JP3326907B2 - In-vivo information continuous measurement device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an intravascular indwelling catheter provided with a sensor for monitoring cardiopulmonary and circulatory functions of a critically ill patient during emergency treatment or surgery, and relates to a sensor sensitivity due to adhesion of a body fluid component of a living body. It is an object of the present invention to provide an in-vivo information continuous measurement device that has a function of preventing a decrease and that reliably monitors various parameters.

[0002]

2. Description of the Related Art A catheter equipped with microsensors capable of instantaneously and continuously measuring oxygen, carbon dioxide, and pH of blood in an artery or a vein by being inserted into a living body, for example, a blood vessel, has a cardiopulmonary function of a patient during surgery. It is widely used for monitoring.
By placing the microsensor catheter, the partial pressure of dissolved gas (oxygen and carbon dioxide) in the blood of the living body during anesthesia, potassium ion concentration (K ⁺ ), hydrogen ion concentration (pH), which are important as parameters for cardiopulmonary function determination Etc. can be measured instantaneously, immediately return these values to the optimal value,
Methods for performing safe anesthesia and surgery have been proposed.
According to this method, as compared with the conventional method of sampling and analyzing blood, it is a very excellent measurement method in that it can quickly respond to fluctuations in blood components. A catheter with a microsensor (catheter sensor) for continuously measuring the above various indices is a method that is attached to the tip of a guide tube, inserted into a blood vessel, and placed in the blood vessel. Exposed. for that reason,
If the sensitive portion of the sensor adsorbs a residue such as protein in the blood on the surface of the contact portion in the flow of the circulating fluid such as blood, the measurement sensitivity is significantly reduced. For this reason, the spread of catheter sensors has been delayed despite the above-mentioned great advantages. As a countermeasure, for example, a method has been proposed in which a sensor is placed in a resilient tubule for a catheter, an anticoagulant solution is poured onto the surface of the sensor-sensitive part, and blood is sucked to refresh the contact with the sensitive part. (JP-A-63-17448, JP-A-63-16063)
No. 5). These methods have a mechanism as shown in FIG. 6. In order to maintain sufficient contact with the blood flow in the sensor-sensitive portion and to completely refresh the blood, an anti-coagulant, for example, a heparin aqueous solution 10 is used. When the solution is poured into the branch portion 12 by the cylinder 11, it is inevitably discharged into the blood vessel, and the blood concentration is reduced, which is not a preferable method.

[0003]

DISCLOSURE OF THE INVENTION The present invention is directed to a biological circulatory system by the structure of a sensor-sensitive part which does not cause washing water such as an aqueous solution of heparin to flow out into the bloodstream, or requires only a small amount of washing out even if it flows out. It is an object of the present invention to provide a biological component continuous measurement device that has little influence on the biological component.

[0004]

Means for Solving the Problems As a result of earnest studies, the present inventors have achieved the above object by providing a balloon for wrapping a sensor in a catheter, thereby closing a catheter tip including the sensor.

That is, the present invention is characterized by the following items. (1) An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is built in at the distal end of the catheter, wherein one end of a balloon is fixed to an inner peripheral surface of the distal end of the catheter by a fixing portion, and an inner periphery slightly inside from the distal end of the catheter. The other end of the balloon is fixed to the surface by a fixing portion, and the balloon is communicated with an inflation / deflation air passage provided in the catheter tube wall. The balloon is inflated by air pressure from the air passage, and the catheter exit passage is opened. An in-vivo information continuous measurement apparatus characterized in that a sensor can be isolated from a body fluid at times other than measurement by closing the body. (2) An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is built in at the distal end of the catheter, wherein one end of a balloon is fixed to an inner peripheral surface of the distal end of the catheter by a fixing portion, and an inner periphery slightly inside from the distal end of the catheter. The other end of the balloon is fixed to the surface by a fixing portion, and the balloon is communicated with an inflation / deflation air passage provided in the catheter tube wall. The balloon is inflated by air pressure from the air passage, and the catheter exit passage is opened. By closing the
An in-vivo information continuous measurement apparatus, which is capable of isolating a sensor from bodily fluids at times other than measurement, and wherein an inner tube for a cleaning liquid is provided inside the catheter to be inserted near an inflation balloon. (3) An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is built in at the distal end of the catheter, wherein the catheter has a double-tube structure including an inner tube having a built-in sensor and an outer tube outside the sensor. The outer tube and the inner tube are slidable, one end of the balloon is fixed to a tip of the outer tube by a fixing portion, and the other end of the balloon is fixed to a tip of the inner tube by a fixing portion. The in-vivo information characterized in that the sensor can be isolated from the body fluid at times other than the measurement by inflating with an air pressure from the inflation / contraction air passage provided in the catheter tube wall and closing the catheter exit passage. Continuous measuring device. The sensor for continuous measurement of in-vivo information used in the present invention includes a blood oxygen gas concentration, a carbon dioxide gas concentration, a metal ion concentration, a hydrogen ion concentration (pH),
A single sensor or a composite sensor for a plasma component, a digestive juice component, or the like can be used. The continuous measurement method based on sensor information used in the present invention can be used without particular limitation as long as the result is fast or automatic recording is possible even if the method is electrochemical, optical or biochemical.

The sensor device for continuous measurement of in-vivo information to which the present invention is applied can be applied to, for example, a sensor for measuring blood components and a sensor for measuring biological functions other than cardiopulmonary functions such as digestion and metabolism. It is particularly useful for measuring blood components. The indwelling catheter equipped with the sensor for continuous measurement of biological information of the present invention, except for the time of measurement, while the end face of the sensor tip is closed by inflation of the balloon,
The sensor tip is wrapped or isolated by a balloon, so that the sensor and the body fluid do not come into contact.Therefore, there is less contamination on the sensor surface compared to the conventional method where the body fluid is always in contact. . Therefore, it is characterized in that the amount of heparin aqueous solution used as a cleaning liquid can be significantly reduced. Further, at a time other than the time of measurement, the balloon is inflated so that a thin inner tube for a cleaning solution is inserted into a space at the tip of the catheter which is isolated from the outside. Is characterized in that it is possible to collect all of them outside the body. As the balloon used in the present invention, a soft resin film or a rubber balloon can be used. Normally,
Both ends of the cylindrical balloon are fixed to the inner surface or outer periphery of the catheter with an adhesive or a winding thread. Hereinafter, the present invention will be described in more detail with reference to Examples, but the invention of the device of the present invention can be applied to any catheter sensor that can continuously measure biological information, such as the type of sensor, measurement method, etc. . In the following embodiments, a continuous measurement apparatus for a biological blood component will be described, but the present invention is not limited thereto.

[0007]

【Example】

Example 1 A sensor lead wire 4 of a sensor 2 is built in a sensor catheter distal end portion 1 of the in-vivo information continuous measurement apparatus of FIG. On the inner peripheral surface of the distal end of the catheter 5, there is a balloon fixing portion 9 to which one end of the cylindrical balloon 3 is fixed, and the other end of the balloon 3 is attached to the inner peripheral surface slightly inside from the distal end of the catheter 5. 8 fixed. The balloon 3 is in communication with an air passage (not shown) provided in the tube wall of the catheter 5 so that the balloon 3 can be inflated as shown in FIG. In this expanded state, the sensor 2 does not come into contact with the body fluid, so that contamination due to adsorption of proteins and the like is reduced. When the air from the balloon 3 is evacuated during the measurement, the balloon 3 contracts as shown in FIG. 2 on the inner surface of the distal end of the catheter, and the sensor 2 is exposed from the distal end of the catheter 5 and comes into contact with the body fluid. After the measurement, when air is injected into the balloon 3, it expands as shown in FIG. When the aqueous solution of heparin flows from the catheter base in this expanded state, the aqueous solution of heparin flows from the gap of T2 to the gap of T1, and the tip of the sensor 2 can be washed. The sensor according to the present embodiment has a short contact time with blood and low contamination, and the passage of the washing liquid is narrowed by the balloon 3, so that the washing efficiency per unit washing liquid amount is good, and the amount of the washing liquid flowing into the blood is small. Can be reduced in significantly smaller amounts than when no balloon is used. In the first embodiment, the balloon 3 can be inflated after the sensor 2 and the lead wire 4 are drawn into the inside of the catheter as shown in FIG.

Embodiment 2 In the embodiment of FIG. 4, a slide tube 7 is provided inside a catheter 5, and the slide tube 7 has a sensor 2 built therein. Slide tube 7
One end of the balloon 3 is fixed to a tip of the catheter 5 by a balloon fixing portion 8, and the other end is fixed to a tip of the catheter 5 by a balloon fixing portion 9. The slide tube 7 is moved to the position shown in FIG. 4 to inflate the balloon 3. Then
When the balloon 3 is deflated, the sensor 2 projects and comes into contact with the bodily fluid. Embodiment 3 The embodiment shown in FIG. 5 is different from the embodiment shown in FIG. 3 in which the sensor 2 can be drawn into the inside, and the inner tube 6 for the cleaning liquid is inserted into the position of the sensor 2 separated by the balloon 3. is there. The cleaning liquid inner tube 6 can be provided outside the sensor 2 and the lead wire 4, or can be provided inside the catheter 5 in parallel with the sensor lead wire 4.
The inner pipe 6 for the cleaning liquid can be used as a pipe for injecting or discharging the cleaning liquid. As described above, if the inner tube for washing liquid 6 is used, the washing liquid does not distill into the blood, and all the washed liquid can be collected outside the body. Further, in the present embodiment, when the balloon 3 is deflated, the sensor 2 can be made to protrude from the distal end of the catheter 5 and come into contact with the bodily fluid.

[0009]

According to the present invention, information on changes in body fluid can be instantaneously grasped, and medical treatment can be immediately applied. Further, there is an advantage that the contamination of the sensor by the body fluid is small, and the amount of the cleaning liquid of the sensor flowing out to the blood can be eliminated or reduced.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view illustrating a distal end structure of an in-vivo information continuous measurement apparatus according to an embodiment of the present invention.

FIG. 2 is a cross-sectional view showing a deflated state of the balloon of the embodiment.

FIG. 3 is a cross-sectional view illustrating a structure of a continuous biological component measuring apparatus according to another embodiment of the present invention.

FIG. 4 is a cross-sectional view illustrating a structure of a continuous biological component measuring apparatus according to another embodiment of the present invention.

FIG. 5 is a cross-sectional view illustrating a structure of an in-vivo information continuous measurement continuous apparatus according to another embodiment of the present invention.

FIG. 6 is a drawing for explaining the structure of a conventional biological component measuring device.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Sensor catheter tip part 2 Sensor 3 Balloon 4 Sensor lead wire 5 Catheter 6 Inner tube for cleaning liquid 7 Slide tube 8 Balloon fixing part 9 Balloon fixing part 10 Heparin aqueous solution 11 Cylinder 12 Branch part

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-63-267339 (JP, A) JP-A-61-125355 (JP, A) JP-A-63-318954 (JP, A) 92645 (JP, U) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61B 5/145 A61M 25/00-25/14

Claims (3)

(57) [Claims] 1. An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is built in a distal end portion of the catheter, wherein one end of a balloon is fixed to an inner peripheral surface of the catheter distal end.
Therefore, fix the inner peripheral surface slightly inside from the tip of the catheter.
The other end of the balloon is fixed by a fixing part,
Air passage for inflation and deflation provided on the catheter tube wall of the balloon
Communicate with each other, and the air pressure from the air passage
The catheter exit passage by inflating the
This allows the sensor to be isolated from body fluids during non-measurements.
An in-vivo information continuous measurement apparatus characterized in that: 2. An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is incorporated at the distal end of the catheter, wherein one end of a balloon is fixed to an inner peripheral surface of the distal end of the catheter.
Therefore, fix the inner peripheral surface slightly inside from the tip of the catheter.
The other end of the balloon is fixed by a fixing part,
Air passage for inflation and deflation provided on the catheter tube wall of the balloon
Communicate with each other, and the air pressure from the air passage
The catheter exit passage by inflating the
Therefore, the sensor can be isolated from body fluids except during measurement.
A is off ones, within the catheter, in vivo information successively measuring apparatus characterized in that a cleaning liquid in a tube which is inserted close to the dilatation balloon. 3. An indwelling sensor catheter in which a sensor for continuous measurement of in-vivo information is built in at the distal end of the catheter, wherein the catheter has a double-tube structure including an inner tube having a built-in sensor and an outer tube outside the inner tube. The outer tube and the inner tube are slidable, and one end of the balloon is fixed to the tip of the outer tube.
And the other end of the balloon is secured to the tip of the inner tube.
The balloon is fixed by the
Inflated by air pressure from the expansion / contraction air passage provided in the pipe wall
Measurement by closing the catheter exit passage
It can isolate the sensor from bodily fluids at other times.
An in-vivo information continuous measurement apparatus characterized in that: