JP3362403B2 - Mouthwash for denture wearers - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a mouthwash for a denture wearer, and more particularly, to keeping the inside of an oral cavity clean while a denture wearer wears a denture. The present invention relates to a mouthwash for a denture wearer which is effective for preventing the onset of denture stomatitis. 2. Description of the Related Art In recent years,
With the advent of an aging society, the use of dentures tends to increase year by year. In using dentures, food debris easily accumulates between the denture and the oral mucosa, and the inside of the mouth tends to be more dirty than healthy people. In comparison, more Candida bacteria are seen, and this is thought to be the cause of denture stomatitis. Conventionally, denture cleaning agents, denture dentifrices and the like have been known as oral hygiene means for denture users. However, although the denture cleaner is very effective against Candida bacteria, it is not suitable for use in the oral cavity because of the strong action of peroxides and the like. Therefore, in order to prevent the growth of Candida bacteria which cause denture stomatitis, it is necessary to wash frequently with a denture cleaner, but it takes time and effort, so it cannot be washed many times a day. Problem. On the other hand, denture dentifrices effectively remove food debris and dirt, but at present have no effect on Candida bacteria. [0004] Further, as means for washing the oral mucosa, mouth washing with water or mouth washing with a commercially available mouth washing agent is performed, but the antibacterial activity against Candida bacteria is insufficient. In particular, commercially available mouthwashes contain a large amount of alcohol, but alcohol is highly harmful to weakened mucosal tissues that have been subjected to compression, abrasion, stomatitis, etc. due to wearing of dentures. Therefore, mouthwash liquid tends to stay between the denture base and the mucous membrane, making it easier for the denture user to feel irritation. Absent. [0005] As described above, no oral composition for dentures has been proposed which can prevent the propagation of Candida bacteria and prevent denture stomatitis by using it with the denture worn. The present invention has been made in view of the above circumstances,
An object of the present invention is to provide a mouthwash for a denture wearer, which can be used while wearing a denture and has a preventive effect on denture stomatitis with little irritation. The present inventors have conducted intensive studies to achieve the above object, and have found that sorbic acid or a salt thereof and benzoic acid or a salt thereof are used in a specific ratio. Specifically, sorbic acid or a salt thereof is used in combination with benzoic acid or a salt thereof in a weight ratio of 1/10 to 3/1, and the blending amount of sorbic acid or a salt thereof is 0% of the whole composition. By setting the amount to 0.11 to 5% by weight, it was found that the use amount of these two components gives a remarkable effect of preventing the proliferation of Candida bacteria by at least a synergistic action of both components, and is extremely effective in preventing denture stomatitis. The present invention has been accomplished. Conventionally, it is known that sorbic acid and benzoic acid are compounded as a preservative in ordinary oral compositions and the like (Japanese Patent Application Laid-Open Nos. 55-90555 and 56-7711).
No., 56-39009, 59-101417, 62
-298517, 63-145213, JP-A-1-
21322, 3-7216, etc.). However, the combined use of sorbic acid or a salt thereof and benzoic acid or a salt thereof at the above-mentioned specific ratio synergistically enhances the inhibitory effect on the growth of Candida fungi. The fact that stomatitis can be prevented is related to a new finding of the present inventors. [0010] Conventionally, chlorhexidines and quaternary ammonium salts have a bactericidal effect, and the present inventors have confirmed that they exhibit an anti-candida fungicidal activity. It is difficult to use for the preparation of the oral composition. However, the combined use of sorbic acid or a salt thereof and benzoic acid or a salt thereof does not reduce its effect in the preparation, and provides excellent anti-candida activity. Hereinafter, the present invention will be described in more detail. The present invention relates to a mouthwash for a denture wearer used while wearing a denture, wherein sorbic acid or a salt thereof and benzoic acid or a salt thereof are represented by a weight ratio. The sorbic acid or the salt thereof is used in an amount of 0.01 to 5% by weight of the whole composition, and the ethanol is used in an amount of 5% by weight of the whole composition. The present invention relates to a mouthwash for a denture wearer for preventing the propagation of Candida bacteria specific to a denture wearer and preventing denture stomatitis, characterized in that: Here, when the combined ratio of sorbic acid or a salt thereof and benzoic acid or a salt thereof is out of the above range, the combined effect of both is not sufficiently exhibited. The preferred range of the combined ratio of the two is 1: 5 to 3: 1, more preferably 1: 3 to 1: 1.
It is. The amount of sorbic acid or a salt thereof is as follows:
0.01 to 5% (% by weight, hereinafter the same) of the whole composition, more preferably 0.05 to 1%, particularly 0.1 to 1%
It is. If the amount is less than 0.01%, it is difficult to provide sufficient anti-candida activity, while if it exceeds 5%, the feeling of use may be reduced. The composition of the present invention may be prepared by mixing other conventional components in a usual dose in addition to the above components according to the kind, dosage form, etc. of the composition of the present invention. In order to avoid irritation during use, the amount of ethanol is 5% or less of the total composition. Further, the pH of the composition is 4 to
It is preferable to adjust to 8.5, especially 5 to 7. According to the mouthwash for denture wearer of the present invention,
By using a specific ratio of sorbic acid or a salt thereof and benzoic acid or a salt thereof, it is possible to effectively prevent the propagation of Candida bacteria specific to denture wearers, to effectively prevent denture stomatitis, It can be used with low or no irritation while wearing a denture. EXAMPLES Hereinafter, the present invention will be described in detail with reference to experimental examples and examples, but the present invention is not limited to the following examples. [Experimental Example 1] The MIC (minimum inhibitory concentration) against Candida was measured when various fungicides and antibacterial agents shown in Table 1 were dissolved in water at the concentrations shown in Table 1.
Table 1 shows the results. Here, Candida fungus was obtained by wiping the mouth corner of a healthy person with a cotton swab and collecting the bacteria in Candida GS medium.
After culturing at 7 ° C. for 2 days and nights, it was confirmed that Candida albicans was Candida albicans by a conventional method, and then used as a test sample. [Table 1] [Experimental Example 2] A mouthwash was prepared according to a conventional method with the following composition, and the minimum growth inhibitory concentration against Candida was measured. Table 2 shows the results. Mouthwash formulation Glycerin 10.0% Polyoxyethylene hydrogenated castor oil 1.5 Citric acid 0.1 Sodium hydroxide pH adjuster Ion exchange water Appropriate amount 100.0% pH 5.5 [Table 2] From the results in Tables 1 and 2, chlorhexidine gluconate and cetylpyridinium chloride, which are generally considered as fungicides, exhibit an anti-candida activity in an aqueous solution type, but in a formulation type (in the presence of an active agent). Completely deactivated. However, potassium sorbate and sodium benzoate did not significantly change the anti-candida activity. EXPERIMENTAL EXAMPLE 3 A preparation was prepared by combining potassium sorbate and sodium benzoate in the mouthwash system of Experimental Example 2, and the minimum inhibitory concentration against Candida was measured. Table 3 shows the results. [Table 3] From the results shown in Table 3, it can be seen that the combination of potassium sorbate and sodium benzoate can suppress the effect of Candida bacteria at a lower concentration and reduce irritation caused by preservatives. Was. Example 1 Mouthwash Glycerin 10.0% Polyoxyethylene hydrogenated castor oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.3 Sodium benzoate 0.3 Fragrance 0 2.5 Ethanol 1.0 Water Balance meter 100.0% [Example 2] Mouthwash glycerin 8.0% Sorbit 4.0 Polyoxyethylene hydrogenated castor oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.1 Sodium benzoate 0.3 Fragrance 0.5 Water Balance meter 100.0% [Example 3] Mouthwash glycerin 8.0% Xylit 4.0 Poly Oxyethylene hydrogenated castor oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.1 Sodium benzoate Example 0.3 Perfume 0.5 Ethanol 2.0 Water Balance meter 100.0% [Example 4] Mouthwash Glycerin 10.0% Pluronic F-127 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 1.0 Sodium benzoate 1.0 Fragrance 0.5 Water Balance meter 100.0% [Example 5] Mouthwash glycerin 10.0% Polyoxyethylene hydrogenated castor oil 2. 0 Phosphoric acid 0.1 Sodium phosphate 0.1 Potassium sorbate 0.1 Sodium benzoate 0.3 Fragrance 0.5 Ethanol 1.0 Water Balance meter 100.0% [Example 6] Mouthwash Glycerin 10.0% Polyoxyethylene hydrogenated castor oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.1 Benzoic acid Sodium 0.3 Fragrance 0.5 Ethanol 5.0 Clove extract 1.0 Cyclodextrin 0.1 Water Balance meter 100.0% [Example 7] Mouthwash glycerin 10.0% Polyoxyethylene cured castor Oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.1 Sodium benzoate 0.3 Fragrance 0.5 Gennoshoco 1.0 Water Balance meter 100.0% [Example 8] Mouthwash Glycerin 10.0% Polyoxyethylene hydrogenated castor oil 2.0 Citric acid 0.1 Sodium citrate 0.1 Potassium sorbate 0.1 Sodium benzoate 0.3 Fragrance 0.5 Sodium chondroitin sulfate 1.0 water balance total 100.0% [0034] example 9 mouthwash glycerin 10.0% poly Kishiechiren hardened castor oil 2.0 Citric acid 0.1 Sodium 0.1 Sodium Potassium sorbate 0.1 benzoic acid Citric acid 0.3 Perfume 0.5 dipotassium glycyrrhizinate 0.05 sodium copper chlorophyllin 0.01 Water Balance Total 100 0.0%

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-3-7216 (JP, A) JP-A-3-246213 (JP, A) JP-A-63-14714 (JP, A) Latest cosmetic science, stock Company Pharmaceutical Daily, April 1, 1981, 1st edition, 2nd printing, pp. 193-194 (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (1)

(57) [Claim 1] In a mouthwash for a denture wearer used with a denture mounted thereon, sorbic acid or a salt thereof and benzoic acid or a salt thereof are 1:10 by weight ratio. And sorbic acid or a salt thereof is 0.01 to 5% by weight of the whole composition, and ethanol is 5% by weight or less of the whole composition. A mouthwash for a denture wearer for preventing the propagation of Candida bacteria peculiar to denture wearers and preventing denture stomatitis.