JP3034652B2 - Composition for removing or suppressing bad breath - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for removing bad breath or suppressing bad breath, particularly a composition for removing bad breath or suppressing bad breath useful as a food for removing bad breath or suppressing bad breath, a pharmaceutical for removing bad breath or suppressing bad breath (hereinafter referred to as a composition). In the description, the concept of halitosis removal is a concept that also encompasses halitosis suppression.)

[0002]

BACKGROUND ART Natural plant extracts having a deodorizing effect, such as green tea extracts, soybean extracts, and camphoraceous plant extracts, are already known. Since these are natural products and are safe, they have recently been used in foods and the like for the purpose of removing bad breath.
However, in the case where the purpose is to remove bad breath, there has not yet been provided anything that can sufficiently achieve the purpose.

[0003] It is an object of the present invention to provide a composition for removing bad breath which has a deodorizing component synergistically having a bad breath removing effect and having a sufficient bad breath removing effect.

[0004]

Means for Solving the Problems In order to achieve the above object, the present inventors have made intensive studies, and found that at least one component selected from Amacailul extract and a plant fiber substance roasted water extract (hereinafter, referred to as the following). It has been found that a composition comprising a polysaccharide (hereinafter, sometimes referred to as a B component) contained in a plant belonging to the genus Sasa has an effect of removing bad breath.

The present invention has been completed on the basis of the above-mentioned new findings, and comprises at least one kind of component selected from Amacailul extract and a roasted water extract of a plant fiber substance and a polysaccharide contained in a plant belonging to the genus Sasa. It is a composition for removing bad breath characterized by comprising.

[0006] Amacail extract used in the present invention is a plant of the Cucurbitaceae family, Gynostemma Penta-
phyllum Makino), preferably an extract extracted from its aerial parts. As the extract, a solvent extraction extract composed of water is preferable. Preferred examples of the solvent composed of water include a single solvent of water and a mixed solvent of water and an alcohol (particularly, ethanol). The mixing ratio of the water and the alcohol in the mixed solvent is usually 250 parts by weight or less, preferably 100 parts by weight or less, more preferably 30 parts by weight or less with respect to 100 parts by weight of water. The solvent consisting of water is usually pH 5 to 9, preferably pH
It is about 5.5 to 8.

[0007] Amacailul extract is prepared, for example, as follows. That is, the raw Amacha or dried product thereof is preferably cut into small pieces, a solvent consisting of water is added thereto, and the mixture is heated and extracted at about 80 to 100 ° C. for about 10 minutes to 2 hours, and then separated by filtration. The extract is prepared by concentrating under reduced pressure to obtain an extract, or by concentrating under reduced pressure and then pulverizing by means such as spray drying.

[0008] As the extract of roasted water of plant fiber substance used in the present invention, for example, those described in JP-A-1-99560 are suitable. As the plant fiber substance roasting water extract, a plant fiber substance roasting water extract, which is further extracted with an organic solvent, is more preferable. A method for preparing a roasted water extract of plant fiber substance is, for example, as follows. That is, plant fiber materials such as soybean (particularly defatted soybean) and bran (particularly defatted bran) are treated at about 170 to 230 ° C. for about 5 minutes to
After roasting (light roasting) for 1 hour, then adding about 10 to 20 times the amount of water, extracting under boiling for about 5 to 80 minutes, and filtering and separating the concentrated extract to a concentration ratio of 0.1 to 0.3. It is preferably prepared by concentrating under reduced pressure, and further spray-drying the above concentrated extract until the water content becomes about 4%. The extract obtained by extracting the concentrated extract thus obtained with an organic solvent and filtering the residue is a more suitable extract. The extract may further contain cyclodextrin (which may be any of α, β, and γ). Examples of the organic solvent used here include lower alcohols such as methyl alcohol, ethyl alcohol and isopropyl alcohol, benzene, chloroform, n-hexane, carbon tetrachloride and the like.

Commercially available extracts of roasted water extract of plant fiber substances include, for example, Desmy P50 (80% mixture of cyclodextrin α, β, γ, rice bran and soybean roast extract 15%, glycerin 5%), Desmy R, Desmy N
(All manufactured by Okuno Pharmaceutical Co., Ltd.).

[0010] Polysaccharides contained in plants belonging to the genus Sasa can be extracted from the plants, and can be extracted from hot water, alkali (pH 8).
There is no particular limitation as long as it has the property of being soluble in the above. For example, Kumazasa (Sasa veitchii (Carr.) Rehde
r), Sasa yahikoensis Makino, Sasa megalophylla Makino et Uchida, Sasa heterotricha Koidz, Sasa septum
entrionalis Makino), Sasa nipponica (M
akino) Makino et Shibata)
Jitsuburo Oi, Masao Kitagawa revised, "New Japanese Botanical Magazine, Flowering Version"
(Showa 58, published by Shibundo). And the like, in particular, polysaccharides that can be extracted from the above-ground part (particularly, the leaves) with a solvent composed of water. Here, as a solvent composed of water, water (the pH is usually pH 5 or more, preferably pH 5
5.5 to 13), and examples of the alkali component for pH adjustment include sodium hydrogen carbonate, potassium hydrogen carbonate, sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, and ammonia. . The polysaccharide contained in the plant may be used as the polysaccharide-containing material (for example, in the form of an extract such as Kumazasa extract).

The polysaccharides contained in the plant, for example, Kumazasa extract, are prepared, for example, as follows. That is, for example, about 80 to 1
The extract is obtained by heating and extracting at 00 ° C. for about 10 minutes to 2 hours and then concentrated under reduced pressure to obtain an extract obtained by filtration under hot conditions, or powdered by means such as spray drying after concentration under reduced pressure. Also, for example, after adding alkaline water to a plant such as Kumazasa and allowing to stand for 2 to 24 hours, filtering, neutralizing and desalting the filtrate, filtering and separating under reduced pressure to obtain an extract, or spraying after concentrated under reduced pressure It is prepared by powdering by means such as drying.

In the present invention, the mixing ratio of the component A and the component B is 100 parts by weight of the component A and 1 to 10 parts of the component B.
000 parts by weight, preferably 5 to 1000 parts by weight, more preferably 5 to 500 parts by weight. B component is 1 to 10
If the amount is out of the range, the synergistic effect may be poor.

The composition of the present invention has a halitosis removing effect on mammals such as humans, dogs, horses, cats and monkeys. The halitosis includes physiological halitosis, pathological halitosis, and halitosis due to food and drink. The composition of the present invention is effective against any of these halitosis, and particularly effective against halitosis due to food and drink.

[0014] The composition of the present invention can be used as foods, pharmaceuticals and the like for the purpose of removing bad breath. The purpose of the breath elimination may be a main purpose or a secondary purpose.

The composition for halitosis of the present invention is usually administered orally, and it is usually preferable to take the composition to reach the stomach and intestines rather than keeping it in the mouth. The composition for removing bad breath according to the present invention includes, as foods, drinking water, candy (for example,
Chewing gum, refreshing candy in the mouth), ice cream, sherbet and other frozen desserts. In addition, pharmaceuticals are formulated as tablets, liquids, capsules, elixirs, granules and the like.

[0016] Such foods and pharmaceuticals can be prepared by means known per se together with only the A component and the B component or with other components. In addition, the composition of the present invention may contain a substance having an ability to remove bad breath other than the above, and other substances, and may further contain other medicinal ingredients in pharmaceuticals. Examples of such components include chlorophyll derivatives such as sodium copper chlorophyllin, crude drugs such as acacia, calyx, fennel, mokko, yakuchi, dragon brain, digestive enzymes such as diastase and lipase,
Masking agents such as menthol and peppermint, inclusion compounds such as cyclodextrin (α, β, γ), amino acids such as glycine, alanine, leucine, isoleucine, asparagine, glutamine, and sweetness such as maltitol, glucose, stevia, thaumatin, etc. Agent, citric acid,
Examples include cooling agents such as menthol, and lubricants such as magnesium stearate.

The composition for halitosis of the present invention is usually administered in an amount of about 0.05 to 2 g as the total amount of the components A and B per adult.

[0018]

Next, the present invention will be described with reference to experimental examples and examples.

REFERENCE EXAMPLE 1 Preparation method of Amacailul extract: Aboveground part 1 of Amacailul extract
After shredding kg, add 10 liters of water and add about 100
The mixture was extracted by heating at about 1 hour. The filtrate, which was filtered while hot, was concentrated under reduced pressure and spray-dried to obtain about 0.2 kg of Amacailul extract.

REFERENCE EXAMPLE 2 While the defatted bran is being rotary-rotated, it is heated at about 170.degree.
For a minute, then put the resulting roast in 10 times the amount of water of the roast, heat the mixture to a boil,
After 40 minutes of boiling, the extract was separated by filtration (total heating time 60 to 90 minutes) to obtain a hot water extract, which was concentrated under reduced pressure to a concentration ratio of 0.2. The concentrated extract thus obtained is spray-dried until the water content becomes about 4%, extracted with a 10-fold amount of 95% ethanol, and after filtering the residue, the ethanol is removed under reduced pressure and concentrated. , Got an extract.

Reference Example 3 Preparation method of Kumazasa extract: 1 kg of the above-ground part of Kumazasa was taken, 20 liters of water was added, and the mixture was heated and extracted at about 100 ° C. for about 2 hours. The filtrate filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of Kumazasa extract. This extract contains about 25-75% solids by weight.

Reference Example 4 Preparation method of Yahikokosa extract: 1 kg above ground part of Yahikokozasa
Was added, 20 liters of water was added, and the mixture was extracted by heating at about 100 ° C. for about 2 hours. The filtrate filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of Yakikosasa extract. This extract is about 25-7
Contains 5% by weight solids.

REFERENCE EXAMPLE 5 Preparation method of P. persica extract: 1 kg of above-ground part of P. persica
Was added, 20 liters of water was added, and the mixture was extracted by heating at about 100 ° C. for about 2 hours. The filtrate that had been filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of P. persicae extract. This extract is about 25-7
Contains 5% by weight solids.

Reference Example 6 Method for Preparing Kutegawazasa Extract: Aboveground part 1 of Kutegawazasa
Take 20 kg, add 20 liters of water,
Extraction was performed by heating for hours. The filtrate filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of Kutegawawasa extract. This extract is about 2
Contains 5-75% by weight solids.

Reference Example 7 Method for preparing beetle extract: 1 kg above-ground part of beetle
Was added, 20 liters of water was added, and the mixture was extracted by heating at about 100 ° C. for about 2 hours. The filtrate that was filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of beetle extract. This extract is about 25-7
Contains 5% by weight solids.

Reference Example 8 Method for preparing Miyakozasa extract: 1 kg above-ground part of Miyakozasa
Was added, 20 liters of water was added, and the mixture was extracted by heating at about 100 ° C. for about 2 hours. The filtrate filtered while hot was concentrated under reduced pressure to obtain 0.1 kg of Miyakozasa extract. This extract is about 25-7
Contains 5% by weight solids.

EXPERIMENTAL EXAMPLE 1 5 ml of an aqueous solution of the composition for halitosis removal shown in Table 1 [Amacha extract (dry powder: solid content 96%) and Kumazasa extract (solid content 35%)] was used as an odorant.
It was added to 1 ml of a 05% trimethylamine solution, and the effect of suppressing the odor of trimethylamine was measured. The results are as shown in Table 1.

[0028]

[Table 1]

When the Amachazur extract and Kumazasa extract were used in combination, the synergistic effect was higher than the deodorizing effect of each extract alone (see FIG. 1).

EXPERIMENTAL EXAMPLE 2 5 ml of an aqueous solution of the composition for removing bad breath shown in Table 2 [Amachazul extract (dry powder: solid content 96%) and yakozasa extract (solid content 45%)] was used as an odorant at 0.05%. It was added to 1 ml of a trimethylamine solution, and the effect of suppressing the odor of trimethylamine was measured. The results are as shown in Table 2.

[0031]

[Table 2]

[0032] In the case of the combination of Amacailul extract and Yakikosa extract, the synergistic effect was higher than the deodorizing effect of each extract alone (see Fig. 2).

Experimental Example 3 5 ml of an aqueous solution of the composition for removing bad breath shown in Table 3 [Amachazul extract (dry powder: solid content: 96%) and Pseudophysalis extract (solid content: 40%)] was used as an odorant in an amount of 0.05%. It was added to 1 ml of a trimethylamine solution, and the effect of suppressing the odor of trimethylamine was measured. The results are as shown in Table 3.

[0034]

[Table 3]

In the case of the combined use of the Amachadul extract and the Pleurotus terrestris extract, the effect was synergistically higher than the deodorizing effect of each of them alone (see FIG. 3).

Experimental Example 4 5 ml of an aqueous solution of the composition for removing bad breath [Desmy P50 and Kumazasa extract (solid content: 35%)] shown in Table 4 was added to 1 ml of a 0.05% trimethylamine solution as an odorant, and trimethylamine odor was added. Was measured. The results are as shown in Table 4.

[0037]

[Table 4]

When Desmy P50 and Kumazasa extract were used together, the synergistic effect was higher than the deodorizing effect of each of them alone (see FIG. 4).

Experimental Example 5 5 ml of an aqueous solution of the composition for removing bad breath shown in Table 5 [Desmy P50 and Yakikosasa extract (solid content 45%)]
It was added to 1 ml of a 0.05% trimethylamine solution as an odorant, and the effect of suppressing the odor of trimethylamine was measured. The results are as shown in Table 5.

[0040]

[Table 5]

When Desmie P50 and Yakikosasa extract were used in combination, the synergistic effect was higher than the deodorizing effect of each of them alone (see FIG. 5).

EXPERIMENTAL EXAMPLE 6 5 ml of an aqueous solution of the composition for removing bad breath shown in Table 6 [Desmie P50 and Psyllium extract (solid content: 40%)] was used.
It was added to 1 ml of a 0.05% trimethylamine solution as an odorant, and the effect of suppressing the odor of trimethylamine was measured. The results are as shown in Table 6.

[0043]

[Table 6]

In the case where Desmy P50 and P. pertussis extract were used in combination, the synergistic effect was higher than the deodorizing effect of each of them alone (see FIG. 6).

EXPERIMENTAL EXAMPLE 7 A test for removing the bad breath of the garlic extract after eating the garlic extract of Amacailul extract and Kumazasa extract: The following evaluations were conducted to see the deodorizing effect of the deodorant. That is, 4 males and 4 females each
After having a subject eat a dish rich in garlic,
One breath of bad breath removing water of Example 1 was taken, and about 5 minutes later, the degree of bad breath was determined. Table 8 shows the results. As can be seen from Table 8, the degree of bad breath was remarkably reduced by taking the refreshing drink for removing bad breath containing the amacha pea extract and Kumazasa extract.

EXPERIMENTAL EXAMPLE 8 Effect of Desmie P50 and Kumazasa Extract on Halitosis Elimination after Garlic Eating: A total of eight subjects, 4 males and 4 females, were fed a dish containing a lot of garlic, and then the halitosis was eliminated in Example 4. Two tablets were taken and about 5 minutes later, the degree of bad breath was determined. Table 8 shows the results. As can be seen from Table 8,
Taking the bad breath removing tablet containing Desmie P50 and Kumazasa extract significantly reduced the degree of bad breath.

Table 7 shows criteria for bad breath determination.

[0028]

[Table 7]

[0049]

[Table 8]

Embodiment 1 Composition of soft drink for halitosis removal Amachadul extract 20 mg Kumazasa extract 50 mg Sucrose 10 g Citric acid 500 mg Flavor 0.1 ml The above components were dissolved in water to make a total amount of 100 ml, thereby preparing a soft drink for bad breath removal.

Embodiment 2 FIG. Jelly for halitosis removal 200g sugar, 4g sodium citrate, gelatin 15
0g, Desmy P50 1000mg, Kumazasa Extract 5
00 mg and 1 liter of water were heated and mixed, and kept at a temperature of 80 ° C. for 10 minutes. Then, 30 g of citric acid was added to the mixture and mixed uniformly. did.

Embodiment 3 FIG. Mouth freshener After mixing at the above ratio, the mixture was tableted to produce tablets (about 972 mg per tablet) as a mouthwash.

Embodiment 4 FIG. Bad breath removal tablets After mixing at the above ratio, one tablet was pressed into a weight of about 551 mg to produce a bad breath removing tablet. Each dose should be 2 tablets.

Embodiment 5 FIG. 100g of chewing gum for removing bad breath.
Add 1000mg of Desmy P50 and Kumazasa extract 5
After mixing 00 mg, maltitol (powder mulch: manufactured by Towa Kasei Kogyo Co., Ltd.) and 300 g of a small amount of fragrance, the mixture was kneaded with a roll according to a conventional method and molded to produce a chewing gum.

Embodiment 6 FIG. Ice cream for halitosis removal Composition Desmy P50 3 g Amachadul extract 2 g Fresh cream 465 g Skim milk 280 g Sugar 150 g Gelatin 5 g After stirring and mixing the above ingredients while heating, the ones filled in cup containers by about 100 g are frozen.

Embodiment 7 FIG. Ice cream for halitosis removal Composition Desmy P50 3 g Yahiko kosasa extract 2 g Fresh cream 465 g Skim milk 280 g Sugar 150 g Gelatin 5 g After stirring and mixing the above ingredients while heating, about 100 g is filled in a cup container and frozen.

Embodiment 8 FIG. Composition of soft drink for bad breath removal Desmy P50 1 g Amachadul extract 0.2 g Omazaza extract 0.2 g Sucrose 10 g Citric acid 0.5 g Fragrance 0.1 ml The above components were dissolved in water to make a total amount of 100 ml and a soft drink for bad breath removal was manufactured. .

Embodiment 9 FIG. Jelly for halitosis removal 200g sugar, 4g sodium citrate, gelatin 15
0 g, Amachazur extract 500 mg, Yahiko kosasa extract 500 mg and 1 liter of water, and mixed by heating.
After maintaining the mixture at 10 ° C for 10 minutes, 30 g of citric acid was added thereto, mixed uniformly, and then aliquoted into 100 ml containers was cooled to produce jelly for removing bad breath.

[0059]

EFFECT OF THE INVENTION In the composition for removing bad breath or suppressing bad breath according to the present invention, the deodorant components incorporated have a synergistic effect on removing bad breath.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 shows the deodorizing effect of a combination of Amachadul extract and Kumazasa extract.

FIG. 2 shows the deodorizing effect of a combination use of Amachadul extract and Yakikozasa extract.

FIG. 3 shows the deodorizing effect of the combination use of Amachadul extract and Pleurotus terrestris extract.

FIG. 4 shows the deodorizing effect when Desmy P50 and Kumazasa extract are used in combination.

FIG. 5 shows the deodorizing effect when Desmy P50 and Yakikosasa extract are used in combination.

FIG. 6 shows the deodorizing effect when Desmy P50 and Pleurotus terrestris extract are used in combination.

[Explanation of symbols]

 ◎ indicates 50% deodorant concentration in a 1: 1 mixture.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI A23G 9/02 A23G 9/02 A23L 1/06 A23L 1/06 2/38 2/38 C A23P 1/02 A23P 1/02 A61K 7/26 A61K 7/26 7/32 7/32 A61P 1/02 A61P 1/02 (56) References JP-A-1-99560 (JP, A) JP-A-59-224664 (JP, A) JP Hei 2-167168 (JP, A) JP-A-61-76412 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 35/78 A61K ⁷ /00-7/50 A61L 9 / 01 A23F 3/00-5/50 A23G 1/00-9/02 A23L 1/00-2/38 A23P 1/02

Claims (3)

(57) [Claims] 1. A method for removing or suppressing bad breath, characterized by comprising at least one component selected from Amacailul extract and a roasted water extract of a plant fiber substance and a polysaccharide contained in a plant belonging to the genus Sasa. Composition. 2. The composition according to claim 1, wherein the polysaccharide contained in a plant belonging to the genus Sasa is contained in the form of the plant extract. 3. The composition according to claim 2, wherein the extract is a solvent-extracted extract comprising water.