JP3167777B2 - Antiviral, antibacterial and bactericide - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antiviral agent, an antibacterial agent and a bactericidal agent containing as an active ingredient an ingredient of Asparasacea linealis belonging to the legume family.

[0002]

2. Description of the Related Art Conventionally, many antibacterial agents and bactericides are known.

[0003]

However, most of these substances act on bacteria, and those that act on viruses or molds are not well known, and their efficacy is weak and they have side effects. There are many things that are dangerous to the human body.

There are many viral diseases such as influenza, hepatitis, measles, Japanese encephalitis, adult T-cell leukemia and AIDS, but there are not many drugs effective against such viruses, and The effect is not clear, and there is no known effect which is particularly effective against retroviruses such as adult T-cell leukemia or AIDS virus.

[0005] Further, there is no known antiviral, antibacterial or bactericidal agent which has no harm to the human body, can be eaten and consumed daily and has a preventive effect.

An object of the present invention is to provide an antiviral, antibacterial and bactericidal agent which solves the above-mentioned problems, is effective against retroviruses, has no side effects, and has a preventive effect.

[0007]

Means for Solving the Problems Accordingly, the present inventors have:
As a result of intensive studies to solve the above-mentioned object, asparathus linealis extract belonging to the legume family has a strong antiviral, antibacterial and bactericidal action, and is a safe anti- body with no side effects on the human body and livestock. The present invention was completed based on the finding that it was a virus or an antibacterial / bactericidal agent.

[0008] The active ingredient of the present invention comprises an extract of Asparathus linealis, which is extracted by extracting leaves or stems of Asparathus linealis with water and / or an organic solvent, and extracting the extraction solvent from the extract. , Or by pulverizing the leaves or stems of Asparasas linealis. Moreover, you may extract similarly to the manufacturing method of normal Japanese tea, Chinese tea, black tea, etc.

In the case of extraction with water, it is preferable to add 50 to 1000 times the amount of water of Asparasaceae linealis, and after boiling, extract by boiling for about 5 to 30 minutes. In addition, when extracting the tea in the same manner as ordinary tea, use hot water at 80 to 100 degrees, which is 50 to 500 times the dried leaves of Asparasacea lineas, and
Leave for about 30 minutes to obtain an extract.

Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for the extraction. In addition, for separation of the extract, conventional means such as decantation and centrifugation can be used.

The extraction solvent can be distilled off by conventional means such as freeze-drying. In addition, asparasas linealis itself can be crushed and powdered for use.

The composition is obtained by mixing the active ingredient with physiologically acceptable carriers, excipients, binders and diluents, for example, granules, powders, hard capsules, soft capsules, coatings and syrups. , Suppositories, orally or parenterally as injections, or mixed as is, solutions, powder granules, tablets,
It may be administered alone in an arbitrary form such as an emulsion or jelly, a concentrated solution may be used, or mixed with other food and drink.

The dosage varies depending on the type and degree of the disease to be treated, but when it is commonly used as a drink, it is 1 to 5 g.
It is preferable to eat and drink 100 ml / l solution / day to 100 ml / day.

Asparasas linealis had no deaths in an acute toxicity test on rats, and no abnormalities were observed in biochemical blood tests and histopathological tests.

[0015]

[Effect] The present invention is to provide an antiviral, antibacterial and bactericidal agent which suppresses the growth of various microorganisms such as viruses, bacteria and molds, sterilizes it, has an effect on retroviruses, has no side effects and has a preventive effect. Can be.

[0016]

【Example】

Production example The leaves (with stem) of the collected asparasas linealis are
After cutting to a length of 5 mm, the leaves are subjected to rolling, enzymatic fermentation, and sun drying to obtain dried leaves. 1-5 g of dried leaves in 1.5-
The mixture was boiled with 2 l for 5 to 30 minutes to obtain an extract.

Example 1 The extract obtained in the Production Example was sterilized, added to an agar culture site, and examined for a normal control group and the growth of microorganisms. Table 1 shows the results.

[Table 1]

After the extract obtained in the Production Example was sterilized, chicken eggs were infected with an influenza virus, and the degree of virus proliferation was examined. Table 2 shows the results.

[Table 2]

After sterilizing the extract of Asparagus lineaealis obtained in the production example, the extract was added to the medium at various dilution concentrations, and the growth status of the bacteria shown in Table 3 was examined. Are shown in Table 3.

[Table 3]

The results of the chemical analysis of Asparasas linearis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoid 41 0.000 mg / 100 g SOD titer 69000 units / g Acid-insoluble protein component 150 mg / 100 g Flavor component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g

As fragrance components, carbonyl compounds (15%), carotenoid decomposition products (17%),
To 12 organic acids (22%), phenol compounds (13
%), An aromatic oxygen compound (7%), an aromatic hydrocarbon (5.5%), a terpenoid (4%), and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.

────────────────────────────────────────────────── ─── Continued on the front page Examiner Hideki Tsurumi (58) Field of investigation (Int. Cl. ⁷ , DB name) A61K 35/78 A01N 65/00 A61P 31/00 BIOSIS (DIALOG) CA (STN) ) WPI / L (QUESTEL)

Claims (1)

(57) [Claims] 1. An antibacterial and bactericidal agent comprising an extract of Asparagus lineaealis as an active ingredient.