JP3058664B2 - Mass spectrometer - Google Patents
Mass spectrometerInfo
- Publication number
- JP3058664B2 JP3058664B2 JP2244002A JP24400290A JP3058664B2 JP 3058664 B2 JP3058664 B2 JP 3058664B2 JP 2244002 A JP2244002 A JP 2244002A JP 24400290 A JP24400290 A JP 24400290A JP 3058664 B2 JP3058664 B2 JP 3058664B2
- Authority
- JP
- Japan
- Prior art keywords
- needle
- sample
- mass spectrometer
- electrode
- needle electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Plasma Technology (AREA)
- Electron Sources, Ion Sources (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は質量分析装置に関する。Description: TECHNICAL FIELD The present invention relates to a mass spectrometer.
質量分析装置は、試料をイオン化し質量分析部に導い
て質量分離することにより、試料成分を分析する装置で
ある。試料をイオン化する方法の一つとして、針状電極
を用いて、コロナ放電を発生させるものが知られている
（例えば、特開昭60−100352号公報、特開昭60−79658
号公報）。The mass spectrometer is a device that analyzes a sample component by ionizing a sample, guiding the ionized sample to a mass spectrometer, and performing mass separation. As a method of ionizing a sample, a method of generating a corona discharge using a needle-like electrode is known (for example, JP-A-60-100352, JP-A-60-79658).
No.).
針状電極の放電では、針状電極の先端付近がもっとも
イオン化の効率が良く、そこからほぼ同心円状にイオン
化効率が下がっていく。したがって、試料の流れの影響
があるものの、ある程度は、試料の通路に近い方がイオ
ン化効率のためには好ましい。In the discharge of the needle electrode, the ionization efficiency is highest near the tip of the needle electrode, and the ionization efficiency decreases almost concentrically from there. Therefore, although it is influenced by the flow of the sample, it is preferable to some extent that it is closer to the path of the sample for ionization efficiency.
しかしながら、従来の技術（例えば、上記した特開昭
60−100352号公報及び特開昭60−79658号公報に記載の
技術）では、試料の移動方向に対して、針状電極が一定
に設定されており、イオン化効率について考慮されてい
なかった。However, the conventional technology (for example,
In Japanese Patent Application Laid-Open Nos. 60-100352 and 60-79658), the needle electrode is set to be constant in the moving direction of the sample, and the ionization efficiency is not considered.
本発明の目的は、イオン化効率の向上が可能な質量分
析装置を提供することにある。An object of the present invention is to provide a mass spectrometer capable of improving ionization efficiency.
上記目的を達成するための本発明の特徴は、試料を供
給する試料供給口と、前記供給された試料をコロナ放電
によりイオン化する針状電極と、前記針状電極を移動さ
せる移動手段と、質量分析部と、前記イオン化された試
料を前記質量分析部に取り込む取込口を有した質量分析
装置であって、前記移動手段は、前記針状電極を固定し
且つ当該針状電極と同軸方向に弾性力を有する弾性体を
内在する固定部材と、回転させることにより前記固定部
材を押圧し且つ非導電性の部材からなる押圧部材とを備
え、前記押圧部材の回転に応じて前記固定部材は前記針
状電極と同軸方向に直線的に移動することである。The features of the present invention for achieving the above object include a sample supply port for supplying a sample, a needle electrode for ionizing the supplied sample by corona discharge, a moving unit for moving the needle electrode, and a mass. An analyzer and a mass spectrometer having an inlet for taking the ionized sample into the mass analyzer, wherein the moving means fixes the needle electrode and coaxially moves with the needle electrode. A fixing member having an elastic body having elastic force therein, and a pressing member that presses the fixing member by rotating and that is made of a non-conductive member is provided, and in accordance with the rotation of the pressing member, the fixing member is It is to move linearly in the coaxial direction with the needle electrode.
上記構成によれば、針状電極を直線的に移動でき、針
状電極の先端を試料の移動路に対して好適な位置に設定
できるため、イオン化効率が容易に向上可能となる。According to the above configuration, the needle electrode can be moved linearly and the tip of the needle electrode can be set at a suitable position with respect to the moving path of the sample, so that the ionization efficiency can be easily improved.
更に、針状電極に高電圧を印加した状態でも、安全且
つ容易に針状電極の移動量を調節することが可能とな
る。Further, even when a high voltage is applied to the needle electrode, the amount of movement of the needle electrode can be adjusted safely and easily.
以下、本発明の一実施例を説明する。 Hereinafter, an embodiment of the present invention will be described.
第２図において、１は液体クロマトグラフ、２はテフ
ロンパイプ、３はジエツト噴霧器、４は脱溶媒室、５は
イオン化室、６は放電電源、７は第１細孔電極、８は第
２細孔電極、９は質量分析部である。In FIG. 2, 1 is a liquid chromatograph, 2 is a Teflon pipe, 3 is a jet nebulizer, 4 is a desolvation chamber, 5 is an ionization chamber, 6 is a discharge power source, 7 is a first pore electrode, and 8 is a second fine electrode. The hole electrode 9 is a mass spectrometer.
今、液体クロマトグラフ１より溶出する試料、および
移動組は、テフロンパイプ２を通つてジエツト噴霧器３
に送られ、ここで熱を加えられることにより霧化され
る。霧化された試料および移動相は、脱溶媒室４におい
て、気化され分子となる。Now, the sample eluted from the liquid chromatograph 1 and the moving set are passed through a Teflon pipe 2 to a jet nebulizer 3.
Where it is heated and atomized by the application of heat. The atomized sample and mobile phase are vaporized into molecules in the desolvation chamber 4.
分子となつた試料および移動相は、イオン化室５に入
り、放電電源６により発生するコロナ放電によつてイオ
ン化される。イオン化された移動相分子は、試料分子と
イオン分子反応を起こし、イオン化がまだされていない
試料分子へ、プロトンを移すことによつて試料分子をイ
オン化する（第４図の式１参照）。このイオン分子反応
によつて試料分子は、穏やかに且つ、ほぼ全ての分子が
イオン化される。The sample and mobile phase that have become molecules enter the ionization chamber 5 and are ionized by corona discharge generated by a discharge power source 6. The ionized mobile phase molecules undergo an ion molecule reaction with the sample molecules, and ionize the sample molecules by transferring protons to the sample molecules that have not yet been ionized (see Equation 1 in FIG. 4). By this ion molecule reaction, the sample molecules are gently and almost all the molecules are ionized.
イオン化された試料分子は、第１細孔７を通つて更
に、第２細孔８を通つて質量分析部９に送られ質量分析
される。The ionized sample molecules pass through the first pores 7 and further pass through the second pores 8 to the mass analyzer 9 where they are subjected to mass analysis.
次に第３図は、針電極部細を示す。 Next, FIG. 3 shows a fine needle electrode portion.
１は針電極部組、２はベースAB、３は針、４は針電極
部組とベースABを接続しているねじ、５は第１細孔電
極、６は放電電源である。1 is a needle electrode assembly, 2 is a base AB, 3 is a needle, 4 is a screw connecting the needle electrode assembly and the base AB, 5 is a first pore electrode, and 6 is a discharge power source.
今、針電極部組１は、ベースAB2に、ねじ４のねじ込
みによつて接続されている。針３を第１細孔電極５に近
づける場合は、針電極部組１の全体を、時計方向に回転
させて移動する。このとき、ねじ４のおねじと、めねじ
のすきまによつて左右に最大で約1mm程度偏芯してしま
い、イオン化の不安定要因となつていた、しかも、針先
の再現性がなく、針を移動させるたびに、イオン量が変
化していた。次に第１図は、改良形の針電極部組を示
す。Now, the needle electrode assembly 1 is connected to the base AB2 by screwing the screws 4. When the needle 3 is brought closer to the first fine electrode 5, the entire needle electrode assembly 1 is rotated clockwise to move. At this time, the gap between the external thread of the screw 4 and the internal thread was eccentric to the left and right by a maximum of about 1 mm, which was a cause of ionization instability. Each time the needle was moved, the amount of ions changed. Next, FIG. 1 shows an improved needle electrode assembly.
１は調節用回転ねじ、２は回転受ボール、３はシヤフ
ト、４は針、５はスプリング、６は針調節用ドライバ
ー、７は放電電源、８は、第１細孔電極、９は回転用ね
じである。1 is a rotary screw for adjustment, 2 is a rotating ball, 3 is a shaft, 4 is a needle, 5 is a spring, 6 is a driver for adjusting a needle, 7 is a discharge power source, 8 is a first fine electrode, and 9 is a rotation. It is a screw.
今、調節用回転ねじ１を、時計方向に回転すると、回
転用ねじ９によつて、調節用回転ねじ１が回転受けボー
ル２を押すことにより、シヤフト３が第１細孔電極８の
方向へ近づけることができる。Now, when the adjusting rotary screw 1 is rotated clockwise, the adjusting screw 1 pushes the rotation receiving ball 2 by the rotating screw 9, and the shaft 3 moves in the direction of the first fine electrode 8. You can get closer.
そして、シヤフト３の先端に針４が固定されているの
で、シヤフト３と同一方向に移動すると、第１細孔電極
８に近ずく、このように、回転運動を、直進運動に変え
ることにより、針４の偏芯を最少限にすることが可能と
なつた。Since the needle 4 is fixed to the tip of the shaft 3, when the needle 4 moves in the same direction as the shaft 3, it approaches the first pore electrode 8, and thus, by changing the rotational motion to the linear motion, The eccentricity of the needle 4 can be minimized.
又、調節用回転ねじ１を、非導電性の部品にすること
により、放電電源７に、高電圧を印加した状態でも、針
調節用ドライバー６を使用し、安全且つ、容易に、イオ
ン量を調節することが可能となつた。Further, by making the adjusting screw 1 a non-conductive part, the needle adjusting driver 6 can be used to safely and easily reduce the ion amount even when a high voltage is applied to the discharge power source 7. It is now possible to adjust.
以上説明したように、本発明によれば、針状電極の先
端を試料の移動路に対して再現性良く好適な位置に設定
できるので、イオン化効率が向上され、質量分析精度の
向上が可能となる。As described above, according to the present invention, the tip of the needle-shaped electrode can be set at a suitable position with good reproducibility with respect to the movement path of the sample, so that ionization efficiency is improved and mass analysis accuracy can be improved. Become.
また更に、針状電極に高電圧を印加した状態でも針状
電極の移動量を調節することが可能となるため、針状電
極の位置調節の安全性及び容易性が一段とできる。Furthermore, since the amount of movement of the needle electrode can be adjusted even when a high voltage is applied to the needle electrode, safety and ease of position adjustment of the needle electrode can be further improved.
第１図は改良形の針電極部組の内部構成図、第２図は本
発明の内部構成図、第３図は針電極部組の内部構成図、
第４図はイオン化原理の反応式を示す図である。 １……調節用回転ねじ、２……回転受ボール、３……シ
ヤフト、４……針、５……スプリング、６……針調節用
ドライバー、７……放電電源、８……第１細孔電極、９
……回転用ねじ。1 is an internal configuration diagram of an improved needle electrode assembly, FIG. 2 is an internal configuration diagram of the present invention, FIG. 3 is an internal configuration diagram of the needle electrode assembly,
FIG. 4 is a diagram showing a reaction formula based on the ionization principle. DESCRIPTION OF SYMBOLS 1 ... Rotating screw for adjustment, 2 ... Rotating ball, 3 ... Shaft, 4 ... Needle, 5 ... Spring, 6 ... Driver for adjusting needle, 7 ... Discharge power supply, 8 ... First fine Hole electrode, 9
.... Rotating screw.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) H01J 27/02 G01N 27/62 H01J 37/08 H05H 1/26 ──────────────────────────────────────────────────の Continued on the front page (58) Field surveyed (Int.Cl. 7 , DB name) H01J 27/02 G01N 27/62 H01J 37/08 H05H 1/26
Claims (3)
れた試料をコロナ放電によりイオン化する針状電極と、
前記針状電極を移動させる移動手段と、質量分析部と、
前記イオン化された試料を前記質量分析部に取り込む取
込口を有した質量分析装置であって、 前記移動手段は、前記針状電極を固定し且つ当該針状電
極と同軸方向に弾性力を有する弾性体を内在する固定部
材と、回転させることにより前記固定部材を押圧し且つ
非導電性の部材からなる押圧部材とを備え、 前記押圧部材の回転に応じて前記固定部材は前記針状電
極と同軸方向に直線的に移動することを特徴とする質量
分析装置。1. A sample supply port for supplying a sample, a needle electrode for ionizing the supplied sample by corona discharge,
Moving means for moving the needle-shaped electrode, and a mass analyzer,
A mass spectrometer having an inlet for taking the ionized sample into the mass spectrometer, wherein the moving means fixes the needle electrode and has an elastic force in a coaxial direction with the needle electrode. A fixing member having an elastic body therein, and a pressing member which presses the fixing member by rotating and is made of a non-conductive member is provided. According to the rotation of the pressing member, the fixing member is connected to the needle-shaped electrode. A mass spectrometer characterized by moving linearly in a coaxial direction.
することにより前記針状電極と同軸方向に移動すること
を特徴とする質量分析装置。2. The mass spectrometer according to claim 1, wherein the pressing member is a rotary screw, and the rotary screw moves coaxially with the needle electrode by rotating.
分析装置。3. The mass spectrometer according to claim 1, wherein the elastic body is a spring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2244002A JP3058664B2 (en) | 1990-09-17 | 1990-09-17 | Mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2244002A JP3058664B2 (en) | 1990-09-17 | 1990-09-17 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04126338A JPH04126338A (en) | 1992-04-27 |
| JP3058664B2 true JP3058664B2 (en) | 2000-07-04 |
Family
ID=17112255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2244002A Expired - Lifetime JP3058664B2 (en) | 1990-09-17 | 1990-09-17 | Mass spectrometer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3058664B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7652693B2 (en) | 2002-09-30 | 2010-01-26 | Panasonic Corporation | Portable telephone capable of recording a composite image |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103760221B (en) * | 2014-02-14 | 2015-12-02 | 厦门大学 | A kind of needle point electric discharge device degraded for solid surface |
-
1990
- 1990-09-17 JP JP2244002A patent/JP3058664B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7652693B2 (en) | 2002-09-30 | 2010-01-26 | Panasonic Corporation | Portable telephone capable of recording a composite image |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04126338A (en) | 1992-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0762473B1 (en) | Mass spectrometer and mass spectrometry for analysing compounds contained in a solution | |
| JP5073168B2 (en) | A fast combined multimode ion source for mass spectrometers. | |
| WO2009146396A1 (en) | Single and multiple operating mode ion sources with atmospheric pressure chemical ionization | |
| JP4581184B2 (en) | Mass spectrometer | |
| JP4415490B2 (en) | Liquid chromatograph mass spectrometer | |
| JP3424376B2 (en) | Liquid chromatograph mass spectrometer | |
| JP3058664B2 (en) | Mass spectrometer | |
| JP2003215101A (en) | Liquid chromatographic mass spectrometer | |
| JP3846417B2 (en) | Atmospheric pressure ionization mass spectrometer | |
| US20040164241A1 (en) | Mass analyzer having improved mass filter and ion detection arrangement | |
| US4808819A (en) | Mass spectrometric apparatus | |
| Thompson et al. | Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler | |
| JPH08297112A (en) | Liquid chromatograph mass spectrometer | |
| JP6747602B2 (en) | Ion source and ion analyzer | |
| WO2017090895A1 (en) | Ionization mass spectrometry method and mass spectrometry device using same | |
| JPH02135655A (en) | Atmospheric pressure ionized mass spectrometer | |
| CA2474836C (en) | Mass spectrometer | |
| Smith et al. | Design and development of an interchangeable nanomicroelectrospray source for a quadrupole mass spectrometer | |
| WO2021234846A1 (en) | Ion analyzer | |
| CN217062017U (en) | Mass spectrum equipment | |
| JPH0542609Y2 (en) | ||
| JP2720034B2 (en) | Chromatographic mass spectrometer | |
| WO2023089685A1 (en) | Mass spectrometer and mass spectrometer control method | |
| JPH1164289A (en) | Liquid chromatograph mass spectrometer | |
| JPH0943201A (en) | Liquid chromatograph mass spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080421 Year of fee payment: 8 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090421 Year of fee payment: 9 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090421 Year of fee payment: 9 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100421 Year of fee payment: 10 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110421 Year of fee payment: 11 |
|
| EXPY | Cancellation because of completion of term | ||
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110421 Year of fee payment: 11 |