JP2914466B2 - Denture stabilizer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a denture stabilizing agent which has good adhesive compatibility between dentures and gums and has an effect of stabilizing the mounting of dentures.

[0002]

2. Description of the Related Art A denture stabilizer prepared by mixing a polyacrylate powder as a tackifier and a low molecular weight organic or inorganic acid as a pH adjuster to this polyacrylate powder (Japanese Patent Application Laid-Open No. 55-38143). JP-A-2-196705) has been devised.

[0003]

However, when the polyacrylate powder alone and a low molecular weight organic or inorganic acid are blended, the adhesiveness and spinnability (ease of use) are still insufficient, and the acidity of the acid is poor. In the formulation, there are inconveniences such as the fact that only the acid is dissolved first in the oral cavity and partially neutralized, the saltiness is felt as a result of the neutralization, and the neutralization heat is felt, and further improvement is desired.

[0004]

The inventors of the present invention have made various studies and found that a composition containing a polyacrylate powder and a carboxymethylcellulose sodium powder can increase the hardness and strength of a water-absorbing gel and increase the water content. It has been found that by controlling the solubility in diffusion, the cushioning property at the time of wearing is moderate, the stickiness in the oral cavity is alleviated, and the duration of adhesion is prolonged. That is, the present invention relates to a denture stabilizer comprising a polyacrylate powder and carboxymethylcellulose sodium powder .

The polyacrylate powder used in the present invention is, for example, a salt of polyacrylic acid such as sodium salt, potassium salt, ammonium salt, calcium salt, magnesium salt, aluminum salt, iron salt and the like. Is generally about 20,000 or more, preferably about 50,000 to 15,000,000, is a water-soluble polymer, and has spinnability. Among the salts, sodium salts are usually preferred. In the case of a polyvalent metal salt such as a calcium salt, a magnesium salt, an aluminum salt, and an iron salt, when the salt having a substitution degree of 100% loses spinnability, in this case, Those having a substitution degree of 50% or less are used.
The polyacrylate powder has an intrinsic viscosity of 0.1.
The particle size is preferably 3 g / liter, more preferably 0.5 g / liter or more, and the particle size is 100 mesh or less, more preferably 200 mesh or less.

The sodium carboxymethylcellulose powder used in the present invention is a non-spinnable polymer for food use or pharmaceutically acceptable, and preferably has an average molecular weight of 10,000 or more. Is preferably not more than 100 mesh, more preferably not more than 200 mesh.

In the denture stabilizer of the present invention, the ratio between the polyacrylate powder and the carboxymethylcellulose sodium powder is about 2: 3 to about 20: 1 (weight), and more preferably about 1: 1. It is about 1 to about 12: 1. or,
The ratio of the polyacrylate powder to the entire denture stabilizer is 10 to 98 W / W%, more preferably 25 to 95 W / W.
W%, while sodium carboxymethylcellulose powder is about 2 to 40 W / W%, more preferably 5 to 40 W / W%.
It is about 30 W / W%.

[0008] The denture stabilizer of the present invention may be in the form of a powder or, if necessary, other components for adjusting the properties of the formulation (referred to as formulation adjusting components) such as an oily base or other auxiliary materials. An agent may be added to change into any shape such as paste, gum, sheet, and the like. In addition, organic and inorganic basic compounds may be added for the purpose of enhancing the inhibition of the growth of oral bacteria. The oily base of the formulation adjusting component used in the present invention includes petrolatum, paraffin, gelled hydrocarbon (such as plastibase) polyethylene glycol, various animal and vegetable oils and fats, waxes, simple ointments, hydrophilic petrolatum, and purified lanolin. Dextrin fatty acid esters, fatty acid glycerides, fatty acids, liquid paraffin, squalane, lanolin alcohol and the like. The mixing ratio of these prescription adjusting components to the entire denture stabilizer is from 0 to about 70 W / W%, preferably from about 5 to about 50 W / W%.

On the other hand, oral bacteria, which is one of the causes of denture stomatitis, are recognized to be suppressed by alkalization, but aqueous solutions of polyacrylate usually show a pH value of 9 to 10, There is little irritation to the oral mucosa. As a 0.2% aqueous solution of the denture stabilizer of the present invention, a pH of 8 to 12 is preferable, and a range of 9 to 10.5 is more preferable. When the ratio of the polyacrylate powder is small and the pH is lowered, one or several appropriate basic compounds may be added to adjust the pH.

The organic and inorganic basic compounds may be any as long as they are food grade or pharmaceutically acceptable. For example, hydroxides such as sodium hydroxide, calcium hydroxide and magnesium hydroxide, and carbonates Carbonates such as sodium, calcium carbonate and magnesium carbonate, phosphates such as sodium hydrogen phosphate, magnesium phosphate and potassium dihydrogen phosphate; citrates such as sodium citrate; tartrate salts such as potassium tartrate; succinates such as sodium succinate And basic metal salts such as acid salts. The ratio of these organic and inorganic basic compounds to the total denture stabilizer is 10
W / W% or less, more preferably about 5 W / W% or less.

Also, in some cases, a surfactant is blended to improve familiarity as long as the tackiness is not impaired, and a pigment and a pigment are blended for the purpose of avoiding an unnatural appearance, and organic and inorganic antioxidants are used. Formulation of a fungicide, formulation of an enzyme such as a bacteriolytic enzyme, and formulation of an active ingredient for disinfection, sterilization, analgesia, and anti-inflammation in the oral cavity can be mentioned.

[0012] The actual optimal formulation range in the present invention is 40 to 45 parts of sodium polyacrylate powder, carboxymethylcellulose - Sunatoriu beam is 10 to 15 parts, Purasuchibe - scan 40-45 parts, those with a total of 100 parts And
The pH of this denture stabilizer as a 0.2% aqueous solution is 9.
It is in the range of 0 to 10.0.

In order to use the denture stabilizer of the present invention, an appropriate amount is placed on a denture base moistened with water or the like, gently set on the gums, and lightly engaged for 2-3 minutes.

[0014]

The effect of the denture stabilizer and polyacrylate powder according to the present invention, which will be described later in the examples, is 0.2% for a single product and a commercial product.
The pH of the aqueous solution, the adhesive strength, the adhesive persistence, and the feeling upon use were observed. 1. Experimental Method I. Measurement of pH of 0.2% aqueous solution Spread 0.6 g of denture stabilizer into a beaker, and add
After adding and dissolving g, measure with a pH meter. II. Measurement of Adhesive Strength 0.5 g of denture stabilizer (0.3 g of powder) was placed on a lower movable methacryl plate of a rheometer (manufactured by Fudo Kogyo Co., Ltd.), and 1.0 ml of water was placed on this. Add and knead with a microsyringe and allow sufficient water absorption. After leaving it for 10 minutes, it is strongly pressed by hand for 15 seconds against the surface of a denture resin plate bonding treatment supporting disk (1.5 cm in diameter) on the tip of a stainless steel spindle fixed to the machine, and left as it is for 2 minutes. Next, the lower movable methacryl plate is moved downward at a speed of 2 cm / min. At this time, the value of the resistance (g: adhesive force) displayed on the meter is read.

III. Observation of Adhesive Persistence Five persons wearing complete dentures alternately use the denture stabilizer of the present invention and a commercially available denture stabilizer to maintain the adhesiveness, that is, the persistence of denture stabilization. Were compared. In the evaluation, when the product of the present invention was found to be very good as compared with the commercially available product, it was assigned a five-point scale of +2, good +1, equivalent 0, bad -1, and very bad -2.

IV. Observation of feeling of use Five people wearing complete dentures alternately use the denture stabilizer of the present invention and the commercially available product, ie, feeling of use, ie, stickiness, saltiness, and roughness in the oral cavity. The feeling of discomfort such as cushioning and the feeling of use during meals were compared. The evaluation was +2 when the product of the present invention was very good as compared with the commercial product, good +1, equivalent 0,
There were five levels of bad-1 and very bad-2. The results are shown in Table 1.

Table 1 Measurement Items Solution pH Adhesive Strength Adhesive Feeling Sample Name (g) Persistence ────── The present invention (Example 1) 9.6 1,720 +2 +1 The present invention (Example 2) 10.2 1,750 +2 +1 The present invention (Example 3) 9.4 1,810 +1 +2 The present invention (Example 4) 9.5 1,880 +2 +2 present invention product (example 5) 9.5 1,960 +2 +2 ratio Comparative examples 1 (polyacrylic acid 9.7 1,460 0 -1 sodium) Comparative example 2 (carboxymethyl 7.6 1,200 0 0 le cellulose sodium) Comparative example 3 ( commercially available) (poly grip S) 7.7 1,580 0 0

[0018]

As is clear from Table 1, the denture stabilizer of the present invention has good adhesion compatibility between dentures and gums.
Further, it is a denture stabilizer having an effect of further stabilizing the mounting of the denture. From the above, the denture stabilizer of the present invention is highly practical.

[0019]

EXAMPLES The present invention will be specifically described below with reference to examples. Example 1 Using a mixer, 90 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.88 g / liter and a particle size of 150 mesh or less, sodium carboxymethyl cellulose 9
Parts, 1 part of calcium chloride, and 100 parts in total, to obtain a product.

Example 2 Using a mixer, 86 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.91 g / liter and a particle size of 200 mesh or less, sodium carboxymethyl cellulose 10
Parts, anhydrous calcium chloride 3 parts, sodium hydroxide 0.5
Parts, magnesium chloride 0.3 parts, potassium chloride 0.18
Parts, Edible Red No. 3 Aluminum Lake 0.02 parts, Total 1
00 parts are uniformly mixed to obtain a product.

Example 3 Using a kneading machine, 44 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.91 g / liter and a particle size of 200 mesh or less, sodium carboxymethyl cellulose 14
Parts, plastibase 50W, 42 parts, a total of 100 parts, are uniformly kneaded, and then filled into an ointment tube to obtain a product.

Example 4 Using a kneading machine, 44.97 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.89 g / liter and a particle size of 200 mesh or less, 15 parts of sodium carboxymethyl cellulose, plastibase After uniformly kneading 100 parts of 50 W 40 parts and Edible Red No. 3 aluminum lake 0.03 part, this is filled into an ointment tube to obtain a product.

Example 5 Using a mixer, 30 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.87 g / liter and a particle size of 200 mesh or less, sodium carboxymethyl cellulose 23
Parts, 40 parts of white petrolatum, 5 parts of liquid paraffin, and 2 parts of anhydrous calcium chloride, a total of 100 parts were uniformly kneaded, and this was filled into an ointment tube to obtain a product.

The formulation of the comparative example is shown below . Comparative Example 1 The limiting viscosity value is 0.91 g / liter and the particle size is 200 mesh.
Or less sodium polyacrylate powder

[0025]Comparative Example 2 Carboxymethyl cellulose having a particle size of 200 mesh or less
Sodium powder

──────────────────────────────────────────────────続 き Continued on the front page (58) Fields surveyed (Int.Cl. ⁶ , DB name) A61K 6/097 A61K 6/00 C08L 33/02

Claims (1)

(57) [Claims] 1. A denture stabilizer comprising a polyacrylate powder and carboxymethyl cellulose sodium powder.