JP3000224B2 - Skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to skin cosmetics, and more particularly, has a sebum secretion promoting action, improves skin roughness, reduces skin inflammation, and prevents / improves skin aging. It relates to skin cosmetics.

[Problems to be solved by conventional technology and invention]

Sebum is mainly composed of triglyceride, squalene and wax ester, and is secreted from sebaceous glands and epidermal cells, and protects skin and hair tissue from external stimuli by forming a film on the surface of skin or hair. Plays an important role.

Further, it is known that the secretion of such sebum decreases with age, and such a deficiency of sebum is considered to be one of the major causes of rough skin, xeroderma and the like. Further, when the sebaceous gland function deteriorates, the beautiful appearance and smooth feel of the skin are also impaired, and the so-called aging skin which has lost its "luster" and "stick" comes to appear.

Therefore, in order to prevent and improve rough skin etc., it is considered that it is a useful means to mix a component having a sebum secretion promoting action with cosmetics and the like, and various studies have been made, but it has a sebum secretion promoting action. Examples of the substance include γ-oryzanol, which is a mixture of ferulic acid esters [Toshio Kobayashi, Ritsuko Hayakawa, Dermatology, 21 , 123 (1979)], and branched fatty acid ester derivatives [Naoshinobu Yoshizuka, Genji Imokawa, Journal of Nisshinkai, 94 , 411 (198
4)], etc., and very few effects have been found, and the obtained effects have not been sufficiently satisfactory.

[Means for solving the problem]

In view of such circumstances, the present inventors have conducted various studies from the viewpoint of promoting sebum secretion, and found that an extract of a crude drug selected from Sophora oleracea, Akiko and Kinsakurako has a remarkable sebum secretion promoting action. Heading, the present invention has been completed.

That is, the present invention provides a skin cosmetic comprising an extract of Sadako.

The method of preparing the crude drug extract obtained from Sophoraceae, Kaeriko and Sakurako used in the present invention is not particularly limited. For example, the crude drug extract is extracted at room temperature to under heating using various suitable solvents.
Examples of the extraction solvent include water; lower alcohols such as methyl alcohol and ethyl alcohol; glycerin,
Liquid polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; and one or more kinds of ethers such as diethyl ether can be used. . Among them, water or a water-soluble solvent, particularly one of water, ethyl alcohol, glycerin and 1,3-butylene glycol, or a mixed solvent of two or more thereof is preferred. The extraction conditions are 1 to 1000 times the volume of the crude drug, especially 5 to 10 times.
It is preferable to carry out the reaction at a temperature of 4 ° C. or more, particularly 15 to 30 ° C., for 1 hour or more, particularly 1 to 3 days, using 0 times the amount of solvent.

The crude drug extract obtained under the above conditions may be used as it is in the extracted solution, but further concentrated if necessary.
Those that have been subjected to a treatment such as filtration can be appropriately used.

In the skin cosmetics of the present invention, one or more crude drug extracts can be blended, and the amount thereof is preferably 0.0001 to 10.0% by weight in total as converted to dry solids, and particularly preferably 0.1 to 0.1% by weight.
The range of 01 to 5.0% by weight is preferred.

The skin cosmetic composition of the present invention may further include a placenta extract such as cows and humans, a thymus extract such as cows and pigs, a spleen extract such as cows and pigs, adenosine triphosphate or a salt thereof, and vitamin A, if necessary. And their derivatives, vitamin D and their derivatives, succinic acid and their derivatives and their salts,
Cell activators such as aloe extract and ginseng extract may be added.

Skin cosmetics of the present invention, in addition to the above components, usually cosmetics,
Aqueous components, powders, surfactants used in quasi-drugs,
It is prepared by appropriately mixing an oil agent, a humectant, an alcohol, a pH adjuster, a preservative, an antioxidant, an ultraviolet absorber, a thickener, a pigment, a fragrance, a cosmetic ingredient, and the like as needed.

The dosage form of the skin cosmetic of the present invention is not particularly limited, and various dosage forms such as a lotion, an emulsion, a cream, a pack, and a cleanser can be used.

〔Example〕

Hereinafter, the present invention will be further described with reference to Test Examples and Examples.

Test Example 1 The effect of each test substance on the sebaceous glands was examined using ear sebaceous glands of Syrian hamsters.

30 g of 70% ethyl alcohol was added to 10 g of each of Sophora Gosei, Akemiko and Sakurako, soaked at room temperature for 2 days with occasional stirring, and filtered to obtain a crude drug extract and 5% γ.
-Oryzanol ethyl alcohol solution was used as the test substance.

A group of 6 female Syrian hamsters of 10 weeks of age was applied to the inside of the right pinna of each Syrian hamster, and 0.05 ml of the above-described test substance was applied daily. Further, 0.05 ml of 70% ethyl alcohol was applied to the inside of the left pinna as a control.

The application was performed for 10 days. On the eleventh day, the left and right auricles were punched out to a predetermined size, and the epidermis and cartilage were peeled off to prepare a dermis sheet. Under the dermis sheet microscope, a photograph was taken at a magnification of 20 times, and the maximum diameter of the sebaceous gland observed in a petal shape was measured at 10 places.

As a result, the size of the sebaceous gland was as shown in Table 1 below, and the sebaceous gland was remarkably enlarged on each of the test substance application sides, and the sebaceous gland activating action superior to γ-oryzanol used for comparison, ie, sebaceous gland A secretagogue was shown.

Example 1 Lotion: (Composition) (% by weight) (1) Glycerin 8.0 (2) 1,3-butylene glycol 12.0 (3) Ethyl alcohol 5.0 (4) Polyoxyethylene sorbitan monolaurate (20E.O) .) 1.0 (5) Sodium pyrrolidonecarboxylate 0.2 (6) Sophora 1,3-butylene glycol extract ^{* 1} 0.5 (7) Urocanic acid 0.1 (8) Sodium hyaluronate 0.02 (9) Collagen 0.1 (10) Preservative Appropriate amount (11) Flavor Appropriate amount (12) Purified water Fuel gauge 100.0 * 1 Contains about 9% of Sophorae extract as dry solids.

(Production method) A. Mix and dissolve (3), (4), (10) and (11).

B. Mix and dissolve (1), (2), (5) to (9) and (12).

C. Mix A and B to make uniform.

Example 2 Cream: (Composition) (% by weight) (1) Beeswax 5.0 (2) Cetanol 5.0 (3) Reduced lanolin 6.0 (4) Squalane 42.0 (5) Glycerin monostearate 4.0 (6) Cholesteryl stearate 0.5 ( 7) Vitamin E linoleate 0.1 (8) Lipophilic glyceryl monostearate 2.0 (9) Polyoxyethylene sorbitan monolaurate (20E.O.) 2.0 (10) Sekiko 50% ethyl alcohol extract ^{* 2} 1.0 (11) ) Sodium deoxyliponucleic acid 0.05 (12) Suitable amount of preservative (13) Suitable amount of fragrance (14) 1,3-butylene glycol 5.0 (15) Purified water Fuel gauge 100.0 * 2 Contains about 7% dry matter extract as dry solids What you did.

(Preparation method) A. Mix (1) to (9) and (12) to (14) and heat to 70 ° C.

B. Mix (10), (11) and (15) and heat to 70 ° C.

C. Add A to B, emulsify uniformly, and cool to 30 ° C.

Example 3 Emulsion: (Composition) (% by weight) (1) Squalane 7.0 (2) Vaseline 0.7 (3) Beeswax 0.3 (4) Sorbitan sesquioleate 0.8 (5) Polyoxyethylene oleyl ether (20E.
O.) 1.5 (6) 1,3-butylene glycol 8.0 (7) Sakurako 70% ethyl alcohol extract ^{* 3} 0.8 (8) Vitamin E 0.1 (9) UV absorber 0.5 (10) Placenta extract 0.5 (11) Dipotassium glycyrrhizinate 0.02 (12) Ethyl alcohol 5.0 (13) Preservatives proper amount (14) Flavors proper amount (15) Purified water Remaining meter 100.0 * 3 Contains about 7% of dried cherry solid extract (manufactured by Method) A. Mix (1)-(9) and (12)-(14) and heat to 70 ° C.

B. Mix (10), (11) and (15) and heat to 70 ° C.

C. Add A to B, emulsify uniformly, and cool to 30 ° C.

Example 4 Pack: (Composition) (% by weight) (1) Polyvinyl alcohol 15.0 (2) Sodium carboxymethylcellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) Gold extract aqueous extract ^{* 4} 0.3 (5) Ethyl alcohol 10.0 (6) Kojic acid 1.0 (7) Appropriate preservative (8) Appropriate flavor (9) Purified water Remaining meter 100.0 * 4 Contains about 11% dry cherry as a dry solid content (Production method) A. Mix (1) to (4), (6) and (9), heat to 70 ° C., and stir to dissolve.

B. Mix (5), (7) and (8).

C. Add B to A, mix and cool.

Test Example 2 Use effect test: The use of the skin cosmetic of the present invention was tested for the effect of improving skin roughness and the effect of preventing aging by a use test.

The use test was carried out by applying a suitable amount of the test cosmetic to the face for two weeks after washing the face twice daily in the morning and at night, using 20 women aged 30 to 50 as panels.
The test cosmetics were the same as in Example 3 except that the lotion of Example 1, the emulsion of Example 3 and the emulsion of Example 3 as a control were corrected with purified water except for the (7) 70% ethanol extract of Kokurako. Was used. The results are shown in Table 2.

 The evaluation was performed according to the following criteria.

・ Skin roughness improvement effect Effective: Skin roughness and roughness were improved.

 Slightly effective: Skin roughness and roughness were slightly improved.

 Ineffective: No change.

・ Anti-aging effect Effective: Wrinkles became inconspicuous and skin became shiny.

 Slightly effective: Wrinkles are slightly less noticeable.

 Ineffective: No change.

As is clear from the results shown in Table 2, the use of the lotion of Example 1 and the emulsion of Example 3 confirmed that the effect of improving skin roughness and the effect of making fine wrinkles less noticeable were at a high effective rate. .

[Effects of the Invention] Since the skin cosmetic of the present invention has a remarkable sebum secretion promoting effect, it has an excellent skin roughness improving effect, an effect of reducing skin inflammation, etc., can be widely applied, and the occurrence of fine wrinkles, It also has the effect of preventing and improving skin aging phenomena, such as loss of skin gloss and stiffness.

Continuation of the front page (56) References JP-A-3-255015 (JP, A) JP-A-3-188008 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7 / 00

Claims (1)

(57) [Claims] (1) A skin cosmetic comprising an extract of Akeboshi.