JP3293692B2 - Fungicide composition for sandbox containing iodine - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an iodine-based germicidal detergent composition for sandboxes,
The present invention relates to a fungicide composition for a sandbox having excellent iodine stability.

[0002]

2. Description of the Related Art A sandbox in a park, a kindergarten, a nursery school, a school or the like has a problem in that dogs and cats can easily enter the sandbox, and the manure is contaminated with microorganisms such as Escherichia coli. For the purpose of disinfecting sandpits contaminated by microorganisms such as Escherichia coli, enzyme-based disinfectants have already been sold or the application of chlorhexidine gluconate has been described in the literature, but the disinfecting effect is not sufficient. However, the goal of sanitizing and sanitizing sandboxes has not been achieved. Hypochlorite has a high bactericidal effect,
There are safety issues such as high skin irritation. The present inventors have conducted various studies on a fungicide composition for a sandbox that can be safely and effectively sterilized, and as a result, have completed the present invention.

[0003]

That is, the present invention provides a fungicide composition for a sandbox, which contains an iodine compound generating iodine or iodine. As iodine used as an active ingredient in the composition of the present invention, iodine alone, a complex of iodine and glycine,
Polyiodoalcohol solutions, complexes of iodine and a surfactant (poloxamer iodine, nonionic surfactant iodine, etc.), polymer iodine complexes, (polyvinylpyrrolidone iodine, polyvinyl alcohol iodine, etc.) and the like are included.
Examples of the polymer capable of complexing iodine include polyvinylpyrrolidone, polyvinyl alcohol, and polyacrylic acid. Examples of the surfactant capable of complexing iodine include alkylbenzene sulfonates, alkyl sulfates, alkyl ether sulfates, α- Olefin sulfonates, anionic surfactants such as alkane sulfonates,
Cationic surfactants such as benzalkonium chloride, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, polyoxyethylene sorbitan fatty acid ester, fatty acid alkanolamide,
Nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene block polymers, polyoxyethylene alkyl phenyl ethers, alkyl glucosides, and amino acid salts (for example, methyl alkylaminopropionate, alkylaminoethyl hydrochloride, etc.) ), Betaine type (eg, stearyl betaine, betaine lauryl dimethylaminoacetate, 2-alkyl-N-carboxymethylhydroxyethyl imidazolium betaine, etc.), sulfate type (eg, N-lauryl-N, N-dimethylaminopropyl sulfone) An amphoteric surfactant such as an acid salt type (for example, N-lauryl-N, N-dimethylaminopropyl sulfonic acid), a phosphate ester type (for example, lecithin), and the like can be given. Ethanol, propanol, isopropanol, etc., and polyols such as propylene glycol, glycerin, polyethylene glycol, ethylene glycol, butylene glycol, sorbitol, etc. Further, as an iodine compound which generates iodine, iodine monochloride, iodate , Iodine salts, etc. that generate iodine when dissolved in water by an oxidizing agent, a reducing agent, or by themselves. Among them, iodine monochloride, when applied to a sand pit, contains iodine in the sand. Since it has almost no peculiar smell and the color of the sand does not change, it has a very favorable advantage for application to a sandbox.

[0004] Further, when an inorganic salt and an acid are added to the composition, the stability of iodine over time is increased. As the inorganic salt, sodium chloride, calcium chloride, potassium chloride and the like are preferable, and sodium chloride is particularly preferable. As the acid, sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, oxalic acid, citric acid and the like are preferable, and hydrochloric acid is particularly preferable.

[0005] The composition may further contain an amino acid such as glycine, alanine, sarcosine, lysine and the like.

[0006] In the composition, the ratio of each component can be variously changed, but iodine or iodine compound generating iodine is 0.001% by weight or more, preferably 0.01 to 4% by weight.
0% by weight, 1 to 50% by weight of inorganic salt, preferably 10 to 3%
0% by weight, acid 0.01 to 30% by weight, preferably 0.1 to
10% by weight and 0.1 to 20% by weight, preferably 1 to 10% by weight of amino acids show preferable properties.

In the present invention, other known components may be blended as long as the performance is not impaired. The present invention
It is manufactured by mixing the respective components by a known method, and the dosage form can be liquid, powder, solid (tablet or the like).

[0008]

Next, the present invention will be specifically described by way of examples and comparative examples. EXPERIMENTAL EXAMPLE 1 About Examples 1-3 and Comparative Examples 1-2, the bactericidal power, the coloring property to sand, and the smell were evaluated by the following methods. (Example 1) Polyvinyl pyrrolidone iodine was dissolved in water to prepare an aqueous solution containing 0.1% of effective iodine. (Example 2) An aqueous solution of 0.1% effective iodine was prepared from an aqueous solution of an iodoglycine complex and potassium iodide. Example 3 A 0.1% aqueous solution of effective iodine was prepared from an aqueous solution of iodine monochloride in hydrochloric acid. Comparative Example 1 An enzyme was dissolved in water to prepare a 0.1% aqueous solution. (Comparative Example 2) Chlorhexidine gluconate (20% aqueous solution) was diluted with water to prepare 0.1% as an effective component.

(Test method for bactericidal activity) 16.5 g of the chemicals prepared in Examples and Comparative Examples or water (control) was mixed with 100 g of sand and left at room temperature for 30 minutes for 7 minutes. 30 g are weighed and extracted with 50 ml of 0.05% Tween-80 in a sterile jar. Using a desoxycholate agar medium as a differentiation medium for coliform bacteria, the number of bacteria in 1 ml of the extraction test solution was measured by a pour plate method, and the bactericidal rate was determined by the equation 1. Culture at 37 ° C
For 24 hours.

[0010]

(Equation 1)

(Colorability to Sand) The presence or absence of coloring of sand when 16.5 g of the chemicals or water (control) prepared in Examples and Comparative Examples was mixed with 100 g of sand was compared with that before mixing. Was evaluated. Evaluation criteria ：: No coloring was observed. Δ: Slight coloring is observed. ×: Clear coloring is observed. (Smell) The chemicals prepared in Examples and Comparative Examples or water (control) were mixed with 16.5 g of sand with respect to 100 g of sand, and the presence or absence of smell of sand was evaluated by comparing with that before mixing. Evaluation criteria ○: There is no resistance in use. ×: There is a feeling of resistance in use. (Comprehensive evaluation) ：: No problem at all 殺菌: Sterilization rate is 99% or more, and any of evaluations of colorability and odor is Δ ×: Sterilization rate is less than 99% The results are shown in Table 1. Show.

[0012]

[Table 1]

From the results shown in Table 1, it was confirmed that the iodine-based germicidal composition of the present invention has a higher initial bactericidal effect and a superior persistence of the effect as compared with other drugs.

Example 4 Iodine monochloride 3% Sodium chloride 30% Hydrochloric acid 1% Water balance

Example 5 Polyvinylpyrrolidone iodine 20% Citric acid 1% Potassium chloride 1% Water balance

Example 6 Iodine alone 2% Glycine 1% Potassium iodide 2% Citric acid 2% Sodium chloride 30% Water Remainder

Example 7 Poloxamer iodine 5% Phosphoric acid 1% Polyoxyethylene alkyl ether 3% Potassium chloride 20% Water balance

Example 8 Potassium iodate 5% Potassium iodide 25% Citric acid 2% Calcium chloride 40% Sodium sulfate 28%

Example 9 Polyvinylpyrrolidone iodine 10% Citric acid 3% Sodium chloride 10% Alcohol 77%

The above fungicide compositions for sandboxes of Examples 4 to 9 were stable in a storage test at 40 ° C. and room temperature without iodine precipitation or sedimentation even after 30 days.

[0021]

According to the present invention, the iodine fungicide composition which can be safely and effectively sterilized prevents microbial contamination such as Escherichia coli by feces of dogs and cats in sandboxes of parks, kindergartens, nurseries, schools and the like. It is possible.

────────────────────────────────────────────────── ─── Continuation of front page (72) Atsushi Utsunomiya, Inventor Page (2) 1900 Togo, Mobara-shi, Chiba Investigator, Mitsui Toatsu Chemicals Co., Ltd. Kenji Hara (56) References JP-A-61-197504 (JP) JP-A-56-77209 (JP, A) JP-A-63-68508 (JP, A) JP-A-63-35506 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB Name) A01N 59/12 A01N 25/22 A01M 17/00 A61L 2/16 CA (STN) REGISTRY (STN) JICST file (JOIS)

Claims (3)

(57) [Claims] 1. A fungicidal composition for a sandbox, comprising iodine monochloride, an inorganic salt and an acid. 2. The fungicidal composition for a sandbox according to claim 1, further comprising 0.001% by weight or more of iodine monochloride, 1 to 50% by weight of an inorganic salt and 0.01 to 30% by weight of an acid. 3. The fungicidal composition for a sandbox according to claim 1, further comprising 0.001% by weight or more of iodine monochloride, 10 to 30% by weight of an inorganic salt and 0.01 to 30% by weight of an acid.