JP3199861B2 - Blood collection device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood or plasma collecting apparatus used for collecting blood or plasma from blood. In particular, the present invention relates to a blood or plasma collecting apparatus having a rocking means for stirring collected whole blood and an anticoagulant and a weight detecting means for detecting the weight of a blood collecting container.

[0002]

2. Description of the Related Art Conventionally, there has been provided a blood collecting apparatus which can be used in a narrow blood donation car and can easily collect plasma by reducing the size of the entire apparatus with a simple circuit configuration. And, as this kind of blood sampling device, rocking means for stirring the collected whole blood and the anticoagulant,
Having a weight detection unit for detecting the weight of the blood collection container,
In order to detect the weight of the blood collection container while swinging and to perform more accurate weight detection, a blood sampling device that detects the weight after stopping the operation of the swinging means at a fixed position has been proposed. The blood sampling apparatus uses an AC induction motor as a rocking means, and stops the rocking motor by electromagnetic brake control.

[0003]

However, in the conventional blood sampling apparatus, when the oscillating motor is stopped (specifically,
(A standby state immediately after the power of the apparatus is turned on, a puncture standby state until the blood sampling needle is punctured, a standby state after the processing is completed, an abnormality occurring during the processing, a temporary standby state by a stop switch), and a swing motor. In this case, the electric circuit was supplied with a current, and the oscillation motor was stopped at a fixed position by the electromagnetic brake. Therefore, considerable power was consumed by the power absorbing resistor or the winding of the oscillation motor. This power consumption has caused a rise in the temperature of the entire apparatus. Therefore, an object of the present invention is to provide a state in which the rocking motor is stopped (a standby state immediately after power-on of the apparatus, a puncturing standby state until a blood sampling needle is punctured, a standby state after the processing is completed, (1) When an abnormality occurs or in a temporary standby state by a stop switch, the power supply of the rocking motor is cut off to provide a blood sampling apparatus that consumes less power and has a small temperature rise in the entire apparatus.

[0004]

What achieves the above object is a blood collection device for controlling a blood collection circuit for collecting whole blood from a blood collector, wherein the blood collection device is provided with the blood collection circuit. A blood collection container weight detection unit that detects the weight of the blood collection container provided in the oscillating unit, a oscillating unit configured by a oscillating motor and a crank mechanism, a rotating body that rotates with the rotation of the oscillating motor, An identification unit provided on the rotating body,
Oscillating means for agitating the collected whole blood and the anticoagulant, identifying part detecting means for detecting an identifying part provided on the rotating body of the oscillating means, and a power supply to the oscillating means in an energized state Or an electric circuit section having a first circuit switch for bringing into a cutoff state, an electromagnetic brake circuit for temporarily stopping the rocking motor, and a second circuit switch for operating the electromagnetic brake circuit. And a control unit having an arithmetic circuit unit for controlling opening and closing of the first circuit switch and the second circuit switch of the electric circuit unit. In order to achieve the above object, a blood collection circuit for collecting whole blood from a blood collector, an anticoagulant addition circuit for adding a blood anticoagulant to the collected whole blood, and an anticoagulant are provided. A plasma separation means for separating the added whole blood into a plasma component and a blood cell component, a plasma collection container for collecting the separated plasma component, and a blood cell component return circuit for returning the separated blood cell component to a blood collector. A blood collection device for controlling a plasma separation circuit having at least a blood collection container weight detection unit for detecting a weight of a blood collection container provided in the blood collection circuit, and a swing motor. And a oscillating part constituted by a crank mechanism, a rotating body that rotates with the rotation of the oscillating motor, and an identification unit provided on the rotating body, and the whole blood to be collected and the anticoagulant Oscillating means for stirring the water, and the rotation of the oscillating means Identification unit detection means for detecting an identification unit provided on a body; a first circuit switch for turning on / off a power supply of the oscillating means; and an electromagnetic switch for temporarily stopping the oscillating motor. An electric circuit unit having a brake circuit and a second circuit switch for operating the electromagnetic brake circuit; and an operation for controlling opening and closing of the first circuit switch and the second circuit switch of the electric circuit unit And a control unit having a circuit unit.

[0005] Then, the control unit is configured to perform any one of a standby state immediately after turning on the power of the blood collection apparatus, a puncture standby state until a blood sampling needle is punctured, or a standby state after the end of processing. It is preferable that the first circuit switch of the electric circuit section is controlled to be in an OFF state, and the power of the rocking means is controlled to be in a cutoff state. Further, when the first circuit switch is turned off, the control unit turns on the second circuit switch.
In the case of the state, it is preferable that after the second circuit switch is turned off, the first circuit switch is controlled to be turned off. Then, the control unit operates the blood collection container weight detection unit when an abnormality occurs during processing or in a temporary standby state by a stop switch, and when the blood collection container weight detection unit detects a weight equal to or less than a set amount, It is preferable that the first circuit switch of the electric circuit section is controlled to be in an OFF state, and the power of the rocking means is controlled to be in a cutoff state. Further, the blood collection device has a start switch for starting blood collection, and when the start switch is pressed by an operator, the first circuit switch of the electric circuit unit is turned on.
It is preferable that the power supply of the oscillating means is restored to a power-on state.

Therefore, a blood sampling apparatus according to the present invention will be described with reference to an embodiment shown in the drawings. The blood collection device of the embodiment is a plasma collection device that can collect not only whole blood from a blood collector but also a plasma component from whole blood. FIG. 1 shows a schematic diagram of the basic configuration of the blood sampling device 1 of this embodiment. FIG. 1 shows a blood sampling device 1 with a single-needle plasma separation circuit attached thereto, and FIG. 2 is a perspective view of an embodiment of the blood sampling device of the present invention without a plasma separation circuit attached. FIG. 3 is a front view of the oscillating means used in the blood sampling apparatus 1 of this embodiment, and FIG. 4 is an electrical diagram of the control unit and the identification unit detecting means of the blood sampling apparatus 1 of this embodiment. FIG. 5 to FIG. 7 are electric circuit diagrams for explaining the operation of the control unit.

The blood collection apparatus 1 of this embodiment includes a blood collection circuit for collecting whole blood from a blood collector, an anticoagulant addition circuit for adding a blood anticoagulant to the collected whole blood, A plasma separation means for separating whole blood to which a coagulant has been added into a plasma component and a blood cell component, a plasma collection container for collecting the separated plasma component, and a blood cell component for returning the separated blood cell component to a blood collector A blood collection device for controlling a plasma separation circuit having at least a return circuit, wherein the blood collection device 1 detects a weight of whole blood collected in a blood collection container 5 provided in the blood collection circuit. A container weight detector 57,
A swinging unit constituted by a swinging motor 60 and a crank mechanism; and a swinging motor 6 attached to a shaft of the swinging motor 60.
A rotating body 63 that rotates with the rotation of 0, an identification section 64 provided on the rotating body 63, and a rocking means 42 for stirring the collected whole blood and the anticoagulant; An identification unit detecting means 67 for detecting an identification unit 64 provided on the rotating body 63, a first circuit switch 80 for turning on / off a power supply of the oscillating means 42, and an oscillating motor 6
And a second circuit switch 81 for activating the electromagnetic brake circuit.
And a first circuit switch 80 and a second circuit switch 8 of the electric circuit unit.
And a control unit 59 having an arithmetic circuit unit for controlling opening and closing of the control unit 1.

[0008] The blood collection circuit of the plasma separation circuit controlled by the blood collection apparatus 1 of this embodiment, as shown in FIG.
Blood collection needle 21, blood collection container 5, first blood supply vessel 2 communicating blood collection needle 21 with blood collection container 5, and second blood supply communicating blood collection container 5 with the blood inlet of plasma separator 7. It is constituted by blood vessels 6. As shown in FIG. 1, the anticoagulant addition circuit includes an anticoagulant storage container 45 and an anticoagulant transport pipe 48 that connects the anticoagulant storage container 45 and the blood collection container 5. ing. Further, the plasma separating means includes a plasma separator 7 and a plasma transport pipe 9 connected to a plasma outlet of the plasma separator 7. further,
A plasma collection container 10 is attached to the plasma transport tube 9. The blood cell component return circuit includes a third blood vessel 8 that communicates the blood outlet (blood cell component outlet) of the plasma separator 7 with the first blood vessel 2.

Further, the blood sampling device 1 of this embodiment
As shown in FIG. 1, a blood collection container 5 provided in a blood collection circuit
The blood collection container weight detection unit 57 for detecting the weight of the whole blood collected at a time, a swinging unit constituted by a swinging motor 60 and a crank mechanism as shown in FIG. A rotating body 63 that is a rotating disk that is attached and forms a rotating body that rotates with the rotation of the swing motor 60;
3 and an oscillating means 42 for stirring the collected whole blood and the anticoagulant. In addition, as shown in FIG. 3, the blood sampling device 1 of this embodiment has a rotating body 63 having three slits (specifically, a first slit 64, a second slit 65, and a second slit 65). Although three slits 66) are provided, only the first slit 64 may be provided. The second slit 65 is provided at a position 180 ° away from the first slit 64, and the third slit 66 is provided near the position where the second slit 65 is provided. . The rotating disk is preferably the above-mentioned rotating body, but may have any shape as long as slits can be detected by the identification unit detecting means described later, and may be, for example, a polygon.
Further, as shown in FIG. 3, the blood collection device 1 of this embodiment includes a slit detecting unit 67 that detects a slit provided in the rotating body 63 of the swinging unit 42, and as shown in FIG.
An electric circuit including a first circuit switch 80 for turning on or off a power supply of the swinging unit 42, a second circuit switch 81 for rotating or stopping the swinging motor 60, and an electromagnetic brake circuit. The control unit 59 includes a circuit unit and an arithmetic circuit unit such as a CPU that controls opening and closing of the first circuit switch 80 and the second circuit switch 81 of the electric circuit unit.

Further, the blood sampling apparatus 1 of this embodiment
The decompression / pressurization means 58 for pressurizing and depressurizing the inside of the blood collection container housing part 41, the plasma separator mounting part to which the plasma separator 7 is detachably attached, and the first blood vessel 2 of the plasma separation circuit First circuit opening / closing means 12 for opening / closing;
A second circuit opening / closing means 13 for opening / closing the blood vessel 6 or the third blood vessel 8 and a third circuit opening / closing means for opening / closing the plasma transport tube 9.
Circuit opening / closing means 14, a fourth circuit opening / closing means 46 for opening / closing the anticoagulant transport pipe 48, and the blood collection container housing 4
1, a pressure detecting unit 55 for detecting the pressure inside, a pressurizing unit 44 for pressing a cuff 49 attached to the arm of the blood collector, and a pressure detecting unit for detecting the pressure of the cuff 49 56 and a plasma weight detector 99 for detecting the weight of the plasma collection container 10. Then, in addition to the first circuit switch 80 and the second circuit switch 81, the pressure reducing / pressurizing unit 58, the pressure detecting unit 55, the slit detecting unit 67, the weight detecting unit 57 of the blood collecting container 5, the plasma collecting container 10 Plasma weight detecting section 99, cuff 49 pressurizing means 44, cuff 49 pressure detecting section 56, leak valve 54, circuit opening / closing means 1
2, 13, 14, and 46 are all electrically connected to the control unit 59 as shown in FIG. And the control unit 5
Reference numeral 9 controls each component as shown in the flowcharts of FIGS.

The blood sampling apparatus 1 according to one embodiment of the present invention will be described more specifically with reference to FIGS. As shown in FIG. 1, the blood collection device 1 is configured such that the first blood supply vessel 2, the second blood supply blood vessel 6, and the anticoagulant transport pipe 48 are connected via a tube connected to the blood collection container 5 and a branch pipe 95.
It communicates with the blood collection container 5. The depressurizing / pressurizing means 58 is connected to the air supply / exhaust circuit 53 and the
1, 52, a vacuum pump 43, and a leak valve 50.

As shown in FIG. 2, the blood sampling apparatus 1 has a lid 83 provided on the upper surface thereof at an angle, and the lid 83 is further provided with a lid open / close detector. ing. The lid opening / closing detecting section is configured, for example, such that a magnet and a Hall IC (not shown) are provided on the lid 83 and open / closed is detected using both. Inside the lid 83, the lid 83
A blood collection container storage section 41 is formed as a closed space when the blood collection container is closed, and a blood collection container storage table 98 is provided inside the blood collection container storage section 41 at an angle.

Then, the blood collection container 5 is
Is installed so that the tube connection side is lower (toward the front side). As shown in FIG. 3, a lower part of the blood collecting container housing table 98 is rotatably supported on the tube connection side, and includes a rocking unit including a rocking motor 60 and a crank mechanism 61. A rotating body 63 attached to the shaft of the dynamic motor 60 and rotating with the rotation of the swing motor 60;
A first slit 64 provided in the rotating body 63, a second slit 65 provided at a position 180 ° away from the first slit 64, and a vicinity of the position where the second slit 65 is provided And a rocking means 42 for stirring the whole blood in the blood collection container 5 and the anticoagulant.

A first slit 64, a second slit 65
In order to stop the rotation of the swing motor 60 at the top dead center or the bottom dead center of the crank mechanism, respectively, a slit detecting means 67 described later detects the slit, and the control unit 59 stops the swing motor 60. The rotation motor 60 is provided at a position in consideration of the rotation amount of the swing motor 60. When an input signal is sent from the slit detecting means 67 to the control unit 59, the third slit 66 transmits the signal to the first slit 64.
This is provided so that the control unit 59 can determine whether the control is performed by the control unit 59 or by the second slit 65. The third slit 66 is + 80 ° to +1 assuming that the position where one slit is provided is 0 ° and the rotation direction of the swing motor is the plus direction.
Preferably, it is provided at a position of 0 °. In this embodiment, as shown in FIG. 3, the third slit 66 is provided at a position + 30 ° from a position where the second slit 65 is provided (this position is assumed to be 0 °). . Thereby, when the swing motor 60 rotates 30 ° after the slit detecting means 67 has detected one slit, the control section 59 detects the slit again. It can be determined that there is.
Note that instead of providing the third slit 66, the size (length or width) of the first slit 64 and the second slit 65 is set to different sizes, and the control unit 59 The second slit 65 may be distinguished.

In this embodiment, the blood collection container storage table 98 has an inclination angle of +2 with respect to the horizontal state in the initial state.
It is set to 0 °, and is configured to be rocked by the rocking means 42 at an amplitude of ± 20 ° with respect to the horizontal state. Then, in the initial state, that is, when the blood collection container housing table 98 is at the position of + 20 °, the swinging means 4
The crank mechanism of No. 2 is located at the top dead center,
When in the 0 ° position, the crank mechanism of the swinging means is set to be at the bottom dead center.

Further, the blood collecting container storage 41 has a structure shown in FIG.
As shown in (1), a blood collection container weight detector 57, for example, a weight sensor is provided. Specifically, the blood collection container 5
As shown in FIG. 3, the whole blood weight detection unit 57 is attached below the blood collection container storage table 98, and more specifically, below the measurement table 69 mounted on the swing table 68. Attached to. The blood collection container weight detection unit 57 detects the weight of blood inside the blood collection container 5, and a load cell is suitably used as the blood collection container weight detection unit 57. Further, as shown in FIG. 3, a blood leak sensor 70 is attached to the lower surface of the blood collecting container housing part 41. The blood leak sensor 70 is attached to the storage table 98 such that the sensor section is exposed on the upper surface of the blood collection container storage table 98. The blood leak sensor 70 is configured, for example, by fixing a spacer on a load cell constituting a weight sensor and fixing a printed circuit board constituting the blood leak sensor 70 thereon.

Further, the blood sampling apparatus 1 is provided with
Has a slit detecting means 67 for detecting a slit provided in the rotating body 63. The slit detecting means 67
The first slit 64 to the third slit 64 electrically connected to the control unit 59 and provided in the rotating body 63 of the swinging unit 42.
When the slit 66 is detected, an output signal is sent to the control unit 59. As the slit detecting means 67, an optical sensor,
An ultrasonic sensor or the like can be suitably used. In this embodiment, as shown in FIG. 3, an optical sensor having a light emitting element and a light receiving element thereof is mounted on an outer surface of a housing of a swing motor 60. In the above description, the case where the slit is used as the identification unit has been described. However, the identification unit is not limited to the slit. For example, a magnetic index is provided on the surface of the rotating body, and the magnetic index is detected as detection means. A sensor using a magnetic sensor may be used. Further, the rotating body 63 is preferably the above-described rotating disk, but is not limited thereto. For example, a rod-shaped body, and further, a Y-shaped rod-shaped body having a branched distal end, which rotates at the center thereof. Alternatively, two or three ends of the rod may constitute an identification unit, and the slit detecting means may detect passage of the end of the rod. Further, a member serving as an identification unit, for example, a magnetic index may be attached to each end of the rod-shaped body.

Further, as shown in FIG. 4, the blood sampling apparatus 1 has a first circuit switch 80 for turning on / off the power supply of the oscillating means 42 and an oscillating motor 60.
And a second circuit switch 81 for activating (ON, OFF) the electromagnetic brake circuit, and an electric circuit unit for temporarily stopping (rotating or stopping) the electromagnetic brake circuit. A control unit 59 having an arithmetic circuit unit such as a CPU for controlling the opening and closing of the first circuit switch 80 and the second circuit switch 81 is provided. FIG. 4 is an electric circuit diagram including the slit detecting means 67, the pressurizing / depressurizing means 58, and the third circuit switch 82 for controlling the pressurizing / depressurizing means 58. Then, the control unit 59 controls the first circuit switch 8
By controlling the opening and closing of the 0 and second circuit switches 81, the electric circuit section is operated as shown in FIGS. That is, in the state of FIG.
The first circuit switch 80 (SSR1) and the second circuit switch 81 (SSR2) are both controlled to be ON. In this state, the thyristor (SCR: OFF when the second circuit switch 81 is turned ON,
Is set to ON when ) Is in the OFF state, so that no current flows through the rectifying diodes D1 and D2 (portions where no current flows are indicated by broken lines). Then, the swing motor 60 is controlled by the phase control capacitor C.
In this case, a current out of phase by 90 ° flows through the main winding and the auxiliary winding, so that the swing motor 60 rotates.

In the state shown in FIG. 6, the control unit 59 determines that the first circuit switch 80 (SSR1) is in the ON state and the second circuit switch 80 (SSR1) is in the ON state.
Of the circuit switch 81 (SSR2) is turned off. In this state, the thyristor (SCR)
Are turned on, so that the rectifier diodes D1 and D1
2, a half-wave rectified current having the same phase flows. Since the same phase current also flows through the main winding and the auxiliary winding of the oscillating motor 60, the electromagnetic brake is applied, and the rotation of the oscillating motor 60 is stopped. When the swing motor 60 is stopped in this state after stopping, the suspension of the swing motor 60 is maintained by the electromagnetic brake, and the swing motor 60 is immediately turned on by turning on the second circuit switch 81. Rotate. Therefore, in the temporary stop state, the swing motor 60 does not rotate, but the power is consumed by the power absorbing resistor and the winding of the motor.

Further, in the state of FIG. 7, the control unit 59
The first circuit switch 80 (SSR1) and the second circuit switch 81 (SSR2) are both controlled to be in the OFF state. In this state, the electric circuit section is cut off from the power supply, so that no current flows through the circuit, and no power is consumed by the power absorbing resistor and the winding of the motor. Therefore, it is possible to provide a blood collection device that consumes less power and has a small temperature rise in the entire device. Then, when the first circuit switch 80 is in the OFF state, the control unit 59 determines that the second circuit switch 81 is in the ON state.
It is preferable that after the second circuit switch 81 is turned off, the first circuit switch 80 is controlled to be turned off. That is, when the second circuit switch 81 is already in the OFF state, control is performed such that only the first circuit switch 80 is in the OFF state. However, when the second circuit switch 81 is in the ON state, the second circuit switch 81 is in the second state. After the first circuit switch 81 is turned off, control is performed so that the first circuit switch 80 is turned off. This allows
After the rotation of the oscillating motor 60 is stopped, the power of the oscillating means 42 is turned off, and even after the power is turned off, the oscillating motor 60 can be prevented from rotating due to inertial force. The first circuit switch 80 and the second circuit switch 81 of the blood collection device 1 of this embodiment are SSR
(Solid state relay) can be suitably used.

Specifically, the blood sampling device 1 of this embodiment
Is controlled by a standby state immediately after turning on the power of the blood collection apparatus 1, a puncturing standby state until the blood sampling needle is punctured, or a standby state after the end of the processing, an abnormality occurring during the processing, or a stop switch. In the temporary standby state, control is performed so that the first circuit switch 80 of the electric circuit unit is turned off, and the power supply of the rocking means 42 is turned off. As a result, the power consumption of the entire apparatus can be reduced in a standby state immediately after the power is turned on, a puncture standby state, a standby state after the end of the processing, or when an abnormality occurs during the processing or a temporary standby state using the stop switch. More specifically, the control unit 59 determines that the blood collection container weight detection unit 57
When the injection of a predetermined amount of the anticoagulant into the blood collection container 5 is detected, control is performed so that the first circuit switch 80 of the electric circuit section is turned off and the power supply of the rocking means 42 is turned off. This can reduce the power consumption of the entire apparatus in the puncture standby state after the anticoagulant is injected into the blood collection container 5 and before blood collection is started. Further, the blood collection device 1 has a plasma weight detection unit 99 for detecting the weight of the plasma collection container 10, and the control unit 59 detects the collection of the set plasma volume by the plasma weight detection unit 99, Control is performed so that the first circuit switch 80 is turned off and the power supply of the oscillating means 42 is turned off. Thus, the power consumption of the entire apparatus in the standby state after the processing is completed can be reduced.

Further, when an abnormality occurs during processing or in a temporary standby state by a stop switch, the control unit 59
When the blood collection container weight detection unit 57 is activated and the blood collection container weight detection unit 57 detects a weight equal to or less than the set amount, the first circuit switch 80 of the electric circuit unit is turned off, and the power supply of the swing unit 42 is turned off. Control to be in the cutoff state. this is,
This takes into account that the blood collection container 5 is detached from the storage table 98 due to occurrence of an abnormality, and that it takes a certain time until the blood collection container 5 returns to the normal state. It is possible to reduce the power consumption of the entire device from recovery to recovery.

Further, the blood sampling device 1 of this embodiment
It has a start switch for starting addition of anticoagulant or blood collection, and when the start switch is pressed by the operator,
The first circuit switch 80 of the electric circuit section is returned to the ON state, and the power supply of the oscillating means 42 is turned on. Thus, the power supply of the swing unit 42 can be turned on only when the operation of the swing unit 42 is necessary. Then, the control unit 59 controls the first circuit switch 80
Is in the OFF state, the slit detecting means 67
When detecting the slit provided in the rotating body 63 of the swing motor 60, the first circuit switch 80 is turned on, the second circuit switch 81 is turned off, and the rotation of the swing motor 60 is stopped. It is preferable to control to stop. This means that the first circuit switch 80 is OFF
When in the state, the electromagnetic brake is not working,
Although it is considered that the swing motor 60 rotates,
At this time, the electromagnetic brake is applied to stop the rotation of the swing motor 60.

The control section 59 is provided with the slit detecting means 6.
7 detects the first slit 64 of the swing means 42,
Second circuit switch 81 (SSR2) of the electric circuit section
Is turned off to control the rotation of the swing motor 60 of the swing means 42 to stop at the top dead center of the crank mechanism. Further, the control unit 59 controls the swing motor 6
After the rotation of 0 is stopped, control is performed so that the blood collection container weight detection unit 57 detects the whole blood weight. This allows
The blood collection device 1 is mounted on a blood collection container
Is stopped, the weight of whole blood can be detected, and more accurate weight measurement can be performed. The reason why the detection is performed by stopping the storage table 98 is that accurate detection is difficult due to the influence of inertia due to the gravity of the weighing object during swinging. This is because the load applied to the container weight detector 57 changes.

Further, when the slit detecting means 67 detects the second slit 65, the control section 59 turns off the second circuit switch 81 (SSR2) of the electric circuit section, thereby turning the swing motor 60 Is controlled to stop at the bottom dead center of the crank mechanism. This allows
The blood collection container housing 98 can be stopped at a position + 20 ° above the horizontal side of the tube connection side of the blood collection container 5 with respect to the horizontal, and the air in the blood collection container 5 is moved to the tube connection side, The air mixed in 5 can be sufficiently removed. Further, when the slit detecting means 67 detects the first slit 64, the control section 59 activates the blood collection container weight detecting section 57 without stopping the swing motor 60 so as to detect the whole blood weight. it can. This allows
Although the accuracy is lower than the case where the weight is detected by stopping the storage table 98, it is also possible to detect the weight of the whole blood that changes sequentially while swinging.

The blood collection container storage section 41 is
The pressurizing means 58 is connected, and the inside of the storage section 41 can be pressurized and depressurized by the depressurizing / pressurizing means 58. As shown in FIG. 1, the pressure reducing / pressurizing means 58 includes a pumping circuit 53, a vacuum pump 43, and two three-port valves 51 and 52. The depressurizing / pressurizing means 58 is in a depressurized state, and
Can be set every 10 mmHg, and the pressure can be set from +50 to +200 mmHg every 10 mmHg. This set pressure is shown in FIG.
Can be input from the front panel 86 shown in FIG. Then, the reduced pressure and the increased pressure are set by the vacuum pump 43.
, A substantially constant pressure is maintained by switching ON / OFF, and the pressure reduction / pressurization state is switched by switching the three-port valves 51 and 52. Therefore, the operation of the pressure reducing / pressurizing means 58 will be described using the operating states of the three-port valves 51 and 52. The three-port valves 51 and 52 are in a ventilation state when in an on state, and are open to the atmosphere when in an off state. Therefore, if only the three-port valve 51 is turned on (the three-port valve 52 is turned off), the vacuum pump 43 operates to evacuate, and the inside of the blood sampling container housing part 41 shown in FIG. Conversely, the 3-port valve 52
If only the three-port valve 51 is turned on (the three-port valve 51 is turned off), suction is performed by the operation of the vacuum pump 43, and the inside of the blood collection container housing part 41 is pressurized.

Further, in the blood collecting container storage section 41, FIG.
As shown in the figure, a pressure detecting means 55 for detecting the pressure inside the storage section 41, for example, a pressure sensor is attached. Specifically, the pressure detecting means 55 is attached so as to communicate with the blood collecting container housing part 41 by a tube. As the pressure detecting means 55, a diffusion type semiconductor pressure detecting means is preferably used.

The circuit opening / closing means 12, 13, 14,
Reference numeral 46 denotes a solenoid pinch valve which is normally closed. Further, as shown in FIG. 2, an ACD bag hanger 85 is provided on the left side surface of the blood sampling device 1. In addition, the blood collection device 1
A plasma separator holder 84 forming a plasma separator mounting portion is provided on the front surface of the plasma separator. This plasma separator holder 84 has a front about 2 mm below about 30 mm from the center.
The plasma separator can be mounted at an angle of 0 °, and the mounted state can be held and released by a latch-type magnet catch. Further, a cuff pressurizing port 93 is provided on the entire surface of the blood sampling device 1, and a tube connected to the cuff 49 can be attached as shown in FIG. The port 93 for pressurizing the cuff is connected to the pump 44 for cuff pressure provided in the blood sampling apparatus 1, and further, the pressure sensor 56 for detecting the pressure inside the port 93 and the leak valve 54 are attached. . Cuff pressurizing pump 4
As 4, a small-sized sphygmomanometer pump can be preferably used, and as the pressure sensor 56, a diffusion-type semiconductor pressure sensor can be preferably used. The pressure applied to the cuff 49 from the cuff pressurizing port 93 can be set at +10 to +100 mmHg every 10 mmHg.
This set pressure can be input from the front panel 86 shown in FIG. Further, the blood collection device 1
Has bubble detecting means 97 for detecting bubbles in the third blood supply vessel as shown in FIG. An ultrasonic bubble sensor can be suitably used as the bubble detecting means.

As shown in FIG. 2, the blood collection apparatus 1 is provided with a plasma weight detection unit 99 for detecting the weight of the plasma collection container 10. An electronic balance with an external output is preferably used.
Is measured at regular intervals, and the measurement data is input to the control unit 59.

[0030]

Next, the operation of the blood sampling apparatus 1 according to the present invention will be described with reference to FIGS. In particular, as a plasma collection circuit, a blood collection needle 21, a blood collection container 5, a first blood vessel 2 communicating the blood collection needle 21 with the blood collection container 5, a plasma separator 7, a blood collection container 5, and a plasma separation circuit. A second blood vessel 6 that communicates with the blood inlet of the blood vessel 7, a third blood vessel 8 that communicates with the blood outlet of the plasma separator 7 and the first blood vessel 2, a plasma collection container 10, A plasma transport tube 9 that connects the plasma outlet of the separator 7 to the plasma collection container 10, an anticoagulant storage container 45, and an anticoagulant transport that connects the anticoagulant storage container 45 and the blood collection container 5 The blood collection device 1 is provided with a blood collection container storage unit 4 using a single-needle plasma separation circuit having a tube 48.
1, depressurizing / pressurizing means 58 for pressurizing and depressurizing the inside of the blood collection container housing 41, and a rocking means 42 for rocking the blood collection container housing 98 of the blood collection container housing 41.
A blood-collecting container weight detecting unit 57 for detecting the weight of the blood-collecting container, a slit detecting unit 67 for detecting a slit provided in the rotating body 63 of the rocking means 42, and the plasma separator 7. A plasma separator mounting portion that is detachably attached,
A first circuit opening / closing means 12 for opening / closing the first blood vessel 2 of the single-needle plasma separation circuit; a second circuit opening / closing means 13 for opening / closing the second blood vessel 6 or the third blood vessel 8; A third circuit opening / closing means 14 for opening / closing the plasma transport tube 9;
It has a fourth circuit opening / closing means 46 for opening / closing the anticoagulant transport pipe 48 and a plasma weight detection unit 99 for detecting the weight of the plasma collection container 10.
Is an anticoagulant that operates the depressurizing / pressurizing means 58 to put the inside of the blood collection container housing 41 into a reduced pressure state and inject a predetermined amount of anticoagulant from the anticoagulant storage container 45 into the blood collection container 5. After the injecting step and the anticoagulant injecting step are completed, the pressure reducing / pressurizing means 58 is operated to put the inside of the blood collection container housing 41 into a reduced pressure state, and a predetermined amount of blood is supplied from the donor into the blood collection container 5. After the blood collection step and the blood collection step are completed, the decompression / pressurization means 58 is operated to put the inside of the blood collection container housing 41 into a pressurized state.
The blood in the blood collection container 5 is returned to the blood donor while the blood in the blood collection container 5 is allowed to flow into the blood collection container 5. The pressurizing means 58 is operated to pressurize the inside of the blood collection container housing 41, and the blood collected inside the blood collection container 5 flows into the plasma separator 7, and flows out from the plasma outlet of the plasma separator 7. The blood plasma component to be collected is collected in the plasma collection container 10 and the blood cell component flowing out from the blood cell outlet of the plasma separator 7 is returned to the donor to perform a separation / blood return step. The blood return step is completed when the plasma weight detector 99 of the plasma collection container 10 detects the weight of the set value.

The blood collection apparatus 1 performs the anticoagulant injection step, the blood collection step, the small amount blood return step, and the separation / blood return step in this order by repeating a set number of times. The steps and the progress of the steps are substantially automated by the control unit 59.

In particular, with reference to FIG. 8 to FIG. 19, a case will be described as an example in which plasma is collected five times using a 200 ml blood collection container 5. First, as shown in FIG. 8, when the power switch of the blood collection device 1 is turned on, the CPU is initialized as an initialization, and then the electrical abnormality of each unit is automatically checked. Subsequently, the blood collection amount (200 ml or 400 ml, 200 ml in the present description) is set, the processing mode [only blood collection or apheresis (plasma collection), the apheresis in the present description] is set, and the number of blood collections (5 times in the present description).
) And the default data of each setting parameter are transferred to the RAM. Further, if necessary, parameters such as blood collection pressure and blood return pressure are changed using a parameter setting switch provided on the front surface of the blood collection device 1. In this state, the blood collection container housing table 98 is stopped at the position in the above-described initial state, that is, at a position of + 20 ° with respect to the horizontal so that the tube connection side of the blood collection container 5 is lowered. Then, as shown in FIG. 8, even when the power switch is turned on, the first circuit switch 80 of the electric circuit unit is in the off state, and the current is supplied to the swing means 42 until the start switch is pressed. It does not flow, and power consumption in the standby state immediately after power-on is reduced.

When the lid 83 is opened, the circuit opening / closing means 1
2 (CL12), 13 (CL13), 14 (CL1
4) and 46 (CL46) are open. The leak valve 50 (LV50) of the pressure reducing / pressurizing means 58 is open, and both the pressure reducing / pressurizing switching valves 51 (V51) and 52 (V52) of the pressure reducing / pressurizing means 58 are open to the atmosphere. I have. Then, the weight of the blood collection container housing table 98 is detected and stored as TWO. Subsequently, when there is no error in the setting of the blood collection container 5, 200 ml of the blood collection amount, the number of blood collections (Ns) = 5, and the processing mode (apheresis) are input as initial values. Then, a tube connected to the cuff 49 is attached to the cuff pressurizing port 93, and the cuff 49 is attached to the blood donor.

When the start switch on the front panel is turned ON after the above setting is completed, the process shifts to [3] in the flowchart of FIG. When the start switch is turned on, the first circuit switch 80 is turned on, and the power supply of the rocking means 42 is turned on. This is because the first circuit switch 80 is configured to be turned on at the same time as the start switch is turned on. Thereafter, the weight of the blood collection container 5 is detected (TW5), and TW5 is equal to or less than TW0 (a value TW0 + ΔTW0, which is slightly larger than the weight of the storage tray 98 (ΔTW0) (TW5 ≦ TW0 + ΔTW0)). in case of,
It is detected that the blood collection container 5 is not stored in the blood collection container storage part 41, an alarm is activated, and the process proceeds to a mounting process routine. In addition, an alarm will be activated if blood leaks or the lid is open.

When these operations are completed, the start lamp is turned on and the mode shifts to the air-bleeding anticoagulant inflow mode and the anticoagulant injecting mode, where N = Ns (N = Ns in this case).
5) is input, and the pressure (BP) of the blood collection container housing portion 41 is input.
Is started. Then, the process proceeds to [5] of the flowchart of FIG. 10 and further to [10] of the flowchart of FIG. The leak valve 50 is closed, the valve 51 is open to the atmosphere, the valve 52 is vented, the vacuum pump 43 is operated, and the inside of the blood collection container housing 41 is pressurized. Then, the second circuit switch 81 is turned on, the swinging means 42 operates, and the slit detecting section 67
When the slit 65 is detected, the second circuit switch 81
Is turned off, the rocking motor 60 stops at the bottom dead center of the crank mechanism, and the rocking means 42 stops. Accordingly, the blood collection container housing table 98 stops at a position where the tube connection side of the blood collection container 5 is at an upper position (in this embodiment, a position which is -20 ° with respect to the horizontal). This operation will be described in more detail. When the second circuit switch 81 is turned on by the control unit 59, the rocking means 42 operates, and the rocking motor 60 and the shaft of the rocking motor 60 are mounted. The rotated rotator 63 rotates, and the slit detector 67 detects the second slit 65 of the rotator 63. Then
The control unit 59 turns off the second circuit switch 81 and applies an electromagnetic brake to the swing motor 60.
Is stopped at the bottom dead center of the crank mechanism.
2 is stopped. Thereby, the air in the blood collection container 5 moves to the tube connection side. Then, when the blood collection container housing table 98 stops at the above position, the circuit opening / closing means 1
2 is opened, and the air that has moved to the tube connection side of the blood collection container 5 is discharged to the outside from the blood collection needle 21 via the first blood supply tube 2. Further, the leak valve 50 is opened to the atmosphere, the pump 43 is turned off, and the circuit
Is closed, and the first air release ends.

Further, an anticoagulant lamp (ACD lamp)
Lights up, the second circuit switch 81 is turned on,
When the swing means 42 operates and the slit detecting section 67 detects the first slit 64, the swing motor 60 stops at the top dead center of the crank mechanism, and the second circuit switch 81 is turned off.
State, and the rocking means 42 is stopped. Thereby, the blood collecting container housing table 98 returns to the above-described initial state position (a position where the tube connection side of the blood collecting container 5 is lowered, in this embodiment, a position which is + 20 ° with respect to the horizontal).
This operation will be described in more detail. When the second circuit switch 81 is turned on by the control unit 59, the rocking means 42 operates, and further, the rocking motor 60 and the shaft of the rocking motor 60 are rotated. Is rotated, and the slit detecting section 67 detects the first slit 64 of the rotating body 63. Then, the control unit 59 turns off the second circuit switch 81 and applies the electromagnetic brake, thereby stopping the rotation of the swing motor 60 at the top dead center of the crank mechanism and bringing the swing means 42 into a stopped state. . And
When the blood collection container storage table 98 stops at the initial position,
Leak valve 50 is closed, valve 51 is vented,
The valve 52 is opened to the atmosphere, the vacuum pump 43 is operated, and the inside of the blood collection container housing 41 is depressurized. Further, the circuit opening / closing means 46 is opened, and a small amount (here, 10 m) is placed in the blood collection container 5 from the anticoagulant container 45.
l) Anticoagulant (eg ACD solution) is injected. In the injection of the anticoagulant, the weight obtained by subtracting the weight (NWo) before filling the anticoagulant from the weight (NWn) of the blood collection container 5 by the blood collection container weight detection unit 57 is the anticoagulant set weight ( W5, here 10 ml) or more (NWn-NWo ≧ W5)
When the above state is reached, the leak valve 50 is opened to the atmosphere, the vacuum pump 43 (VP43) is turned off, the circuit opening / closing means 46 is closed, and the anticoagulation is stopped. The agent injection operation is completed. Before NWn−NWo ≧ W5,
It is always determined whether an error has occurred, and if an error occurs, an error process is performed.

When the injection of the anticoagulant is completed, the second circuit switch 81 is turned on again, the oscillating means 42 is operated, and the slit detector 67 is turned on by the second slit 6.
When 5 is detected, the second circuit switch 81 is turned off, the rocking motor 60 stops at the bottom dead center of the crank mechanism, and the rocking means 42 stops. Thereby, the blood collection container housing table 98 is positioned at a position where the tube connection side of the blood collection container 5 is at the top (−20 with respect to the horizontal in this embodiment).
Stop at the position indicated by ゜). And the leak valve 50
Is in a closed state, the valve 51 is in an open state, the valve 52 is in a vented state, the vacuum pump 43 is operated, and the inside of the blood sampling container housing part 41 is in a pressurized state. Further, circuit switching means 1
By opening 2, the residual air in the blood collection container 5 is completely evacuated from the blood collection needle 21 via the first blood supply vessel 2, and the first blood supply vessel is filled with the anticoagulant. During that time, the blood collection container weight detection unit 57 detects the weight (NW) of the blood collection container 5.
n) is sequentially detected, and NWn is the weight (NW) before filling with the anticoagulant.
If the value NW0 + △ NW0 or less (NWn ≦ NW0 + △ NW0), which is slightly larger (△ NW0) than (0), the leak valve 50 is open to the atmosphere and the vacuum pump 43 (VP43) is turned off.
The state is switched to the FF state, the circuit opening / closing means 46 is closed, and the second air venting operation is completed. In addition, NW
While n> NW0, it is always determined whether or not an abnormality has occurred. If an abnormality has occurred, abnormality processing is performed. As described above, the blood collection apparatus 1 of the present invention can completely remove the residual air mixed in the blood collection container 5 by performing the air removal operation twice. This ends the air bleeding and anticoagulant inflow step (mode).

When the air bleeding operation in the blood collection container 5 is completed, the processing mode, in this case, the apheresis is determined, and the flow shifts to [6] in the flowchart shown in FIG. 12, where the leak valve 50 is closed. The pressure reduction / pressure switching valve 51 is ventilated, the circuit opening / closing means 46 is opened, the vacuum pump 43 is operated, and the inside of the blood collection container storage 41 is depressurized, and the blood collection from the anticoagulant storage container 45 is performed. An anticoagulant (here, 20
ml) is injected. In the case of blood collection only, it is shown in FIG.
Move to [7]. In the injection of the anticoagulant, the weight obtained by subtracting the weight (NW0) before filling the anticoagulant from the weight (NWn) of the blood collection container 5 by the blood collection container weight detection unit 57 is as follows.
The operation is performed until it is detected that the weight of the anticoagulant reaches the set weight (Wo) or more (NWn−NW0 ≧ Wo). When the above state is reached, the first circuit switch 80 is turned off, and the swing means 42 The power is turned off. This is the control unit 5
9 is a predetermined amount (in this embodiment, set to 20 ml) into the blood collection container 5 by the blood collection container weight detector 57.
When the injection of the anticoagulant is detected, the first circuit switch 80 of the electric circuit section is turned off and the power of the oscillating means 42 is turned off.
Here, by turning off the power of the rocking means 42, the power consumption of the apparatus in the puncturing standby state until the blood collection is started can be reduced.

Thereafter, the vacuum pump 43 (VP4
The operation of 3) is stopped, the circuit opening / closing means 46 is closed, the leak valve 50 is opened, and the injection of the anticoagulant ends. Also, within a predetermined time, N
Until Wn−NW0 ≧ Wo, it is always determined whether or not an abnormality has occurred. If an abnormality has occurred, abnormality processing is performed. Subsequently, the cuff pressure (CPR) is detected, the leak valve 54 is closed, and the cuff pressurizing pump 44 (CP44) operates. When the cuff pressure becomes higher than the set value (P2) (CPR ≧ P2), a standby alarm is activated,
The ACD lamp turns off and the start lamp blinks. Also,
As long as CPR ≧ P2 is not reached within a predetermined time, it is always determined whether or not the cuff pressure is abnormal. If an abnormality occurs, abnormal processing is performed, and the process proceeds to [7] in the flowchart.

Then, the blood collection needle 21 is punctured into the vein of the blood donor, and after confirming that the blood has flowed into the blood supply tube from the blood collection needle by the blood pressure of the blood donor, the start switch provided on the front panel 86 is operated. turn on. As a result, the first circuit switch 80 is turned on, and the swinging means 42
Is turned on. Then, the flow shifts to a flowchart [8] shown in FIG. 13, in which the cuff pressurizing pump 44 maintains the operating state, and as described later, the pressure is increased to a predetermined pressure by ON / OFF operation of the pump similarly to the vacuum pump 43. Maintained within range. By the operation of the vacuum pump 43, the blood flows into the blood collection container 5, the second circuit switch is turned on, and the rocking means 42 operates. Further, the blood collection lamp and the start lamp are turned on. The oscillating means 42 oscillates the storage table 98 at a constant cycle (in this embodiment, about 1 second cycle). During the oscillating operation, the blood collection container weight detector 57 detects the initial position (storage table). Is + 20 ° with respect to the horizontal), and the whole blood weight is sequentially detected. This is because, when the slit detecting section detects the first slit 64, the control section 59 activates the blood collection container weight detecting section 57 without stopping the rotation of the swing motor 60, and swings the whole blood while swinging. By controlling to detect weight.

Then, the whole blood weight is -50 m of the set blood collection amount.
l (here, 150 ml), every cycle
The swing is stopped (about 1 second) at the initial position, and more accurate weight detection is performed. Further, when the weight (NWn) of the blood collection container 5 reaches the set weight [W1 = set blood collection weight + anticoagulant weight (Wo)] or more (NWn ≧ W1), the circuit opening / closing means 12 is closed, and the leak valve is closed. 50 is opened, the operations of the vacuum pump 43 and the cuff pressurizing pump 44 are stopped, the valve 51 is also opened to the atmosphere, and the blood sampling operation is completed. Further, thereafter, in order to sufficiently collect the blood and the agitation of the anticoagulant, the rocking means 42 continues to operate, and after performing the stirring several times continuously, the blood collection lamp is turned off. Then, the second circuit switch 81 is turned off, and the swing means 42 is stopped. Also, within a predetermined time, NW
Unless n ≧ W1, it is always determined whether an abnormality has occurred. If an abnormality has occurred, abnormality processing is performed.

Then, the processing mode (only blood collection or apheresis, in this case, apheresis) is determined, and the flow shifts to [9] in the flowchart shown in FIG. From here, the mode is shifted to the small blood return mode, and the separated blood return lamp is turned on. In the small-volume blood return mode, the blood in the first blood supply vessel 2 is in a state in which the anticoagulant is not added after the blood collection, and if left as it is, the blood in the first blood supply blood vessel 2 will coagulate. By returning a small amount of blood, the blood in the first blood vessel 2 is returned to the donor, and the blood to which the anticoagulant in the blood collection container 5 is added flows into the first blood vessel 2. This is performed to prevent blood coagulation in the blood supply vessel 2. In the small-volume blood return mode, the leak valve 50 is closed, the valve 51 is open to the atmosphere, the valve 52 is vented, the vacuum pump 43 is operated, and the inside of the blood collection container housing 41 is pressurized. Is stored as TW3, and the circuit opening / closing means 12 is opened. The weight of this small amount of blood returned is the weight obtained by subtracting the weight (NWn) of the blood collection container 5 from the weight (TW3) of the blood collection container 5 before blood return. [Set blood return weight of anticoagulant-added blood (W2)] The above operation is performed until (TW3−NWn ≧ W2), and when the set weight is reached, the small-volume blood return operation is completed, the mode is shifted to the separation / blood return mode, and the circuit opening / closing means 12 is closed.
The circuit opening / closing means 13 is opened. Unless TW3−NWn ≧ W2 within a predetermined time, it is always determined whether or not an abnormality has occurred. If an abnormality has occurred, abnormality processing is performed. Then, the number of remaining blood sampling times (N) is determined, and N =
Ns (N = 5 in this case), that is, when it is determined that this is the first time, the circuit opening / closing means 14 is slightly delayed to be in the open state. This is because the opening timing of the circuit opening / closing means 14 is delayed by 10 to 20 seconds so that the plasma is not diluted by the priming liquid (saline) filled in the plasma separator 7 only for the first time. (Saline) only. In the separation / blood return mode, the circuit opening / closing means 13 and 14 are open, and the operation of the vacuum pump 43 is maintained. Therefore, the blood inside the blood collection container 5 flows into the plasma separator 7, and the plasma component separated by the plasma separator 7 flows into the plasma collection container 10 through the plasma transport pipe 9. The blood cell component flowing out of the plasma separator 7 passes through the third blood supply vessel 8 and is returned to the donor.

The weight of the plasma collection container 10 is measured by the plasma weight detector 99 at a constant cycle.
Then, in this operation, when the weight of the plasma collection container 10 does not reach the set plasma collection amount, the blood collection container 5 has a set threshold value, in other words, the weight (NWn) of the blood collection container 5 The weight obtained by subtracting the weight (TW5) of the blood collection container 5 before blood collection is equal to or less than the set weight (Wth) (NWn−TW5 ≦
Wth), and the next blood collection amount is calculated from the collected blood collection weight and the blood collection amount, and the next blood collection amount is calculated as follows. Plasma collection efficiency (η) = Current plasma collection volume / Set blood collection volume ...
・ ・ (1) Remaining plasma collection amount = set plasma collection amount-integrated plasma collection amount ・ ・
・ ・ ・ ・ (2) Next expected plasma collection volume = set blood collection volume × η ・ ・ ・ ・ ・ ・ (3) When remaining plasma collection volume ≥ next expected plasma collection volume Next blood collection volume = set blood collection volume ...・ ・ (4) In case of remaining plasma collection volume <next expected plasma collection volume Next blood collection volume = remaining plasma collection volume / η + α (5) (where α is the increase in blood hematocrit of the donor) The amount is set in consideration of a decrease in the efficiency of plasma collection due to a decrease in the performance of the plasma separator 7 and is usually 10 to 30.
The value is about g. )

When the weight of the plasma collection container 10 reaches the set plasma collection amount, the circuit opening / closing means 13 and 14 are closed, the valves 51 and 52 are open to the atmosphere, and the operation of the vacuum pump 43 is stopped. , The separation and blood return work is completed,
The process proceeds to the flowchart [11] in FIG. Then, the first circuit switch 80 is turned off, and the swing means 4
The power supply of the second power supply is shut off. This is because the control unit 57 turns off the first circuit switch 80 of the electric circuit unit when the plasma weight detection unit 99 detects the set plasma collection amount,
This is because the power of the rocking means 42 is controlled to be in the cutoff state. Thereby, power consumption in the standby state after the processing is completed can be reduced. Until the weight of the plasma collection container 10 does not reach the set plasma collection amount within a predetermined time, it is determined whether an abnormality has occurred. If an abnormality has occurred, an abnormality process is performed. Then, it is determined whether the remaining number of blood collection times is one (N: 1).
The process proceeds to [12] in the flowchart shown in FIG.
−1 is input, the number of times is counted down, and the weight of the blood collection container 5 is stored as TW1. In this description, the embodiment in which the number of times is input is used. However, the number of times may not be input in consideration of the above-mentioned amount of collected plasma. Again, the ACD lamp lights up and the leak valve 5
0 is closed, valve 51 is vented, valve 52 is open to atmosphere, vacuum pump 43 is activated, circuit opening / closing means 46 is open, leak valve 54 is closed, and cuff pressurizing pump 44 is closed. Activates the anticoagulant (for example, AC) from the anticoagulant storage container 45 into the blood collection container 5.
D) is less than the set weight (Wo) of the anticoagulant by subtracting TW1 from the weight (NWn) of the blood collection container 5 (NWn-T
When the above weight is reached, the circuit opening / closing means 46 is closed, the operation of the vacuum pump 43 is stopped, and the ACD lamp is turned off. Also,
Unless NWn−TW1 ≧ Wo is reached within a predetermined time,
It is always determined whether an error has occurred, and if an error occurs, an error process is performed. Then, when the cuff pressure becomes higher than the set value (CPRn ≧ P2), the flow shifts to [13] in the flowchart shown in FIG. 13, and blood collection is started again.
Unless CPRn ≧ P2 within a predetermined time, it is always determined whether or not an abnormality has occurred, and if an abnormality has occurred, an abnormality process is performed.

Also, when it is determined that the remaining number of times of blood collection is one (N = 1), the first circuit switch 80 is turned off, and the power of the rocking means 42 is cut off. Then, the end alarm sounds, the start lamp and the separated blood return lamp are turned off, the end lamp is turned on, and the blood collection needle 21 is removed from the donor. Further, by opening the lid of the blood sampling device 1, the circuit opening / closing means 12, 13,
14 and 46 are all in the open state, the end lamp is turned off, the blood collection container 5 is taken out from the blood collection container housing 41, and the plasma separator 7 is removed from the plasma separator mounting portion, thereby completing the plasma collection operation. . Further, if necessary, without opening the lid, inputting the number (N) from the number key and pressing the start key again, [1] in the flowchart of FIG.
4], and again to the ACD injection mode.

In the blood sampling apparatus 1 of this embodiment, when an abnormality occurs in the detection of the weight and the cuff pressure of the blood collecting container 5, the abnormality is detected and an abnormality process is performed. Next, an abnormality processing flow of the blood sampling apparatus 1 of the present invention will be described with reference to FIGS. In this abnormal processing warning flow, as shown in the route on the left side of FIG. 17, the stop switch is pressed during the operation of the blood collection device 1, the blood collection flow rate is reduced, and the lid is opened. It is sequentially determined whether or not there is a blood leak, whether or not air bubbles are detected during the plasma separation and blood return modes. When YES is determined, the process proceeds to the warning flow [20]. It is configured as follows. First, when a decrease in the blood collection flow rate is detected, it is determined whether it is during blood collection, and if so, A = 1 (if A = 1, it means that the blood collection flow rate has decreased again). Judge, A =
If it is not 1, the flow shifts to subroutine A shown in FIG. In this blood collection device 1, the blood collection container storage unit 4
(1) The pressure is maintained within the above range by repeatedly turning ON / OFF the vacuum pump so that the internal pressure has a set pressure as an upper limit and a predetermined lower limit (for example, 0.9 times the set pressure) as a lower limit. Is controlled to be.

The detection of the weight by the blood collection container weight detection unit 57 provided in the blood collection container storage unit 41 is performed for each swing cycle of the swinging means 42 of the blood collection container storage unit 41, and , Is configured to detect a decrease in blood collection flow rate by comparing with a previously detected weight.
When the decrease in the blood collection flow rate is detected, the process proceeds to the subroutine A shown in FIG. 18 as described above. And
The leak valve 50 is opened, and this state is maintained for one second (T4). Then, the blood collection pressure (P) is automatically set to 1/2 of the set pressure (P1), that is, P1 / 2, the leak valve 50 is closed, A = 1 is automatically input, and blood collection is started again. Then, when the blood collection flow rate decreases again, as shown in the flowchart of FIG. 17, A = 1 is determined.
= 0 is automatically input, the alarm is activated, the flow shifts to [20] in the flowchart of FIG. 19, and the vacuum pump 43 and the oscillating means 42 are stopped as shown in FIG. The valve 54 is opened, then all the circuit opening / closing means are closed, the start switch blinks, and the interruption switch blinks.

Subsequently, ON / OFF of the start switch and ON / OFF of the interruption switch are determined. When the start switch is turned on and the lid 83 is closed, the interruption lamp is turned off, the start lamp is turned on, the alarm lamp is turned off, and the flow shifts to the flowchart [21] of FIG. On the other hand,
By turning on the interruption switch, the blood collection container weight detection unit 57 detects the weight (NWn) of the blood collection container 5 and
If Wn is a value TW0 + 重量 TW0 or less (NWn ≦ TW0 + △ TW0) slightly larger than TW0 (the weight of the storage table 98), it is determined that the blood collection container 5 has been removed from the storage unit 41, and the first The circuit switch 80 is turned off, and the power supply of the swing unit 42 is turned off. This is because the control unit 59 determines whether the blood collection container weight detection unit 5
7 is operated, and when the blood collection container weight detection unit 57 detects a weight equal to or less than the set amount, the first circuit switch 80 of the electric circuit unit is turned off, and the power of the rocking unit 42 is turned off. By doing. Thereby, power consumption at the time of occurrence of an abnormality can be reduced. Then, the alarm lamp, the start lamp, and the interruption lamp are turned off, and the process shifts to [2] in the flowchart of FIG. 8 to stop the plasma sampling operation. If (NWn> TW0 + △ TW0), it is determined that it does not take a long time to recover, and the first
When the circuit switch 80 is maintained in the ON state and the start switch is turned ON, the closing of the lid 83 is detected, the interruption lamp is turned off, the start lamp is turned on, and the alarm lamp is turned off. Move on to [21].

Further, when the first circuit switch 80 is in the OFF state, the control section 59 controls the slit detection section 6
7 detects the slit provided in the rotating body 63 of the rocking motor 60, turns on the first circuit switch 80, turns off the second circuit switch 81, and turns the rotation of the rocking motor 60 on. Is controlled to be stopped.
This is because when the first circuit switch 80 is in the OFF state,
In consideration of the case where the rocking motor 60 is rotated because the electromagnetic brake is not effective,
The swing motor 60 can be stopped by applying an electromagnetic brake.

[0050]

The blood collecting apparatus of the present invention is a blood collecting apparatus for controlling a blood collecting circuit for collecting whole blood from a blood collector, and the blood collecting apparatus is provided in the blood collecting circuit. A blood collection container weight detection unit for detecting the weight of the blood collection container, a swing unit configured by a swing motor and a crank mechanism, a rotating body that rotates with the rotation of the swing motor, and a rotating body provided on the rotating body. Oscillating means for stirring the whole blood to be collected and the anticoagulant, and an identifying section detecting means for detecting an identifying section provided on the rotating body of the oscillating means,
A first circuit switch for turning on / off a power supply of the oscillating means; an electromagnetic brake circuit for temporarily stopping the oscillating motor; and a second circuit switch for operating the electromagnetic brake circuit. An electric circuit unit for a rocking motor having a circuit switch, and a control unit having an arithmetic circuit unit for controlling opening and closing of the first circuit switch and the second circuit switch of the electric circuit unit. I have. Therefore, in this device, when the rocking motor is temporarily stopped, the electromagnetic brake circuit can be operated by the second circuit switch, and the rocking motor can be temporarily stopped. By stopping the operation of the circuit, the swing motor can be rotated immediately. Further, when the rocking motor is stopped for a certain period of time (specifically, a standby state immediately after power-on of the apparatus, a puncturing standby state until a blood collection needle is punctured by a blood sampling needle, a standby state after the processing is completed, At the time of occurrence of an error or a temporary standby state by the stop switch).
The power of the oscillating motor can be turned off by the circuit switch described above, whereby the power consumption of the entire apparatus can be reduced and the temperature of the apparatus can be prevented from rising.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of an embodiment of a blood sampling device of the present invention with a plasma separation circuit attached.

FIG. 2 is a perspective view of an embodiment of the blood sampling apparatus of the present invention without a plasma separation circuit attached.

FIG. 3 is a schematic view of a swinging means of one embodiment of the blood sampling apparatus of the present invention.

FIG. 4 is an electric circuit diagram of a control unit and an identification unit detection unit of one embodiment of the blood collection device of the present invention.

FIG. 5 is an electric circuit diagram for explaining the operation of the electric circuit section of the blood collecting apparatus according to one embodiment of the present invention.

FIG. 6 is an electric circuit diagram for explaining the operation of the electric circuit section of one embodiment of the blood collecting apparatus of the present invention.

FIG. 7 is an electric circuit diagram for explaining the operation of the electric circuit unit of one embodiment of the blood collection device of the present invention.

FIG. 8 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 96 is a flowchart for explaining the operation of the blood sampling apparatus according to the embodiment of the present invention.

FIG. 10 is a flowchart for explaining the operation of the blood sampling apparatus according to the embodiment of the present invention.

FIG. 11 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 12 is a flowchart for explaining the operation of the blood sampling apparatus according to the embodiment of the present invention.

FIG. 13 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 14 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 15 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 16 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 17 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 18 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

FIG. 19 is a flowchart for explaining the operation of the blood sampling device according to the embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood collection apparatus 2 1st blood supply vessel 5 Blood collection container 6 2nd blood supply blood vessel 7 Plasma separator 8 3rd blood supply blood vessel 9 Plasma transport tube 10 Plasma collection container 12 First circuit opening and closing means 13 Second circuit opening and closing means 14 Third circuit opening / closing means 41 Blood sampling container storage section 42 Swing means 57 Blood sampling container weight detecting section 58 Pressure reducing / pressurizing means 59 Control section 60 Swing motor 61 Crank bar 63 Rotating body 64 First slit 65 First Second slit 66 Third slit 67 Slit detecting means 68 Swing table 69 Weighing table 70 Blood leak sensor 80 First circuit switch 81 Second circuit switch 82 Third circuit switch 98 Blood sampling container housing 99 Plasma weight Detector

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-2-144045 (JP, A) JP-A-1-131644 (JP, A) JP-A-4-71564 (JP, A) JP-A-2- 195963 (JP, A) JP-A-3-90154 (JP, A) JP-A-3-170160 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61M 1/02

Claims (1)

(57) [Claims] 1. A blood collection device for controlling a blood collection circuit for collecting whole blood from a blood collector, wherein the blood collection device detects a weight of a blood collection container provided in the blood collection circuit. A blood sampling container weight detector, a rocking unit including a rocking motor and a crank mechanism, a rotating body that rotates with the rotation of the rocking motor, and an identification unit provided on the rotating body. Oscillating means for agitating the whole blood collected in the blood collection container and the anticoagulant; identifying part detecting means for detecting an identifying part provided on the rotating body of the oscillating means; First means for turning on or off the power supply of the means;
A circuit switch, an electromagnetic brake circuit for temporarily stopping the rocking motor, a second circuit switch for operating the electromagnetic brake circuit, a rocking motor electric circuit portion, and the electric circuit portion. A blood collecting apparatus, comprising: a controller having an arithmetic circuit for controlling the opening and closing of the first circuit switch and the second circuit switch.