JP3321268B2 - Ion-selective electrode - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a flow-type ion-selective electrode for measuring the concentration of electrolyte components in blood or urine, for example.

[0002]

2. Description of the Related Art In general, an a.
Examples of the on-selective electrode cell include a flow-type electrode cell as shown in FIGS. This ion selective electrode
Cell 1 is generally used for measurement purposes (eg, Na, K, Cl)
Are connected according to the number. Three ion selective electrodes
The pole cells 1 are arranged in a line and are held by an electrode holding unit 2. Main body 3 of each ion-selective electrode cell 1
Are provided with positioning pins 4 for three ion selections.
The selective electrode cell 1 is positioned by engaging the positioning pins 4 with each other.

[0003] In the main body 3 of each ion-selective electrode cell 1, an ion-selective reaction membrane 5 is adhered, and an electrode internal liquid 6 for taking out signals of the ion-selective reaction membrane 5 is sealed. . Further, a channel 7 for flowing a test liquid is formed in the ion-selective electrode cell 1, and the ion-selective reaction membrane 5 faces the channel 7. Three Lee
The channels 7 of the on-selective electrode cell 1 are connected to each other.
Further, the main body 3 is provided with an electrode output section 8 projecting therefrom, and the electrode output section 8 is immersed in the electrode internal liquid 6.

Since the performance of the ion selective reaction membrane 5 gradually deteriorates, it is necessary to replace the deteriorated ion selective reaction membrane 5.

[0005]

In the conventional ion-selective electrode cell 1 as described above, the electrode output section 8 is connected to a concentration measuring circuit 10 via a lead wire 9. Therefore, re upon desorption of ion-selective electrode cell 1 - lead wire 9 must also be detached, ion-selective electrode cell
The work of attaching and detaching the le 1 is troublesome.

Further, for example, when the lead wire 9 is
If the electrode cell 1 is repeatedly attached and detached, the lead wire 9 deteriorates, and the possibility of disconnection occurs.

On the other hand, the lead wire 9 has an advantage that it can be connected regardless of the distance between the ion-selective electrode cell 1 and the concentration measuring section 10 depending on the selection of the length.
Since an extra portion of the lead wire 9 is routed while avoiding peripheral devices, there is a problem that the lead wire 9 is easily affected by external noise.

Further, since the lead wire 9 must be connected while confirming the use of the plurality of electrode output sections 8, for example, the electrode output section for Na and the electrode output section for K may be incorrectly wired. Or may be.

It is an object of the present invention to provide an ion-selective electrode that can be easily attached and detached and that can prevent connection errors.

[0010]

SUMMARY OF THE INVENTION In order to achieve the above object, the present invention provides a main body having a flow path through which a test solution flows while enclosing a signal transmission medium; It has an ion selective reaction membrane for selectively transmitting the signal to the signal transmission medium, an electrode output portion projecting out of the main body and outputting a signal from the signal transmission medium to the outside of the main body, and is used in combination with a plurality of electrodes. In the ion-selective electrode, one end protrudes from the main body and the other end is provided with an electric signal passing portion exposed from the main body, and the electric signal passing portion is provided with an electrode output portion or an electric signal passing portion of another ion-selective electrode cell. Connected, so that the signal at the electrode output of another ion-selective electrode cell passes.

By doing so, the present invention provides ion selection
Another object of the present invention is to make it easy to attach and detach a selective electrode cell and to prevent connection errors.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described below with reference to FIGS. The same parts as those described in the section of the related art are denoted by the same reference numerals, and description thereof will be omitted.

1 to 6 show an embodiment of the present invention, in which reference numerals 21a to 21c denote ion-selective electrode cells . These ion-selective electrode cells 21a to 21c
As shown in FIG. 6, three are stacked one above the other and held by the electrode holding unit 22. here,
Since most of the structures of the ion-selective electrode cells 21a to 21c are the same, one ion-selective electrode cell 21a will be described below, and the other ion-selective electrode cells 21a will be described.
As for b and 21c, only different parts will be described.

The ion-selective electrode cells 21a to 21c are:
Each of them has a hollow main body 23 formed in a rectangular parallelepiped shape, and a convex portion 24 and a concave portion 25 for positioning are provided on the front and back of the main body 23, respectively. The shapes of the convex portion 24 and the concave portion 25 are both perfectly circular, and they are located concentrically. Further, the diameters of the convex portion 24 and the concave portion 25 are set substantially equal. In addition, the convex portion 24 and the concave portion 25 are
3 offset from the center.

A channel 7 for flowing a test liquid is interposed between the convex portion 24 and the concave portion 25. The flow channel 7 is formed at the center of the surface of the convex portion 24 and at the center of the bottom surface of the concave portion 25. And open to the. An O-ring 26 made of an elastic material is embedded in the convex portion 24 on a concentric circle slightly apart from the opening of the flow path 7. Further, an ion selective reaction membrane 5 is adhered to the main body 23, and the ion selective reaction membrane 5
Faces. Further, in the main body 23, various electrode internal liquids 6 (for example, KCl solution, NaCl solution, etc.) having excellent conductivity for taking out signals of the ion selective reaction film 5 are sealed.

The main body 23 is provided with an electrode output section 27 and an electric signal passing section 28. The electrode output portion 27 is an L-shaped rod made of a conductive material, and is immersed in the electrode internal liquid 6 in a state where the tip portion or the whole thereof is exposed. It protrudes from the surface 29 substantially vertically so as to be able to conduct electricity. The L-shaped tip of the electrode output unit 27 is separated from the ion selective reaction membrane 5 by a certain distance. The tip portion may be directly connected to the reaction film 5 by an appropriate conductive wire if necessary. The electric signal passage section 28 is a stepped rod made of a conductive material, and has a connection section 30 at one end. Further, the electric signal passage portion 28 projects partly from the front surface 29 of the main body 23 so as to be able to conduct electricity.
The connection part 30 which can be energized from is exposed. here,
The electrical signal passing portion 28 and the electrode internal liquid 6 are subjected to appropriate electrical insulation treatment.

The electrode output section 27 and the electric signal passing section 2
As the cross-sectional shape of 8, various shapes such as a circle, a rectangle, and a polygon can be adopted. In addition, various general ones can be adopted as the connection part 30 used for connecting the electrode output part 27 and the electric signal passage part 28. For example,
As the connecting portion 30, a type that holds the electrode output portion 27 and the electric signal passing portion 28 using the spring force of a conductive member is conceivable.

The number and arrangement of the electrode output sections 27 and the electric signal passing sections 28 differ for each ion-selective electrode cell . That is, the uppermost ion-selective electrode cell 21a is provided with one electrode output portion 27 and two electric signal passage portions 28, 28 as shown in FIG. Are arranged at substantially equal intervals on the curved arc. The electrode output section 27 is arranged at the center, and the electric signal passing sections 28, 28 are arranged at both ends.

The ion-selective electrode cell 2 shown in the middle stage
As shown in FIG. 4, 1b is provided with one electrode output part 27 and one electric signal passage part 28, and these are inserted into the electric signal passage part 28 of the upper ion selective electrode cell 21b. It is electrically connected. Further, the ion-selective electrode cell 21c shown in the lower is provided with only the electrode output section 27, the electrode output section 27 middle ion
It is inserted into and electrically connected to the electric signal passage section 28 of the selective electrode cell 21b.

The electrode output section 27 and the electric signal passing sections 28, 28 of the upper ion selective electrode cell 21a are connected to the electrode input sections 32a to 32c (1) protruding from the electrode holding section 22.
(Only one is shown). Electrode input units 32a-3
2c is an L-shaped rod made of a conductive material, and at the end of the electrode input portions 32a to 32c in the electrode holding portion 22,
The connection part 30 is provided similarly to the electrode passage part 28.
The other end portions of the three electrode input portions 32a to 32c protrude from the electrode holding portion 22 in a line. These electrode output sections 32a to 32c are connected to a concentration measuring circuit 10 via a lead wire 9.

The electrode output section 27 of the ion-selective electrode cell 21c shown in the lower part of FIG. 6 is connected to the electrode output part 32c through the middle and upper electric signal passages 28. Further, the electrode output section 2 of the middle-stage ion-selective electrode cell 21b
7 is an electrode output unit 32 through an electric signal passing unit 28 in the upper stage.
b. In addition, the upper ion-selective electrode
The electrode output section 27 of the cell 21a is directly connected to the electrode output section 32a.

On the other hand, a detachable pushing block 22 'is fixed to the lower end portion of the electrode holding portion 22 by an appropriate engaging or screwing structure. Here, the pushing block 22 includes a convex portion 24 corresponding to the rear surface concave portion 25 of the main body 23.
′, And an O-ring 26 and a flow path 7 are provided.

Further, the upper end opening of the flow path 7 of the electrode holding part 22 and the lower end opening of the flow path 7 of the pushing block 22 'are
The liquid is connected to a sample supply unit and a waste liquid recovery unit (not shown), and the liquid is transported upward or downward continuously or intermittently. Here, the sample supply unit appropriately includes a diluting / mixing unit, a constant temperature control unit, a flow rate control unit, a sample switching unit, and the like.

The ion selective electrode cell 21a as described above
When mounting the ~21c the electrode holding portion 22, first the protrusion 24 provided on the main body 23, next to the ion-selective electrode cell
Fitted in a recess 25 provided on le of the body 23, the ion selection
The selective electrode cells 21a to 21c are overlapped in a state where they are positioned concentrically with each other. At this time, the ion selective electrode
The sealing property between the cells 21a to 21c is ensured by the O-ring 26.

The ion-selective electrode cells 21a to 21a
Simultaneously, the electrode output section 27, the electric signal passing section 28, and the electrode output sections 32a to 32c are connected via the connection sections 30, and the electric wiring for concentration measurement is completed.

That is, the connection of the lead wire 2 is made to the electrode input section 3.
2a-32c only, so ion selectivity
There is no need to connect the lead wire 9 to the electrode cells 21a to 21c. Therefore, the ion-selective electrode cells 21a to 21c
Li during desorption of - the lead wire 9 is not necessary to desorption ion
The detachment of the selective electrode cells 21a to 21c is easy, and the complexity of replacing with another ion selective electrode cells 21a to 21c can be reduced. Further, since it is not necessary to frequently remove and attach the lead wire 9, the lead wire 9 is hardly deteriorated, and disconnection is hardly caused.

Further, since the electrode input sections 32a to 32c and the concentration measuring section 10 are connected by the lead wire 9, the lead is
The length of the lead wire can be easily selected, and a lead wire having a fixed length can be used. Therefore, it is less susceptible to irregular external noise.

Next, the set of the electrode main bodies 23 is
After attaching the push block 22 ′ to the holding section 22 after the flow path 7 and the connection section 30 on the upper side of 2 are attached, the mounting is completed. The holding section 22 is designed to be maintained at an appropriate temperature by an appropriate constant temperature means (heater and / or cooler) as necessary, so that the holding section 22, the pushing block 22 ′, and the ion selecting section 22 are selected. sex
Each channel 7 of the electrode cells 21a to 21c can be kept under a constant temperature condition for a long time.

The electrode output section 27 is connected to each ion-selective electrode.
Only one pole cell 21a to 21c is provided,
Because these configurations are different from each other ,
The connection mistake of the electrode cells 21a to 21c can be prevented.

The present invention can be variously modified without departing from the gist.

For example, in the above-described embodiment, three main bodies 23 are set in order to measure three kinds of electrolytes. However, if necessary, a main body having a reference electrode and a function of measuring other various electrolytes are provided. The number may be changed as appropriate by replacing or adding a main body. In some cases, each ion
A reference electrode may be added to the non- selective electrode cells 21a to 21c and the electrode holding unit 22. In any case, each body 23
The number of electrode input sections 32 corresponding to the number n of types of ion selective reaction membranes provided in the above, the electrode holding sections 22 having the lead wires 9 and the main body 23 having n-1 electric signal passing sections 28 are provided.
Use at least one on the side closest to the electrode input section,
As other conduction from the electrode output section in each ion selective electrode cell is uninterrupted, 7 or electrical signal unit 8
By designing and arranging as described above, the concentration of any kind of electrolyte can be measured once or plural times.

In the above embodiment, the push-in block 22 'is detachable. However, a guide groove is formed along the mounting direction with respect to the inner wall of the electrode holder 22, and the push-in block 22' slides at least. While freely fitting,
The pushing block 22 ′ may be urged by an urging member such as a spring, rubber, or a magnet so as to generate a pushing force. By doing so, the ion selectivity for mounting
Mounting or replacement according to the increase or decrease in the number of electrode cells can be easily performed.

In this embodiment, the electrode output section 27 and the electric signal transmitting section 28 protrude upward from the main body 23, but they may be protruded downward to transmit electric signals from top to bottom.

Furthermore, in this embodiment, the upper and middle Lee
In the on-selective electrode cells 21a and 21b, the electrode output unit 27 and the electric signal transmission unit 28 are arranged in an arc shape with the flow path 7 as a center. However, the present invention is not limited to this. These may be arranged at different positions on a straight line.

The positioning projection 24 may be a plurality of positioning pins, and the recess 25 may be an engagement hole for receiving the positioning pin.

The electrode output unit 2 is provided for each ion selection electrode.
Although the arrangement and the number of the 7 and the electric signal passing section 28 are different in the above embodiment, for example, as shown in FIG. 8, the numbers of the electrode output section 27 and the electric signal passing section 28 can be matched. . In this case, each ion selection electrode 31a-3
1c can be arranged at random heights, and the stacking order is not limited. Then, if the arrangement of the respective power output units 27 is made different, as in the case of FIG.
The output signals of 31c can be individually extracted. The number of parts increases, but usability improves.

Further, as shown in FIG. 9, when the number of ion selection electrodes 41a to 41i is increased, they are arranged in parallel in a predetermined number in the horizontal direction (3 × 3 rows in FIG. 9).
It is possible. By doing so, it is not necessary to increase the number of electric signal passage portions 28 of one ion selection electrode.

In FIG. 9, the channel 42 is branched into three, and the same or different samples can be simultaneously or sequentially selected from the sample supply unit 44 through the branch channel 45 for sample transport. As shown in FIG. 10, if necessary, all the channels in the holding unit 43 are connected by a meandering channel 42 ′ formed in the electrode holding unit 43 and the pushing block 43 ′, and nine channels are formed by one channel. The sample may be sequentially passed through the ion selective electrode. In this example, the channel 42 '
Both the electrode holding part 43 and the pushing block 43 'are formed in a U-shape, and communicate the outlet and the inlet of each channel of the adjacent ion selective electrode cell . Push block 4
3 'has a size corresponding to three rows.

[0039]

As described above, according to the present invention, a signal transmission medium is sealed and a main body having a channel through which a test liquid flows, and specific ions are selected from the test liquid and transmitted to the signal transmission medium. An ion-selective electrode that has an electrode output portion that projects out of the main body and outputs a signal from a signal transmission medium to the outside of the main body, and is used in combination with a plurality of one end. an electrical signal passing portion to which the other end is exposed from the body while protruding from the main body is provided, the electrode output section or the electric signal passing portion of the other ion selective electrode cell is connected to the electrical signal passing portion, the other b
The signal at the electrode output of the on-selective electrode cell passes through.

Accordingly, the present invention provides an ion selective electrode cell.
Together to facilitate the desorption of Le lies in capable of preventing the wrong connection.

[Brief description of the drawings]

FIG. 1 shows an ion arranged at the top of one embodiment of the present invention.
The top view which shows a selective electrode cell .

FIG. 2 is a sectional view taken along the line IV-IV in FIG.

FIG. 3 is a sectional view taken along the line VV in FIG. 1;

FIG. 4 is a diagram showing a middle-stage ion-selective electrode cell according to an embodiment of the present invention.
Plan view of a Le.

FIG. 5 is an ion-selective electrode cell at the lower stage of one embodiment of the present invention.
Plan view of a Le.

FIG. 6 is a cross-sectional view showing an example of using the ion-selective electrode of one embodiment of the present invention.

FIG. 7 is a front view showing an example of use of the ion-selective electrode of one embodiment of the present invention.

FIG. 8 is a front view showing a modification.

FIG. 9 is a front view showing another modification.

FIG. 10 is a front view showing another modification.

FIG. 11 is a plan view showing a conventional ion-selective electrode cell .

FIG. 12 is a sectional view taken along the line VI-VI in FIG. 11;

FIG. 13 is a sectional view showing an example of use of a conventional ion-selective electrode.

[Explanation of symbols]

5: ion selective reaction membrane, 6: electrode internal liquid, 7: flow path, 9
... Li - lead wire, 10 ... concentration measurement circuit, 21a~21c ... Lee
On-selective electrode cell , 23 ... body, 27 ... electrode output section,
28: electrical signal passing section, 32a to 32c: electrode input section.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁷ , DB name) G01N 27/28 321 G01N 27/416

Claims (1)

(57) [Claims] A main body having a flow path through which a test liquid flows;
An ion-selective reaction membrane that selects specific ions from the test solution to provide electrical responsiveness, and an electrode that projects out of the main body and outputs a response signal from the ion-selective reaction membrane to the outside of the main body And an ion-selective electrode cell having an output section.
In an ion-selective electrode used in combination with a plurality of electrodes, one end protrudes from the main body at a position different from the electrode output section and the other end has an electric signal passing section exposed from the main body . Reduce the number of electrode cells to 1
Combination, this electric signal passage to another ion selective electrode
The electrode output part or electric signal passage part of the cell is connected,
An ion-selective electrode characterized by being arranged so that a signal from an electrode output section of another ion-selective electrode cell passes therethrough.