JP3333676B2 - Transfusion device for stored blood products - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for adjusting ion concentration in blood and removing leukocytes when transfusing stored blood products.

[0002]

2. Description of the Related Art The applicant has proposed a blood transfusion apparatus for stored blood products in Japanese Patent Application No. 6-49901. In this blood transfusion apparatus, the ion concentration adjusting body loaded in the ion concentration adjusting chamber is fixed from above and below by a flat support filter, but the cross-sectional area of the support filter is substantially equal to the cross-sectional area of the ion concentration adjusting chamber. Because of the same, the effective filtration area is small, and when filtering an old stored blood product, clogging by microaggregates (blood aggregates) may occur. In addition, since the supporting filter is used at two upper and lower portions, assembly is troublesome, and the number of parts increases, which increases the cost.

[0003] Further, a connecting tube is connected to the upper part of the ion concentration adjusting chamber, a connecting needle is mounted at the tip, a blood transfusion tube is connected to the lower part, a syringe needle is mounted at the rear end, and a roll is provided in the middle of each tube. The clamp is attached. Also, when integrating with a blood bag, the communication piece must be further arranged between the connecting tube and the blood bag, so the number of accessories increases, and the ion concentration adjusting device itself is bulky and difficult to operate. There was an indication. After the assembly is completed, the ion concentration adjusting device is subjected to high-pressure steam sterilization before shipment. However, since the water droplets remain in the tubes 3 and 10, the tubes 3 and 10 are whitened, which requires a long drying time.

Further, the applicant has conducted intensive studies on these ion concentration adjusting devices for the purpose of further improving the performance thereof, and as a result, has arrived at the following invention. When only the cation exchange resin or only the anion exchange resin was used as the ion concentration adjuster, a small amount of eluate was produced in each case, although it was not inconvenient for treatment. In the case of using a mixture of cation exchange resin and anion exchange resin, not only can adsorption of potassium ions and citrate ions, which are the respective objects of adsorption, be performed at the same time, but also in the case where each was conventionally used alone. It was found that no eluate was formed. It is presumed that the eluate from the cation exchange resin is adsorbed by the anion exchange resin, and the eluate from the anion exchange resin is adsorbed by the cation exchange resin.

[0005]

Means for Solving the Problems [1] According to the present invention, an ion concentration adjusting body (8a) capable of adjusting a specific ion concentration in blood is loaded into an ion concentration adjusting chamber (6a). A blood bag is placed above the ion concentration control chamber (6a) .
A connecting needle (2) is connected to the blood transfusion port to introduce stored blood, and the transfusion is inserted into the lower part of the ion concentration adjusting chamber (6a).
Transfusion port (78) to which a transfusion needle of a blood member can be connected
And a protector (77) is attached to the blood transfusion port (78).
Io during high-pressure steam sterilization to bear the said connecting needle (2)
Absorbing the air expanded in the concentration control chamber (6a)
Is completed and the balloon part (79a) is cut off by sealing the base.
Provided is a blood transfusion device (1L) for a stored blood product, which is provided with a flexible sealing member (79) capable of being mounted thereon. [2] According to the present invention, an ion concentration adjusting body (8a) capable of adjusting a specific ion concentration in blood is loaded into an ion concentration adjusting chamber (6a).
At the top of a), a connecting needle (2) is connected to the blood transfusion port of the blood bag to introduce stored blood, and the ion concentration is adjusted.
Connecting the transfusion needle of the transfusion member to the lower part of the chamber (6a) .
Possible transfusion opening (78) is attached, up to該輸Chiguchi (78)
Cover the protector (77) and apply high pressure to the connecting needle (2).
It expands in the ion concentration adjustment chamber (6a) during steam sterilization.
Balloon that can absorb air and seal the base
A blood transfusion device (1L) for a stored blood product in which a flexible sealing member (79) capable of detaching a part (79a) is attached, and an ion concentration adjusting body (8a) is fixed by a hat-shaped support filter (7c). 1m). [3] The present invention relates to a blood transfusion device for a preserved blood product comprising a tube (3, 41, 10, 42) for guiding a preserved blood product and a syringe needle (11, 47) for injecting the preserved blood product to a patient. An ion concentration adjusting chamber (6a, 40, 61) is provided in the middle of the guide tube (3, 41, 10, 42) for the stored blood product, and the ion concentration adjusting chamber (6
a, 40, 61), ion concentration adjusters (8a, 5a) capable of adjusting a specific ion concentration in blood.
1) is provided, and a blood transfusion apparatus (1a, 1e, 1j, 1k, 1m) of a stored blood product in which the ion concentration adjusting bodies (8a, 51) are fixed by a hat-shaped support filter (7c) is provided. [4] The present invention provides the ion concentration adjusting chamber (6) according to [3].
A blood reservoir (30) for temporarily storing the stored blood product that has passed through the ion concentration adjusting chamber (6a) is disposed in the guide tube (10) downstream of a), and the blood reservoir (3) is provided.
0), a blood transfusion tube (32) is connected, and the blood reservoir (30) is connected to the guide tube (10) and the blood transfusion tube (3).
The blood transfusion device (1a, 1) of the stored blood product placed between 2)
e, 1g, 1m). [5] In the present invention, the ion concentration adjusting bodies (8a, 51) loaded into the ion concentration adjusting chambers (6a, 40, 61) according to [1] to [4] have an ion exchange capacity of 1 to 5 mEq /. m
l, the particle size is 0.2-1.5 mm, preferably the ion exchange capacity is 1.5-3.5 mEq / ml, and the particle size is 0.4
Blood transfusion device (1a, 1e, 1g, 1j, 1k, 1L, 1
m). [6] In the present invention, the ion concentration adjusting bodies (8a, 51) loaded in the ion concentration adjusting chambers (6a, 40, 61) according to [1] to [4] have an ion exchange capacity of 0.5 to 0.5. 4mEq
/ Ml, particle size of 0.2 to 1.5 mm, preferably anion exchange resin having an ion exchange capacity of 0.8 to 2.5 mEq / ml and a particle size of 0.4 to 1.0 mm. Transfusion devices for stored blood products (1a, 1e, 1g, 1j, 1k, 1
L, 1m). [7] The present invention relates to a blood transfusion device for a preserved blood product comprising a tube (3, 41, 10, 42) for guiding a preserved blood product and a syringe needle (11, 47) for injecting the preserved blood product to a patient. An ion concentration adjusting chamber (6a, 40, 61) is provided in the middle of the guide tube (3, 41, 10, 42) for the stored blood product, and the ion concentration adjusting chamber (6
a, 40, 61), ion concentration adjusters (8a, 5a) capable of adjusting a specific ion concentration in blood.
1), and a blood transfusion device (1a, 1e, 1g, 1j) of a stored blood product loaded with a mixture of a cation exchange resin and an anion exchange resin as an ion concentration adjuster (8a, 51).
1k, 1m). [8] The present invention provides an ion concentration adjusting body (8a, 51) as a cation exchange resin and an anion exchange inside the ion concentration adjusting chamber (6a, 40, 61) according to [1] to [4]. Transfusion device for stored blood products loaded with resin mixture (1
a, 1e, 1g, 1j, 1k, 1L, 1m). [9] The present invention provides a blood transfusion device (1a, a preservation blood product) containing a priming solution harmless to the human body inside the ion concentration adjusting chamber (6a, 40, 61) according to [1] to [8].
1e, 1g, 1j, 1k, 1L, 1m). [10] In the present invention, a leukocyte removal filter (52) for removing leukocytes in a stored blood product is provided in the ion concentration adjustment chamber (6a, 40, 61) according to [1] to [3], [7]. Blood transfusion devices (1a, 1e, 1g, 1
j, 1k, 1L, 1m). [11] In the present invention, the leukocyte removal filter (52) has the same ion concentration adjusting chamber (4) as the ion concentration adjusting body (51).
0) A blood transfusion apparatus (1a, 1e, 1g, 1j, 1L, 1m) of the preserved blood product according to [10], which is arranged in (0). [12] In the present invention, the leukocyte removal filter (52) and the ion concentration adjusting body (51) are housed independently in the leukocyte removal chamber (60) and the ion concentration adjustment chamber (61), respectively [3]. The blood transfusion device (1) of the stored blood product according to [7].
a, 1e, 1g, 1k, 1m).

[0006]

FIG. 1 is a schematic diagram of a blood transfusion apparatus 1L.
In the blood transfusion apparatus 1L, a connecting needle 2 for introducing stored blood is mounted on an upper part of the ion concentration adjusting chamber 6a, and a blood transfusion port 78 covered with a protector 77 is mounted on a lower part of the ion concentration adjusting chamber 6a. The connecting needle 2 is provided with a sealing member 79 (preferably a balloon-shaped member having flexibility and capable of absorbing air expanded in the ion concentration adjusting chamber 6a during high-pressure steam sterilization of the blood transfusion apparatus). Have been. An ion concentration adjusting body 8a is loaded inside the ion concentration adjusting chamber 6a,
Support filters 7a and 7b are mounted on both upper and lower ends of the ion concentration adjuster 8a.

In the present invention, a cation exchange resin or an anion exchange resin is used as the ion concentration adjuster 8a. The cation exchange resin has an exchange capacity of 1 to 5 mEq / ml and a particle size of 0.2 to 1.5 mm, and preferably has an exchange capacity of 1.5 to 1.5 mEq / ml.
A particle having a particle size of 0.4 to 1.0 mm with a particle size of 0.4 to 3.5 mEq / ml, for example, sodium polystyrene sulfonate, calcium polystyrene sulfonate, polystyrene sulfonic acid, sodium methacrylate, or the like is used. The anion exchange resin has an exchange capacity of 0.5 to 4 mEq /
ml, the particle size is 0.2 to 1.5 mm, preferably the exchange capacity is 0.8 to 2.5 mEq / ml, and the particle size is 0.4 to
Used those 1.0 mm, for example, terminal Cl of such trimethyl ammonium chloride - can be used of a type ^- and that of ^(chloride ion) type, OH dimethyl ethanolamine. The ion concentration adjusting chamber 6a is formed of a synthetic resin such as a vinyl chloride resin in a cylindrical or bag shape.

An example of a method of using the blood transfusion apparatus 1L will be described. After assembling the blood transfusion device 1L as shown in FIG. 1 and performing high-pressure steam sterilization, the base of the balloon-shaped sealing member 79 is sealed (S in FIG. 1 is a seal portion), and the balloon portion 79a is cut off. When the stored blood product is transfused into a patient by the blood transfusion apparatus 1L, the sealing member 79 is detached and the blood transfusion member 80 (a roll clamp 82 is attached in the middle of the blood transfusion tube 81, as shown in FIG. The blood transfusion needle 83 is connected to the blood transfusion port 78, and the blood bag 14 containing the stored blood product is suspended at a predetermined height. 2 is inserted and connected to the blood transfusion port 85 of the blood bag 14, and the roll clamp 82 closing the blood transfusion tube 81 is opened. As a result, the stored blood product inside the blood bag 14 passes through the connecting needle 2, the ion concentration adjusting chamber 6 a, and the blood transfusion tube 81 in the order of the head difference, and the injection needle 84.
Is transfused while adjusting the flow rate of the preserved blood product using the roll clamp 82.

The blood transfusion devices 1e, 1g , 1j, and 1k shown in FIGS. 5 , 6 , 7 , and 10 to be described later are similarly connected to the connection tube 3 (41) and the blood transfusion tube 10 (42) similarly to the blood transfusion device 1L. Is omitted, the connecting needle 2 equipped with the sealing portion 79 is connected to the upper part of the ion concentration adjusting chamber 6a, and the blood transfusion port 78 covered with the protector 77 is connected to the ion concentration adjusting chamber 6a.
And used together with the blood transfusion member 80 like the blood transfusion apparatus 1L. In the case of the blood transfusion apparatus 1g shown in FIG. 6, the blood transfusion member 80 is provided between the blood storage bag 30 and the blood transfusion chamber 33 in the middle of the blood transfusion tube 81.
(From the upstream to the downstream, the blood transfusion needle 83, the blood storage bag 30, the roll clamp 82, the blood transfusion chamber 3
3. Arrange in the order of injection needle 84). Also shown in FIG.
In the case of the blood transfusion apparatus 1k, the blood transfusion member 80 is a blood transfusion tube.
The leukocyte removal filter 52 is provided in the middle of the
Arrange the leukocyte removal chamber 60 (transfer from upstream to downstream)
Blood needle 83, leukocyte removal chamber 60, roll clamp 82, injection
Arranged in the order of the shooting needles 84).

[0010] Figures 4-6 transfusion device 1m in Figure 3 to the blood transfusion device 1L and later, blood transfusion apparatus 1 shown in FIG. 10
a, 1e, 1g , 1k The ion concentration adjusting bodies 8a , 51 are fixed in the ion concentration adjusting chambers 6a , 61 , and the plate-shaped support filters 7a, 7b , 62a, 6 for removing foreign substances are fixed.
A hat-shaped filter 7c is used in place of 2b . The plate-shaped support filters 7a and 7b have a small filter area and may be clogged with microaggregates (blood aggregates) when filtering old blood products, whereas the hat-shaped support filter 7c is The filter filter has a larger filter area than the flat support filters 7a and 7b, and allows blood to pass through quickly.

In the blood transfusion devices 1L and 1m of the present invention and the blood transfusion devices 1a, 1e , 1g, 1j and 1k to be described later, a mixture of a cation exchange resin and an anion exchange resin is used as the ion concentration adjusters 8a and 51. By using, both potassium ion and citrate ion can be adsorbed simultaneously. Further, the eluate from the cation exchange resin can be adsorbed by the anion exchange resin, and the eluate from the anion exchange resin can be adsorbed by the cation exchange resin, so that both eluates can be suppressed. It is possible.

Embodiment An ion concentration adjusting chamber 6 constituting the blood transfusion apparatus 1a shown in FIG.
a in which the average particle diameter is 0.4 m as the ion concentration adjusting body 8a.
A mixture of 20 ml of a cation exchange resin (sodium polystyrenesulfonate) and 5 ml of an anion exchange resin (trimethylammonium chloride) having an average particle size of 0.6 mm is charged into the ion concentration adjuster 8a as a filling liquid. 25 ml of the saline solution is filled at 60 ° C. for 5 days to 15 days.
Saved for days. Thereafter, the total amount of organic substances in the filling liquid was measured. As a comparative example, 20 ml of a cation exchange resin (sodium polystyrene sulfonate) having an average particle diameter of 0.4 mm was loaded as the ion concentration adjusting member 8a, and a physiological saline solution was used as a filling liquid in the ion concentration adjusting member 8a.
Using the blood transfusion apparatus 1a filled with 5 ml, the total amount of organic substances was measured in the same manner as in the example. Table 1 shows the results.

[0013]

[Table 1]

From the results shown in Table 1, it can be seen that the amount of organic substances detected in the examples of the present invention is smaller than that in the comparative examples.
It is considered that the eluate from the cation exchange resin is adsorbed on the anion exchange resin and the eluate from the anion exchange resin is adsorbed on the cation exchange resin.

The blood transfusion apparatus 1a, 1e, 1g , 1j, 1 can be used by appropriately selecting the features of the present invention.
k will be described with reference to FIG. 4 below. The blood transfusion apparatus 1a shown in FIG. 4 has an ion concentration adjusting chamber 6a, a connection tube 3 which is a guide tube for a stored blood product, and a blood transfusion tube 10. The ion concentration adjusting chamber 6a has an inlet 5 and an outlet 9 for a stored blood product, the connecting tube 3 is connected to the inlet 5, and the blood transfusion tube 10 is connected to the outlet 9. A connecting needle 2 for introducing stored blood is mounted on the distal end of the connecting tube 3, and a roll clamp 4 a is mounted in the middle of the connecting tube 3. An injection needle 11 is attached to the rear end of the blood transfusion tube 10, and a roll clamp 4b is provided in the middle of the blood transfusion tube 10.
Is installed. The connection tube 3 and the blood transfusion tube 10 are made of a synthetic resin such as a flexible vinyl chloride resin. An ion concentration adjusting body 8a is loaded inside the ion concentration adjusting chamber 6a, and support filters 7a and 7b are mounted on both upper and lower ends of the ion concentration adjusting body 8a.

When a stored blood product is to be transfused into a patient by the blood transfusion apparatus 1a shown in FIG. 4, a blood bag (not shown) containing the stored blood product is suspended at a predetermined height, and the connecting needle 2 is moved to the predetermined position. The roll clamps 4a and 4b that close the connection tube 3 and the infusion tube 10 are opened by inserting the blood bag into the blood transfusion port for connection. Thereby, the stored blood product in the blood bag flows out in the order of the connecting tube 3, the ion concentration adjusting chamber 6a, the blood transfusion tube 10, and the injection needle 11 due to the head difference. After confirming the outflow from the injection needle 11, the roll clamp 4b of the blood transfusion tube 10 is closed once, the injection needle 11 is punctured into the blood vessel of the patient, and then the roll clamp 4b is gradually opened to adjust the blood flow rate to perform transfusion. .

The blood transfusion apparatus 1e shown in FIG. 5 is an example in which a priming processing apparatus is provided in the blood transfusion apparatus 1a shown in FIG. 4 so that priming processing can be performed before use. That is, the priming liquid inlet 5a is provided in the ion concentration adjusting chamber 6a.
And an outlet 9a are provided.
Is filled in advance with a priming solution such as a physiological saline solution or Ringer's solution. A priming container 23 in which the above-described priming liquid 22 is sealed is connected to an inlet 5a of the ion concentration adjusting chamber 6a via a connection tube 24. A connection port of the priming container 23 with the connection tube 24 is connected to the inlet 5a. The communication piece 25 having the above-described configuration is mounted. A waste liquid container 28 is connected to the outlet 9 a via a connection tube 27, and a communication piece 26 is also attached to a connection port between the waste liquid container 28 and the connection tube 27.

In the priming process, the communication piece 25 of the priming container 23 and the communication piece 26 of the waste liquid container 28 are broken, and the priming liquid 22 in the priming container 23 is adjusted through the connection tube 24 through the inlet 5a to adjust the ion concentration. It is introduced into the chamber 6a. As a result, the priming liquid previously filled in the ion concentration adjusting chamber 6a is pushed out from the outlet 9a and collected in the waste liquid container 28 via the connecting tube 27. Then, the positions near the inlet 5a and the outlet 9a of the connection tubes 24 and 27 are sealed, and the tubes 24 and 27 are cut.

The blood transfusion apparatus 1g shown in FIG. 6 is connected to a connecting tube 10 connected to the outlet 9 of the ion concentration adjustment chamber 6a of the blood transfusion apparatus 1a shown in FIG. This is an example in which a blood storage bag 30 is connected as a blood storage unit for temporarily storing the blood. A blood transfusion tube 32 is connected to the outlet of the blood storage bag 30 via a communication piece 31, and a blood transfusion chamber 33 and a blood transfusion needle 34 are connected to the blood transfusion tube 32.
A roll clamp 35 is mounted in the blood transfusion tube 32. According to the blood transfusion apparatus 1g, the stored blood product that has passed through the ion concentration adjustment chamber 6a is temporarily stored in the blood storage bag 30 through the connection tube 10. Next, the communication piece 31 of the blood storage bag 30 is broken, the blood storage bag 30 is opened, and the blood transfusion needle 34 is punctured into the blood vessel of the patient. Then, the blood flow rate is adjusted by the roll clamp 35, and the inside of the blood storage bag 30 is adjusted. Is transfused into the patient from the transfusion needle 34 through the transfusion chamber 33.

[0020] The blood transfusion device 1j in FIG.
Adjusting ion concentration and simultaneously removing leukocytes
Device. This infusion device 1j is connected to a blood processing chamber 40 (see FIG.
1 ion concentration adjustment chamber 6a).
A connecting tube 41 is connected to the inlet 40a of the liquid processing chamber.
The blood transfusion tube 42 is connected to the outlet 40b.
You. A connecting needle 48 is attached to the distal end of the connecting tube 41.
In the middle of the tube 41, there is a roll clamp 4
4 is attached. Also at the rear end of the blood transfusion tube 42
Is equipped with an injection needle 47, and
A lip chamber 46 and a roll clamp 45 are attached
ing. Inside the blood processing chamber 40, as shown in FIG.
The ion concentration adjuster 51 is wrapped in the leukocyte removal filter 52.
It is attached. The ion concentration used in this example
The degree adjusting body 51 is composed of the above-described cation exchange resin and an anion.
Exchange resin is used, and the leukocyte removal filter 52 has a diameter
A nonwoven fabric of 20 μm or less is used. FIG. 9 shows a blood treatment
This is a modified example of the chamber 40, and is a bag-shaped white color communicating with the introduction port 40a.
The blood cell removal filter 52 and the leukocyte removal filter 52
Ion concentration adjustment between the bag-shaped support filters 53
The manipulating body 51 is loaded. The support filter 53 is
Has a mesh hole that can hold the ion concentration adjusting body 51
It is composed of screen mesh. According to this embodiment
Then, the leukocytes are captured inside the bag-shaped leukocyte removal filter.
Will be done.

[0021] The blood transfusion apparatus 1k of FIG.
This is an example in which a chamber 61 and a leukocyte removal chamber 60 are separately arranged.
That is, the same ion as in FIG.
A concentration adjustment chamber 61 is provided, and the ion concentration adjustment chamber is provided.
The above-mentioned ion concentration adjuster 51 is vertically supported inside 61.
It is filled between the holding filters 62a and 62b. Ma Was
As shown in FIG. 11, the inside of the leukocyte removal chamber 60 has a bag shape.
The leukocyte removal filter 52 is provided. This infusion
According to the device 1k, adjustment of the ion concentration of the stored blood product,
The leukocyte removal processing will be performed separately. Note that
The ON concentration adjusting chamber 61 and the leukocyte removal chamber 60 are reversed in order.
May be provided. Leukocyte removal shown in FIGS. 7 to 11
The filter has the ion concentration control shown in FIGS. 4 to 6 described above.
It can also be used for arranging rooms.

[0022]

The blood transfusion apparatus 1L of the present invention (the tube is omitted like the blood transfusion apparatus 1L, and the ion concentration adjusting chamber 6a
The sealing member 79 is attached to the upper part of the
Blood transfusion device 1e, 1
g , 1j, and 1k ) are compact because they do not include extra tubes and communication pieces, are easy to dry after high-pressure steam bacteria, and are easy to use without bulk when used. Blood transfusion device 1m of the present invention (similar to blood transfusion device 1m,
Blood transfusion apparatus 1a, 1 using hat-shaped support filter 7c
e, 1g , 1j, 1k , and 1L) use the supporting filter 7c having a large filter area, so that blood can be passed more quickly in the ion concentration adjusting chamber 6a. Blood transfusion apparatus 1 using a mixture of a cation exchange resin and an anion exchange resin as ion concentration adjuster 8a
From 1a to 1m, the eluate from the cation exchange resin can be adsorbed by the anion exchange resin, and the eluate from the anion exchange resin can be adsorbed by the cation exchange resin. It is possible to significantly suppress the objects.

[Brief description of the drawings]

FIG. 1 is a schematic diagram showing an embodiment of a blood transfusion apparatus 1L of the present invention.

FIG. 2 is a schematic diagram showing a use state of the embodiment of the blood transfusion apparatus in FIG. 1;

FIG. 3 is a schematic diagram showing an embodiment of a blood transfusion apparatus 1m of the present invention.

FIG. 4 is a schematic diagram showing an embodiment of the blood transfusion apparatus 1a of the present invention.

FIG. 5 is a schematic view showing an embodiment of a blood transfusion apparatus 1e of the present invention.

FIG. 6 is a schematic diagram showing an embodiment of a blood transfusion apparatus 1g of the present invention.

FIG. 7 is a schematic diagram showing an embodiment of a blood transfusion apparatus 1j of the present invention .
FIG .

FIG. 8 FIG. 8 is a schematic sectional view taken along line BB of FIG. 7.

FIG. 9 Another embodiment of the blood processing chamber of the embodiment of FIG.
FIG.

FIG. 10 Outline showing an embodiment of a blood transfusion apparatus 1k of the present invention.
FIG.

FIG. 11 FIG. 11 is a schematic sectional view taken along the line CC of FIG. 10.

[Explanation of symbols]

 1a, 1e, 1g,1j, 1k,1L, 1m transfusion device 2 Connecting needle 3, 41 Connecting tube (induction tube for stored blood products)
B) 4a, 4b, 35, 82 Roll clamp 5, 5a Inlet 6a, 6b, 40, 61 Ion concentration adjustment chamber 7a, 7b, 62a, 62b Support filter (flat) 7c Support filter (hat) 8a, 51 Ion concentration adjuster 9, 9a Outlet 10, 32, 42 Transfusion tubes (induction of stored blood products)
Tube) 11 injection needle 14 blood bag 17, 18, 78 transfusion port 22 priming liquid 23 priming container 24, 27 connecting tube 25, 26, 31 communication piece 28 waste liquid container 30 blood storage bag (blood storage unit) 33 blood transfusion chamber 34 blood transfusion needle40 blood processing room (ion concentration adjustment room) 40a Inlet (blood processing room) 40b Outlet (blood processing room) 46 drip chamber 52 Leukocyte removal filter 53 Support filter (bag shape) 60 Leukocyte removal chamber  77 Protector 79 Sealing member 79a Balloon part 80 Blood transfusion member S Seal part

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁷ , DB name) A61M 1/02-5/165 A61J 1/00-3/00

Claims (12)

(57) [Claims] The blood concentration in the ion concentration adjusting chamber (6a).
Concentration that can adjust the specific ion concentration of
The adjustment body (8a) is loaded, and the upper part of the ion concentration adjustment chamber (6a)Blood bag transfusion port
Connect toEquipped with a connecting needle (2) for introducing stored blood
WearOf the ion concentration control room (6a) At the bottomBlood transfusion needle
Can be linkedPut on the blood transfusion port (78),The blood transfusion
Cover the mouth (78) with a protector (77),  To the connecting needle (2)Adjust ion concentration during high-pressure steam sterilization
Is it possible to absorb the air expanded in the room (6a)?
Of the balloon part (79a) by sealing the base
FlexibilityThat the sealing member (79) was attached.
Characterized blood transfusion device for stored blood products (1 L). 2. An ion concentration adjusting body (8a) capable of adjusting a specific ion concentration in blood is loaded into the ion concentration adjusting chamber (6a), and blood is placed above the ion concentration adjusting chamber (6a). Bag transfusion opening
A connecting needle (2) for introducing stored blood by connecting to a blood transfusion member of a blood transfusion member is provided below the ion concentration adjusting chamber (6a).
Transfusion port capable of connecting (78) is mounted, 該輸blood
The mouth (78) is covered with a protector (77), and the connecting needle (2) is subjected to an ion concentration adjusting chamber (6 ) during high-pressure steam sterilization.
a) can absorb the air expanded in and
The balloon part (79a) can be separated by sealing.
A flexible sealing member (79) is attached, and the ion concentration adjusting body (8a) is attached to a hat-shaped support filter (7).
A blood transfusion device (1 L, 1 m) for a stored blood product, which is fixed in c). 3. A tube (3, 4) for inducing a stored blood product.
1, 10, 42) and a blood transfusion apparatus for a preserved blood product provided with an injection needle (11, 47) for infusing the preserved blood product to a patient.
10, 42) in the middle of the ion concentration adjusting chamber (6a, 40, 40).
61), and the ion concentration adjusting chamber (6a, 40, 6) is provided.
An ion concentration adjuster (8a, 51) capable of adjusting a specific ion concentration in blood is loaded in 1),
A blood transfusion device (1a, 1e, 1j, 1k, 1m) for a stored blood product, wherein the ion concentration adjusters (8a, 51) are fixed by a hat-shaped support filter (7c). 4. The ion concentration adjusting chamber according to claim 3,
A blood reservoir (30) for temporarily storing the stored blood product that has passed through the ion concentration adjusting chamber (6a) is disposed in the guide tube (10) downstream of a), and the blood reservoir (3) is provided.
0), a blood transfusion tube (32) is connected, and the blood reservoir (30) is connected to the guide tube (10) and the blood transfusion tube (3).
2) A blood transfusion device (1a, 1e, 1g, 1m) for a stored blood product, which is disposed between 2). 5. The ion concentration adjusting body (8a, 51) loaded in the ion concentration adjusting chamber (6a, 40, 61) according to claim 1 has an ion exchange capacity of 1 to 5 mEq / ml.
And a particle size of 0.2 to 1.5 mm, preferably an ion exchange capacity of 1.5 to 3.5 mEq / ml and a particle size of 0.4 to
A blood transfusion device (1a, 1e, 1g, 1j, 1) for a stored blood product, which is a 1.0 mm cation exchange resin.
k, 1 L, 1 m). 6. The ion concentration adjusting body (8a, 51) loaded in the ion concentration adjusting chamber (6a, 40, 61) according to claim 1 has an ion exchange capacity of 0.5 to 4 mEq / m.
l, the particle size is 0.2 to 1.5 mm, preferably the ion exchange capacity is 0.8 to 2.5 mEq / ml, and the particle size is 0.4
A transfusion device for stored blood products (1a, 1e, 1g, 1j,
1k, 1L, 1m). 7. A tube (3, 4) for inducing a stored blood product.
1, 10, 42) and a blood transfusion apparatus for a preserved blood product provided with an injection needle (11, 47) for infusing the preserved blood product to a patient.
10, 42) in the middle of the ion concentration adjusting chamber (6a, 40, 40).
61), and the ion concentration adjusting chamber (6a, 40, 6) is provided.
An ion concentration adjuster (8a, 51) capable of adjusting a specific ion concentration in blood is loaded in 1),
A blood transfusion apparatus (1a, 1e, 1g, 1) for a stored blood product, wherein a mixture of a cation exchange resin and an anion exchange resin is loaded as an ion concentration adjuster (8a, 51).
j, 1k, 1m). 8. An ion concentration adjusting body (8) inside the ion concentration adjusting chamber (6a, 40, 61) according to claim 1.
a, 51) a blood transfusion apparatus (1a, 1e, 1g, 1j, 1k, 1L, 1L,
m). 9. A blood transfusion device (1a, 1a, 1b) for a stored blood product, wherein a priming solution harmless to the human body is filled in the ion concentration adjusting chamber (6a, 40, 61) according to any one of claims 1 to 8. 1e, 1g, 1j, 1k, 1L, 1m). 10. A leukocyte removing filter (52) for removing leukocytes in a stored blood product is provided in the ion concentration adjusting chamber (6a, 40, 61) according to any one of claims 1 to 3 and 7. Transfusion device for stored blood products (1a, 1e, 1
g, 1j, 1k, 1L, 1m). 11. The preservation blood product according to claim 10, wherein the leukocyte removal filter (52) is disposed in the same ion concentration adjusting chamber (40) as the ion concentration adjusting body (51). Blood transfusion devices (1a, 1e, 1g, 1j, 1
L, 1 m). 12. A leukocyte removal filter (52) and an ion concentration adjusting body (51) are housed independently in a leukocyte removal chamber (60) and an ion concentration adjustment chamber (61), respectively. Item 7. A blood transfusion device (1a, 1e, 1g, 1k, 1m) for a stored blood product according to items 3 and 7.