JP3157128B2 - Sheet for polypropylene press-through pack - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a PTP commonly used for packaging solid preparations in the field of pharmaceutical packaging.
It relates to a polypropylene sheet for (press through pack).

[0002]

2. Description of the Related Art In the field of pharmaceutical packaging, PTP packaging, which is generally used for packaging solid tablets such as tablets and capsules, is mainly made of rigid polyvinyl chloride in terms of transparency, moldability, rigidity, and cost. Is used as a bottom material, the bottom material is formed into a pocket shape, and a solid agent (tablet,
Capsules) and sealed with a lid made of aluminum foil, which was put into practical use and widespread in the early 1960s.

[0003] Most of the tablets, capsules, etc., which are the contents, are deteriorated or deformed due to the absorption of moisture.
This has been dealt with by providing secondary packaging such as pillow packaging with a composite film containing aluminum foil, or by using a sheet made of a rigid polyvinyl chloride sheet that is composited with a coating of polyvinylidene chloride resin with excellent moisture resistance. These are expensive and have a problem in cost. In addition, the tendency of polyvinyl chloride resin to be avoided due to the problem of disposal is increasing. In recent years, sheets made of polypropylene resin, which is an olefin-based resin, have been attracting attention for their moisture-proof properties, low cost, and easy processing.
It has been used as a TP packaging sheet.

[0004] However, polypropylene as a PTP sheet has a problem in that the range of molding conditions is narrower than polyvinyl chloride, and there is a problem in terms of appearance due to curling of the product or compatibility with an automatic packaging line. These problems are attributable to the fact that polypropylene is a crystalline resin, and attempts have been made to increase the crystallinity of polypropylene in order to improve curl, using a nucleating agent or slow cooling during sheeting. In addition, methods such as annealing the sheet were performed, but the moldability was conversely deteriorated, and was not suitable for actual use. Attempts have also been made to reduce the degree of crystallinity by quenching during sheeting in order to improve the formability. However, in this method, the stiffness of the sheet is significantly reduced, and the sheet cannot be used for practical use. In order to improve the moldability, a method of suppressing crystallinity by adding a petroleum resin to a homopolymer of polypropylene has been adopted, but this method has a disadvantage that the impact resistance is significantly impaired. .

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made as a result of conducting various studies to solve the above-mentioned problems in the polypropylene-based PTP sheet. An object of the present invention is to provide a polypropylene-based PTP sheet which is wide, has little curl, and is excellent in transparency and moisture resistance required for PTP packaging.

[0006]

According to the present invention, there is provided a three-layered PP-based sheet having a thickness of 0.15 to 0.45 mm, wherein both outer layers have a thickness of 0.005 to 0.095 mm and ethylene-propylene A resin composition comprising a block copolymer, wherein the intermediate layer comprises an ethylene-propylene block copolymer and a petroleum resin;
The present invention relates to a PP-based PTP sheet characterized by having a crystallinity of 2 to 30% by a line diffraction method. More preferably, the present invention relates to a polypropylene-based PTP sheet in which the amount of the petroleum resin in the intermediate layer is 5 to 30% by weight based on the total resin amount, and the petroleum resin is a hydrogenated petroleum resin.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION As the ethylene-propylene block copolymer used in the outer layer and the intermediate layer of the present invention, any polymerization method such as a solvent polymerization method, a bulk polymerization method, a gas phase polymerization method, etc. For example, the catalyst may be manufactured using a titanium trichloride catalyst, a magnesium chloride-supported catalyst, a metallocene catalyst, or the like. In addition, nucleating agents, antistatic agents, UV absorbers,
Additives such as lubricants and antioxidants may be added.
The amount of ethylene / propylene / rubber in the ethylene-propylene block copolymer is not particularly limited, but is preferably in the range of 3 to 30% by weight. ethylene·
If the propylene rubber amount is less than 3% by weight, the impact resistance is poor, and if it exceeds 30% by weight, the moisture resistance is impaired, which is not preferable.

[0008] The petroleum resin used for the intermediate layer of the present invention comprises:
A dicyclopentadiene resin obtained by thermally polymerizing a cyclopentadiene fraction, an aromatic (C9) petroleum resin obtained by cationic polymerization of a C9 aromatic olefin mixture, and an aliphatic (C5) obtained by cationic polymerization of a C5 chain olefin mixture. System) Petroleum resins and copolymers or blends of at least two components selected from these, furthermore, hydrogenated petroleum resins, and blends of at least two components selected from hydrogenated petroleum resins. Among them, a hydrogenated petroleum resin excellent in color tone, odor and stability is preferable, and a dicyclopentadiene-based hydrogenated petroleum resin is more preferable.

The softening point of petroleum resin is 50 to 16
0 ° C. is preferable, and more preferably 100 to 16 ° C.
The molecular weight is 0 ° C., and the molecular weight is preferably 3000 or less, more preferably 1000 or less. If the softening point of the petroleum resin is less than 50 ° C., there is a problem of elution, and if it exceeds 160 ° C., there is a problem that moldability deteriorates. If the molecular weight of the petroleum resin exceeds 3,000, there is a problem that moldability deteriorates.

The amount of petroleum resin added to the intermediate layer is 5 to 30% by weight, preferably 10 to 25% by weight, and more preferably 15 to 20% by weight. If the addition amount of the petroleum resin is less than 5% by weight, the moldability of PTP will be poor, and if it exceeds 30% by weight, it is not preferable in terms of cost and hygiene.

The thickness of the polypropylene-based PTP sheet of the present invention is 0.15 to 0.45 mm, preferably 0.20 to 0.40 mm, and more preferably 0.1 to 0.40 mm.
23 to 0.35 mm. If the thickness is less than 0.15 mm, the stiffness of the sheet is weakened, the curl is increased, and the appearance is poor. On the other hand, if the thickness exceeds 0.45 mm, the sheet becomes hard and the push-through property deteriorates. The thickness of both outer layers of the present invention is 0.005 to 0.095 mm, and more preferably 0.01 to 0.06 mm.
If the thickness of the outer layer is less than 0.005 mm, there is a problem of elution of the petroleum resin from the intermediate layer, which is not preferable. Also, 0.09
If it exceeds 5 mm, the moldability deteriorates, which is not preferable.

[0012] The crystallinity of the polypropylene-based PTP sheet according to the present invention by wide-angle X-ray diffraction is 2 to 30%, more preferably 2 to 20%. As a method of measuring the crystallinity by the wide-angle X-ray diffraction method, the measurement conditions are as follows: tube voltage = 50 (kv), tube current = 200 (mA), angle measurement range = 5 to 60 (deg), detector scanning speed = 4 (de
g / min), X-ray irradiation is performed from the sheet surface,
The crystallinity is calculated from the following equation using the total integrated intensity (A) of the crystalline peak of the obtained diffraction angle versus the diffraction intensity curve and the integrated intensity (B) of the amorphous halo. Crystallinity (%) = (A / (A + B)) × 100 If the crystallinity is less than 2%, the moisture-proof property becomes poor, so that it is not preferable as a sheet for PTP, and if it exceeds 30%, the moldability deteriorates. Not preferred.

The method of producing a three-layer sheet in the present invention is not particularly limited, but is a co-extrusion method in which the resin is melt-extruded by several extruders and led to a multilayer die or a feed block to form a sheet. It is used in combination with a dry lamination method, an extrusion lamination method in which a single-layer sheet or film forming each layer is laminated using an appropriate adhesive, and a combination of these methods.

[0014]

【Example】

(Examples 1 to 5, Comparative Examples 1 and 2)
It was melt-extruded from a multi-layer co-extrusion die (three-layer multi-manifold die) to produce a three-layer sheet having a layer configuration of 0.30 mm in thickness consisting of polypropylene / polypropylene + petroleum resin / polypropylene. The thickness of each layer is 0.015
/0.27/0.015 mm.

The raw materials used are as follows. <For outer layer> PP-1: Ethylene-propylene block copolymer (ethylene / propylene rubber [hereinafter abbreviated as EPR] amount = 10% by weight, MFR = 2.5) <For intermediate layer> PP -2: Block copolymer of ethylene-propylene (EPR amount = 10% by weight, MFR = 0.6)-Petroleum resin-1: Dicyclopentadiene-based hydrogenated petroleum resin-Petroleum resin-2: Aliphatic hydrogenation Petroleum resin ・ Petroleum resin-3: Aliphatic petroleum resin (non-hydrogenated)

The composition of the intermediate layer is as shown in Table 1.

[Table 1]

Comparative Example 3 Instead of PP-1 in Example 2, propylene homopolymer (MFR = 2.3), PP-2
Was replaced with a propylene homopolymer (MFR = 0.5), and the other sheets were the same as in Example 2. (Comparative Example 4) The composition of the outer layer and the intermediate layer was the same as in Example 2, and a three-layer sheet having a thickness of each layer of 0.1 / 0.1 / 0.1 mm was produced in the same manner as in Example 1.

Table 2 shows the evaluation results of the sheets obtained in Examples 1 to 5 and Comparative Examples 1 to 4 by the following methods.
Examples 1 to 5 satisfy all the evaluations, but Comparative Examples 1, 2, 3, and 4 are inferior in crystallinity, moldability, and impact resistance.

[Table 2]

Crystallinity: measured by a wide-angle X-ray diffraction method. -PTP moldability: In a PTP molding machine (FBP-M2 manufactured by CKD Corporation),
Using a tablet type (diameter 10mmφ, depth 5mm)
Forming, forming temperature range, uniformity of forming pocket thickness distribution, aluminum seal, curl after punching, etc. were comprehensively evaluated. -Transparency; JIS-K-7105 for the internal haze of the sheet
It measured based on. -Impact resistance: 23 in accordance with JIS K7211
The DuPont impact value at ° C. was measured.

[0020]

The PP-based PTP sheet of the present invention improves the formability and impact resistance, which are the conventional problems of the poppypropylene-based sheet, and is widely used as a PTP sheet. Useful as a replacement for PVC.

Claims (6)

(57) [Claims] The thickness of the three layers is 0.15 to 0.45.
mm polypropylene- based sheet, both outer layers each have a thickness of 0.005 to 0.095 mm and are made of an ethylene-propylene block copolymer, and the intermediate layer is ethylene-propylene.
A resin composition containing the block copolymer and petroleum resin propylene, Poripuropi the crystallinity by wide-angle X-ray diffraction of the sheet is characterized in that it is a 2-30%
Sheet for Len press-through pack . 2. The polypropylene system according to claim 1, wherein the amount of the petroleum resin in the intermediate layer is 5 to 30% by weight based on the total amount of the resin.
Sheet for press-through pack . 3. The polypropylene press according to claim 1, wherein the petroleum resin of the intermediate layer is a hydrogenated petroleum resin.
Lupac sheet. 4. The polyhydric resin according to claim 3, wherein the hydrogenated petroleum resin in the intermediate layer is a hydrogenated dicyclopentadiene petroleum resin, an aromatic petroleum resin, or a hydrogenated petroleum resin.
Sheet for propylene press-through pack . 5. The hydrogenated petroleum resin of the intermediate layer is a hydrogenated product of a copolymer of at least two components selected from dicyclopentadiene petroleum resin, aromatic petroleum resin, and aliphatic petroleum resin. 3. Polypropylene pre - press
Sheet for through-pack . 6. The hydrogenated petroleum resin of the intermediate layer is at least two components selected from hydrogenated dicyclopentadiene petroleum resin, hydrogenated aromatic petroleum resin, and hydrogenated aliphatic petroleum resin. 4. A blend of
The sheet for a polypropylene- based press-through pack described in the above.