JP2870656B2 - Ginkgo biloba extract-containing syrup - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a syrup containing a water-containing organic solvent extract (Ginkgo biloba extract) obtained from Ginkgo biloba leaves.

[Conventional technology]

Conventionally, in France, Germany and the like, therapeutic agents containing an aqueous organic solvent extract (Ginkgo biloba extract) obtained from Ginkgo biloba as an active ingredient have been widely used for the purpose of improving cerebral circulation metabolism.

The ginkgo biloba extract has a pharmacological action that relaxes smooth muscle of blood vessels contracted by stress and tension, reduces resistance of peripheral arteries and cerebral circulatory system, enhances vasodilation and blood circulation speed, and increases capillary tissue. Is known to have a pharmacological action to increase blood flow. In addition, peripheral vascular diseases or antiallergic effects have been observed, and almost no side effects have been observed.

For this reason, the ginkgo biloba extract is partly marketed not only as a pharmaceutical but also as a health food, and is expected to be widely spread in the future.

[Problems to be solved by the invention]

However, the ginkgo biloba extract is soluble in organic solvents such as alcohols, but is hardly soluble in water.Therefore, when trying to take the aqueous organic solvent extract without using alcohol, the extract powder is hard capsuled as it is. It has been limited to use as a solid preparation, such as filling into a tablet or tableting into a tablet. However, elderly people, minors, and sick people are more likely to eat liquid preparations than solid preparations, and the absorption rate in the body is generally higher than liquid preparations. It is desired to provide as.

As a means for solving such a problem, the present inventors have previously proposed a soft drink in which ginkgo biloba extract is stably dissolved in water using polydextrose (Japanese Patent Application No. 63-29).
No. 5372).

[Means for solving the problem]

However, the ginkgo biloba extract soft drink is provided by diluting the ginkgo biloba extract with water in advance, so that the appropriate ginkgo biloba extract intake per adult (about 120 mg) and the appropriate Considering the amount of dilution, the concentration of ginkgo biloba extract is inevitably 0.04 ~
It becomes a dilute aqueous solution of about 0.2%, which is not only troublesome to purchase and store when used regularly at home, but also has a problem that a large amount of containers must be used and discarded.

In order to solve such problems, it is better to prepare a solution containing ginkgo biloba extract at a high concentration, dilute it with water when drinking, and take ginkgo biloba extract in fact in France and Germany. It is commercially available in the form of a highly concentrated solution. However, this high-concentration solution uses a high ethanol-containing solution of about 30 to 50% to dissolve ginkgo biloba extract, so if it is marketed as a pharmaceutical, it will be unspecified as a health food Not suitable for commercial sale. In addition, in Japan, the content of ethanol in beverages is regulated to 1% or less, so that such a high ethanol content liquid cannot be marketed as a beverage.

On the other hand, as a method for preparing a high concentration solution of ginkgo biloba leaf extract without using an organic solvent such as ethanol, there is a method of dissolving the ginkgo biloba leaf extract in water at a high concentration using a sugar alcohol. The present inventors have already pointed out that when this method is applied to the preparation of a ginkgo biloba extract soft drink, the amount of sugar alcohol becomes too large to be suitable for drinking (Japanese Patent Application No. 63-295372). As described above, in the case of a high-concentration liquid, the above-described problem does not occur because the liquid is diluted with water at the time of drinking.

However, according to the study of the present inventors, even if an attempt is made to prepare a high-concentration aqueous solution of ginkgo biloba leaf extract using a monosaccharide alcohol such as sorbitol as the sugar alcohol, the stabilizing effect of the monosaccharide alcohol is small. It was found that it was difficult to obtain a stable high-concentration aqueous solution.
On the other hand, if a large amount of monosaccharide alcohol is blended in order to obtain a stable high-concentration aqueous solution, there is a problem that the monosaccharide alcohol is precipitated as crystals during storage. It has also been found that when an oligosaccharide alcohol having a high molecular weight is used as the sugar alcohol, the viscosity and transparency of the aqueous solution are reduced, so that it is difficult to obtain a practical high-concentration aqueous solution.

The present invention has been studied on liquid preparation of ginkgo biloba leaf extract, and completed the present invention by solving the above problems.

An object of the present invention is to provide a high-concentration aqueous solution of a ginkgo biloba leaf extract excellent in storage stability.

[Means for solving the problem]

The present invention relates to a ginkgo biloba extract containing 1% by weight or more of a water-containing organic solvent extract obtained from ginkgo biloba, and containing 30 to 75% by weight of at least one of a disaccharide alcohol and a trisaccharide alcohol. Contains syrup.

In order to obtain a water-containing organic solvent extract from ginkgo leaves, extraction is performed using a water-containing organic solvent such as water-containing methanol, water-containing ethanol, water-containing acetone, and water-containing methyl ethyl ketone according to a conventional method, and then the solvent in the obtained extract is extracted. It only needs to be distilled off. The aqueous organic solvent extract (Ginkgo biloba extract) contains flavoglycoside, biflavone, ginkgolide and the like as active ingredients that are hardly soluble in water.

Considering a proper ginkgo biloba extract intake per adult and a proper dilution in a beverage, the ginkgo biloba extract content in the syrup containing ginkgo biloba extract should be at least 1% by weight. Next, examples of the disaccharide alcohol used in the present invention include maltitol, lactitol, reduced palatinose, etc., and maltitol is particularly preferred. Examples of the trisaccharide alcohol include maltotriitol (also referred to as maltotriol). These di- and trisaccharide alcohols may be used alone or in combination of two or more. Further, a monosaccharide alcohol produced by reducing a hydrolyzate of starch or a di- or trisaccharide alcohol in which a small amount of a tetrasaccharide or a higher sugar alcohol is mixed may be used.

These sugar alcohols need to be contained in the range of 30 to 75% by weight of the total amount of the ginkgo biloba extract-containing syrup. When the content of sugar alcohol is less than 30% by weight,
It becomes difficult to dissolve ginkgo biloba extract in water in a stable state. If its content exceeds 75% by weight,
During storage, a part of the sugar alcohol may be precipitated as crystals. From the viewpoint of dissolving the ginkgo biloba extract in water in a stable state and preventing the precipitation of sugar alcohol, trisaccharide alcohol is superior to disaccharide alcohol. Therefore, when a disaccharide alcohol and a trisaccharide alcohol are used in combination, the trisaccharide alcohol is used in an amount of 1/2 of the total amount of both.
It is preferable to contain the above.

The ginkgo biloba extract of the present invention contains a thickener (such as gum arabic), an organic solvent acceptable as a food additive (such as ethanol and propylene glycol), a sweetener (such as sugars, aspartame and stevia) and a flavor. When an appropriate amount is added to the syrup, the stability of the ginkgo leaf extract is further improved. In particular, the addition of gum arabic or ethanol (less than 1%) is effective.

The ginkgo biloba leaf extract-containing syrup of the present invention can be prepared by simply dissolving the above ginkgo biloba leaf extract and disaccharide alcohol (and / or trisaccharide alcohol) in water at the above ratio and uniformly dispersing the same. The ginkgo biloba extract-containing syrup has excellent aqueous solution stability of the ginkgo biloba leaf extract and can be stably stored without causing precipitation for a long period of time. In addition, its viscosity is appropriate, small amount at home (1-20ml
) And dilute it with water (aqueous drinks such as hot water and juices) to obtain a transparent aqueous solution that is easy to drink. Furthermore, since this ginkgo biloba extract-containing syrup is a concentrated solution, there is an advantage that it is not troublesome to purchase and store the syrup when it is commonly used at home, and that only a small number of containers are required.

 Hereinafter, the present invention will be described in detail with reference to examples.

[Example 1] 2 g of dry powder of ginkgo biloba extract, oligotose H-70
(Trade name; manufactured by Mitsubishi Kasei Foods Co., Ltd., reduced starch hydrolyzate, liquid containing about 35% by weight of maltitol, about 47% by weight of maltotriitol, solid content of about 70% by weight) 115 g,
10 g of water was uniformly dispersed using a homogenizer while heating to obtain a transparent syrup. This syrup is at 20 ° C
It had a viscosity of 200 cps and quickly became a clear aqueous solution when diluted with water. This syrup could be stably stored at 30 ° C. for one month and at 4 ° C. for three months.

Example 2 A transparent syrup was obtained in the same manner as in Example 1 except that 10 g of a 10% by weight aqueous solution of gum arabic was used instead of 10 g of water. This syrup had a viscosity of 1500 cps at 20 ° C. and quickly became a clear aqueous solution upon dilution with water. This syrup is 6 months at 4 ° C and 6 months at 30 ° C
It could be stored stably for months.

Example 3 2 g of dry powder of ginkgo biloba extract, 115 g of amalty syrup (trade name; aqueous solution containing 75% by weight of maltitol, manufactured by Towa Kasei Kogyo Co., Ltd.), and 10 g of water were uniformly dispersed using a homogenizer. A clear syrup was obtained. This syrup had a viscosity of 1900 cps at 20 ° C. and quickly became a clear aqueous solution upon dilution with water. This syrup is 1
It could be stored stably for months or at 4 ° C for 2 months.

[Example 4] 40 g of milk tol (trade name; lactitol, manufactured by Towa Kasei Kogyo Co., Ltd.) and powdered mulch (trade name;
Towa Kasei Kogyo Co., Ltd., maltitol) 40 g and sorbitol 5 g
A transparent syrup was obtained in the same manner as in Example 3 except that 40 g of the aqueous solution was used and heated. This syrup had a viscosity of 4200 cps at 20 ° C. and quickly became a clear aqueous solution upon dilution with water. This syrup is
It could be stored stably for 1 month at 30 ° C and for 3 months at 4 ° C.

[Example 5] 1.5 g of dry powder of ginkgo biloba extract, oligotose H-
70 g of sorbitol, 30 g of sorbitol, and 20 g of a 10% by weight aqueous solution of gum arabic were uniformly dispersed using a homogenizer while heating. This syrup has a viscosity of 350 cps at 20 ° C,
Upon dilution with water, it quickly became a clear aqueous solution. This syrup could be stably stored at 30 ° C. for one month and at 4 ° C. for two months.

Comparative Example 1 A transparent syrup was obtained in the same manner as in Example 1 except that a 70% by weight aqueous solution of sorbitol was used in place of oligotose H-70. This syrup is 400c at 20 ° C
It had a viscosity of ps and became cloudy when diluted with water. 30 ℃
And sorbitol crystals precipitated after one day.

[Comparative Example 2] A 70% aqueous solution of a reduced starch hydrolyzate containing 60% by weight or more of a solid content of a sugar alcohol of a tetramer or more (such as maltotetraol) was used in place of the oligotose H-70, A syrup was obtained by treating in the same manner as in Example 1. This syrup was transparent immediately after production, but became turbid after 3 days, reducing its commercial value.
The viscosity at ℃ was 8500 cps and could not be easily separated. In addition, it became cloudy when diluted with water.

[Comparative Example 3] Oligotose H instead of Oligotose H-70 (80 g)
A syrup having a viscosity of 105 cps at 20 ° C was obtained by treating in the same manner as in Example 5 except that 60 g of -70 and 20 g of water were used. This syrup became cloudy when diluted with water.
Further, when left at 30 ° C., it became cloudy after 5 days.

Comparative Example 4 A syrup was obtained in the same manner as in Example 4 except that 40 g of a 10% by weight aqueous solution of gum arabic was changed to 15 g. This syrup was fluid at high temperatures, but became a very viscous liquid without fluidity when cooled to 30 ° C. In addition, it took a long time to dilute with water, and it was not a practical syrup.

〔The invention's effect〕

As described above, the ginkgo leaf extract-containing syrup of the present invention containing 1% by weight or more of the ginkgo leaf extract and containing at least one of the disaccharide alcohol and the trisaccharide alcohol in the range of 30 to 75% by weight is Excellent in aqueous solution of ginkgo biloba extract, can be stored stably without causing sedimentation for a long period of time, suitable in viscosity, transparent, easy to drink just by dispensing a small amount at home and diluting in water Since it is a concentrated solution, which can quickly obtain a suitable aqueous solution, it has excellent effects such as not having to be troublesome in purchase and storage at the time of regular use at home, and requiring only a small number of containers.

──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Naomi Yoshida 2-14-2 Takadanobaba, Shinjuku-ku, Tokyo Inside Freund Sangyo Co., Ltd. (72) Inventor Seiichi Umeda 2- 14-2 Takadanobaba, Shinjuku-ku, Tokyo Examiner in Freund Sangyo Co., Ltd. Midori Tominaga (56) References JP-A-2-142456 (JP, A) JP-A-2-223526 (JP, A) JP-B-51-12707 (JP, B1) (58) Field surveyed (Int. Cl. ⁶ , DB name) A23L 2/00-2/40

Claims (3)

(57) [Claims] 1. A ginkgo leaf containing 1% by weight or more of a water-containing organic solvent extract obtained from a ginkgo leaf, and containing at least one of a disaccharide alcohol and a trisaccharide alcohol in a range of 30 to 75% by weight. Extract containing syrup. 2. The syrup containing ginkgo biloba extract according to claim 1, wherein the disaccharide alcohol is maltitol. 3. The syrup containing ginkgo biloba extract according to claim 1, wherein the trisaccharide alcohol is maltotriitol.