JP2881333B2 - Whitening cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a whitening cosmetic for preventing or preventing blackening of the skin due to sunburn (ultraviolet rays) or pigmentation of the skin such as spots and freckles. About.

[Related Art and Problems] Conventionally, as a whitening cosmetic composition, a composition containing a tyrosinase activity inhibitor that produces melanin from tyrosine, such as vitamin C and its derivatives, a reducing agent, and a placenta extract, is known.

For example, Japanese Patent Application Laid-Open No. 61-194008 describes a cosmetic containing one or more selected from L-ascorbic acid (vitamin C) and its ester, and a luffa sap. JP-A-57-77610 describes a melanin production inhibitory action of cucurbits.

However, these conventional whitening cosmetics show melanin production inhibitory effects in in vitro experiments using cultured cells, but when applied to actual skin, sufficient effects such as disappearance of pigmentation or lightening cannot be obtained. Side effects such as irritation to the skin.

An object of the present invention is to provide a cosmetic having an excellent whitening effect and having no irritation to the skin.

[Means for Solving the Problems] The present inventors have conducted intensive studies to obtain an excellent whitening cosmetic, and as a result, by adding specific components such as placentan extract, linoleic acid, and vitamin A to luffa water. ,
The present inventors have found that the tyrosinase activity inhibitory action is enhanced and that cosmetics with less skin irritation can be obtained, and have completed the present invention.

That is, the present invention relates to the use of luffa water; placenta extract, linoleic acid and its salts or esters, linolenic acid and its salts or esters, eucalyptus extract, eicosapentaenoic acid and its salts or esters, hexadocosaenoic acid and its salts or Ester, pantothenic acid and its salt or ester, vitamin A, vitamin B, vitamin E and its salt or ester, photosensitizer
An object of the present invention is to provide a whitening cosmetic comprising at least one component selected from No. 201 and No. 401.

"Loofah" used in the present invention is Cucurbitacea
e) Luffa cylindrica Roem. The luffa water used in the present invention is a sap that exudes from a luffa fruit or stem, and can be collected by a known method.

If the collected loofah water is left as it is, decay, propagation of bacteria, etc. occur. For this purpose, the collected luffa water contains ethanol, paraoxybenzoic acid ester or its salt, benzoic acid or its salt, salicylic acid or its salt, sorbic acid or its salt, dehydroacetic acid or its salt, isopropylmethylphenol, orthophenylphenol, cresol, It is desirable to appropriately add a preservative such as phenoxyethanol.

The amount of luffa water in the cosmetic of the present invention is 3 to
It is 99% by weight, preferably 5 to 95% by weight, more preferably 5 to 90% by weight.

If the amount of loofah water is less than 3%, the pigmentation of the skin disappears or the effect of lightening is low, while if it exceeds 99%, the formulation of preservatives, stabilizers, and preservatives is limited, and the loofah water is preserved. It is not preferable because the stability decreases.

Ingredients to be blended with luffa water in the cosmetic of the present invention include placenta extract, linoleic acid and its salts or esters, linolenic acid and its salts or esters, eucalyptus extract, eicosapentaenoic acid and its salts or esters, hexadocosaenoic acid And salts or esters thereof, pantothenic acid and salts or esters thereof, vitamin A, vitamin B, vitamin E and salts or esters thereof, and Photosensitizer No. 201 and Photosensitizer No. 401. These may be used alone or in combination.

Derivatives of linoleic acid include potassium linoleate,
Salts such as sodium linoleate, and esters such as methyl linoleate, ethyl linoleate, isopropyl linoleate.

Linolenic acid includes α-linolenic acid and γ-linolenic acid, and derivatives thereof include salts such as sodium α-linolenate and esters such as ethyl γ-linolenate.

Derivatives of pantothenic acid include salts such as calcium pantothenate and sodium pantothenate, pantothenyl ethyl ether, acetyl pantothenyl ethyl ether and the like.

Derivatives of vitamin A (retinol) include esters such as retinol acetate, retinol palmitate, and dehydroretinol.

Derivatives of vitamin E (DL-α-tocopherol) include dl-α-tocopherol acetate, dl-α linoleate
Esters such as tocopherol and linolenic acid dl-α-tocopherol.

Conventionally, it has not been known that the combination use of these components with luffa water enhances the whitening effect on the skin.

The results of evaluating the pigmentation-inhibiting action of a cosmetic containing these components and luffa water are shown below.

Test method: Shaving the back of English brown guinea pig,
Ultraviolet rays (UVB intensity: 1 J / cm ² ) were irradiated. This operation was repeated for three days, during which the samples shown in Table 1 below (Test Examples 1 to 5)
24) was applied to an ultraviolet irradiation part. After standing for 10 days, the degree of pigmentation was visually determined according to the following criteria.

 -: No pigmentation ±: Slight pigmentation +: Moderate pigmentation ++: Intense pigmentation The results are shown in Table 1.

As is clear from Table 1, when luffa water and a component such as placenta extract are used in combination, remarkable lightening of pigmentation is observed as compared with the other cases.

The amounts of the components to be added to the cosmetic of the present invention together with the luffa water are appropriately adjusted according to each component. Placenta extract; linoleic acid, linolenic acid, eicosapentaenoic acid, hexadocosaenoic acid, and salts or esters thereof are all incorporated at 0.05 to 50% by weight, preferably 0.1 to 10% by weight, based on the total amount of the cosmetic. Touki extract, kojic acid and its salts or esters,
0.05 to 10% by weight, preferably 0.1 to 5% by weight.
In addition, pantothenic acid and its salts or esters are 0.
01 to 10% by weight, preferably 0.1 to 10% by weight. Vitamin A, Vitamin B and Vitamin E are added in an amount of 0.001 to 10% by weight, preferably 0.01 to 5% by weight. Photosensitive element 201
No. 401, 0.0001 to 0.5% by weight, preferably 0.1% by weight.
001-0.1% by weight is blended.

If the amount of each component blended in the cosmetic of the present invention together with the luffa water is less than the above range, a sufficient whitening effect cannot be obtained, while if it exceeds the upper limit, skin irritation occurs.

The whitening cosmetic of the present invention is a cloam by a known method,
It is prepared as cosmetics such as emulsions, lotions, packs, foundations and essences. In addition, the cosmetic of the present invention, within a range that does not impair the performance according to the type,
Known components can be appropriately blended. That is, the cosmetic of the present invention, in addition to the above essential components, components usually used and blended in cosmetics, for example, oil, ultraviolet absorber,
Antioxidants, surfactants, preservatives, fragrances, water, alcohols, thickeners, dyes, and the like can be appropriately added as necessary.

EXAMPLES Next, the present invention will be described more specifically based on examples. All amounts are by weight.

Example 1 (Cream) Ingredient Ingredients Sorbitan monostearate 2.0 Self-emulsifying glycerin monosteering acid 3.0 Cetyl myristate 1.5 Isopropyl myristate 3.0 Cetanol 2.0 Stearic acid 2.0 Liquid paraffin 7.0 Triethanolamine 0.4 Methyl paraoxybenzoate 0.2 Paraoxybenzoate Butyl acid 0.1 1,3-butylene glycol 6.0 Loofah water 50.0 Ethanol 2.0 Placenta extract 5.0 Touki extract 1.0 Perfume 0.2 Purified water balance Total 100 Example 2 (Emulsion) Ingredient Content Self-emulsifying glyceryl monostearate 3.0 Stearic acid 1.5 Cetanol 1.0 Liquid paraffin 5.0 Isopropyl palmitate 2.0 Triethanolamine 0.3 Polyoxyethylene monostearate sorbitan (20E.O.) 1.0 Ethyl paraoxybenzoate 0.3 Propylene glycol 5.0 Loofah water 60 .0 Carboxyvinyl polymer 0.3 Linoleic acid 3.0 Photosensitizer No. 401 0.002 Perfume 0.15 Purified water Balance 100 Total Example 3 (Lotion) Ingredients Polyoxyethylene hydrogenated castor oil (40E.O.) 0.7 Ethanol 12.0 Perfume 0.1 Photosensitivity Element 201 0.002 1,3-butylene glycol 5.0 citric acid 0.2 sodium citrate 0.3 d1-pyrrolidone carboxylate 1.0 luffa water 70.0 placenta extract 5.0 purified water balance total 100 Example 4 (pack) Ingredient Content Polyvinyl alcohol 15.0 Ethanol 14.0 Propylene glycol 4.0 Polyoxyethylene (20.EO) Cetyl ether 0.6 Fragrance 0.15 Loofah water 50.0 Kojic acid 0.5 Titanium oxide 5.0 Talc 2.0 Ethyl linoleate 1.0 Purified water Balance Total 100 Example 5 (cosmetic essence) Ethyl icosapentaenoate 1.0 Glycerin 15.0 Ethanol 8.0 Polyoxy Tylene-hardened castor oil (60E.O) 0.9 Ethyl paraoxybenzoate 0.1 Loofah water 65.0 Fragrance 0.1 Carboxyvinyl polymer 0.6 Triethanolamine 0.3 Purified water Balance Total 100 Example 6 (Powder component blending amount Hexadocosaenoic acid 2.0 Dextrin 90.0 talc 2.0 Decaglyceryl stearate 1.0 Luffa water 5.0 Example 7 (pack) Ingredients Compounding amount Calcium pantothenate 2.0 Luffa water 45.0 Vinyl acetate / styrene copolymer 10.0 Polyvinyl alcohol 10.0 Sorbit 5.0 Titanium oxide 6.0 Kaolin 5.0 Ethanol 8.0 Perfume 0.2 Paraoxybenzoate Example 8 (Emulsion) Ingredients Retinol acetate 0.02 Luffa water 70.0 Liquid paraffin 5.0 Vaseline 2.0 Beeswax 2.0 Sorbitan sesquioleate 2.0 Polyoxyethylene oleyl ether (20E.O) 2.5 Para Ethyl oxybenzoate 0.3 Propylene glycol 5.0 Carboxyvinyl polymer 0.5 Potassium hydroxide 0.3 Perfume 0.1 Purified water Balance Total 100 Example 9 (Cream) Ingredient Ingredient Tocopherol linoleate 1.0 Salami beeswax 4.0 Cetanol 2.0 Stearic acid 2.0 Isopropyl myristate 5.0 Lanolin 2.0 Liquid paraffin 6.0 Self-emulsifying glyceryl monostearate 3.0 Polyoxyethylene sorbitan monostearate (20E.O) 1.8 Propyl parahydroxybenzoate 0.1 Methyl paraoxybenzoate 0.3 Propylene glycol 5.0 Loofah water 50.0 Perfume 0.2 Purified water Remaining 100 Total Examples 10 (Lotion) Ingredients Compounding amount Pyridoxine hydrochloride 0.1 Glycerin 4.0 Ethanol 10.0 Luffa water 50.0 Polyoxyethylene hydrogenated castor oil (40E.O) 0.5 Methyl parahydroxybenzoate 0.05 Citric acid 0.05 Citric acid Thorium 0.07 dl-pyrrolidone Calvin sodium 1.0 Purified water balance Total 100 cosmetics of Examples 1 to 10 are all had excellent whitening effect.

[Effect of the Invention] The whitening cosmetic of the present invention has an excellent whitening effect and has no irritation to the skin.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/00-7/50

Claims (1)

(57) [Claims] 1. With luffa water; placenta extract, linoleic acid and its salts or esters, linolenic acid and its salts or esters, touki extract, eicosapentaenoic acid and its salts or esters, hexadocosaenoic acid and its salts or esters, Pantothenic acid and its salts or esters, vitamin A, vitamin B, vitamin E
And a salt or ester thereof, and at least one component selected from photosensitive elements 201 and 401.