JP2803045B2 - Antibacterial agent - Google Patents
Antibacterial agentInfo
- Publication number
- JP2803045B2 JP2803045B2 JP18593590A JP18593590A JP2803045B2 JP 2803045 B2 JP2803045 B2 JP 2803045B2 JP 18593590 A JP18593590 A JP 18593590A JP 18593590 A JP18593590 A JP 18593590A JP 2803045 B2 JP2803045 B2 JP 2803045B2
- Authority
- JP
- Japan
- Prior art keywords
- genus
- antibacterial agent
- yucca
- results
- experiment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明はユッカを含んで成る抗菌剤に関する。更に詳
しくは、一般食品、健康食品、超高圧食品、機能性食品
等の食品用に使用しうる抗菌剤に関する。Description: FIELD OF THE INVENTION The present invention relates to an antibacterial agent comprising Yucca. More specifically, the present invention relates to an antibacterial agent that can be used for foods such as general foods, health foods, ultrahigh-pressure foods, and functional foods.
［従来の技術］ 従来、食品用として使用されうる抗菌剤として安息香
酸及びその塩、ジフェニル、ソルビン酸及びその塩、チ
アベンダゾール、デヒドロ酢酸及びその塩、パラオキシ
安息香酸及びそのエステル類、プロピオン酸及びその塩
等の化学合成品が多数知られている。又、天然の抗菌剤
としてはグリシン、フェニルアラニン等が公知である。[Prior art] Conventionally, benzoic acid and its salts, diphenyl, sorbic acid and its salts, thiabendazole, dehydroacetic acid and its salts, paraoxybenzoic acid and its esters, propionic acid and its Many chemically synthesized products such as salts are known. Glycine, phenylalanine and the like are known as natural antibacterial agents.
［発明が解決しようとする課題］ しかしながら、化学合成品から成る抗菌剤は使用基準
が厳しく定められており、使用量を誤ると人体に対して
有害で、安全性の面で課題が残されている。又、天然品
であるグリシン及びフェニルアラニン等は安全面での課
題はないのであるが、抗菌力が弱く多量に投与しなけれ
ば化学合成品程の効力を示さないため一般に敬遠されが
ちである。[Problems to be Solved by the Invention] However, antibacterial agents composed of chemically synthesized products are strictly defined in terms of use, and improper use is harmful to the human body, leaving a problem in terms of safety. I have. In addition, natural products such as glycine and phenylalanine have no safety problems, but are generally avoided because they have weak antibacterial activity and do not show the efficacy of chemically synthesized products unless administered in large amounts.
従って、化学合成品に匹敵するだけの抗菌力を持ち、
しかも人体に悪影響を及ぼさない安全性に優れた天然品
からなる抗菌剤の発明は人類にとって極めて有意義なも
のである。Therefore, it has antibacterial activity comparable to that of chemically synthesized products,
Moreover, the invention of an antibacterial agent made of a natural product excellent in safety and having no adverse effect on the human body is extremely significant for human beings.
［課題を解決するための手段］ しかるに本発明者等は上記問題を解決すべく鋭意研究
を重ねた結果、ユッカが抗菌力を持つという新規な事実
を見出し本発明を完成するに至った。[Means for Solving the Problems] However, as a result of intensive studies to solve the above problems, the present inventors have found a novel fact that Yucca has antibacterial activity, and have completed the present invention.
ユッカは古くから食糧とされている植物であり、近年
は関節炎・リューマチの治療、消化機能の改善、高血圧
の低下等の効果が注目されており、又、起泡剤としての
添加も認められている等生体に対して安全であることが
確認されている。Yucca is a plant that has been used as food for a long time.In recent years, attention has been paid to the effects of treating arthritis and rheumatism, improving digestive functions, reducing hypertension, and the like. Has been confirmed to be safe for living organisms.
更に抗菌力も従来の天然品と比較すると数段強く、化
学合成品と同等程度の効力を持つため化学合成品に代わ
る抗菌剤としての活用が十分可能である。Furthermore, the antibacterial activity is several times stronger than that of conventional natural products, and has the same level of effect as chemically synthesized products, so that it can be sufficiently used as an antibacterial agent in place of chemically synthesized products.
以下、本発明について詳細に説明する。 Hereinafter, the present invention will be described in detail.
本発明における抗菌剤は、シュウドモナス属（Pseudm
onas属）、スタフィロコッカス属（Staphylococcus
属）、ビブリオ属（Vibrio属）、バチルス属（Bacillus
属）、クロストリジウム属（Clostridium属）、キャン
ピロバクター属（Campylobactor属）、エアロモナス属
（Aeromonas属）、フラボバクテリウム属（Flavobacter
ium属）、エスシェリヒア属（Escherichia属）、サルモ
ネラ属（Salmonella属）等から選ばれる微生物の少なく
とも一種に対して作用を示すものである。The antibacterial agent in the present invention is a Pseudomonas genus (Pseudm
genus onas), Staphylococcus
Genus), the genus Vibrio, the genus Bacillus
Genus), genus Clostridium, genus Campylobacter, genus Aeromonas, genus Aeromonas, genus Flavobacterium
gen), Escherichia, Salmonella and the like.
抗菌剤となるユッカは、ユッカのすべての部分、即ち
花、種子、種子莢、果実、葉、茎及び根を用いることが
でき、常法により乾燥して得られる粉末や抽出液などと
して用いられる。As the antibacterial agent, all parts of yucca, that is, flowers, seeds, seed pods, fruits, leaves, stems and roots can be used, and are used as powders and extracts obtained by drying according to a conventional method. .
尚、前記ユッカの抽出物をうる方法としては、例えば
前記ユッカを沸騰水により煮沸する方法、アルコールな
どの有機溶媒で抽出する方法、ユッカを単に圧搾する方
法などが挙げられるが、本発明はこれらの方法のみに限
定されるものではない。In addition, as a method of obtaining the extract of Yucca, for example, a method of boiling the Yucca with boiling water, a method of extracting with an organic solvent such as alcohol, a method of simply squeezing Yucca, etc. However, the present invention is not limited to only the above method.
前記ユッカから成る抗菌剤は、対象物に対してユッカ
粉末或は抽出液を0.1％以上、好ましくは0.5％以上添加
することが望ましい。添加割合が0.1％以下の場合目的
とする抗菌作用が充分に発揮されにくくなる傾向があ
る。It is desirable that the antibacterial agent composed of Yucca is added with 0.1% or more, preferably 0.5% or more of Yucca powder or extract to an object. When the addition ratio is 0.1% or less, the desired antibacterial action tends to be hardly exerted.
抗菌剤は例えば、ジュース類、魚肉練製品、チーズ、
バター、マーガリン、菓子類などの食品に添加され作用
を示す。Antibacterial agents include, for example, juices, fish meat products, cheese,
It is effective when added to foods such as butter, margarine and confectionery.
抗菌剤の効果のある範囲は、PHが３〜９、好ましくは
４〜８の範囲で効果が強く、又、０〜70℃、好ましくは
０〜40℃が有利である。The effective range of the antibacterial agent is strong when the PH is in the range of 3 to 9, preferably 4 to 8, and 0 to 70 ° C, preferably 0 to 40 ° C is advantageous.
本発明の抗菌剤は、用途に応じて種々の形態、例えば
粉末、乾燥固型、水飴状、懸濁液、水溶液などの任意の
形態で用いることができる。The antibacterial agent of the present invention can be used in various forms depending on the use, for example, in any form such as powder, dried solid, starch syrup, suspension, and aqueous solution.
［作用］ 本発明のユッカを含んで成る抗菌剤は天然品であるた
め人体に無害であり、安全性が確認されている。しかも
強い抗菌力を持つ。[Action] Since the antibacterial agent containing yucca of the present invention is a natural product, it is harmless to the human body and its safety has been confirmed. Moreover, it has strong antibacterial power.
［実施例及び対照例］ 以下、実施例を挙げて本発明を更に詳しく説明する。Examples and Control Examples Hereinafter, the present invention will be described in more detail with reference to Examples.
実施例１ シュウドモナス・フルオレセンス（Pseudmonas Fluo
resens,IFO 13922）を保存スラントから１白金耳増殖
用培地（肉エキス3g/、ペプトン10g/、食塩5g/を
混合溶解し、1N−NaOH水溶液でPH7に調節して製造）に
植菌して30℃、24時間で前培養した。この培養液を５×
105個/mlまで希釈した後、表１で示す濃度のユッカを予
め添加した試験用培地（肉エキス3g/、ペプトン10g/
、食塩5g/を混合溶解し、1N−NaOH水溶液でPH7に調
節して製造）49mlに1ml接種して30℃で培養を行い３日
後及び７日後の生菌数を標準平板寒天法により測定し
た。結果を表１に示す。Example 1 Pseudmonas Fluosense
resens, IFO 13922) was inoculated from a stock slant into a platinum loop growth medium (mixed and dissolved with 3 g of meat extract, 10 g of peptone, and 5 g of salt, adjusted to PH7 with 1N-NaOH aqueous solution). Preculture was performed at 30 ° C. for 24 hours. 5 ×
After diluting to 10 5 cells / ml, a test medium (meat extract 3 g /, peptone 10 g /
, Mixed and dissolved with 5 g of common salt, adjusted to PH7 with 1N-NaOH aqueous solution) 1 ml was inoculated into 49 ml, cultured at 30 ° C, and the viable cell counts after 3 days and 7 days were measured by a standard plate agar method. . Table 1 shows the results.
実施例２ 実施例１において培養菌をスタフィロコッカス・オウ
レウス（Staphylococcus aureus,IFO 12732）とした
以外は同例に準じて実験を行った。結果は表２に示す。 Example 2 An experiment was performed in the same manner as in Example 1 except that the culture was Staphylococcus aureus (IFO 12732). The results are shown in Table 2.
実施例３ 実施例１において培養菌をビブリオ・パラケモリティ
カス（Vibrio Parachemolyticus,IFO 12711）とした
以外は同例に準じて実験を行った。結果は表３に示す。 Example 3 An experiment was performed in the same manner as in Example 1 except that the culture was changed to Vibrio Parachemolyticus (IFO 12711). The results are shown in Table 3.
実施例４ 実施例１において培養菌をバチリス・サブチリス（Ba
tillus Subtilis,IFO 3009）とした以外は同例に準じ
て実験を行った。結果は表４に示す。 Example 4 In Example 1, the culture was subjected to Bacillus subtilis (Ba
The experiment was performed according to the same example except that tillus Subtilis, IFO 3009) was used. The results are shown in Table 4.
実施例５ 実施例１において培養菌をクロストリジウム・ペルフ
リゲンス（Clostridium perfrigens,ATCC 13124）と
した以外は同例に準じて実験を行った。結果は表５に示
す。 Example 5 An experiment was performed in the same manner as in Example 1 except that the culture was Clostridium perfrigens (ATCC 13124). The results are shown in Table 5.
実施例６ 実施例１において培養菌をキャンピロバクター・ジェ
ジュニ／コリ（Campylobactor jejuni/coli,ATCC 335
59）とした以外は同例に準じて実験を行った。結果は表
６に示す。 Example 6 In Example 1, the culture was cultured using Campylobacter jejuni / coli, ATCC 335.
The experiment was carried out according to the same example except that it was 59). The results are shown in Table 6.
実施例７ 実施例１において培養菌をエアロモナス・ソルビア
（Aeromonas Sorbia,ATCC 9071）とした以外は同例に
準じて実験を行った。結果は表７に示す。 Example 7 An experiment was performed in the same manner as in Example 1 except that the culture was Aeromonas Sorbia (ATCC 9071). The results are shown in Table 7.
実施例８ 実施例１において培養菌をフラボバクテリウム・ルテ
センス（Flavobacterium lutescens,IFO 12997）とし
た以外は同例に準じて実験を行った。結果は表８に示
す。 Example 8 An experiment was performed in the same manner as in Example 1 except that the culture was changed to Flavobacterium lutescens (IFO 12997). The results are shown in Table 8.
実施例９ 実施例１において培養菌をエスシェリヒア・コリ（Es
cherichia coli,IFO 3301）とした以外は同例に準じ
て実験を行った。結果は表９に示す。 Example 9 In Example 1, the culture was subjected to Escherichia coli (Es
The experiment was performed in accordance with the same example except that cherichia coli (IFO 3301) was used. The results are shown in Table 9.
実施例10 実施例１において培養菌をサルモネラ・エンテロチデ
ィス（Salmonella Enterotidis,IFO 3313）とした以
外は同例に準じて実験を行った。結果は表10に示す。 Example 10 An experiment was performed in the same manner as in Example 1 except that the culture was changed to Salmonella enterotididis (Salmonella Enterotidis, IFO 3313). The results are shown in Table 10.
対照例１〜10 実施例１においてユッカの代わりに同じ天然品から成
る抗菌剤のグリシンを用い表10に示す菌を使用して同例
に準じて実験を行った。結果を表10に示す。 Comparative Examples 1 to 10 The same experiment as in Example 1 was carried out, except that the antibacterial agent glycine of the same natural product was used in place of Yucca and the bacteria shown in Table 10 were used. Table 10 shows the results.
対照例11〜20 実施例１においてユッカの代わりに同じ天然品から成
る抗菌剤のフェニルアラニンを用い、表11に示す菌を使
用して同例に準じて実験を行った。結果を表11に示す。 Control Examples 11 to 20 The same experiment as in Example 1 was carried out, except that the antibacterial agent phenylalanine consisting of the same natural product was used in place of Yucca and the bacteria shown in Table 11 were used. Table 11 shows the results.
［効果］ 本発明のユッカを含んで成る抗菌剤は、天然品である
ため人体に無害であり安全性が確認されている。しかも
強い抗菌力を持っているので人類にとって極めて有意義
な抗菌剤である。 [Effect] Since the antibacterial agent containing yucca of the present invention is a natural product, it is harmless to the human body and its safety has been confirmed. Moreover, it has a strong antibacterial activity and is therefore a very significant antibacterial agent for human beings.
フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A01N 65/00 ＢＩＯＳＩＳ（ＤＩＡＬＯＧ) ＷＰＩ（ＤＩＡＬＯＧ)Continuation of the front page (58) Field surveyed (Int. Cl. 6 , DB name) A01N 65/00 BIOSIS (DIALOG) WPI (DIALOG)
Claims (2)
フィロコッカス属（Staphylococcus属）、ビブリオ属
（Vibrio属）、バチルス属（Bacillus属）、クロストリ
ジウム属（Clostridium属）、キャンピロバクター属（C
ampylobactor属）、エアロモナス属（Aeromonas属）、
フラボバクテリウム属（Flavobacterium属）、エスシェ
リヒア属（Escherichia属）、サルモネラ属（Salmonell
a属）から選ばれる微生物の少なくとも一種に対して作
用を示す請求項１記載の抗菌剤2. The genus Pseudmonas, the genus Staphylococcus, the genus Vibrio, the genus Bacillus, the genus Clostridium, the genus Campylobacter (C)
ampylobactor), Aeromonas (Aeromonas),
The genus Flavobacterium, the genus Escherichia, the genus Salmonell
2. The antibacterial agent according to claim 1, which has an action on at least one microorganism selected from the genus a).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18593590A JP2803045B2 (en) | 1990-07-13 | 1990-07-13 | Antibacterial agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18593590A JP2803045B2 (en) | 1990-07-13 | 1990-07-13 | Antibacterial agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0474105A JPH0474105A (en) | 1992-03-09 |
| JP2803045B2 true JP2803045B2 (en) | 1998-09-24 |
Family
ID=16179459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18593590A Expired - Fee Related JP2803045B2 (en) | 1990-07-13 | 1990-07-13 | Antibacterial agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2803045B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7485110B2 (en) | 2001-12-20 | 2009-02-03 | Kimberly Clark Worldwide, Inc. | Wipe comprising a pathogen selective antimicrobial |
| US7154018B2 (en) | 2001-12-20 | 2006-12-26 | Kimberly-Clark Worldwide, Inc. | Absorbent article |
| US6891079B2 (en) | 2001-12-20 | 2005-05-10 | Kimberly-Clark Worldwide, Inc. | Wipe |
-
1990
- 1990-07-13 JP JP18593590A patent/JP2803045B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0474105A (en) | 1992-03-09 |
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