JP2914589B2 - Hair growth and hair growth fees - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair growth and fostering agent, and more particularly to a hair growth and fostering material containing an extract component extracted from Indian serpent tree and having excellent hair growth and fostering effects. Is what you do.

[0002]

2. Description of the Related Art At present, there are baldnesses typified by young baldness, senile baldness, alopecia areata and the like. These phenomena are accompanied by shame in the daily life, and their interest in treatment is unusual. Conventionally,
Various compounds or herbal extracts can be used as hair growth and hair growth agents, such as vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ′, 5′-
Cyclic monophosphate, etc. (JP-A-64-566)
08, JP-A-1-261321, JP-A-2
-204406), and extracts such as yokuinin, ginkgo, cashew, etc.
JP-A-13451, JP-A-2-48512, JP-A-2-48514) and the like.

[0003]

As described above, various compounds, herbal extract extracts, and the like are applied to the hair growth and hair growth products provided so far, but most of them show a remarkable effect. Those having no effect and having a certain degree of effect have drawbacks such as irritation so strong as to cause dermatitis and difficulty in continuous use. Therefore, to search for a hair growth and hair growth promoter that is excellent in hair growth and hair growth effect and has sufficient safety to withstand long-term use, and to develop a hair growth and hair growth material that uses this as an active ingredient Was an issue.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that Indian serpent trees [Rauwolfia verticillate bail (Rauwolfia ver.)
ticillate Bail) or Rauwolfia serpentina Bentham or Apocynaceae: Chinese name Rafuboku] is extracted with water and / or a water-soluble organic solvent, and the resulting extract is used as an extract component. The present inventors have found that this extract component is effective as a hair growth and hair growth agent, and can solve the above-mentioned problems, and have reached the present invention. That is, the present invention relates to a hair growth / hair restoration material characterized by extracting Indian snake tree with water and / or a water-soluble organic solvent, using the resulting extract as an extract component, and blending the extract. The hair growth and fostering material of the present invention has no adverse effects on the scalp,
It can be used safely.

Hereinafter, the present invention will be described in detail. The Indian snake tree applied to the present invention is an evergreen shrub to a small tree of the oleander family, and is Rauwolfia verticillate Bail (Rauwolfia verticillate Bail) or Rauwolfia Serpentina Bentham (Rauwolfia).
serpentina Bentham) or Apocynacea
e) In China, it is called Rafu-boki and is used as a blood pressure lowering and stabilizing agent (Mitsuru Hotta, Encyclopedia of Useful Plants, p 893 (1989)). In the present invention, whole grass of Indian serpent tree, preferably root or rhizome is used. So far, it has not been known that the extract of Indian serpent has an effect of promoting hair growth and hair growth, and it has been found for the first time by the present inventors.

[0006] The production of an extract component having an effect of promoting hair growth and hair growth from Indian serpent tree is performed by removing the whole plant of Indian serpent tree, preferably the root or rhizome, with water or a water-soluble organic solvent such as methanol, ethanol, propanol, butanol. Or a primary alcohol such as acetone, tetrahydrofuran, dioxane or the like alone or the primary alcohol or acetone, tetrahydrofuran, dioxane or the like.
Extraction by digestion with a water-containing organic solvent containing at least% by weight. In the extraction operation, the solvent was added to 100 g of Indian snake tree for 0.1 g.
Using 5 to 5 liters, perform digestion extraction once or twice at room temperature to the boiling point of the solvent for 7 to 10 days at room temperature and for 4 to 8 hours at heating. The extract extracts are combined, filtered by suction, and then concentrated under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained crude drug extract is dissolved or dispersed and diluted with an appropriate solvent or the like as it is, and is blended with a base to obtain the hair growth and hair growth agent of the present invention. Here, the content of the crude drug extract of Indian serpent tree contained as an active ingredient of the hair growth and fostering agent according to the present invention is 0.001 to 10% by weight, preferably 0.05 to 5% by weight. When the content is 0.001% by weight or less, a sufficient hair growth effect is not exhibited in a hair growth test using mice described below, and when the content is 10% by weight or more, the stability as a cosmetic is not sufficient.

[0007] Next, the effect of the crude drug extract on hair growth in mice will be examined. <Experimental Methods and Results> (1) Sample A 70% ethanol aqueous dispersion containing 1% of a crude drug extract extracted from Indian snake tree with 70% ethanol water applied to the present invention, and a hair growth and hair growth effect conventionally 70% aqueous ethanol dispersion containing 1% of vitamin E known as a component having
An aqueous ethanol solution was used.

(2) Hair growth test method using mice This test method uses a 9-week-old C3H mouse and
Make 0 groups and make 4 groups, 2.0x2.0c of these backs
The following day after removing the hair to the site where the hair was removed to the size of
After the application of 4 g, on days 5 and 14, the density of hair growth at the site was determined as the degree of black increase using a color difference meter.

(3) Result

[0010]

[Table 1]

As is clear from Table 1, in the extract of Indian serpentine tree applied to the present invention, the L value decreases and the black color increases. On the other hand, in vitamin E, the L value was hardly reduced. This can be presumed to be the result of the Indian snake tree extract of the present invention stimulating hair roots, increasing blood circulation around hair follicles, and activating metabolism.

[0012] Other raw materials used in the hair growth / hair restoration of the present invention include hydrocarbons, waxes, oils and fats, esters, higher fatty acids, higher alcohols which are usually applied to cosmetics. A surfactant, a humectant, a fragrance, a coloring matter, a preservative, an antioxidant, an ultraviolet ray protective agent, a pH adjuster, and a medicinal ingredient suitable for the purpose of the present invention are appropriately selected and prepared. Furthermore, it can be used in combination with a known and used hair growth and hair growth component. Moreover, the hair growth and hair growth agent of the present invention include various dosage forms, for example, hair lotion, hair tonic, hair cream, pomade and the like.

[0013]

The hair growth and fostering agent of the present invention stimulates hair roots, activates blood circulation around hair follicles, activates metabolism, and promotes hair growth and fostering.

[0014]

EXAMPLES The present invention will be described below with reference to examples and comparative examples, but the present invention is not limited to these examples.
In addition, the compounding amount is a weight part. Production of Indian snake tree extract (1) 50 g of rhizome of Indian snake tree is 70% ethanol 1
The extract was immersed and extracted at room temperature for 10 days, the residue was filtered off with filter paper, and the filtrate was evaporated to dryness to obtain an extract (yield 15%). (2) 50 g of Indian serpent tree roots are immersed in 1 liter of ethanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. Thereafter, the mixture is cooled, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 1).
0%). (3) 50 g of Indian serpent tree roots are immersed in 1 liter of acetone, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. Thereafter, the mixture is cooled, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 7).
%). (4) 50 g of Indian serpent tree roots are immersed in 1 liter of butanol, transferred to a Soxhlet extractor, and subjected to warm extraction for 8 hours. Thereafter, the mixture is cooled, the residue is filtered off with filter paper, and the filtrate is evaporated to dryness to obtain an extract (yield 6).
%).

[0015]

Embodiment 1

[Comparative Example 1]

[Comparative Example 2] Hair lotion

[0016]

[Table 2]

(Production method) The above-mentioned raw materials are dissolved by heating and solubilized to obtain a product.

Next, a test for the effect of hair growth and hair growth by humans is conducted. <Experimental methods and results> (1) Samples Hair lotion of Example 1 and Comparative Examples 1 and 2 (2) Test method The hair lotion shown in Example 1 was continuously given to 20 panelists complaining of alopecia and alopecia for 6 consecutive months. A hair growth / hair growth effect test was conducted by using the composition. The method of application was to apply it evenly twice a day to the head in the same manner as the usual lotion usage. The evaluation was performed at the third and sixth months after the start of use, and the degree of increase in the number of subjects who felt that the naive hair and hard hair had increased was measured. They also reported at the end of the test that they had improved their scalp condition and reduced dandruff.

(3) Result

[0020]

[Table 3]

As is apparent from Table 3, the hair lotion containing the extract of the Indian snake tree extract of the present invention has a hair growth due to an increase in the number of hairy and hard haired people. The effect was recognized. On the other hand, it was found that the effect was weak when the Indian snake tree extract was 0.005%. At the end of the test, there were six users who reported a reduction in gray hair to the user of the hair lotion of Example 1. In addition, the condition of the scalp was also improved, and there were eight people who reported reduction in the occurrence of dandruff. Therefore, the hair lotion containing the extract of Indian snake tree of the present invention showed a hair-growth effect. In addition, no skin damage such as deterioration of the condition of the scalp or inflammatory reaction was observed in any of the panelists during the use test period, confirming that the product of the present invention has high safety.

[0022]

Example 2 Hair Tonic (Prescription) Indian Snake Tree Ethanol Extract 5.0 Menthol 0.2 Ethanol 57.0 Purified Water 37.8 (Preparation Method) To which purified water is added.

[0023]

Example 3 Hair Cream (Prescription) Indian Snake Tree Acetone Extract 1.0 1.0 Vitamin E 1.0 Vaseline 7.0 Beeswax 8.0 Liquid Paraffin 37.0 Lipophilic Glycerin Monostearate 5.0 Purified Water 41 0.0 (production method) is heated and dissolved at 80 ° C. 80 ° C in advance
The mixture is gradually added to the mixture which has been heated and emulsified, and cooled to 30 ° C. to produce the mixture.

[0024]

Example 4 Pomade (Formulation) Indian Snake Tree Butanol Extract 0.0
5 Isopropyl myristate 10.0 Cetanol 2.0 Squalane 6.0 Microcrystalline wax 10.0 Polyoxyethylene hydrogenated castor oil 10.0 Purified water 61.9
5 Heat the (production method) at 70 ° C. To this is added with stirring, previously heated to 70 ° C. It is manufactured by cooling to 40 ° C. with stirring.

[0025]

The hair growth and fostering composition containing the extract of Indian snake tree of the present invention shows a hair growth effect in a hair growth test using mice, and further shows a hair growth and fever growth in a practical use test for humans. The effect was recognized, no skin damage due to long-term use was recognized, and the safety was also excellent.

──────────────────────────────────────────────────続 き Continuing on the front page (72) Katsuo Matsumoto, Inventor 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside the Yokohama Laboratory, Polar Chemical Industry Co., Ltd. (72) Inventor Masami Suzuki 27, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa 1. Polar Chemical Industry Co., Ltd. Yokohama Research Laboratory (56) References JP-A-63-303915 (JP, A) JP-A-63-198613 (JP, A) JP-A-4-202116 (JP, A) 1-261321 (JP, A) JP-A-2-48512 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/06

Claims (1)

(57) [Claims] 1. A hair-growing / hair-growing agent comprising extracting an Indian snake tree with water and / or a water-soluble organic solvent, and using the resulting extract as an extract component.