JP3027428B2 - Cosmetics - Google Patents
CosmeticsInfo
- Publication number
- JP3027428B2 JP3027428B2 JP03033338A JP3333891A JP3027428B2 JP 3027428 B2 JP3027428 B2 JP 3027428B2 JP 03033338 A JP03033338 A JP 03033338A JP 3333891 A JP3333891 A JP 3333891A JP 3027428 B2 JP3027428 B2 JP 3027428B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- lichi
- production example
- water
- reishi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002537 cosmetic Substances 0.000 title claims description 10
- 240000008397 Ganoderma lucidum Species 0.000 claims description 13
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000222336 Ganoderma Species 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 241000271274 Cleopatra Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 244000183278 Nephelium litchi Species 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000123326 Fomes Species 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 235000019493 Macadamia oil Nutrition 0.000 description 1
- 235000015742 Nephelium litchi Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- -1 Polyoxyethylene Polymers 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- 241000134968 Sapindales Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 239000010469 macadamia oil Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は美白、肌荒れにきく化粧
品に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics which are effective in whitening and rough skin.
【０００２】[0002]
【従来の技術】茘枝は学名をLitchi chinensis Sonnera
t と称するもので、双子葉植物網、離弁花亜網、むくろ
じ目、むくろじ科、れいし属の植物で、中国南部広東
省、福建省原産で果樹として東南アジア、九州南部で栽
培される。雌雄異株で果実は肉が白く、汁が多く甘く、
古くから食用とされ、古くは楊貴妃が好んで食したとい
うものである。しかし、化粧料への利用は、いまだなさ
れていない。2. Description of the Related Art Lichi has a scientific name of Litchi chinensis Sonnera.
those referred to as t, dicot network, Hanareben flower Amo, sapindales, Sapindaceae, with litchi plants of the genus, southern China Guangdong Province, Southeast Asia as fruit trees in Fujian origin, is grown in southern Kyushu. Dioecious fruit with white flesh, juicy and sweet,
It has been edible for a long time, and in the old days it was eaten favorably by Yang Guihime. However, it has not yet been used in cosmetics.
【０００３】一方、霊芝は菌植物門、帽菌目、さるのこ
しかけ科、マンネンタケ属の植物で、学名をGanoderma
lucidum {Fomes japonicum (Fr.) Sacc.｝と言い、これ
も生薬として利用されている。免疫賦活作用等があり、
安全性の点についても実際の利用により確認されてい
る。化粧料への利用も行われている。[0003] On the other hand, Reishi is a plant belonging to the fungal phylum, Caphynophora, Chironospermaceae, and the genus Ganoderma.
lucidum {Fomes japonicum (Fr.) Sacc.｝, which is also used as a crude drug. There are immunostimulatory effects, etc.
The safety point has also been confirmed by actual use. It is also used for cosmetics.
【０００４】[0004]
【発明が解決しようとする課題】合成薬品がその有効性
にも拘らず、種々の副作用、皮膚への感作性などの問題
を有するのにかんがみ、本発明の目的は天然物で、古く
より食用等によって安全性が実証され、皮膚への安全性
も十分であると考えられるもので、化粧料として種々な
有効性を具備した化粧品原料を検索し、提供することで
ある。In view of the fact that synthetic drugs, despite their effectiveness, have various side effects and problems such as sensitization to the skin, it is an object of the present invention to provide a natural product, The purpose of the present invention is to search for and provide cosmetic raw materials having various effectiveness as cosmetics, for which the safety has been proved by edible use or the like and the safety on the skin is considered to be sufficient.
【０００５】[0005]
【課題を解決するための手段】本発明者らは、クレオパ
トラが真珠を酢に溶かして飲用し、その美しさを保った
と言われており、それをもとに開発された真珠関連の化
粧料原料がさまざまな効果を発揮しているように、東の
クレオパトラともいうべき楊貴妃が愛用したという茘枝
が美しさを保つ効果があるのではないかと着目し、さま
ざまな実験を繰り返した。Means for Solving the Problems It is said that the present inventors have maintained the beauty of Cleopatra by drinking pearl in vinegar by dissolving it in vinegar, and developing pearl-related cosmetics based on it. Just as the raw materials are exhibiting various effects, we repeated various experiments, focusing on whether or not the lichi, which was favored by the cleopatra of the east, could maintain the beauty of the lichi.
【０００６】その結果、茘枝単独でも効果があることが
わかったが、これに更に霊芝を組み合わせるとさらに効
果があることを見い出し本発明を完成した。すなわち本
発明は茘枝の抽出物と霊芝の抽出物とを含む化粧料であ
る。[0006] As a result, it was found that lichi alone was effective. However, it was found that it was more effective when reishi was combined with it, and the present invention was completed. That is, the present invention is a cosmetic containing the lichi extract and the reishi extract.
【０００７】茘枝の抽出方法は、茘枝の果実（これを茘
子ということがある）を水溶性有機溶媒、例えばエタノ
ール、メタノール、ブタノール、アセトン等により、必
要により水を加えて抽出する。化粧品原料として許可さ
れているエタノールが最適である。水を加える場合、そ
の割合は水溶性有機溶媒の種類によって異なるが、０〜
８０重量％の範囲が適当である。[0007] In the method of extracting lichi, the fruit of lichi is extracted with a water-soluble organic solvent such as ethanol, methanol, butanol, acetone or the like, if necessary, with the addition of water. Ethanol, which is approved as a cosmetic ingredient, is optimal. When adding water, the ratio varies depending on the type of water-soluble organic solvent,
A range of 80% by weight is suitable.
【０００８】一方、霊芝の抽出方法は、霊芝を細断し、
乾燥したものに、水と水溶性有機溶媒例えばエタノー
ル、メタノールの単独又は混合溶媒で抽出すればよい。
また、その他化粧品として配合する油類、界面活性剤、
薬剤の制限はなく、また、必要により他の生薬類との併
用もまた問題はない。On the other hand, the method of extracting Ganoderma turf is to shred Ganoderma lucidum,
The dried product may be extracted with water or a water-soluble organic solvent such as ethanol or methanol alone or in a mixed solvent.
In addition, other oils, surfactants,
There is no restriction on the drug, and there is no problem in combination with other crude drugs if necessary.
【０００９】本発明の茘枝の抽出物と霊芝の抽出物を併
用すると皮膚の美白作用に優れ、その保湿性により、肌
荒れを防止ししっとり感を与える効果が大きい。When the lichi extract and the reishi extract of the present invention are used in combination, the skin whitening effect is excellent, and the moisturizing effect has a great effect of preventing rough skin and giving a moist feeling.
【００１０】[0010]
【実施例】以下に本発明を実施例、比較例により、更に
具体的に説明するが、本発明はこの実施例により限定さ
れるものではない。 （製造例１） 茘枝抽出物 茘枝９０ｇに、５０重量％エタノール１リットルを加
え、２４時間攪拌抽出した。その後これを凍結乾燥し
た。EXAMPLES The present invention will be described more specifically with reference to examples and comparative examples, but the present invention is not limited to these examples. (Production Example 1) Lichi extract 1 liter of 50% by weight ethanol was added to 90 g of lichi and extracted with stirring for 24 hours. Thereafter, it was freeze-dried.
【００１１】（製造例２） 霊芝抽出物 霊芝乾燥物５０ｇに水を加え、２４時間攪拌抽出した。
この後、これを凍結乾燥した。(Production Example 2) Reishi Extract Extract 50 g of dried Ganoderma lucid was added to water and extracted with stirring for 24 hours.
Thereafter, it was freeze-dried.
【００１２】（実施例１） 化粧水 重量部 製造例１の茘枝抽出物 １．０ 製造例２の霊枝抽出物 １．０ エタノール ３０．０ 精製水 ６８．０(Example 1) Lotion lotion by weight Lichi extract of Production Example 1 1.0 Lingae extract of Production Example 2 Ethanol 30.0 Purified water 68.0
【００１３】（実施例２） クリーム 重量部 スクワラン ２５．０ マカデミア油 ５．０ ステアリルアルコール ３．０ モノステアリン酸グリセリン ２．０ ポリオキシエチレン（６０E.O.）硬化ヒマシ油 １．０ 精製水 ５３．０ グリセリン １０．０ 製造例１の茘枝抽出物 １．０ 製造例２の霊芝抽出物 １．０(Example 2) Cream parts by weight Squalane 25.0 Macadamia oil 5.0 Stearyl alcohol 3.0 Glycerin monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Purified water 53 2.0 Glycerin 10.0 Lichi extract 1.0 of Preparation Example 1.0 Reishi extract 1.0 of Preparation Example 1.0
【００１４】（比較例１）実施例１より製造例１の茘枝
抽出物を除いたもの。 （比較例２）実施例１より製造例２の霊芝抽出物を除い
たもの。 （比較例３）実施例１より製造例１の茘枝抽出物と、製
造例２の霊芝抽出物を除いたもの。(Comparative Example 1) Example 1 except that the lichi extract of Production Example 1 was omitted. (Comparative Example 2) A product obtained by removing the Ganoderma lucidum extract of Production Example 2 from Example 1. (Comparative Example 3) The litter extract of Production Example 1 and the Ganoderma lucidum extract of Production Example 2 were removed from Example 1.
【００１５】（比較例４）実施例２より製造例１の茘枝
抽出物を除いたもの。 （比較例５）実施例２より製造例２の霊芝抽出物を除い
たもの。 （比較例６）実施例２より製造例１の茘枝抽出物と製造
例２の霊芝抽出物を除いたもの。(Comparative Example 4) A product obtained by removing the lichi extract of Production Example 1 from Example 2. (Comparative Example 5) A product obtained by removing the Reishi extract of Production Example 2 from Example 2. (Comparative Example 6) The litter extract of Production Example 1 and the Reishi extract of Production Example 2 were removed from Example 2.
【００１６】チロシナーゼ活性阻害 （試験方法） Mcllvaln緩衝液０．９ml、１．６６mM Tyrosine 溶液
１．０ml、試料溶液１．０mlをスクリューバイアルにと
り、３７℃恒温水槽中で５分以上加温した。チロシナー
ゼ溶液（Sigma 社製、マッシュルーム由来、９１４ユニ
ット／ml）０．１mlを加え、３７℃恒温水槽中で保温
し、１０分後に４７５nmで吸光度を測定した。対照とし
て、上記試料液のかわりに純水を加え同様に測定した。
なお、試料溶液は１０倍希釈液（水で希釈）である。Inhibition of tyrosinase activity (Test method) 0.9 ml of Mcllvaln buffer solution, 1.0 ml of 1.66 mM Tyrosine solution and 1.0 ml of sample solution were placed in a screw vial and heated in a constant temperature water bath at 37 ° C for 5 minutes or more. 0.1 ml of a tyrosinase solution (manufactured by Sigma, from mushrooms, 914 units / ml) was added, the temperature was kept in a constant temperature water bath at 37 ° C., and the absorbance was measured at 475 nm after 10 minutes. As a control, pure water was added instead of the sample solution, and the measurement was performed in the same manner.
The sample solution is a 10-fold diluted solution (diluted with water).
【００１７】（計算式） チロシナーゼ活性阻害率（％）＝｛Ｂ−（Ａ−Ｐ）｝／Ｂ×１００ 但し Ａ：試料検体の吸光度 Ｂ：対照の吸光度 Ｐ：試料検体の着色による吸光度（３倍希釈） 各検体はエタノールを除き、その分、精製水を加えた。 （結果） 表１に示す(Calculation formula) Tyrosinase activity inhibition rate (%) = {B- (AP)} / B × 100 where A: absorbance of sample specimen B: absorbance of control P: absorbance by coloring of sample specimen (3 (Double dilution) For each sample, ethanol was removed and purified water was added accordingly. (Results) Table 1
【表１】 [Table 1]
【００１８】（使用試験）女性８０名に対し、顔面を左
右に分け、実施例或いは比較例の試料を２検体評価して
もらった。３月間使用して評価した。 (Usage test) Eighty females were asked to evaluate two samples of the examples or comparative examples by dividing the face into left and right faces. It was used for three months and evaluated.
【００１９】結果を表２に示す。The results are shown in Table 2.
【表２】 [Table 2]
【００２０】[0020]
【発明の効果】本発明の化粧料は、茘枝抽出物と霊芝抽
出物の両者を配合したので、肌の美白作用に優れ、更に
保湿作用により肌荒れを防止し、しっとりとした感じを
保持させる効果がある。何れも古くより食用にされた
り、内用漢方薬として使用されて来たもので、肌に対す
る安全性については保証されており、又その両面から原
料確保も容易である。EFFECT OF THE INVENTION The cosmetic of the present invention, which contains both the lichi extract and the reishi extract, is excellent in skin whitening effect, and furthermore, moisturizing effect prevents rough skin and maintains a moist feeling. effective. All of them have been edible or used as an internal medicine for a long time, and their safety to the skin is guaranteed, and it is easy to secure raw materials from both sides.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/48 ＣＡ（ＳＴＮ)──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 7 , DB name) A61K 7/ 00-7/48 CA (STN)
Claims (1)
粧料。1. A cosmetic comprising an extract of lichi and an extract of Reishi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03033338A JP3027428B2 (en) | 1991-02-04 | 1991-02-04 | Cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03033338A JP3027428B2 (en) | 1991-02-04 | 1991-02-04 | Cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04247009A JPH04247009A (en) | 1992-09-03 |
| JP3027428B2 true JP3027428B2 (en) | 2000-04-04 |
Family
ID=12383784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03033338A Expired - Fee Related JP3027428B2 (en) | 1991-02-04 | 1991-02-04 | Cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3027428B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1247527A1 (en) * | 2001-04-03 | 2002-10-09 | Cognis France S.A. | Cosmetic and/or pharmaceutical preparations containing extracts of the plant Litchi chinensis Sonn |
| KR100789631B1 (en) * | 2001-07-05 | 2007-12-27 | 주식회사 엘지생활건강 | Skin whitening cosmetics containing plant extracts with melanin inhibitory activity |
| US7575764B2 (en) | 2005-10-01 | 2009-08-18 | Elc Management Llc | Compositions comprising hypsizygus ulmarius extract |
-
1991
- 1991-02-04 JP JP03033338A patent/JP3027428B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04247009A (en) | 1992-09-03 |
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