JP2757984B2 - Transdermal medication system - Google Patents
Transdermal medication systemInfo
- Publication number
- JP2757984B2 JP2757984B2 JP61140238A JP14023886A JP2757984B2 JP 2757984 B2 JP2757984 B2 JP 2757984B2 JP 61140238 A JP61140238 A JP 61140238A JP 14023886 A JP14023886 A JP 14023886A JP 2757984 B2 JP2757984 B2 JP 2757984B2
- Authority
- JP
- Japan
- Prior art keywords
- drug
- medicine
- transdermal administration
- transdermal
- medication system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims description 19
- 229940079593 drug Drugs 0.000 title description 14
- 230000036760 body temperature Effects 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
Description
【発明の詳細な説明】
本発明は、経皮投薬を行なうシステムに関する。
針、カニューレによる薬液の体内投与は、経皮投薬に
おいて効果的な方法であるが、慢性疾患患者、高齢者、
衰弱患者に対して連続的に用いることができず、しかも
毎回受ける刺痛は、患者にとって耐えがたいものであ
る。
一方、経皮投薬手段であって、体内に薬物の導入経路
を埋入せずに、皮膚表面に薬物を配置し、電気力あるい
は浸透圧を利用して薬物を導入する方法が近時注目され
つつあるが、皮膚表面、特にバリヤー層の組織的解明が
未だ不充分である為、実用化には至っていない。
上記に鑑み本発明者らは鋭意研究の結果、皮膚組織表
面上に経皮投与システムを配置し、体温による膨張する
膨張体により薬物を押圧することにより、汗腺及び毛穴
を通じ、体内への薬液浸透が行なわれることを知見し、
本発明に到達したものである。
以下、本発明経皮投薬装置につき実施例を用いて詳細
に説明する。
第１図は本発明の一実施例を示す断面図であり、保持
体（１）の鍔部（６）の接着部（３）によって密閉され
た保持体内部空間は、薬物部（４）及び加圧体（２）が
充填されている。加圧体（２）はフロンガス等を充填し
た伸縮する球状体から成り、生体の体温等によって膨張
し、薬物部が皮膚組織（５）を押圧、薬物部（４）の薬
剤が皮膚に浸透する。図に示すごとく、例えばポリエチ
レン等により、１体部材として構成するのが製造の観点
から好ましい。接着剤３としては、例えばビニルエマル
ジョン系接着剤が好ましい。
以上詳述の如く本発明経皮投薬システムは、皮膚表面
に配置した薬物部を少量の力によって押圧することによ
り、投薬が行なわれることから、簡単な構成で安全にし
かも確実に経皮投薬が行なわれる等、効果を奏効するも
のである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a system for transdermal administration. Intravenous administration of a drug solution via a needle or cannula is an effective method for transdermal administration.
The stinging that cannot be used continuously for debilitated patients and is received every time is unbearable for patients. On the other hand, a method of transdermal administration, in which a drug is placed on the skin surface without implanting a drug introduction route in the body and the drug is introduced using electric force or osmotic pressure, has recently attracted attention. However, the systematic elucidation of the skin surface, especially the barrier layer, is still insufficient, so that it has not been put to practical use. In view of the above, the present inventors have conducted intensive studies and as a result, arranged a transdermal administration system on the surface of skin tissue, and pressed the drug with an inflating body that expanded due to body temperature, thereby penetrating the drug solution into the body through sweat glands and pores. Knowing that
The present invention has been reached. Hereinafter, the transdermal administration device of the present invention will be described in detail using examples. FIG. 1 is a cross-sectional view showing one embodiment of the present invention, wherein an inner space of a holder sealed by a bonding portion (3) of a flange portion (6) of the holder (1) includes a drug part (4) and a drug part (4). The pressure body (2) is filled. The pressurized body (2) is made of a spheroidal body filled with Freon gas or the like, expands due to the body temperature of the living body, etc., the drug part presses the skin tissue (5), and the drug in the drug part (4) penetrates the skin. . As shown in the figure, it is preferable from a manufacturing standpoint to constitute it as a one-piece member with, for example, polyethylene. As the adhesive 3, for example, a vinyl emulsion adhesive is preferable. As described in detail above, the transdermal drug delivery system of the present invention performs drug delivery by pressing the drug portion disposed on the skin surface with a small amount of force, so that transdermal drug delivery can be performed safely and reliably with a simple configuration. It has an effect such as being performed.
【図面の簡単な説明】
第１図は、本発明経皮投薬システムの一実施例を示す断
面図である。
（１）……保持体、
（２）……加圧体、
（３）……接着剤、
（４）……薬物部、
（５）……皮膚組織、
（６）……鍔部。BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a sectional view showing an embodiment of the transdermal administration system of the present invention. (1) ... holding body, (2) ... pressurized body, (3) ... adhesive, (4) ... drug part, (5) ... skin tissue, (6) ... brim part.
Claims (1)
保持体内に収容されており、且つ体温により膨張する膨
張体が充填されている伸縮性の加圧体を有し、装着後の
体温による加圧体の膨張により前記薬剤を生体方向に加
圧することができる経皮投与システム。(57) [Claims] A medicine, a medicine holding body for holding the medicine, and a stretchable pressurized body that is housed in the medicine holding body and is filled with an inflatable body that expands due to body temperature. A transdermal administration system capable of pressurizing the medicine in the body direction by expanding a pressure body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61140238A JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61140238A JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62298375A JPS62298375A (en) | 1987-12-25 |
| JP2757984B2 true JP2757984B2 (en) | 1998-05-25 |
Family
ID=15264121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61140238A Expired - Lifetime JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2757984B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
| JP4608187B2 (en) * | 2002-02-28 | 2011-01-05 | リンテック株式会社 | Transdermal preparation |
| JP2008125577A (en) * | 2006-11-17 | 2008-06-05 | Eisuke Imanaga | Medicinal component delivery system, cup for operation and composition containing medicinal component |
| MX2009010524A (en) * | 2007-03-29 | 2010-03-18 | Cupola Medical Ltd | Device and system for skin treatment. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534140B1 (en) * | 1982-10-12 | 1986-01-31 | Fournier Laboratoires | NEW DEVICE FOR PERCUTANEOUS ADMINISTRATION OF MEDICINES |
| JPS59155267A (en) * | 1983-02-23 | 1984-09-04 | 帝国製薬株式会社 | Capsule pad adhering agent for subcateneous absorption |
-
1986
- 1986-06-18 JP JP61140238A patent/JP2757984B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62298375A (en) | 1987-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |