JP3355562B2 - Industrial disinfecting and bacteriostatic agents and industrial disinfecting and bacteriostatic methods - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION This invention, industrial sterilization and bacteriostatic agents and to industrial sterilization and bacteriostatic method. More specifically, papermaking process water in the paper and pulp industry, cooling water and washing water for various industries, metalworking oils, fiber oils, paints, antifouling paints, paper coating liquids, latex, sizing agents, starch slurries, etc. Industrial germicidal and bacteriostatic agents useful for preservatives and bactericidal and bacteriostatic
It relates to a typical sterilization / bacteriostatic method.

[0002]

2. Description of the Related Art In recent years, slimes of various types of water have frequently caused troubles due to microbial contamination, and have caused various adverse effects. Here, slime means a viscous mass to muddy substance mainly generated by propagation of microorganisms.For example, when slime is generated in a heat exchanger or a pipe of a cooling water system such as a chemical plant, the cooling efficiency is reduced. In some cases, if pipes are blocked or slime is generated in water or pulp slurry in the papermaking process of a paper or pulp mill, when this is separated and mixed with stock or pulp, the operation of the process may be interrupted due to paper breakage. or, or that trouble has occurred, such as spots or colored paper and pulp damage the quality of the product occurs.

[0003] A starch slurry used for a surface sizing agent, a coating color or the like is prepared in a slurry dissolving tank and then temporarily or temporarily stored in a storage tank or the like. Due to the prolonged storage period, fluctuations in the storage temperature, and the incorporation of microorganisms from other routes, the liquid material decomposes and degrades, which causes the generation of putrefactive odor and a decrease in pH. A qualitative change occurred,
In addition to being unusable, slime is generated on the walls of the vessel, and the slime is peeled off, thereby causing obstacles in work such as blocking strainers and paths.

[0004] In addition, calcium carbonate slurries, muddy water polymers, fiber oils, cutting oils, latexes, synthetic resin emulsions and water-based so-called water-soluble metal processing oils (coolants) are often used for industrial applications. As with the above-mentioned starch slurry, the aqueous liquid material is liable to be deteriorated in quality or impaired in operation due to microorganisms. Various industrial disinfectants have been developed to prevent the troubles caused by these microorganisms.

For example, recently, 5-chloro-
2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 4,5-dichloro-2-n-octyl-isothiazolin-3-one, 2-
Isothiazolones represented by n-octyl-isothiazolin-3-one and 2-bromo-2-nitropropane-
1,3-diol, 2,2-dibromo-2-nitro-1
Organic bromine compounds represented by ethanol, 1,2-bis (bromoacetoxy) ethane, methylenebisthiocyanate, 3,5-dimethyltetrahydro-1,3,3
5-2H-thiadiazin-2-one, 2- (4-thiocyanomethylthio) benzothiazole and the like are widely used as industrial germicides. Drug Encyclopedia ”).

[0006] However, if the same bactericide is used for a long period of time among microorganisms, only bacteria having high resistance to the bactericide will proliferate in the system, and the bactericide conventionally used has been used. It is known that the bactericidal effect is significantly reduced at a concentration. Therefore, it has been proposed to use two types of fungicides in combination in order to expect a so-called synergistic effect. For example, 2,2-dibromo-3-nitrilopropionamide is 2-bromo-2-nitro-1,3-diacetoxypropane or 1,4-bis- (bromoacetoxy) -2.
It is known that a synergistic effect is exhibited when used in combination with a known industrial disinfectant such as butene (Japanese Patent Laid-Open No. 22007/2007).
No. and JP-B-52-46285).

[0007]

In recent years, regulations on drainage and the like have become strict in order to prevent environmental pollution, and so-called closed processes have been promoted in pulp and paper mills, so that the process water has been frequently recycled and the waste paper has been reused. Due to the higher rate, eutrophication in the system has occurred and the propagation speed of various microorganisms has increased, and the frequency of slime damage has increased more than before.

[0008] On the other hand, in the newspaper-making system, starch is used as a fixing agent in association with the production of many color-printed newspapers, and slime disorders are particularly frequent. Also, once slime is formed, it forms a mucosal layer (Slime layer) made of viscous gelatinous polysaccharides, which are metabolites of microorganisms, and this mucus layer prevents contact between microorganisms in the slime and fungicides. The fact has been confirmed. In many cases, the number of bacteria in the slime is extremely large, such as 10 ⁹ to 10 ¹² , due to the growth of the bacteria. In some cases, the bacteria migrated from the slime into the water, and further caused slime and spoilage.

Under these circumstances, the use of conventional industrial germicides has the problem that the bactericidal effect decreases with time, and no effective bactericidal effect can be expected over a long period of time, and the growth inhibiting effect becomes insufficient. . On the other hand, 2,2-dibromo-3-
Nitrilopropionamide has a remarkable bactericidal activity at a lower concentration than other industrial germicides, but has a drawback that its action of suppressing the growth of viable cells for a long time is small.

[0010] The industrial fungicide according to the combination of the two components containing 2,2-dibromo-3-nitrilopropionamide as one of the above-mentioned proposals has improved sustainability of the bactericidal effect and an effect of suppressing the growth, but is still insufficient. However, it is not necessarily effective as a slime control agent in the process water of the paper and pulp industry under the above circumstances and as a preservative such as starch slurry, coating color, cutting oil, latex, etc., which requires sustained sterilization efficacy. Was not.

An object of the present invention is to provide 2,2-dibromo-3.
In a two-component industrial germicide containing nitrilopropionamide, an industrial bacteriostatic / bacteriostatic agent having a further enhancement of bactericidal effect, improvement of sustainability of bactericidal effect and prolongation of growth inhibition time is provided. .

[0012]

From this viewpoint, the inventors of the present invention have studied the combination of 2,2-dibromo-3-nitrilopropionamide with various industrial germicidal components, and as a result, have found two types of known germicidal components. By combining a small amount of an isothiazolone compound with an industrial bactericide in a specific ratio, a so-called synergistic bactericidal effect can be enhanced against a wide variety of microorganisms, as compared to a single component or a combination of two components. The surprising fact that the effect of improving the sustainability of the plant and prolonging the growth inhibition time is exhibited.

Thus, according to the present invention, (a) 2,2-dibromo-3-nitrilopropionamide (hereinafter referred to as "DBNPA"); (b) 2-bromo-2-nitro-1,3- Diacetoxypropane (hereinafter referred to as “DBNDAP”), 1,2-
Bisbromoacetoxyethane (hereinafter referred to as "BBAE"), 1,2-bisbromoacetoxypropane (hereinafter referred to as "BBAP"), and 1,2,3-trisbromoacetoxypropane (hereinafter referred to as "TBAP"). )
And a bromide-containing polyacetoxyalkylene derivative selected from 1,4-bis (bromoacetoxy) -2-butene (hereinafter referred to as “BBAB”); and (c) 5-chloro-2-methyl-4- isothiazoline- 3
-ON (hereinafter referred to as "CL-MIT") and 4,5
-Dichloro-2-n-octyl-4- isothiazoline-
It contains 3-isothiazolone-based compounds selected from 3-ones (hereinafter referred to as “DCOT”), and their proportions are
Component (b) is 0.1 to 5 parts by weight with respect to 1 part by weight of component (a), and (c) with respect to 1 part by weight of the total amount of component (a) and component (b).
There is provided an industrial bactericidal / bacteriostatic agent, wherein the component is 0.01 to 1 part by weight.

As described above, all of the starting compounds used in the present invention are known fungicides, and commercially available ones can be used. The synergistic effect of the combination of the present invention is 1/1 by weight relative to a two-component industrial fungicide containing 2,2-dibromo-3-nitrilopropionamide.
It was exhibited when a small amount of a 3-isothiazolone compound as small as 30 was combined, and the bactericidal effect was so remarkable that it could not be predicted from the bactericidal effect of each.

In the industrial bactericidal / bacteriostatic agent of the present invention,
The ratio of achieving a synergistic effect is generally 0.05 to 10 parts by weight of component (b), more preferably 1 to 5 parts by weight of component (a) as 1 part by weight of component (a) and component (b). Component (c) is used in an amount of 0.01 to 2.5 parts by weight, preferably 0.01 to 1 part by weight, more preferably 0.0 to 1 part by weight, based on 1 part by weight of the total amount of the components.
The mixing ratio is 2 to 0.5 parts by weight.

Further, taking specific compounds as examples, preferred compounding ratios of each component exhibiting a synergistic effect are as follows. DBN D AP 0.05 to 1) DBNPA as 1 part by weight
A 10 parts by weight, 3-isothiazolone compound as 1 part by weight of the total amount of DBNPA and DBN D AP is zero.
2 to 2.5 parts by weight 2) 0.1 to 10 parts by weight of BBAE based on 1 part by weight of DBNPA
Parts by weight, and the amount of the 3-isothiazolone-based compound is 0.01 to 2.
5 parts by weight 3) BBAP is 0.1 to 10 with 1 part by weight of DBNAP
Parts by weight, and the total amount of DBNPA and BBAP is 1 part by weight, and the amount of the 3-isothiazolone-based compound is 0.01 to 2.
5 parts by weight 4) TBAP is 0.1 to 10 with 1 part by weight of DBNPA
Parts by weight, and the total amount of DBNPA and TBAP is 1 part by weight, and the amount of the 3-isothiazolone-based compound is 0.01 to 2.
5 parts by weight 5) BBAB is 0.05 to 1 with 1 part by weight of DBNPA
0 parts by weight, and the total amount of DBNPA and BBAB is 1 part by weight, and the amount of the 3-isothiazolone compound is 0.01 to 0.01 parts by weight.
2.5 parts by weight is preferable because a synergistic effect is exhibited. 6) DBNDAP is 0.1 to 0.1 part by weight based on 1 part by weight of DBNPA.
5 parts by weight, and the total amount of DBNPA and DBNDAP is 1 part by weight, and the amount of the 3-isothiazolone-based compound is 0.02.
7) BBAE is 0.2 to 5 parts by weight based on 1 part by weight of DBNPA, and 0.01 to 0.5 part by weight of 3-isothiazolone compound based on 1 part by weight of the total amount of DBNPA and BBAE.
8 parts by weight 8) BBAP is 0.2 to 5 parts by weight based on 1 part by weight of DBNPA, and 0.01 to 0.5 part by weight of 3-isothiazolone compound based on 1 part by weight of the total amount of DBNPA and BBAP.
Parts 9) DBNPA TBAP is as 1 part by weight and 0.2 to 5 parts by weight, as 1 part by weight of the total amount of DBNPA and T BAP, 3- isothiazolone compound from 0.01 to 0.
5 parts by weight 10) BBAB is 0.2 to 5 with 1 part by weight of DBN PA
It is more preferable that the total amount of DBNPA and BBAB be 1 part by weight and that the amount of the 3-isothiazolone-based compound be 0.02 to 1 part by weight because a more remarkable synergistic effect is exhibited.

The industrial bactericidal / bacteriostatic agent of the present invention is usually prepared in the form of a liquid containing each active ingredient, and is used for various industrial bactericidal / bacteriostatic target systems. In particular, when the target system for disinfection / bacteriostatic is various aqueous systems such as process water for industrial papermaking or industrial cooling water, starch slurry, synthetic resin emulsion, etc., the hydrophilicity is considered in consideration of the dissolution and dispersibility of the active ingredient. It is preferable that the solution is a solution using an organic solvent and, if necessary, a dispersant (a surfactant or the like).

Examples of the hydrophilic organic solvent include amides such as dimethylformamide, glycols such as ethylene glycol, propylene glycol, diethylene glycol and dipropylene glycol, methyl cellosolve, phenyl cellosolve, diethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, Glycol ethers such as tripropylene glycol monomethyl ether, alcohols having up to 8 carbon atoms or methyl acetate, ethyl acetate, 3-methoxybutyl acetate, 2-ethoxymethyl acetate, 2-ethoxyethyl acetate, propylene carbonate, dimethyl glutarate, etc. Esters.

As the dispersant, a cationic surfactant,
Anionic surfactants, nonionic surfactants or amphoteric surfactants are suitable, and nonionic surfactants are preferred from the viewpoint of stability as a preparation. Examples of the nonionic surfactant include higher alcohol ethylene oxide adduct (ethylene oxide is hereinafter abbreviated as EO), alkylphenol (EO) adduct, fatty acid (EO) adduct, polyhydric alcohol fatty acid ester (EO) adduct,
Higher alkylamine (EO) adducts, fatty acid amide (EO) adducts, (EO) adducts of fats and oils, propylene oxide [P. Abbreviated as O] (EO) copolymer, alkylamine (PO) (EO) copolymer adduct, fatty acid ester of glycerin, fatty acid ester of pentaerythritol, fatty acid ester of sorbitol and sorbitan, Examples include sugar fatty acid esters, polyhydric alcohol alkyl ethers, and alkylolamides.

[0020] These formulations, the total amount 1 to 70 parts by weight of industrial biocidal material active ingredient, preferably in a hydrophilic organic solvent such as a balance. If necessary, at least 0.01 part by weight of a dispersant may be blended with respect to 1 part by weight of the active ingredient in total. In the case where the system to be sterilized is an oil system such as a cutting oil or an oil-based paint, it is preferably a liquid formulation using a hydrocarbon solvent such as kerosene, heavy oil, or spindle oil as a medium. May be used.

Further, for the sterilization target system in which the active ingredient of the present invention can be directly dissolved or dispersed, powders directly or diluted with a solid diluent (for example, kaolin, clay, bentonite, carboxymethylcellulose, etc.) And various surfactants may be used. Industrial sterilization / bacteriostatic agents that can effectively use the industrial sterilization / bacteriostatic agent of the present invention include: i) a papermaking process in the paper and pulp industry and a cooling water system in various industries; ii) use in a paper / pulp mill. Paper coating liquid (coating color), calcium carbonate slurry, synthetic resin emulsion (styrene-butadiene rubber latex, etc.),
Iii) Others: Metal processing oils (cutting oil, rolling oil, etc.), textile oils, various paints (emulsion paints, oil paints, etc.), various adhesives, pastes, latex compounds, cement dispersants, etc. Industrial products.

In particular, a papermaking process in the paper and pulp industry, in which slime damage directly affects products, is one of the preferable target systems because the effects of the present invention are remarkably exhibited. The added amount of the industrial bacteriostatic / bacteriostatic agent of the present invention varies depending on the industrial target system, but is usually the same as the active ingredient (a).
The concentration of the total amount of the component (b) and the component (c) is 0.1 to 200 mg /
L, preferably about 0.5 to 100 mg / L is sufficient.

If the amount added is less than 0.1 mg / L, an effective bactericidal and bacteriostatic effect is not exhibited, which is not preferable.
/ L may be added, but is not preferred for economic reasons. Each bactericidal / bacteriostatic active ingredient of the present invention may optionally be added to the system to be sterilized simultaneously or separately as separate preparations.

Further, according to the present invention, (a) 2,2-dibromo-3-nitrilopropionamide and (b) 2-bromo-2-nitro-1,3 are used in industrial sterilization / bacteriostatic target systems. −
Diacetoxypropane, 1,2-bisbromoacetoxyethane, 1,2-bisbromoacetoxypropane, 1,
2,3-trisbromoacetoxypropane and 1,4-
Brom-containing polyacetoxyalkylene derivatives selected from bis (bromoacetoxy) -2-butene, and
(c) 5-chloro-2-methyl-4- isothiazoline- 3
-One and 4,5-dichloro-2-n-octyl-4-
A 3-isothiazolone-based compound selected from isothiazolin -3-ones is used in a proportion that exhibits a synergistic effect, and these proportions are 0.1 to 5 parts by weight of the component (b) per 1 part by weight of the component (a). Yes, based on 1 part by weight of the total amount of the components (a) and (b)
(c) an industrial disinfecting / bacteriostatic method comprising simultaneously or separately adding the component in an amount of 0.01 to 1 part by weight and a total effective disinfecting component concentration of 0.1 to 200 mg / L. Is provided.

In this case, the combination ratio of each active ingredient is the same as that of the industrial bactericidal / bacteriostatic agent of the present invention, wherein component (a) is 1 part by weight, component (b) is 0.05 to 10 parts by weight, More preferably, the amount is 0.1 to 5 parts by weight, and the total amount of the components (a) and (b) is 1 part by weight, and the component (c) is 0.01 to 2.5 parts by weight, preferably 0.01 to 2.5 parts by weight. A remarkable synergistic effect is exerted when used together in an amount of from 1 to 1 part by weight, more preferably from 0.02 to 0.5 part by weight.

In the method of the present invention, when the above-mentioned active ingredients are added simultaneously, it is convenient to use them as the same preparation as described above, but the same effect is exerted even if they are added separately. Also in this case, the above-mentioned formulation form is preferable. In the present invention, the amount of the active ingredient (the total amount of the components (a), (b), and (c)) varies depending on the target system for industrial sterilization and bacteriostasis.
1 to 200 mg / L, preferably about 0.5 to 100 mg / L is sufficient.

If the addition amount is less than 0.1 mg / L, an effective bactericidal effect is not exhibited, which is not preferable.
More than L may be added, but is not preferred for economic reasons. The industrial sterilization and bacteriostatic target system industrial sterilization and bacteriostatic method of the invention is applied, it includes industrial products described above. In particular, a papermaking process in the paper and pulp industry, in which slime damage directly affects products, is one of the preferred target systems because the effects of the present invention are remarkably exhibited.
This invention is illustrated by the following formulation examples and test examples.

[0028]

The following examples are preparations comprising the active ingredients (three compounds) of the present invention. As comparative examples, one or two of the active ingredients of the present invention may be used. This is a preparation prepared by adding a known bactericide. Examples Formulation Example 1 DBNPA 8 parts by weight DBNDAP 8 parts by weight CL-MIT 1 part by weight Ethylene glycol 83 parts by weight Formulation Example 2 DBNPA 13 parts by weight BBAB 8 parts by weight CL-MIT 2 parts by weight Propylene carbonate 77 parts by weight Formulation Example 3 DBNPA 12 parts by weight BBAB 10 parts by weight CL-MIT 2 parts by weight Propylene carbonate 76 parts by weight Formulation Example 4 DBNPA 12 parts by weight BBAB 7 parts by weight CL-MIT 2.5 parts by weight Diethylene glycol monomethyl ether 78.5 parts by weight Formulation Example 5 DBNPA 10 parts by weight DBNDAP 7 Parts by weight DCOT 2 parts by weight Diethylene glycol monomethyl ether 20 parts by weight Propylene carbonate 61 parts by weight Formulation Example 6 DBNPA 12 parts by weight DBNDAP 12 parts by weight DCOT 2 parts by weight Diethylene glycol Preparation Example 7 DBNPA 20 parts by weight DBAB 20 parts by weight DCOT 2 parts by weight Diethylene glycol monomethyl ether 58 parts by weight Preparation Example 8 DBNPA 10 parts by weight BBAB 15 parts by weight DCOT 2 parts by weight Diethylene glycol monomethyl ether 73 parts by weight Preparation Examples 9 to 22 are shown in Table 2. Comparative Example Comparative Formulation Example 1 DBNPA 10 parts by weight DBNDAP 10 parts by weight propylene carbonate 80 parts by weight Comparative Formulation Example 2 DBNPA 20 parts by weight CL-MIT 15 parts by weight Diethylene glycol 65 parts by weight Comparative Formulation Examples 3 to 13 are shown in Table 3.

The above abbreviations mean the following compounds. DBNPA: 2,2-dibromo-3-nitrilopropionamide DBNDAP: 2-bromo-2-nitro-1,3-diacetoxypropane BBAB: 1,4-bis (bromoacetoxy) -2-butene Cl-MIT: 5 -Chloro-2-methyl-4-isothiazolin-3-one DCOT: 4,5-dichloro-2-n-octyl-4-
Isothiazolin-3-one

Test Example 1 [Slime Adhesion Suppression Effect Recognition Test on Papermaking White Water] Paperboard making white water collected from a papermaking company (waste paper utilization rate 50
%, PH 5.4, viable cell count 1.1 × 10 ⁷ CFU / ml, cell count:
Alcaligenes sp. Pseudomonas sp. Bacillussp.) 1L
Was placed in a beaker in which a 2 mm acrylic plate cut to 90 mm x 70 mm was immersed, and 3 mg / L of various industrial germicides were added thereto. The solution temperature was adjusted to 30 ° C and continuous operation was performed at 50 rpm for one week. did. The acrylic plate after the test was taken out, and the amount of slime adhered was measured. Table 1 shows the results.

[0031]

[Table 1]

Evaluation: The degree of slime adhesion was evaluated on a scale from 0 to 5. Evaluation Criteria 5: Slime adhered to the entire surface (100%) of the acrylic plate. 4: Slime deposition of are found in 70% to 90% of A click drill plate. 3: Slime deposition of are found in 50% to 70% of A click drill plate. 2: Slime deposition of is observed in 30% to 50% of A click drill plate. 1: slime adherence of are found in 10% to 30% of A click drill plate. 0: slime adhesion of is not observed in A click Lil plate. The higher the value, the greater the degree of dirt.

Test Example 2 [Test for Confirming Bacteriostatic Effect with Neutral Papermaking White Water] Neutral papermaking white water collected from a papermaking company (waste paper utilization rate 40
%, PH 7.5, viable cell count 6.1 × 10 ⁶ CFU / ml, bacterial species: A
lcaligenes sp.Pseudomonas sp.Flavobacterium s
p.) is filtered and dispensed into an L-shaped tube, and the reagent is added to a predetermined concentration. A bouillon medium was added as a nutrient, and the mixture was cultured with shaking at 30 ° C. for 24 hours, and the minimum growth inhibitory concentration (MIC 24 hr: concentration at which no turbidity due to bacterial growth was observed at an absorbance of 660 nm) was measured. The results are shown in Figs.
As shown in FIG.

Test Example 3 [Test for confirming the bacteriostatic effect of acidic papermaking white water] Acidic papermaking white water collected from a certain paper company (waste paper utilization rate 50
%, PH 4.5, viable bacterial count 8.4 × 10 ⁶ CFU / ml, bacterial species: B
Acillus sp. Pseudomonas sp. Flavobacterium sp.) is filtered and dispensed into an L-shaped tube, and the reagent is added to a predetermined concentration. Add bouillon medium as a nutrient source and add 3
Incubate with shaking at 0 ° C for 24 hours,
24 hr: concentration at which no turbidity due to bacterial growth was observed at an absorbance of 660 nm). The results are shown in FIGS.

Test Example 4 [Test for confirming the fungicidal effect of acidic papermaking white water] Acid papermaking whitewater collected from a papermaking company (waste paper utilization rate of 10
0%, pH 4.3, or beauty bacteria number 3.4 × 10 ³ CFU / ml,
Bacterial species: Cladosporium sp. Asperugirus sp. Fusarium s
p.) is filtered and dispensed into an L-shaped tube, and the reagent agent is dispensed at a concentration of 10 mg / 1 per active ingredient.
After culturing with shaking at 30 ° C. for 30 minutes, the number of viable fungi (CF
U / ml) and the fungicidal rate was determined from the following equation. The results are shown in FIGS. Mold kill rate (%) = (Bacterial count of blank−Bacterial count of drug additive) / Bacterial count of blank × 100

Test Example 5 [Test for Confirming Bacteriostatic Effect Using Neutral Paper Papermaking Process White Water] Neutral paper papermaking process white water of a certain paper mill [pH: 7.9, viable cell count 6.0]
× 10 ⁷ CFU / ml (species: Bacillus sp. Pseudomonas sp. Fl
avobacterium sp.), waste paper utilization rate of 50%] was filtered and used as test water to conduct a test for confirming the growth inhibitory effect. (Test method) The liquid obtained by adding a liquid bouillon medium to the test water is placed in a previously sterilized L-shaped test tube. Next, a predetermined amount of the drug was added thereto, followed by shaking culture at 30 ° C. Twenty-four hours later, turbidity based on bacterial growth was measured at 660 nm absorbance to determine the effect. The minimum addition amount (mg / l) at which no increase in absorbance was observed upon addition of each drug, that is, the minimum growth inhibitory concentration (MIC 24Hr) was determined. The test results are shown in Tables 2 and 3.

[0037]

[Table 2]

[0038]

[Table 3]

[0039]

The industrial bacteriostatic / bacteriostatic agent of the present invention comprises:
By combining a specific two-component industrial germicidal component containing 2-dibromo-3-nitrilopropionamide and a 3-isothiazolone-based compound in a specific small proportion,
Compared to the combination of components, for a wide variety of microorganisms,
So-called synergistic enhancement of the bactericidal effect, improvement of the sustainability of the effect, and prolongation of the growth inhibition time are exhibited.

The present invention is particularly useful as a bactericidal / bacteriostatic agent and a bactericidal / bacteriostatic method for water in the papermaking process in the paper and pulp industries where slime damage directly affects products.

[Brief description of the drawings]

FIG. 1 is an MIC diagram showing a synergistic effect of DBNPA, DBNDAP, and Cl-MIT.

FIG. 2 is an MIC diagram showing a synergistic effect of DBNPA, DBNDAP, and Cl-MIT.

FIG. 3 is an MIC diagram showing a synergistic effect of DBNPA, DBNDAP, and Cl-MIT.

FIG. 4 is an MIC diagram showing a synergistic effect of DBNPA, BBAB, and Cl-MIT.

FIG. 5 is an MIC diagram showing a synergistic effect of DBNPA, BBAB, and Cl-MIT.

FIG. 6 is an MIC diagram showing a synergistic effect of DBNPA, BBAB, and Cl-MIT.

FIG. 7 is a graph of the fungicidal rate showing the synergistic effect of DBNPA, DBNDAP, and DCOT.

FIG. 8 is a graph of the fungicidal rate showing the synergistic effect of DBNPA, BBAB, and DCOT.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-3-7205 (JP, A) JP-A-2-42007 (JP, A) JP-A-56-154403 (JP, A) JP-A-2- 117604 (JP, A) JP-A-5-201810 (JP, A) JP-A-54-44024 (JP, A) JP-A-1-197412 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A01N 43/80 102 A01N 37/02 A01N 37/34

Claims (2)

(57) [Claims] (1) 2,2-dibromo-3-nitrilopropionamide, (b) 2-bromo-2-nitro-1,3-diacetoxypropane, 1,2-bisbromoacetoxyethane, 2
-Brominated polyacetoxyalkylene derivatives selected from -bisbromoacetoxypropane, 1,2,3-trisbromoacetoxypropane and 1,4-bis (bromoacetoxy) -2-butene; and (c) 5-chloro-2 -Methyl -4- isothiazoline- 3
-One and 4,5-dichloro-2-n-octyl-4-
It contains a 3-isothiazolone-based compound selected from isothiazolin -3-one, and the proportion thereof is 0.1 to 5 parts by weight of the component (b) with respect to 1 part by weight of the component (a); Component (c) is 0.01 with respect to 1 part by weight of the total amount of component and component (b).
An industrial bactericidal / bacteriostatic agent characterized by being 1 to 1 part by weight. 2. A system for industrial sterilization and bacteriostasis, comprising (a) 2, 2
-Dibromo-3-nitrilopropionamide, (b) 2-
Bromo-2-nitro-1,3-diacetoxypropane,
Brom-containing polyacetoxy selected from 1,2-bisbromoacetoxyethane, 1,2-bisbromoacetoxypropane, 1,2,3-trisbromoacetoxypropane and 1,4-bis (bromoacetoxy) -2-butene Alkylene derivatives and (c) 3-isothiazolones selected from 5-chloro-2-methyl-4- isothiazolin -3-one and 4,5-dichloro-2-n-octyl-4- isothiazolin -3-one The compound is used in a ratio that exhibits a synergistic effect, and these ratios are such that the component (b) is 0.1 to 5 parts by weight per 1 part by weight of the component (a), and the component (a)
Component (c) is present in an amount of 0.01 to 1 part by weight of the total amount of component (b).
1 part by weight, and 0.1 to 0.1
An industrial disinfecting and bacteriostatic method, characterized by simultaneously or separately adding 200 mg / L.