JP2764075B2 - Method for producing polyoxyalkylene polyamine having secondary amino group at molecular terminal - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a method for producing a polyoxyalkylene polyamine having a secondary amino group at a molecular terminal, and more particularly, to a method for producing a primary amino group β at a molecular terminal. A polyoxyalkylene polyamine having an aminoalkyl ether group and a compound represented by the formula RX (R is a C _{1 to} C ₂₀ saturated hydrocarbon group, a C _{3 to} C ₂₀ unsaturated hydrocarbon group, a C _{6 to} C ₁₀ aromatic hydrocarbon group; Hydrogen group, or C
Aralkyl group ₇ -C _10; X is fluorine, chlorine, bromine or iodine and halogen compound represented by), is reacted in the presence of a base, polyoxyalkylene polyamine having a secondary amino group in the molecular end, And a method for producing the same.

The polyether having an amino group at the terminal provides a polyurea by a polyaddition reaction with a polyisocyanate, and is used as a raw material for a polyurea-based RIM, elastomer, flexible foam, rigid foam and the like. Also, it is a compound useful as a plastic raw material such as epoxy resin, polyamide, and polyimide.

[Conventional technology]

Many attempts have heretofore been made for polyoxyalkylene polyamines having an amino group at a terminal, and unique ones have been provided.

Those produced by reacting terminal hydroxyl groups of polyoxyalkylene polyol with ammonia under high temperature and high pressure using a hydrogenation-dehydrogenation catalyst (for example, Belgian Patent 677124),
A product prepared by reacting a terminal hydroxyl group of a polyoxyalkylene polyol with a primary amine using a Raney metal catalyst (for example, Japanese Patent Publication No. 45-7289). A product produced by catalytic reduction (for example, JP-B-53-95906), an aminobenzoate derivative of a polyether polyol obtained by a transesterification reaction between an aminobenzoate and a polyoxyalkylene polyol (for example, JP-B-60-38412) issue),
Reacting paranitrobenzoic acid chloride with a polyoxyalkylene polyol, and then reducing the nitro group to obtain a paraaminobenzoic acid ester of a polyol (US Pat. No. 4,328,322), and isatoic anhydride with a strong base such as sodium hydroxide. Anthranyl ester of polyether obtained by reacting with polyether polyol in the presence (JP-A-46-5245), compound having isocyanate terminal group by reacting polyoxyalkylene polyol with excess amount of polyisocyanate Wherein the isocyanate compound is produced by hydrolyzing a polyketimine, polyaldimine or polyenamine obtained by reacting a ketimine, aldimine or enamine having a hydroxyl group formed by the reaction of hydroxylamine with an aldehyde or ketone. Polyamine (Japanese Patent Publication No. 57-57051), etc. have been known.

[Problems to be solved by the invention]

The conventionally known polyoxyalkylene polyamines having an amino group at the terminal are those in which the terminal amino group is composed of an aliphatic primary amino group (the section of the prior art), and those in which the terminal amino group is an aromatic amino group. (Prior Art,...). Further, when the present inventors conducted an experiment based on the method described in the section of the prior art,
Certainly, a polyoxyalkylene polyamine composed of a secondary amino group was obtained, but when the molecular structure was analyzed in detail, it was a secondary compound due to an intermolecular reaction, and the polyoxyalkylene polyamine which is the object of the present invention was It turned out that the structure was different.

An object of the present invention is to provide a simple method for producing a polyoxyalkylene polyamine having an aliphatic secondary amino group at a molecular terminal.

[Means for solving the problem]

The present inventors have diligently studied to achieve the above object,
Finally, the present invention has been achieved.

That is, the present invention provides a primary amino group β-
A polyoxyalkylene polyamine having an aminoalkyl ether group, and a compound represented by the formula RX (R is a C _{1 to} C ₂₀ saturated hydrocarbon group, a C _{3 to} C ₂₀ unsaturated hydrocarbon group, and a C _{6 to} C ₁₀ aromatic hydrocarbon; group or an aralkyl group C ₇ ~C _10,; X is fluorine, chlorine, bromine or a halogen compound represented by iodine), characterized in that the reaction is carried out in the presence of a base, secondary to molecular end This is a method for producing a polyoxyalkylene polyamine having an amino group.

The polyoxyalkylene polyamine having a primary amino group at a molecular terminal used in the present invention can be produced by a method such as reacting a terminal hydroxyl group of a polyoxyalkylene polyol with ammonia, and is, for example, one known under the trade name of Jeffamine. Is used. Here, the polyoxyalkylene polyol is obtained by subjecting an alkylene oxide to ring-opening polymerization using a basic catalyst such as an alkali metal hydroxide under an appropriate initiator. As the initiator, propylene glycol, dipropylene glycol,
Tripropylene glycol, other polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, other polyethylene glycol, glycerin, diglycerin, pentaerythritol, sorbitol, sucrose, other polyhydric alcohols, bisphenol A, bisphenol S, resole, Examples include novolak, other polyphenols, triethanolamine, diethanolamine, and other alkanolamines. As the alkylene oxide, propylene oxide, ethylene oxide, and butylene oxide are usually used alone or in any combination.

As used in the present invention, the formula RX (R is a C _{1 to} C ₂₀ saturated hydrocarbon group, a C _{3 to} C ₂₀ unsaturated hydrocarbon group, a C _{6 to} C ₁₀ aromatic hydrocarbon group, or a C _{7 to} C 10 ₁₀ aralkyl group; X is fluorine, chlorine, and bromine or a halogen compound represented by iodine), methyl chloride, methyl bromide, methyl iodide, ethyl chloride, ethyl bromide, ethyl iodide, propyl chloride, Propyl bromide, propyl iodide, isopropyl chloride, isopropyl bromide, isopropyl iodide, butyl chloride, isobutyl chloride, t-butyl chloride, amyl bromide, octyl bromide,
Halogenated saturated hydrocarbons such as decyl iodide, lauryl iodide, myristyl chloride, palmityl bromide, stearyl iodide, propenyl chloride, propenyl bromide, propenyl iodide, isopropenyl chloride, allyl chloride, methallyl bromide, bromide Halogenated unsaturated hydrocarbons such as butenyl and oleyl iodide, fluorobenzene, chlorobenzene, bromobenzene, iodobenzene, p-bromotoluene, p
Halogenated aromatic hydrocarbons such as -bromo t-butylbenzene, benzyl chloride, benzyl bromide, benzyl iodide,
Aralkyl halides such as p-methylbenzyl chloride, o-methylbenzyl chloride, p-isopropylbenzyl chloride and the like are mentioned as examples.

Examples of the base used in the present invention include alkali metal carbonates such as sodium carbonate and potassium carbonate, alkali metal hydrogencarbonates such as sodium hydrogencarbonate and potassium hydrogencarbonate, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, Examples thereof include alkaline earth metal hydroxides such as calcium hydroxide and magnesium hydroxide, and tertiary amine compounds such as trimethylamine, triethylamine and tributylamine.

The amount of the halogen compound to be used is determined according to the secondary amine content of the desired product, but is usually 5 to 200 equivalent%, preferably 10 to 150 equivalent%, more preferably 20 to 200 equivalent%, based on the amino group. 100 equivalent% is used. The halogen compound may be charged all at once, but it is preferable to add the halogen compound sequentially or dividedly according to the progress of the reaction.
An excessive amount of a halogen compound in the reaction system is not preferable because a tertiary amine is generated by a side reaction and the selectivity of the secondary amine is lowered.

The base is used to trap hydrogen halide, and is usually used in an equivalent to 10-fold equivalent amount with respect to the halogen compound.

Water and an organic solvent may or may not coexist in the reaction system. Solvents which are inert under the reaction conditions;
Examples thereof include lower alcohols such as methanol and ethanol, and aromatic hydrocarbons such as toluene and xylene.

The reaction conditions of the present invention vary depending on the starting materials used, particularly the boiling point and reactivity of the halogen compound, and are not particularly limited.In general, the reaction temperature is from room temperature to 150 ° C.,
The reaction pressure is 0 to 10 kg / cm ² G, and the reaction time is 1 to 20 hours. If the temperature is too low, the reaction rate is low, and if it is too high, side reactions and the like occur, which is not preferable.

After the completion of the reaction, excess base or by-produced salt is neutralized, removed by a method such as washing with water, and then dried, filtered, and the like.
The objective polyoxyalkylene polyamine having a secondary amino group at the molecular terminal can be obtained.

〔Example〕

 Hereinafter, the present invention will be described with reference to examples.

Example 1 Jeffamine T-5000 (trifunctional, amine value 27.7 mgKOH /
g, average molecular weight 5000) 250 g, and potassium carbonate 10.5 g dissolved in 150 g of water were charged into a 500 ml glass four-necked flask equipped with a stirrer, a condenser, a thermometer, and a dropping funnel, and heated to 100 ° C. Warm, then benzyl chloride 19.
0 g was dropped from the dropping funnel over 1 hour. afterwards,
The reaction was continued for another 5 hours. The aqueous layer was separated by standing liquid separation, and washing was repeated with a large amount of water. After dehydration under reduced pressure and filtration, polyoxypropylene triamine was obtained. When the amine value was determined by the azomethine method, the total amine value was 26.0 mg.
The secondary amine value was 18.8 mgKOH / g with respect to KOH / g. The tertiary amine was quantified by the acetylation-perchloric acid acetic acid method, but no tertiary amine was detected. The results are shown in Table 1.

Example 2 A reaction was performed under the same conditions as in Example 1 except that sodium carbonate was used instead of potassium carbonate. The results are shown in Table 1.

Example 3 A reaction was carried out under the same conditions as in Example 1 except that the reaction temperature was changed to 80 ° C. and the reaction time was changed to 3 hours. The results are shown in Table 1.

Example 4 A reaction was carried out under the same conditions as in Example 3 except that the equivalent ratio of T-5000, benzyl chloride, and potassium carbonate was changed to 1 / 0.5 / 0.5. The results are shown in Table 1.

Example 5 A reaction was carried out under the same conditions as in Example 1 except that isopropyl iodide was used instead of benzyl chloride, water was used in the presence of 75 g, and the reaction temperature was changed to 95 ° C. The results are shown in Table 1.

Example 6 In Example 5, T-5000, isopropyl iodide,
The reaction was carried out under the same conditions as in Example 5, except that the equivalent ratio of potassium carbonate was changed to 1/1/10 and the reaction temperature was changed to 102 ° C. The results are shown in Table 1.

Example 7 In Example 5, T-5000, isopropyl iodide,
The reaction was carried out under the same conditions as in Example 5, except that the equivalent ratio of potassium carbonate was changed to 1 / 0.8 / 1. The results are shown in Table 1.

Example 8 In Example 1, methyl iodide was used instead of benzyl chloride, and triethylamine (NE) was used instead of potassium carbonate.
Example 3 except that the equivalent ratio of T-5000, methyl iodide, and triethylamine was changed to 1/1/5 and the reaction temperature was changed to 40 ° C. without using water in the system using t ₃ ). The reaction was performed under the same conditions. The results are shown in Table 1.

Example 9 A reaction was carried out under the same conditions as in Example 1 except that lauryl bromide was used instead of benzyl chloride. The results are shown in Table 1.

Example 10 A reaction was carried out under the same conditions as in Example 1 except that alkali chloride was used instead of benzyl chloride. The results are shown in Table 1.

Example 11 In Example 1, Jeffamine D was used instead of T-5000.
-400 (bifunctional, amine value 281 mg KOH / g, average molecular weight 40
The reaction was carried out under the same conditions as in Example 1, except that i) was used in place of benzyl chloride and the reaction time was changed to 8 hours. The results are shown in Table 1.

Example 12 A reaction was carried out under the same conditions as in Example 1 except that benzyl chloride was charged at the same time as T-5000 and a base. When the tertiary amine was quantified, it was 3.0 mgKOH / g. The results are shown in Table 1.

(Effect of the Invention) The present invention has a different structure from the conventionally provided polyoxyalkylene polyamine having an amino group at a terminal,
An object of the present invention is to provide a simple method for producing a polyoxyalkylene polyamine having a secondary amino group at a molecular terminal.

The compound obtained by the method of the present invention can be effectively used as a plastic raw material, for example, by reacting with an isocyanate to obtain a polyurethane resin through a urea bond.

Claims (10)

(57) [Claims] 1. A polyoxyalkylene polyamine having a β-aminoalkyl ether group which is a primary amino group at a molecular terminal, and a compound represented by the formula RX (R is a C _{1 to} C ₂₀ saturated hydrocarbon group, C _{3 to} C
₂₀ unsaturated hydrocarbon groups, C _{6 to} C ₁₀ aromatic hydrocarbon groups,
Or an aralkyl group C ₇ ~C _10; X is fluorine, chlorine, bromine or a halogen compound represented by iodine), which comprises reacting in the presence of a base, secondary amino group in the molecular end, A method for producing a polyoxyalkylene polyamine having 2. After charging a polyoxyalkylene polyamine having a β-aminoalkyl ether group which is a primary amino group at a molecular terminal and a base, a compound represented by the formula RX (R is a C _{1 to} C ₂₀ saturated hydrocarbon group; unsaturated hydrocarbon group having ₃ -C _20, aromatic hydrocarbon group having C ₆ -C ₁₀ or C ₇ -C ₁₀ aralkyl group,; X is fluorine, chlorine, bromine or iodine) halogen compound represented by the The method for producing a polyoxyalkylene polyamine according to claim 1, wherein 3. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the polyoxyalkylene polyamine having a primary amino group at a molecular terminal has an average molecular weight of 400 or more. 4. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the halogen compound is a benzyl halide. 5. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the halogen compound is a methyl halide. 6. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the halogen compound is isopropyl halide. 7. The method according to claim 1, wherein the base is an alkali metal carbonate.
Or the method for producing a polyoxyalkylene polyamine according to 2. 8. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the base is an alkali metal hydroxide. 9. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the base is a tertiary amine compound. 10. The method for producing a polyoxyalkylene polyamine according to claim 1, wherein the polyoxyalkylene polyamine having a β-aminoalkyl ether group as a primary amino group at the molecular terminal is a polyoxypropylene polyamine.