JP2815136B2 - Food and drink containing lignan glycosides - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a food or drink comprising a water-soluble lignan glycoside which reduces blood cholesterol and / or blood neutral lipid.

[0002]

2. Description of the Related Art In recent years, blood cholesterol and neutral lipids (triglycerides) have been used in Western countries as well as in Japan.
High values of hyperlipidemia are increasing. Hyperlipidemia is considered to be a risk factor that eventually causes symptoms such as arteriosclerosis. The amount of cholesterol and neutral lipids in the blood is regulated by endogenous ones synthesized in the body and exogenous ones derived from dietary components, but in order to prevent the excess, such as tocopherol nicotinate Nicotinic acid derivatives,
Hyperlipidemic agents such as soysterol and dextran sulfate have been developed, and it has been recommended to reduce the intake of animal fats mainly composed of dietary cholesterol and saturated fatty acids.

As a method of reducing cholesterol and fat in animal raw materials among daily dietary ingredients, a cooking method is sometimes devised to remove fat and cholesterol coexisting therewith. This leads to a decrease in the flavor and texture of the material.
It has also been proposed to reduce the cholesterol content by, for example, emulsifying egg yolk with fats and oils (Japanese Patent Laid-Open No. 5-3).
No. 44868), it is undeniable that the production cost increases.

[0004] On the other hand, some of the raw materials used for ordinary meals contain components that lower blood cholesterol and blood neutral lipids. For example, the soysterol is an unsaponifiable sterol contained in soybean, and JP-A-3-53866 discloses a lignans compound derived from sesame oil, which is mixed with butter and mayonnaise such as butter and mayonnaise. Things have been suggested. These components reduce blood cholesterol and blood neutral lipids when administered as ordinary pharmaceuticals or taken as a dietary form. However, these are all oil-soluble substances, and in order to be taken in a form compatible with a living body, they must be formulated into a liposome or disclosed in the above-mentioned publication (Japanese Unexamined Patent Publication No.
As described in JP-A-53866), it was necessary to include a lignan compound in cyclodextrin and blend it into an aqueous food or drink.

In sesame seeds, sesaminol having antioxidant activity: tetrahydro-1- [6-hydroxy-3,4- (methylenedioxy) phenyl] -4-
[3,4- (methylenedioxy) phenyl] -1H, 3
H-Flo [3,4-C] furan, P-1: tetrahydro-1- (3-methoxy-4-hydroxyphenyl) -4
-[3,4- (methylenedioxy) phenyl] -1H,
3H-Flo [3,4-C] furan, sesamolinol: tetrahydro-1- [3-methoxy-4-hydroxyphenoxy] -4- [3,4- (methylenedioxy) phenyl] -1H, 3H-furo 3,4-C] furan, pinoresinol: tetrahydro-1,4-di (3methoxy-4
-Hydroxyphenyl) -1H, 3H-furo [3,4-
C] It is well known that phenolic lignans such as furan are contained. It is also known that many of these lignans are present as sugar compounds (lignan glycosides) in sesame seeds or their defatted meals (Biosci. Bi).
otech. Biochem. , 56 volumes, 2087-2
088, 1992).

[0006]

In view of such circumstances, the present invention is a natural substance-derived safe substance commonly used as a raw material for meals, and can reduce blood cholesterol and / or blood neutral lipid. It is an object of the present invention to provide a food or drink that contains a substance that can be suitably used in an aqueous or emulsified state.

[0007]

Means for Solving the Problems The present inventors have made intensive studies in order to achieve the above object, and as a result, lignan glycosides contained in humidified or germinated bodies of sesame seeds are safe substances, The present inventors have found that they have a function of reducing blood cholesterol and / or neutral lipid in blood, and that they can be conveniently blended especially in aqueous or emulsified foods and drinks, and have completed the present invention. That is, the gist of the present invention is a food or drink comprising a water-soluble lignan glycoside obtained from a humidified substance or a germinated body of sesame seed or a substance containing the same, wherein the water-soluble lignan glycoside is more preferable. It is preferably one containing lignan diglucoside and / or lignan triglucoside as a main component, and more preferably selected from sesaminol diglucoside, sesaminol triglucoside and lignan glycoside represented by the following chemical structural formula (I). At least one or more of these.

[0008]

Embedded image (In the formula (I), R represents one kind of glucosyl residue selected from the group consisting of glucose, galactose and fructose, m represents any one of integers from 1 to 3, and n represents an integer of 0 or 1) Represents a numerical value.)

Prior to the present invention, the present inventors have developed a method for collecting a large amount of water-soluble lignan glycosides from sesame seeds and applied for a patent (Japanese Patent Application No. 5-3160).
No. 79, Japanese Patent Application No. 6-336644). The water-soluble lignan glycoside used in the present invention and a substance containing the same can be obtained by the methods described therein. That is, the sesame seeds used as a raw material can be used irrespective of the type and production area thereof, and can be used in an unroasted or unheated state in a suitable medium that can contain water or moisture, such as agar, quartz sand, and sea sand. , Absorbent cotton, sand, soil and the like, preferably evenly spread on a sterilized medium, 15 to 50 ° C, preferably 30 to 50 ° C.
Cultivation is performed at 40 ° C. for 5 to 100 hours, preferably for 24 to 72 hours, while supplementing water appropriately. The culture may be carried out under light or dark conditions. Thus, a humidified substance swelled with water or a germinated sesame germ (a humidified or germinated body of sesame seeds) is obtained.

In the present invention, the humidified matter or germinated body of the sesame seed thus obtained is separated from the culture medium and, if necessary, subjected to an appropriate cleaning treatment such as washing with water, and then subjected to a mortar and a mortar. , Using a crushing or grinding means such as a mixer, a blender, a homogenizer or the like to form a kneaded crushed product, or freeze-drying the humidified material or the sesame germinated material to form a dried product, and further, a dried product thereof. Is treated with a pulverizer such as a mixer or a blender to form a pulverized product, and any one or more of these can be incorporated into foods and drinks as a so-called food material containing the water-soluble lignan glycoside of the present invention. .

Further, in the present invention, a higher concentration of a water-soluble lignan glycoside-containing substance can be added to food or drink. To this end, an extract containing a higher purity water-soluble lignan glycoside is prepared from the humidified or germinated sesame seed obtained as described above by extraction and concentration treatment as described below, This can also be used.

That is, first, a humidified sesame seed or a crushed, dried, or crushed germinated body is obtained as described above. Here, the pulverized material or the like may be defatted lees obtained by extracting and removing an oil component with an organic solvent such as n-hexane. Next, a water-containing alcohol from which a water-soluble lignan glycoside can be extracted, specifically, a linear or side-chain lower alcohol having 1 to 4 carbon atoms such as methanol, ethanol, n-propanol, isopropanol, and n-butanol, and water And the alcohol concentration adjusted to 30 to 100% (volume / volume), preferably 50 to 95% (volume / volume), and added 1 to 10 times (volume / weight) to the seed material. Then, if necessary, grinding and extraction operations are repeated, and solids are removed by a conventional method such as filtration or decantation to obtain a hydroalcoholic extract containing a water-soluble lignan glycoside. The hydroalcoholic extract excluding alcohol and water is a mixture containing various sugar chain compounds in addition to the water-soluble lignan glycoside. The content of the water-soluble lignan glycoside in the aqueous alcohol extract is about 2 to 10% by weight.

[0013] In order to remove impurities other than the water-soluble lignan glycoside in the extract, the following treatment can be performed. That is, in order to remove oil-soluble impurities, the extract is extracted by adding 2 to 10 times (volume / weight) of a water-insoluble organic solvent, for example, ethyl acetate or n-hexane and water,
Separate into two phases by centrifugation or the like. Excluding the organic solvent phase,
The aqueous phase is concentrated to dryness. At this time, the desired water-soluble lignan glycoside is concentrated on the aqueous phase side. In order to remove water-soluble impurities, a small amount, preferably 1 to 5 times (volume / weight) of the same alcohol hydrate (alcohol concentration: 30 to 100% (volume / volume)) with respect to the extract is used to remove water-soluble impurities. It is dispersed and dropped into a relatively large amount, preferably 10 to 200 times (volume / weight) of the same alcohol, which is gently stirred. After standing, precipitates are removed by centrifugation or fractional filtration, and the mixture is concentrated to dryness. These operations are repeated if necessary.

The lignan glycoside contained in the purified product of the hydroalcoholic extract thus obtained is a mixture of a known glycoside using lignans as aglycone and a novel glycoside using lignan as aglycone. Known glycosides containing lignans as aglycone include sesaminol as a main component and lignans such as sesamolinol, P-1, and pinoresinol (in lignans, sesaminol: 80 to 90).
% By weight, sesamolinol, P-1, pinoresinol: 2
0 to less than 0% by weight) and saccharides such as glucose and galactose (glucose in the saccharide: 50 to 100% by weight), particularly two or three molecules of glucose. The glycoside having a novel lignan as an aglycone is represented by the following chemical structural formula (I), more preferably the following chemical structural formula (II-a), (II-b) or (II-b)
(II-a: 25 to 35% by weight, II-b: 35 to 45% by weight, II-c) : 30 to 3
5% by weight).

[0015]

Embedded image (In the formula (I), R represents one kind of glucosyl residue selected from the group consisting of glucose, galactose and fructose, m represents any one of integers from 1 to 3, and n represents an integer of 0 or 1) Represents a numerical value.)

[0016]

Embedded image (In the formula (II-a), Glc represents a glucose residue.)

[0017]

Embedded image (In the formula (II-b), Glc represents a glucose residue.)

[0018]

Embedded image (In the formula (II-c), Glc represents a glucose residue.)

The ratio of known lignan glycosides to novel lignan glycosides is 1: 1.5 to 3 (weight ratio). These are water-soluble substances soluble in butanol, ethanol, methanol, water and the like. If necessary, silica gel,
Using an adsorbent such as ODS, sesaminol diglucoside or sesaminol triglucoside, the chemical structural formula (II)
It can be further fractionated and purified into individual components such as -a), (II-b) or (II-c). Chemical structure of each component of the lignan glycoside, the components purified to high purity by the above method, for example, hydrolyzed with hydrochloric acid to divide the lignan part and the sugar part, these are trimethylsilylated and subjected to gas chromatography, Alternatively, it can be analyzed and confirmed by nuclear magnetic resonance spectroscopy, mass spectroscopy, or the like.

Many of such water-soluble lignan glycosides themselves do not have antioxidant properties, but exist as precursors of antioxidant components and undergo hydrolysis of sugar bonds, for example, in vivo. It is a substance whose activity is expected specifically. In addition, as compared with known phenolic lignans derived from sesame seeds having antioxidant properties, that is, sesaminol, P-1, sesamolinol, pinoresinol, etc., the water-soluble lignan glycoside according to the present invention also has high heat stability. (The decomposition rate after heating at 50 ° C. for 24 hours is 5% or less).

These lignan glycosides are obtained from sesame seed 100
Although only about 240 mg is contained in the sesame seed, if the sesame seed is humidified under appropriate conditions as described above, the content of the lignan glycoside in the sesame seed increases with swelling or germination. Produces and accumulates glycosides in large quantities. Compared to the sesameol glycoside content in the humidified sesame seeds, for example, after 48 hours of humidification, the sesameol glycoside can be obtained at least three times (by weight) or more. Further, the chemical structural formulas (II-a) and (II-b)
The novel lignan glycoside represented by and (II-c) is a component that hardly exists before humidification and germination of sesame seeds, and is newly formed together with swelling or germination,
Increases and accumulates in humidified or germinated bodies. As a result, for example, the total amount of lignan glycosides in the germinated body of sesame seeds is 5 to 6 times (weight) or more as compared to the sesame seeds before germination, and reaches about 3% by weight per dry matter of the sesame germinated body. .

As described above, the water-soluble lignan glycoside used in the present invention may be used as it is as a humidified sesame seed or a crushed or dried germinated body, a dried product or a crushed product thereof, or a water-soluble lignan glycoside may be used. The method for extracting lignan glycosides as described above is simple, but the method is not limited to this as long as the water-soluble lignan glycosides have the above-mentioned structure and composition.

In the present invention, a humidified or germinated crushed or dried sesame seed, or a crushed product thereof, containing a water-soluble lignan glycoside or a water-soluble lignan glycoside obtained by the above method. Alternatively, there is provided a food or beverage comprising an extract (hydrous alcohol extract or purified product thereof) as an essential component. Here, the type of food or drink is not particularly limited, but since the properties of the lignan glycoside to be compounded or the above-mentioned ingredients containing the same are water-soluble or water-dispersible, they are uniformly dissolved or dispersed to be contained. Is preferably an aqueous or emulsified food or drink. Specifically, water (drinking water), fruit juice, vegetable juice,
Juices, carbonated drinks, soft drinks, drinks containing various nutrients, soups, soy sauce, sauces, other liquid seasonings, ice cream, yogurt, soy milk, milk, butter, margarine, cream, salad dressing, non-oil salad dressing, Mayonnaise, mayonnaise-like food, and the like can be exemplified.

The content of the aqueous lignan glycoside in these foods and drinks is generally at least 0.002% by weight, preferably 0.02% by weight.
02 to 30% by weight. 1 in the case of humidified sesame seeds or crushed germinated material containing water-soluble lignan glycosides
% By weight, preferably 1 to 70% by weight, and 0.02% by weight or more, preferably 0.02 to 50% by weight in the case of humidified sesame seeds or dried germinated material or crushed material thereof.
In the case of an extract from such a crushed product, a dried product or a crushed product, the content is 0.01% by weight or more, preferably 0.01 to 40% by weight, in the case of the aqueous alcohol extract. A water-soluble lignan glycoside mixture obtained by removing oil-soluble impurities and / or water-soluble impurities from a water-containing alcohol extract, such as sesaminol diglucoside, sesaminol triglucoside, and the above-mentioned chemical structural formula (II-
In the case of individual purified lignan glycosides such as a), (II-b) and (II-c), the content is 0.002% by weight or more, preferably 0.002 to 30% by weight. Below the lower limit, the effect of reducing blood cholesterol and / or blood neutral lipid is small. Further, it may be contained in excess of the above upper limit, but in this case, a further effect of reducing blood cholesterol and / or blood neutral lipid corresponding to the large content cannot be expected. The method of incorporating the water-soluble lignan glycoside or the extract containing the same into a food or drink is not particularly limited, but is previously dissolved or dispersed in an aqueous phase,
Then, it is good to prepare food and drink by a conventional method.

[0025]

【Example】

REFERENCE EXAMPLE 1 Quartz sand previously sterilized was spread evenly over a 300 cm ² stainless steel vat with a thickness of 5 mm, and 100 g of sesame seeds produced in China.
g, and germinated by culturing in a constant temperature bath at 40 ° C. for 48 hours while sufficiently spraying distilled water. The germination rate was 80%. A fixed amount of germinated bodies having the same germination state were sampled to obtain sesame germinated products. After washing the sesame germ with water, it was ground with a crusher to obtain a crushed sesame germ. The sesame germ was dried with a freeze dryer to obtain a dried sesame germ. Further, the dried sesame germ product was pulverized with a crusher to obtain a dried and crushed sesame germ product. Dried and ground sesame germ 10
g of 100 ml of aqueous ethanol (ethanol concentration: 80).
% (Vol / vol)) in a blender. The residue was filtered off, and the filtrate was concentrated to dryness.
The aqueous ethanol extract) was washed twice with n-hexane and ethyl acetate to obtain a purified mixture of the aqueous ethanol extract. 100 parts of the purified mixture of aqueous ethanol extract
It was redissolved in ml of hydrous ethanol and subjected to HPLC for composition analysis.

The HPLC apparatus was equipped with a pump (CCPM, manufactured by Tosoh Corporation) and a column (Soken Pak ODS-W).
5μ, 10mmφ × 250mm), UV absorption detector (UV-
8000, manufactured by Tosoh Corporation), elution was performed using a linear gradient of 90:10 water: methanol to 10:90 after 60 minutes, a flow rate of 1 ml / min, and a detection wavelength of 2
It was 88 nm.

Further, the aqueous ethanol extract was repeatedly subjected to preparative HPLC under the above conditions, and purified until each component became single. After that, lignans and sugars constituting each component were analyzed by the following method. That is, 1N hydrochloric acid was added to the purified product of each component, hydrolyzed at 100 ° C. for 30 minutes, extracted with ethyl acetate, and separated into an ethyl acetate layer and an aqueous layer. The ethyl acetate layer is concentrated to dryness at 40 ° C or less, and then TMS-PZ
The product was subjected to trimethylsilylation treatment (manufactured by Tokyo Chemical Industry Co., Ltd.) and subjected to gas chromatography (GLC) to quantitatively analyze lignan (external standard: sesamin).

GLC conditions are as follows. GLC apparatus: 5890 manufactured by Hewlett-Packard Company, column: DB-1
7HT (15m × 0.319mm, film thickness: 0.
15 μm, manufactured by J & W SCIENTIFIC), injection method: split method (split ratio: 1/10), column temperature: 270 ° C., carrier gas: helium.

Further, the aqueous layer was subjected to a pretreatment filter for HPLC (pore size: 0.2 μm, Meishoridisk W-13).
2, Tosoh Corporation), add 5 ml of acetone to the filtrate, concentrate under reduced pressure to dryness, then perform trimethylsilylation treatment with TMS-PZ (same as above), and subject it to GLC for quantitative analysis of sugar. (External standard: glucose, galactose, fructose).

The GLC conditions were as follows: Column: DB-1701
(15m × 0.25mm, film thickness: 1.0μm,
J & W SCIENTIFIC), injection method: split method (split ratio 1/50), column temperature: 180
The procedure is the same as in the case of the lignan analysis except that the temperature is set to ° C.

As a result, the water-soluble lignan glycoside content in the aqueous ethanol extract was 5.5% by weight, and the lignan glycoside in the HPLC analysis sample (purified mixture of the aqueous ethanol extract) was obtained. The content is 1460 mg per 100 g of sown sesame seeds, and is defined as the ratio of the water-soluble lignan glycoside by the chemical structural formula (II-a) described above.
Lignan glycoside represented by: 20.9% by weight, lignan glycoside similarly represented by (II-b): 28.1% by weight, lignan glycoside similarly represented by (II-c): 2
4.2% by weight, sesaminol triglucoside: 7.8% by weight, sesaminol diglucoside: 14.4% by weight, a total of 4.6% by weight of sesamolinol glycoside, P-1 glycoside and pinoresinol glycoside % Lignan glycoside as a main component.

Test Example 1 Seven 4-week-old SD male rats were used as one test group, and group A was a test substance (crushed sesame germ products obtained by the method described in Reference Example 1, dried sesame germ products). Each of the test group and the group B containing 10% by weight of each of the pulverized products) contained a test substance (a hydroalcoholic extract obtained by the method described in Reference Example 1, a purified mixture of the extract, and a purified product of each lignan glycoside). The breeding test was performed by dividing into a test group containing 0.3% by weight of each and a control group to which no test substance was added. The test feed was prepared by dissolving or dispersing each test substance (100 g for group A, 3 g for group B) in 100 ml of mineral water described in Example 1 described below in the components shown in Table 1 or an aqueous suspension 10. % By weight and kneaded. After breeding for 3 weeks with water and each of the above-mentioned feeds freely taken, the total amount of cholesterol, neutral lipid and phospholipid in blood and liver of each group of rats was measured.
The results are shown in Tables 2 and 3.

[0033]

[Table 1]

[0034]

[Table 2]

[0035]

[Table 3]

[0036] In the group to which each test substance of crushed sesame germ, dried and crushed, hydrated alcoholic extract, purified mixture of the extract, and each purified lignan glycoside was added, the total cholesterol in the blood was measured. The concentrations of the sex lipids and phospholipids were significantly lower than those of the group without the test substance (control group) (Table 2). When these test substances were added, the total cholesterol and neutral lipid levels in the liver were significantly reduced as compared to the control group (Table 3). From these results, the above-mentioned chemical structural formulas (II-), (II-
-B) a water-soluble lignan glycoside containing a lignan glycoside or a sesaminol glycoside represented by (II-c) as a main component, or a crushed product of a germinated product of sesame seed containing the glycoside , Dried products, dried and crushed products, aqueous alcoholic extracts, purified mixtures of the extracts, and feeds containing the purified lignan glycosides, can be used to ingest blood cholesterol levels and blood neutrality. It was found to lower lipid levels.

[0037]

【Example】

Example 1 To 100 ml of commercially available mineral water, a hydroalcoholic extract obtained by the method described in Reference Example 1, a purified mixture of the extract, 0.3% by weight of each of sesaminol diglucoside and sesaminol triglucoside were added. The mixture was slowly stirred and dissolved to obtain a drinking water containing the water-soluble lignan glycoside of the present invention.

Example 2 A French dressing was prepared at the compounding ratios shown in the following table.

[Table 4] That is, dry and crushed xanthan gum and sesame germ are added to water, half of vinegar and sugar dissolved,
Hydrated for 15 minutes with vigorous stirring. All the remaining ingredients except soy salad oil were mixed and added to this. Further, after adding soybean salad oil little by little, the mixture was passed through a colloid mill to obtain a highly stable water-soluble lignan glycoside-containing dressing of the present invention.

Example 3 3 kg of steamed round soybeans were ground in a 5-fold weight of hot water at 80 ° C. using a homomixer. The obtained go was further treated with a homogenizer, and then this was indirectly sterilized with a plate (130).
℃, 20 seconds), and okara was removed by centrifugation to obtain soymilk. To this soymilk, 1% by weight of the hydroalcoholic extract obtained by the method described in Reference Example 1 was added and dissolved to obtain a water-soluble lignan glycoside-containing soymilk of the present invention.

Example 4 Orange, grape, apple and tomato juices, 100 each
To each ml, 10 g of the hydroalcoholic extract obtained by the method described in Reference Example 1 was added and dissolved to obtain a water-soluble lignan glycoside-containing juice of the present invention.

Example 5 20 parts by weight of butter oil, 10 parts by weight of hardened soybean oil, 0.2 part by weight of lecithin and 0.2 part by weight of glycerin fatty acid ester ("EXCEL O-95R" manufactured by Kao Corporation) were used in the oil phase. On the other hand, 3 parts by weight of skim milk powder, 5 parts by weight of sorbitol, 10 parts by weight of fresh cream, polyglycerin fatty acid ester (manufactured by Sakamoto Yakuhin Co., Ltd., "SY Glister MS-
310 ") 15 parts by weight of a purified mixture of a hydroalcoholic extract obtained by the method described in Reference Example 1 was added to 0.5 parts by weight and 51.1 parts by weight of water, and dissolved to obtain an aqueous phase. Then, the oil phase portion heated to the same temperature was added to the water phase portion heated to 80 ° C., and after preliminarily emulsified at 70 to 75 ° C., the mixture was homogenized by treatment with a homogenizer at a pressure of 50 kg / cm ^2. After cooling to room temperature, an oil-in-water cream containing the water-soluble lignan glycoside of the present invention was obtained.

Example 6 0.5 parts by weight of glycerin fatty acid ester ("Emulgy MU", manufactured by Riken Vitamin Co., Ltd.) was added to 83 parts by weight of a fat and oil composed of hardened soybean oil / prepared salad oil = 2/3 (weight ratio).
0.1 parts by weight of lecithin and a trace amount of β-carotene were added,
Further, 15 parts by weight of an aqueous solution obtained by dissolving 5 g of an equal weight mixture of sesaminol diglucoside and sesaminol triglucoside obtained in the method described in Reference Example 1 in 100 ml of water and 1.4 parts by weight of sodium chloride were added to emulsify. And kneaded while quenching to obtain margarine containing the water-soluble lignan glycoside of the present invention.

[0043]

According to the present invention, sesame seeds, especially humidified or germinated bodies thereof, can be easily obtained as a raw material, there is no concern about safety, and blood cholesterol and / or Foods and drinks containing a water-soluble lignan glycoside having an action of reducing neutral lipids in blood, particularly various water-based or emulsified foods and drinks can be provided.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A23L 1/36 A23L 1/36 2/52 A61K 31/70 ADN A61K 31/70 ADN 35/78 35/78 A23L 2/00 F (58) Field surveyed (Int.Cl. ⁶ , DB name) A23L 1/30 C07H 17/04 CA (STN)

Claims (6)

(57) [Claims] 1. A food or drink comprising a water-soluble lignan glycoside obtained from humidified or germinated sesame seeds or a substance containing the same. 2. The food or drink according to claim 1, wherein the substance containing the water-soluble lignan glycoside is a humidified or germinated body of sesame seeds or a dried product thereof. 3. The food or drink according to claim 1, wherein the content containing the water-soluble lignan glycoside is a humidified sesame seed or a hydrated lower alcohol extract of a germinated body, or a concentrate of the extract. 4. The food or drink according to claim 1, wherein the water-soluble lignan glycoside comprises lignan diglucoside and / or lignan triglucoside as a main component. 5. The lignan diglucoside and / or lignan triglucoside is sesaminol diglucoside, sesaminol triglucoside, having the following chemical structural formula (I): (In the formula (I), R represents one kind of glucosyl residue selected from the group consisting of glucose, galactose and fructose, m represents any one of integers from 1 to 3, and n represents an integer of 0 or 1) The food or drink according to claim 4, which is at least one member selected from lignan glycosides represented by the following numerical values: 6. The lignan glycoside represented by the chemical structural formula (I) according to claim 5, wherein the lignan glycoside is represented by the following chemical structural formula (II-
a), (II-b) or (II-c) (In the formula (II-a), Glc represents a glucose residue.) (In the formula (II-b), Glc represents a glucose residue.) (In formula (II-c), Glc represents a glucose residue.) The food or drink according to claim 5, which is a lignan glycoside represented by the formula: