.05 (3) 70% ethanol extract of lavender (dry matter) 0.1 (4) 75% ethanol Residue Example 8 (1) Dimethyllaurylamine oxide 0.06 (2) Sodium laurylmethyl taurine 0.04 (3) 50% ethanol extract of lemon (dry product) 0.1 (4) 75% ethanol Residue Example 9 (1) Betaine laurylaminoacetate 0.03 (2) Lauroyldiethanolamide 0.02 ( 3) Geranium 1,3-butylene glycol extract (dry product) 0.1 (4) 75% ethanol Residue Example 10 (1) Dimethyllaurylamine oxide 0.05 (2) Spirulina 70% ethanol extract (dry product) 0.05 (3) Methanol extract of dried black beans (dry matter) 0.05 (4) Propagation of Kokugan Nol extract (dry matter) 0.05 (5) 75% ethanol residue As is clear from Table 4, the effect on hair regrowth was observed in each Example.

Example 11 Heartnic A tonic having the composition shown below was prepared, and its effects on symptoms such as dandruff, hair growth and hair loss were examined by actual use.

20 men (aged) with symptoms such as dandruff, hair growth, and hair loss
(24 to 60 years old) was applied once or twice a day at a rate of 1 to 5 ml for 4 months, and the results shown in Table 5 were obtained. It had excellent symptoms such as dandruff, hair growth and hair loss.

(1) Thyme 70% ethanol extract (dry matter) 0.05 (2) Lavender 90% ethanol extract (dry matter) 1.0 (3) Sage methanol extract (dry matter) 0.5 (4) Dimethyllaurylamine oxide 0.3 ( 5) Sodium lauryl sulfate 0.05 (6) Propylene glycol 5.0 (7) Sodium hyaluronate 0.01 (8) 75% ethanol Residual In Table 5 above, the effect evaluation was performed according to the following criteria.

1. Dandruff prevention effect test "Ineffective" means no improvement is seen despite treatment.

 "Effective" means that the occurrence of dandruff has been reduced.

 "Excellent effect" means that the occurrence of dandruff has stopped.

2. Hair growth test "Ineffective" means no improvement is seen despite treatment.

“Effective” means that hair growth is observed in more than 2/3 of the hair loss area.

 "Excellent effect" means that the hair has grown on the epilation area.

3. Hair loss effect test "Ineffective" means no improvement is seen despite treatment.

 "Effective" means that the progress of hair loss was reduced.

 "Effectiveness" means that hair loss has stopped.

Example 12 Heartonic (1) Methanol extract of Chromatome (dry matter) 0.05 (2) 80% Ethanol extract of Kokugan (dry matter) 0.05 (3) Thyme 1,3-butylene glycol extract (dry matter) ) 0.05 (4) 90% ethanol extract of Kokugan (dry product) 0.05 (5) Hot water extract of sage (dry product) 0.05 (6) 70% ethanol extract of cedar wood (dry product) 0.05 (7) Polyoxyethylene (8 mol) oleyl alcohol ether 0.05 (8) 1,3-butylene glycol 0.05 (9) 60% ethanol Residue The effect of the cosmetic of Example 12 on hair growth was also effective.

Example 13 Shampoo (1) Sodium cocoyl methyl taurine 6.0 (2) Betaine lauryl dimethylaminoacetate 8.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1.5 (5) Propylene glycol 2.0 (6) 70% of lavender Ethanol extract (dry matter) 1.0 (7) 50% ethanol extract of juniper (dry matter) 1.0 (8) Methanol extract of lemon (dry matter) 1.0 (9) Propylene glycol extract of geranium (dry matter) 0.2 (10) 2-sodium edetate 0.1 (11) Perfume proper amount (12) Purified water Remainder Example 14 Rinse (1) Stearyl trimethyl ammonium chloride 1.5 (2) Cetyl alcohol 2.0 (3) Silicon oil 3.0 (4) Polyoxy Ethylene (10 mol) Oleyl alcohol ether 1.0 (5) Glycerin 5 .0 (6) Chromato methanol extract (dry matter) 0.5 (7) Lavender methanol extract (dry matter) 0.5 (8) Cedarwood hot water extract (dry matter) 1.0 (9) Geranium 70% ethanol Extract (dry product) 1.0 (10) Purified water 84.0 (11) Preservative proper amount (12) UV absorber proper amount Example 15 Hair Cream (1) Beeswax 3.0 (2) Vaseline 15.0 (3) Liquid paraffin 42.0 (4) Polyoxyethylene (5 mol) Stearic acid ester 3.0 (5) Polyoxyethylene (6 mol) Oleyl alcohol ether 1.0 (6) Thyme 90% propanol extract (dry product) 0.3 (7) Geranium 50% methanol extract (Dry product) 0.2 (8) 70% ethanol extract of juniper (dry product) 0.4 (9) Purified water 35.1 (10) Perfume proper amount (11) Preservative proper amount Examples 12 to 15 are all It was excellent in hair effect.

[Effects of the Invention] The hair restorer of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant, so that various properties (e.g., For example, hair growth, hair growth, hair loss prevention effects, etc.).

Front page continuation (72) Inventor Reiji Miyahara 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Research Institute Co., Ltd. (56) Reference JP-A-54-140737 (JP, A) JP-A-56-79617 ( JP, A) JP-A-2-17118 (JP, A)

Claims (4)

(57) [Claims] 1. A hair nourishing agent containing one or more crude drug extracts selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, geranium, and pearl oyster. 2. Thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina,
One or two or more crude drug extracts selected from the group consisting of black soybeans and Kokrugan, one or more anionic surfactants, and a surfactant having a nitrogen atom in the molecule other than the anionic surfactant. A hair nourishing agent comprising one or more agents. 3. Thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina,
Selected from the group consisting of one or more crude drug extracts selected from the group consisting of black soybeans and black sorghum, and an amphoteric surfactant, dimethyllaurylamine oxide, and bis- (2-hydroxyethyl) laurylamine oxide. A hair nourishing agent containing one or more surfactants and one or more nonionic surfactants having a nitrogen atom in the molecule. 4. Thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina,
A hair nourishing agent comprising one or more crude drug extracts selected from the group consisting of black soybeans and black soybeans and amine oxide.