JP3077019B2 - Excretion enhancer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an excretion enhancer using Hakutsuru Reishi.

[0002]

2. Description of the Related Art Excretion disorders such as oliguria, diuresis, dysuria and constipation are very painful in themselves, and include uremia, electrolyte abnormality, palpitations, abdominal pain, anorexia, and breakouts. It is known to cause serious secondary disability to the human body. Such excretion disorders may be caused by organic disorders of the urinary and digestive organs, or may be caused by psychological causes such as stress. Therapeutic agents for excretion disorders include parasympathetic stimulants such as β-blockers, sympathetic nerve suppressants such as α-blockers, diuretics such as thiazides, and large intestinal irritants, small intestinal irritants, infiltration, and various other types. Laxatives have been used, but frequent occurrences of, for example, irritability, nausea, vomiting, dizziness, abdominal pain and other side effects have been pointed out in proportion to their effectiveness (Pocket Drug Collection 1989).
Year Edition, pp. 150-152, 247-249, 57
0, Shirabunsha, 1989). Excretion disorders caused by psychological causes are relatively mild in many cases, and in such cases, drugs having no side effect even with a mild therapeutic effect are more useful. For example, if a leaf root vegetable or a wild grass that has been used as a safe food or a health food has been found to have such an effect, high versatility is expected.

[0003] Rhinacanthus nasuta (L.) Kur
z) is an evergreen shrub belonging to the linaceae of the genus Linacanthus, which is native to the Deccan Plateau in southern India, and its entire plant (linacanthus) is known to have antibacterial activity against anthelmintic, anti-inflammatory and skin fungi. (Primary Color Makino Kazoku Herb Encyclopedia, p. 492, Hokuryukan, 1988), is mainly used as a herbal medicine in China, Taiwan, etc., and also recently in Japan. However, it is not known that the white and / or organic solvent extract of Hakutsuru reishi or Hakutsuru reishi has an excretion promoting effect.

[0004] Reishi (Ganoderma lucidum), also known as Ganoderma lucidum, is a basidiomycete fungus belonging to the genus Asternaceae, which grows in various parts of Japan. Powders of this kind are used for weak fatigue, insomnia, nervous breakdown, indigestion,
It is said to be effective for bronchial diseases, etc. (China Pharmaceutical Dictionary, Vol. 4, pp. 2731-2733, Shogakukan, 198
5 years), used as medical and health food.
Houttuynia cordana Thumberg
It is a perennial plant commonly found in Honshu, Shikoku, Kyushu and Okinawa, belonging to the genus Dokudami. It is said that the water immersion liquid has an antihypertensive effect, the decoction has a diuretic and defecation effect, and it is said that it has an antibacterial and antibacterial effect. 1, Hokuryukan, 1988), which is also used as a medical and health food.

[0005]

DISCLOSURE OF THE INVENTION The present inventors have attempted to obtain a product of Hakutsuru Reishi, which is conventionally used as a Chinese medicine, in a form that is healthy and easy to take. A questionnaire survey was conducted on the feeling of use after adding dokudami to make tea and drinking it for a specified number of people, and surprisingly, a large number of people who reported excretion promoting effects such as diuresis and bowel movement were recognized . Based on these results, the present inventors further investigated each raw material, and found out that they had an excellent excretion promoting action, especially from Hakutsuru Reishi, and completed the present invention.

[0006]

SUMMARY OF THE INVENTION The present invention provides an excretion enhancer comprising a water and / or organic solvent extract of Hakutsuru reishi as a main component, and a remedies comprising Hakutsuru reishi and reishi and / or dokudami. An excretion enhancer characterized in that it contains water and / or an organic solvent extract of a mixture of the above as a main component.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION As the white cranes used in the present invention, commercially available leaves, whole plants (aboveground parts) or a mixture of these with roots may be used. Preferably, these are sun-dried and / or drum-dried and pulverized with a pulverizer to 20 mesh or less, preferably 12 mesh or less. If necessary, this Hakutsuru Reishi may be obtained by sun-dried and / or drum-dried and roasted by a roaster.

[0008] As the reishi used in the present invention, a commercially available fruit body, preferably an umbrella portion thereof, is dried and ground using a pulverizer to a size of 20 mesh or less, preferably 12 mesh or less. If necessary, this reishi is dried and pulverized and roasted with a roaster for use. The amount of roasted reishi used is 1 to 30% by weight, preferably 10 to 20% by weight, and most preferably 15% by weight based on Hakutsuru reishi.
Is the ratio of

Further, as for the dokudami used in the present invention, commercially available leaves, whole plants (aboveground parts) or a mixture of these with roots, preferably whole plants, may be used. These materials are dried, pulverized, and pulverized by a pulverizer to a size of 20 mesh or less, preferably 12 mesh or less. If necessary, this dokudami is roasted with a roaster and used. The amount of roasted Reishi used is 1 for Hakutsuru Reishi
%, Preferably 10 to 20%, most preferably 15% by weight.

[0010] The white crane reishi, reishi and dokudami used in the present invention are not individually treated, but are obtained by mixing the dried and crushed materials, roasting if necessary, and classifying them to a predetermined mesh or less. You may make it.

The thus-obtained excretion enhancer according to the present invention is obtained by extracting the thus-obtained Hakutsuru Reishi or a mixture of Hakutsuru Reishi with Reishi and Dokudami in a predetermined ratio with water and / or an organic solvent. Get.

In the present invention, the water used for the extraction includes cooling water, room temperature water and hot water.

In the present invention, the organic solvent used for extraction includes ethanol, methanol, propanol,
Alcohols such as 1,3-butylene glycol, ethers such as dimethyl ether, diethyl ether and methyl ethyl ether, ketones such as acetone, phenols such as benzene, hexane, heptane, liquid paraffin,
Examples thereof include hydrocarbons such as squalane and the like, and these can be used alone or as a mixture of two or more.

The resulting water and / or organic solvent extract of Hakutsuru Reishi or Hakutsuru Reishi with the addition of Reishi and Dokudami is odorless to slightly fragrant, having a distinctive rich taste and a clear, green color. It is a brown to deep green liquid and may be used as it is. However, it is preferably purified by filtration, centrifugation, or other methods, and further appropriately concentrated by means such as distillation. Further, this extract may be used as a transparent green-brown to deep green fine powder having an odorless or slight aroma and a unique rich taste obtained by further treatment by distillation to dryness, freeze-drying or the like. It is possible.

Next, the present invention will be described with reference to Examples, Comparative Examples and Test Examples, which do not limit the technical scope of the present invention.

Example 1 Sun-dried and then drum-dried Hakutsuru Reishi whole plant (sold by Daikyo Bussan Co., Ltd .; hereafter the same place for purchasing Hakutsuru Reishi) 1k
g is crushed by a crusher, roasted in a roaster, and further crushed, and the obtained crushed material is sieved and classified to 12 mesh or less to obtain about 0.8 kg of a ground crushed white crane Reishi. Was. Approximately 1 kg of dried, crushed and roasted dokudami whole plant (sold by Yamamoto Pharmaceutical Co., Ltd .; hereafter dokudami is purchased from)
Was again pulverized by a pulverizer, put in a roaster and roasted, and then classified to 12 mesh or less to obtain about 0.8 kg of ground pulverized whole plant. Approximately 1 kg of dried and ground Lingzhi seeds (sold by Kyoritsu Pharmaceutical Co., Ltd .; the same place for purchasing Lingzhi) is again ground and roasted, and then classified into 12 mesh or less to form Lingzhi seeds. About 0.8 kg of pulverized material was obtained. To 2.0 g of the ground white cranes of Reishi grass, 0.3 g of ground crushed dokudami whole plant and 0.2 g of ground crushed Lingzhi fruit body were mixed to produce 2.5 g of a mixture. This mixture is added to hot water 1
Dipped in 00ml, filtered and slightly jasmine-like fragrance,
A green-brown transparent liquid extract with a unique rich taste was obtained.

Example 2 2.5 g of ground white ground crane Reishi was immersed in 100 ml of water.
Filtration gave a clear, greenish-brown liquid extract with a slight aroma and a unique rich taste.

Example 3 2.5 g of the ground leaf of Hakutsuru Reishi was immersed in 100 ml of ethanol and filtered to obtain a deep green transparent liquid extract with a slight aroma and a unique rich taste. .

EXAMPLE 4 2.5 g of ground crumbs of white crane reishi leaves, stems and roots were immersed in 100 ml of 1,3-butylene glycol and filtered to give a deep green color with a slight aroma and a unique rich taste. A clear liquid extract was obtained.

EXAMPLE 5 2.4 g of a mixture of 2.0 g of ground and white ground crane reishi leaves and roots and 0.4 g of ground pomegranate whole plant was immersed in 100 ml of 1: 1 ethanol water and filtered to give a slight aroma. A deep green transparent liquid extract with a unique rich taste was obtained.

EXAMPLE 6 2.0 g of ground crushed white crane ganoderma leaf and 0.4 g of partially ground ganoderma umbrella
Was immersed in 100 ml of hot water and filtered to obtain a green-brown transparent liquid extract with a slight aroma and a unique rich taste.

Example 7 Example 3 except that acetone was used instead of ethanol
To give a deep green transparent liquid extract with a slight aroma and a unique rich taste.

Example 8 Example 3 except that ether is used instead of ethanol
To give a deep green transparent liquid extract with a slight aroma and a unique rich taste.

Example 9 Example 3 except that benzene was used instead of ethanol
To give a deep green transparent liquid extract with a slight aroma and a unique rich taste.

Example 10 Sun-dried and then drum-dried whole grass and roots of Hakutsuru Reishi were crushed by a crusher, roasted by a roaster, and further crushed. It is sieved and classified to 12 mesh or less.
Except to obtain g, treat in the same manner as in Example 1 to give a slight aroma,
A green-brown transparent liquid extract with a unique rich taste was obtained.

Example 11 100 ml of the extract obtained by treating in the same manner as in Example 1 was freeze-dried to obtain about 1 mg of a greenish brown fine powder having a slight aroma and a unique rich taste. .

Example 12 100 ml of the extract obtained by treating in the same manner as in Example 2 was freeze-dried to obtain about 1 mg of a greenish brown fine powder having a slight aroma and a unique rich taste. .

Example 13 100 ml of the extract obtained in the same manner as in Example 3 was freeze-dried to obtain about 1 mg of a deep green fine powder having a slight aroma and a unique rich taste. .

Example 14 100 ml of the extract obtained in the same manner as in Example 4 was freeze-dried to obtain about 1 mg of a deep green fine powder having a slight aroma and a unique rich taste. .

Comparative Example 1 Approximately 1 kg of dried, ground and roasted dokudami whole plant
Again crushed by a crusher and roasted in a roaster,
This was classified to 12 mesh or less to obtain about 0.8 kg of ground pulverized whole plant. Further, about 1 kg of the dried and ground Lingzhi fruit body was again ground and roasted, and then classified to 12 mesh or less to obtain about 0.8 kg of ground Lingzhi fruit body.
1.2 g of this ground pulverized whole plant and 1.3 g of ground ground Lingzhi fruit body were mixed to produce 2.5 g of a mixture. This mixture was immersed in 100 ml of hot water and filtered to obtain a brown transparent liquid extract with a slight aroma and a unique taste.

Test Example 1 The efficacy of a liquid extract obtained in the same manner as in Example 1 was investigated by a questionnaire method using 37 volunteer monitors, and the extract had an excretion promoting effect. Was found. The test was performed using 2.0 g of the ground white grass crucible Reishi ground obtained by the method of Example 1 and 0.3 g of the ground pulverized whole grass shrub.
g and a mixture of 0.2 g of ground granulated Lingzhi fruit bodies are packaged in a tea bag, and 25 bags are given to each monitor, and each bag is immersed in about 100 ml of hot water for 25 days for extraction. The solution was allowed to be drunk, and a questionnaire was taken on the last day. As a control, for the next 25 days, using the same 37 volunteer monitors, 1.2 g of ground pulverized dokudami obtained by the method of Comparative Example 1 and 1.3 g of ground pulverized Lingzhi fruit body were mixed. Each subject was given 25 bags of 2.5 g packed in a tea bag, and the same treatment was performed as described above. In the questionnaire survey, the specific contents were freely described except for checking whether the flavor was good or bad, ease of drinking, effects, and the presence or absence of side effects. The results are shown in Table 1. As for the effect, 19 cases except 6 cases of no response in the first test were valid, and there were cases in which diuresis and improvement of bowel movement were specified as specific contents of the described effect. More were observed compared to controls. As described above, the decoction of dokudami is said to have diuretic and bowel movements. However, in this test, the extract of Example 1 contains 1/4 the dokudami component of the extract of Comparative Example 1. Considering the fact that is contained, it is suggested that the other components still have an excretion promoting action exceeding that of the dokudami component.

[0031]

[Table 1]

Test Example 2 The efficacy of a liquid extract obtained in the same manner as in Example 2 was investigated by a questionnaire method using 20 volunteer monitors, and the extract had an excretion promoting effect. Was found. The test was for the whole plant grounds of Hakutsuru Reishi 2.5
g in a tea bag packaged on 10 monitors
Give 5 capsules each, soak one extract per day in about 100 ml of water for 25 days, drink the extract, and make a questionnaire survey in the same manner as in Test Example 1 except that the extract is checked for diuresis and bowel movement. Made by the way. As a control, 10 monitors were provided with 25 packs of dokudami tea (contents: 3 g) packaged in a commercially available tea bag and tested in the same manner as described above. Table 2 shows the results. Although one person inadvertently discontinued drinking in the Hakutsuru Reishi group, the excretion promoting effect was superior to that of the control group. There were no complaints of side effects from any of the 20 monitors. 9 excluding
Of the five monitors, 5 had a diuretic effect (55.5)
%), And 4 persons who had a bowel movement effect (44.4%) showed good excretion promoting action.

[0033]

[Table 2]

Test Example 3 Deep green fine powder 1 obtained in the same manner as in Example 3
The excretion promoting effect of the ethanol extract of the whole plant of Hakutsuru Reishi was tested in the same manner as in Test Example 2 except that mg was wrapped in medicine wrapping paper (the control group was omitted). As a result, of the 10 monitors, 5 (50.0%) had a diuretic effect,
Good excretion promoting action was observed in three subjects (30.0%) who had a bowel movement effect. No adverse reactions were reported by any of the 10 monitors.

Except that 1 mg of a deep green fine powder obtained by treating in the same manner as in Example 4 was wrapped in a paper wrapper,
In the same manner as in Test Example 3, the effect of promoting the excretion of ethanol extract from the whole plant of Hakutsuru Reishi was tested. As a result, out of the 10 monitors, 4 (40.0%) had a diuretic effect and 3 (30.0%) had a bowel movement effect, and a favorable excretion promoting effect was observed. No adverse reactions were reported by any of the 10 monitors.

[0036]

Industrial Applicability The excretion enhancer of the present invention has an excellent excretion promoting action and is highly safe because it is an extract of water and / or organic solvent of a natural product. There are benefits that have no detrimental effects. In addition, since it has a flavor suitable for daily eating and drinking that makes use of the characteristics of Hakutsuru Reishi, Reishi and Dokudami used as necessary, it is good for human health and versatility that does not get tired even after long-term use High product. ================================================== == 1995-12-19 11:15:40 << Start >> D: \ 6RINYOU.TXT << End >> D: \ 6RINYOU.TXT ________________________________________________________________________ ================ ===================================== 1995-12-19 11:41:06 << Start >> F: \ 6RINYOU.TXT << End >> F: \ 6RINYOU.TXT _________________________________________________________________________ =============================== ====================== 1995-12-19 18:34:07 << Start >> D: \ 6RINYOU.TXT << End >> D: \ 6RINYOU.TXT ________________________________________________________________________

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ identification code FI A61P 1/10 A61P 1/10 7/10 7/10 (58) Investigated field (Int.Cl. ⁷ , DB name) A61K 35 / 78 A23L 1/28 A23L 1/30 A61K 35/84 BIOSIS (DIALOG) CA (STN) MEDLINE (STN)

Claims (2)

(57) [Claims] 1. An excretion enhancer comprising a water and / or organic solvent extract of Hakutsuru Reishi as a main component. 2. An excretion enhancer comprising, as a main component, a water and / or organic solvent extract of a mixture of Hakutsuru Reishi and Reishi and / or Dokudami.