JP3197938B2 - Cosmetic for preventing skin aging - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic, and more particularly, to a cosmetic for preventing skin aging which has an excellent skin aging preventive action, skin roughness improving action and the like.

[0002]

2. Description of the Related Art Pharmaceutical ingredients conventionally used for improving skin roughness and preventing skin aging include allantoin, aloe extract, ginseng extract, placenta extract, bovine blood deproteinizing substances, and fermentation metabolites. Are known. However, cosmetics containing these medicinal components cannot provide a sufficient effect, and there has been a demand for the development of cosmetics having more excellent effects.

On the other hand, anti-inflammatory and anti-allergic effects ("Oil Chemistry", 37, p9, (1988), "Oil Chemistry", 40,
Oils and fats containing eicosapentaenoic acid (hereinafter abbreviated as "EPA") and docosahexaenoic acid (hereinafter abbreviated as "DHA") have attracted attention as compounds having p203, (1991)) and the like. It has long been known that EPA and DHA are contained in fish oil in a large amount and have pharmacological effects such as antithrombotic activity and antiarteriosclerosis activity. In recent years, it has been found that local administration has a vasomotor and vasodilator effect (Japanese Patent Laid-Open No.
-48528).

[0004]

SUMMARY OF THE INVENTION The present inventors have developed an EPA
Focusing on the above-mentioned effects of DHA and DHA, an attempt was made to blend this into cosmetics, especially cosmetics intended to prevent skin aging. However, when EPA, DHA or fats and oils containing EPA or DHA alone are blended alone, the effect of preventing skin aging and the effect of improving skin roughness are not sufficient, and due to the influence of other bases and the like, these substances originally have these effects. It was a fact that the effect could not be fully exerted.

[0005] Furthermore, in order to obtain higher effects, EPA
And / or DHA or fats and oils containing it at a high concentration has a limited effect, and conversely,
There is also a problem in that the production of specific colors and odors of these compounds themselves causes limitations in the product aspect such as the compounding amount and dosage form.

[0006]

Means for Solving the Problems In view of the above-mentioned circumstances, the present inventors have conducted intensive studies in order to fully exploit the effects of EPA and / or DHA or fats and oils containing the same. As a result, it has been found that the combination of these and specific components exerts an excellent effect of preventing skin aging and improving skin roughness in a stable and synergistic manner, and completed the present invention.

That is, the present invention relates to EPA and / or D
Provided is a cosmetic for preventing skin aging, comprising HA or an oil or fat containing the same, and one or more components selected from assembly extract, camphor, nicotinic acid or a derivative thereof, garlic extract, cepharanthin and pepper tincture. Is what you do.

[0008] As described above, EPA and / or DHA are unsaturated fatty acids contained in fish oils such as sardine oil, saury oil, herring oil, mackerel oil, and cod oil. For example, sardine oil contains about 16% EPA and DHA about 8.4%, and saury oil contains about 4.9% EPA and about 1% DHA.
0.5%, mackerel oil contains about 8.1% EPA and about 1% DHA
0.6%, cod oil about 13.3% EPA, DHA about 1
3.7% each.

The EPA and / or DHA or fats and oils containing DHA used in the present invention may be those separated and purified from fish oil by a conventional method, but may be obtained by simply extracting fish oil. And / or fats and oils containing DHA may be used. The method for extracting fish oil is not particularly limited, and a known method for extracting fats and oils such as a critical gas extraction method, a molecular distillation method, and a liquid chromatography method can be employed.

The fats and oils containing EPA and / or DHA may be used as they are in the cosmetics of the present invention, or may be further purified by steam distillation, activated carbon treatment, acid clay treatment and the like.

The content of EPA and / or DHA in the cosmetic of the present invention is 0.0001 to 10% by weight (hereinafter simply referred to as “%”), and more preferably 0.01 to 10% by weight.
5%. When using a fat or oil having a low purity of EPA and / or DHA, the content of EPA and / or DHA may be within the above range.

When the content of EPA and / or DHA is 0.5%
If it is less than 0001%, a sufficient effect may not be obtained, and even if it exceeds 10%, no further increase in the effect can be seen. Product problems such as precipitation may occur.

On the other hand, components such as assembly extract, camphor, nicotinic acid or a derivative thereof, garlic extract, cepharanthin and chili tincture which are other essential components in the present invention (hereinafter collectively referred to as "second component")
Are all components conventionally blended in cosmetics.

Among these second components, assembly extract, camphor, garlic extract, cepharanthin and pepper tincture are substances obtained by extraction from natural products.

[0015] That is, the assembly extract is obtained from the assembly [Swertia japonica Makino].
(Gentianaceae)], which is obtained by extracting with ethanol, purified water, or a mixture thereof from the whole plant at the time of flowering, and camphor is a camphor tree [Cinna
mom camphora Line (Laur
aceae)]. What
In addition, camphor can be obtained as a synthetic product.

The garlic extract is made of garlic (Alli
um scordoplasm L. or Allium sativum L.), purified water, absolute ethanol, propylene glycol,
It is an extract obtained by extraction with 1,3-butylene glycol or a mixture thereof.

Further, cepharanthin is a plant belonging to the family Aphididae (Stephaura cepharantha Haya).
It is obtained by extracting from the root of ta). Furthermore,
Pepper tincture is a pepper [Capsicum annuum Li
nne (Solanaceae)] or a variant thereof is leached with ethanol. In any case, there is no particular limitation on the extraction method and the purification treatment method.

On the other hand, nicotinic acid and its derivatives are a kind of vitamin B and may be those obtained by extracting from beef liver or rice bran or the like, or those obtained by synthesis. In addition to nicotinic acid, nicotinamide, nicotinic acid amide and nicotine Acid D
Nicotinic acid derivatives such as L-α-tocopherol and methyl nicotinate are exemplified.

The content of these second components in the cosmetic of the present invention is generally 0.0001-5%, preferably 0.001.
~ 3%. If the content of these components is less than 0.0001%, sufficient effects may not be obtained,
Also, the effect is almost constant even if it exceeds 5%,
No increase is seen.

The cosmetic composition for preventing skin aging according to the present invention comprises, according to a conventional method, EPA and / or DHA as essential components or oils and fats containing the same, and a second component as another essential component. It can be prepared by mixing with various types of bases known as additives.

Examples of the form of the cosmetic are not particularly limited, and may be, for example, cosmetics such as emulsions, creams, lotions, packs, dispersions, and detergents. Bases according to the form of these cosmetics, for example,
Purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, various cosmetic ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances, and the like can be used.

[0022]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

EXAMPLES 1-4 Creams: Creams having the compositions shown in Table 1 below were prepared, and the effects of improving skin roughness were examined. The results are also shown in Table 1. In addition,
The method for producing and evaluating the cream is as follows.

(Production method) A. Components (8) and (10) to (14) are mixed by heating and maintained at 70 ° C. B. Components (1) to (7) and (9) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix and emulsify uniformly. D. After the above C was cooled, (15) was added and mixed uniformly to obtain a cream.

(Evaluation method) 135 healthy males were used as panels, and 15 males per group. The creams of Examples 1 to 4 or Comparative Examples 1 to 5 were applied to one half of the face, and the cream of Comparative Example 6 was applied to the other half. Was applied once a day for 2 weeks. Two weeks later, facial skin replicas were collected and evaluated according to the criteria shown below. The value obtained by subtracting the score of the replica of the cream-applied part of Comparative Example 6 from the obtained score of the replica of the cream-applied part of Examples 1-4 and Comparative Examples 1-5 was defined as the degree of skin roughness improvement. The score before the test was 1
Or I chose 2 men.

Skin Condition Score: [Score] [State] 1 Skin groove of skin is unclear and exfoliation of keratin is recognized. 2 Skin crevices are slightly unclear or strongly unidirectional. 3 Skin sulcus is recognized, but shallow or slightly unidirectional. 4 Skin sulcus is recognized or slightly reticulated. 5 Skin crevices are clearly recognized or have a fine mesh.

(Result)

[Table 1]

From the above results, it is clear that the cosmetic of the present invention in which DHA and the second component are blended exhibits a remarkable skin roughness improving effect as compared with the case where DHA or the second component is blended alone. .

EXAMPLES 5-6 Cream: A cream was prepared by the composition shown in Table 2 and by the following method, and its anti-aging effect was examined by the following method.

[0030] * Kurita Water Industries Ltd. ** Ethyl alcohol leachate from pepper cuts *** Nicotinic acid amide (Synthetic Organic Chemicals)

(Production method) A. Components (9) to (11) and (13) are mixed by heating and maintained at 70 ° C. B. Components (1) to (8) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix and emulsify uniformly. D. After cooling the above C, the component (12) was added and mixed uniformly to obtain a cream.

(Evaluation Method) Fifteen females aged 26 to 52 years were used as panels, and an appropriate amount of the test cream was applied to the face twice daily for 12 weeks, morning and night, after washing the face. The beautiful skin effect and the skin aging prevention effect of the application were evaluated according to the following criteria.

Skin beautiful effect: [Evaluation] [Contents] Effective Skin dullness became inconspicuous. Slightly effective The dullness of the skin became slightly less noticeable. Ineffective No change from before use.

Anti-aging effect of skin: [Evaluation] [Contents] Effective Skin peeling and gloss were improved. Slightly effective Skin glue, gloss slightly improved. Ineffective No change from before use.

(Results) The results are shown in Table 3.

[0036]

As is evident from the results in Table 3, the creams of Examples 5 and 6 are effective in preventing and improving the occurrence of "glossy" and "bleeding" of the skin and the prevention of skin aging. The effect was recognized.

Example 7 Cosmetic Water: <Formulation> (%) (1) Polyoxyethylene hydrogenated castor oil (60E.0.0) 1.0 (2) Ethyl alcohol 10.0 (3) Preservative 0.1 (4) Appropriate amount of fragrance (5) Sardine extracted oil and fat 1.0 (6) Assembly extract ^* 0.5 (7) Sorbitol (70% aqueous solution) 3.0 (8) Sodium pyrrolidonecarboxylate 3.0 (9) Purification water remaining amount * scan e Ruchianin [made Ichimaru Pharcos Co., Ltd.]

(Production Method) A. Components (1) to (5) are heated and mixed and dissolved. B. Heat and mix and dissolve components (6)-(9). C. The above A and B were mixed to make uniform, and a lotion was obtained.

Example 8 Emulsion: <Formulation> (%) (1) Polyoxyethylene sorbita 1.0 monostearate (10E.O.) (2) Polyoxyethylene sorbita 0.5 Ethate (60E.O.) (3) Glycerin monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Refined avocado oil 4.0 (7) Tri-2-ethylhexanoic acid G 4.0 Lyserin (8) Preservative 0.1 (9) DHA ^* 1.0 (10) Witch hazel extract 0.1 (11) Xanthan gum (2% aqueous solution) 7.0 (12) 1,3-butylene Glycol 5.0 (13) Campha ^** 1.0 (14) Cepharanthin ^*** 1.0 (15) Residual water (16) Appropriate perfume * Serdary Research Lab. Inc. ** Campha [Takasago perfume Industrial Co., Ltd.] *** Sepharanthin (Maruzen Pharmaceutical Co., Ltd.)

(Preparation method) A. Components (10) to (15) are mixed by heating and maintained at 70 ° C. B. Components (1) to (9) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix and emulsify uniformly. D. After cooling the above C, (16) was added and mixed uniformly to obtain an emulsion.

Example 9 Ointment: <Formulation> (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Saury oil / fat 2.0 (6) Garlic extract ^* 1.0 (7) Remaining purified water * Reisogen [manufactured by Takeyama Garlic Chemical Co., Ltd.]

(Production Method) A. A part of the components (3), (4) and (7) is mixed by heating and kept at 75 ° C. B. Components (1), (2) and (5) are mixed by heating.
Keep at 5 ° C. C. The above A is gradually added to the above B. D. While cooling C, (6) dissolved in the rest of (7) was added to obtain an ointment.

[0044]

As described above, according to the present invention, EPA is used.
And / or DHA or fats and oils containing DHA is blended to obtain a cosmetic having a stable and excellent effect of preventing skin aging and improving skin roughness.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-2-48528 (JP, A) JP-A-62-138411 (JP, A) JP-A-62-87506 (JP, A) JP-A-47-1987 43347 (JP, A) JP-A-63-174911 (JP, A) JP-A-60-209508 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/00-7 / 50

Claims (1)

(57) [Claims] 1. One or two or more components selected from eicosapentaenoic acid and / or docosahexaenoic acid or fats and oils containing the same and assembly extract, camphor, nicotinic acid or a derivative thereof, garlic extract, cepharanthin and pepper tincture. And a cosmetic for preventing skin aging.