JP3367709B2 - Cosmetics from rice - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention is a cosmetic characterized by using rice or sprouted rice, which not only has an excellent moisturizing effect on human skin, and also has a slippery effect. Whitening effect, UV absorption effect, anti-aging effect,
The present invention relates to a cosmetic material that is also excellent in exfoliating effect.

[0002]

2. Description of the Related Art Conventionally, cosmetics have been mixed mainly with oils, amino acids and polysaccharides to provide moisturizing properties. More recently, safety of cosmetics has become a problem, and natural oils, hyaluronic acid, and natural moisturizers such as placenta extract have been developed, but they have drawbacks such as stickiness. However, it is the current situation that the effect of smoothing the skin is not clearly known. In addition, recently, cosmetics with added value such as whitening cosmetics containing koji acid and UV cosmetics containing an ultraviolet absorber or an ultraviolet blocking agent have been released, but they are natural and have a moisturizing effect (moisturizing effect). )
It has a remarkable effect on the skin, and has a remarkable effect of smoothing the skin.
Moreover, a cosmetic having a whitening effect, an ultraviolet absorbing effect, an anti-aging effect, and a keratin removing effect has not yet been known.

On the other hand, rice has been used as a staple food, as well as sake, shochu, mirin, vinegar, koji, etc., and has long been indispensable for daily life. In addition to this, bran bags are known for cosmetic purposes. These are believed to be due to the fact that rice was viewed as merely a staple food, or at best, as a source of starch. Also, even if the bran bag is said to be good for the skin, it has been customarily used as it is, and there was no concept of an active ingredient and no idea of utilizing that ingredient.

[0004]

At present, there is a problem in the safety of the human body in cosmetics as well, and in addition, the pursuit of added value such as whitening, stain removal, aging prevention (unchasing), wrinkle removal, etc. ing. Therefore, it is safe for the human body, has no stickiness to the skin, and also has a moisturizing effect (moisturizing effect) and a smoothing effect on the skin, and also has a whitening effect, an ultraviolet absorbing effect, and an anti-aging effect. In addition, cosmetics that are excellent in exfoliating effect are desired.

[0005]

[Means for Solving the Problems] From the viewpoint of animal and plant harmony, the present inventors have conducted research on various plant components centering on rice, which is a staple food. In the process, it has become clear that rice has many unpredictable possibilities and effects. Therefore, we have conducted a comprehensive utilization study of rice, focusing on rice, which is used as a staple food and has been demonstrated to have the highest safety. As one of the themes, we have earnestly studied cosmetics from rice. In the process, the inventors of the present invention invented a cosmetic from rice obtained by extracting rice with water or organic solvent (Japanese Patent Application No. 3-349748).

[0006] However, as a cosmetic from rice, a cheaper or more remarkable cosmetic from rice was found, and the present invention was completed. That is, the present invention, by using rice or a germinated product of rice, is simple, inexpensive, yet completely safe, has a moisturizing effect and a slippery effect, and further has a whitening effect, an ultraviolet absorbing effect, and an antiaging effect. In addition, it was possible to obtain a cosmetic product which was also excellent in terms of the exfoliating effect. That is, the present invention (1) is a cosmetic product from rice, which is composed of a hydrolyzed product of germinated rice with a starch-degrading enzyme or koji, or containing the same. Further, the present invention (2) is
It is a cosmetic product made from rice which is obtained by extracting germinated rice with water or organic solvent or containing the same. Further, the present invention (3) comprises, when extracting germinated rice, a starch degrading enzyme or koji which has been allowed to act before, at the same time as or after the extraction, or which contains the rice. Cosmetics from.

When activating a starch-degrading enzyme or koji,
First, crushed or pulverized rice has a larger surface area, and thus is much more effective. This method may be a general method using a crusher or a rice mill. It is not necessary to grind, but in this case, it takes a long time to decompose and saccharify the rice tissue by the starch decomposition reaction. In activating the starch-degrading enzyme or koji, rice is hydrolyzed as it is, preferably ground or powdered. The rice may be brown rice or white rice. Further, bran of 92% or less which appears at the time of whitening may be used, which is inexpensive and economical. The amount of water added is effectively 1 to 5 times that of rice, but may be appropriately selected depending on the yield, workability, purpose of final use and the like.

Next, an enzyme is added to carry out the starch decomposition reaction. Here, the enzyme used in the starch-decomposing reaction refers to all enzymes including a starch-degrading enzyme and starch-degrading enzymes such as koji and malt. When koji is used, it may be a commonly used one, and the type of koji mold and the variety of rice are not limited as long as it has an amylase titer. In addition, by having enzymes such as proteolytic enzyme and lipolytic enzyme act together, those having higher effects were obtained.

The enzyme reaction is carried out at a suitable temperature by applying a starch degrading enzyme used in the starch degrading reaction and a product containing the starch degrading enzyme at a suitable temperature to 1-2.
The reaction may be carried out for 4 hours, but the reaction time may be short or long and the reaction temperature may be high or low as long as the effect is exhibited. After completion of the starch decomposition reaction, the extraction is completed when the mixture is heated to a boiling state. After the extraction is completed, squeezing and filtration are performed to obtain a clear extract. Further, although the active ingredient as a cosmetic has not been clarified, it has been confirmed that this unknown active ingredient is stable to heat. Therefore, the extraction temperature at the time of water extraction is efficiently high. If it is left at a low temperature for a long time, it can be sufficiently extracted. However, in the case of a low temperature of 40 ° C. or lower, it is necessary to make the pH acidic or alkaline or to add a preservative to treat the rice so that it does not spoil. The extraction time may be several minutes in the case of boiling extraction, but in the case of medium temperature below that, several hours to one day is required. When the temperature is low, it takes several days to one month depending on the crushed state of rice. However, even in this case, it is more effective to heat at the end as much as possible. The extraction may be carried out at normal pressure or reduced pressure. The starch decomposition reaction may be carried out at the same time as the extraction or after the extraction.
The effect is recognized. However, if the starch decomposition reaction is carried out after extraction, the effect is weak due to poor extraction efficiency.

Further, the active ingredient as a cosmetic is an acid,
Probably because it is stable to alkali, the starch decomposition reaction and acid extraction,
It is also effective to carry out alkali extraction. As described above, a starch-degrading enzyme or koji-acting product and an extracted product can be desugarized to give a product having a good feeling without stickiness. As the method of sucrose removal, coagulation and precipitation with microorganisms (aeration culture, alcoholic fermentation, etc.) or alcohol may be performed, and the effect was the same.
Furthermore, the same effect can be obtained by performing organic acid fermentation such as lactic acid fermentation. In addition, by sprouting rice, it is possible to obtain one having a further excellent effect.

When germinating rice, germinated rice is immersed in water to germinate. The temperature of the water to be germinated is 15 to 15.
40 ° C is preferable, but it may be repeated as long as it germinates. However, since there is a risk of water spoilage, it is preferable to replace the water so as not to spoil it or to carry out some kind of preservative. The term "germination" as used herein refers to the germination from immediately before germination to the germinated one. Any rice may be used, such as non-glutinous rice and glutinous rice.

Next, the germinated rice is thoroughly washed, dried and ground or pulverized. When extraction is performed, the germinated rice is crushed or powdered and extracted as described above. If the gelatinization phenomenon occurs, the gelatinization phenomenon can be prevented by adding amylase. When performing extraction, extraction with an organic solvent such as alcohol or acetone is also an effective means. Further, as described above, it is more effective if the starch-degrading enzyme or koji is made to work, or extraction or saccharification and extraction are combined, and further, these are desugarized.

Next, specific effects will be described based on the test. First, in order to exemplify the effect that the skin becomes slippery and the texture becomes fine, the product of the present invention was applied to the right arm site of the panelist twice a day for 1 month, and the application site of the product of the present invention was measured by a dynamic friction meter. The same part of the left arm was used as a control. Five panelists were used, and the average is shown in Table 1. The measurement conditions are as follows. Temperature 25 ℃ Humidity 60% Sensor used KES-SE Friction tester S
E-2 type (0.5mm piano wire used) Friction static load 50gf Measuring speed 1mm / sec Measuring distance 30mm (Integral effective range 20m
m)

[0014]

[Table 1] As can be seen from Table 1, it was found that all of them were effective. In addition, the starch-degrading enzyme or koji obtained in Example 1 was effective but weak, but since it can be obtained by a simple operation of activating the starch-degrading enzyme or koji, anyone can do it. Yes, it is a very economical and effective means.

The coefficient of variation of 0.0102 in rice with starch degrading enzyme or koji was 0.0102.
It was proved to be clearly effective as 0.0087 in the one in which the starch degrading enzyme or the koji was made to act on the germinated rice. Furthermore, it has been found that the effect is further enhanced by combining extraction. In addition,
The same applies to the coefficient of friction. From these facts, it was found that the product of the present invention has the effects of smooth skin and fine texture. Furthermore, in order to demonstrate the whitening effect of the present invention, a test for tyrosinase activity inhibitory action was conducted.

The operation method is as follows: substrate solution (0.04% tyrosine solution), buffer solution (Mcllvaine Buff)
er pH 6.8) Accurately take 1 ml of each in an absorption cell,
1 m of water and the product of the present invention obtained in Example 1
Add exactly 1 part each time, stir and mix, keep at 35 ° C., and after 5 minutes, adjust the absorbance scale to 475 nm wavelength for zero correction, and then perform tyrosinase solution (tyrosinase 5.3).
0.02 mg dissolved in 0.9% NaCl solution)
ml was added exactly and immediately stirred and incubated. The absorbance at this time was measured over time (every 3 minutes) and is shown in Table 2.

[0017]

[Table 2] Note 1: The tyrosinase activity inhibition rate was calculated based on how much tyrosinase activity was suppressed by comparing water with water after 30 minutes using water as a control. Note 2: In Examples 4 and 8, alcohol was completely evaporated by a rotary evaporator and then diluted to the original amount.

As can be seen from Table 2, the product of the present invention was found to have a tyrosinase activity inhibitory action. From these, it can be said that the product of the present invention has a whitening effect.
Further, the absorption spectrum of the product of the present invention was measured in order to demonstrate the ultraviolet absorption effect of the product of the present invention obtained in Example 6 as data. The results are shown in Fig. 1.

From FIG. 1, the product of the present invention is particularly 280 to 32.
It was found that the absorption effect is excellent in the UVB region of 0 nm and the low wavelength region (about 320 to 340 nm) of 320 to 380 nm UVA.

Since the product of the present invention has sufficient absorption only in the vicinity of the UVB region, it may be considered that the effect is not sufficient, but the shortest wavelength of ultraviolet rays reaching the surface of the earth is 295.
In terms of nm, the longest wavelength is said to be 320 to 330 nm, and therefore, it can be said that the ultraviolet absorption capacity is substantially sufficient. In addition, this is approximately three times as high as the absorbency of the natural herb extracts and natural herb ingredients (oil-soluble licorice extract P-U, lycochalcone A, baicalein, γ-oryzanol, etc.) that have natural ultraviolet absorption capacity. . In addition, also in the other examples, similar results with UV absorption were obtained.
Also from this, it was proved that the product of the present invention has an excellent ultraviolet absorbing ability.

Next, in order to demonstrate the strength of the moisturizing effect of the product of the present invention obtained in Example 6 as data, a moisture meter (S
The coating test was conducted once using KICON 200).
An environment in which the room temperature was 20 ° C. and the relative humidity was 65% was set as the measurement condition, and the panelists were allowed to rest in the above environment for about 10 minutes before the measurement. The test site (both sides) was selected on the flexion side of the forearm where no rash was observed. The panelists were 5 people.

The average value of changes in the water content of the stratum corneum between the main test and the control test (using water) read from the moisture meter is shown in FIG. The measurement method of the one-time application test is as follows. Measurement method 1) A test site and a control site of 5 × 5 cm are set on the forearm flexion side of the panel. 2) Measure the water content of the stratum corneum at each site. 3) Measure the water content of the stratum corneum immediately after coating the sample and after 30, 60, 90 and 120 minutes. From FIG. 2, in the test site to which the product of the present invention was applied, immediately after application, the water content of the stratum corneum was increased by about 13 times that of the control. In addition, when it is observed from 30 minutes to 120 minutes after application, in the application site of the present invention, 2-3 of the control is observed.
You can see that it maintains double the water content. Similar results were obtained for the other examples. From this,
It was found that the product of the present invention is extremely rich in moisturizing effect.

Next, in order to check the skin rejuvenation effect, 7
The present invention product obtained in Example 4 was applied to 6 female monitors aged 0 to 80 on the back of the hand for 1 week, the place was collected by the sump method, and the sump image was taken with a micrograph to obtain the present product. A comparison was made with fresh skin.

As shown in FIG. 3, in the skin of a 21-year-old female monitor, not only the sulcus 1 is clearly recognized in multiple directions, but also the skin crest (turtle shell pattern) 2 is clearly shown. However, as shown in FIG. 4, in the 71-year-old monitor, only the unidirectional sulcus 1'is observed, and no crust is observed at all. It is said that the skin loses elasticity as it grows older, and the skin groove becomes shallower due to its tightness, and the cuticles gradually disappear. However, when the product of the present invention obtained in Example 4 was applied for 1 week, as shown in FIG. 5, the skin groove 1'which was observed only in one direction before use was formed in multiple directions. It was clearly recognized. Not only that, but also up to the skin mounds (turtle shell pattern) 2'which were not seen before application, became clearly visible, almost no substitute for the skin of a 21-year-old woman. Also, the feel is more elastic,
A rejuvenating effect was observed. This phenomenon was similarly observed in the remaining 5 monitors. It can be said that, by using the product of the present invention, the original function of the skin is directed to the recovery direction, and a clear and regular skin pattern appears. Similar results were obtained for the other examples. From this, it was demonstrated that the product of the present invention has a clear rejuvenating effect.

Next, in order to demonstrate the anti-aging effect, 4
Five female monitors in their 0's were allowed to continuously use the product of the present invention on the back of the hand for one week, and microscopic observation was performed by the Sump method.
As the product of the present invention, the product manufactured according to Example 4 was used.
As shown in FIG. 6, in the skin not coated with the product of the present invention, only the skin groove 3 in one direction was conspicuous, and the skin groove 3 ′ orthogonal to the skin groove was unclear. As shown in FIG. 7, the skin which had been continuously used for 1 week showed not only the unclear skin groove 3 ', but also a fine skin groove. This phenomenon similarly appeared in the other 4 monitors. From this, it was demonstrated that the product of the present invention also has an effect of helping to prevent skin aging. Furthermore, when the skin to which the product of the present invention was continuously applied for one month was observed, the effect was further recognized. Similar results were obtained for the other examples.

It was also found that the product of the present invention also has a keratin removing effect. When 10 panelists with horny elbows were applied with the product of the present invention obtained in Example 12 twice a day for 1 week, 8 persons found that the hard keratin was broken in the 1st week and became smooth. did. Also, the same results were obtained when the remaining two people were used for two weeks. In addition, it is said that everyone feels good and is not sticky. The same applies to the other examples. As described above, it was also found that the product of the present invention has an excellent keratin removing effect.

Next, the effectiveness of the product of the present invention in actual use was examined. First, 10 panelists were continuously applied with the product of the present invention obtained in Example 12 twice a day for one month, and the effectiveness in actual use was examined. As a result, 7 out of 10 people said that they had an effect of making their skin clearly white. Regarding the remaining three people, the effect was not clear because the skin was originally white. However, everyone said that the skin seemed to be moist and smooth, and that the texture of the skin had become smooth. As a result, it was found that even in actual use, a clear effect was obtained, and it was found that it has a very excellent effect as a cosmetic.

[0028]

EXAMPLES Examples of the present invention will be described below. (Example 1) To 500 g of crushed powdered white rice,
1000 ml of water and 300 g of koji were added, and the mixture was left at 55 ° C. for 20 hours. After that, squeeze with a squeezing machine, 730 ml of the product
And 1000 g of residue was obtained. (Example 2) 1 kg of rice without germ was soaked in water at 25 ° C for 3 days to germinate rice. This sprouted rice was thoroughly washed, dried at 50 ° C. for 24 hours, and then finely pulverized to 500 g, and the same operation as in Example 1 was carried out to obtain another 700 ml of the present product. (Example 3) To 500 g of the ground product of germinated rice obtained in the same manner as in Example 2, 10 g of liquefying enzyme and 1000 ml of water were added. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, the product was squeezed with a squeezing machine to obtain 680 g of the product of the present invention and 740 g of a residue. (Example 4) To 500 g of the ground product of germinated rice obtained in the same manner as in Example 2, 1000 ml of 95% ethanol was added and left for 5 days. Then, the product was squeezed with a squeezing machine to obtain 800 g of the product of the present invention and 660 g of a residue. (Example 5) To 500 g of the crushed product of germinated rice obtained in the same manner as in Example 2, 1000 ml of 0.1N-hydrochloric acid was added, and the mixture was allowed to stand for 5 days. After that, squeeze with a squeezing machine and clear solution 8
00 g and 650 g of residue were obtained. 1N-Na was added to this clear solution.
Neutralization with OH gave 890 g of the product of the present invention. (Example 6) As in Example 1, saccharified rice 200
0 g was obtained. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, it was squeezed with a squeezing machine to obtain 950 ml of the product of the present invention and 1000 g of a residue. (Example 7) The same operation as in Example 6 was carried out by using 500 g of the ground product of germinated rice obtained by the same operation as in Example 2 to obtain another 900 ml of the product of the present invention. (Example 8) To 500 g of crushed white rice, 1000 ml of 40% ethanol and 200 g of koji were added, and the mixture was stirred at 55 ° C for 48 hours.
Left for hours. Then, it was cooled and squeezed with a squeezing machine to obtain 750 ml of the product of the present invention and 900 g of a residue. (Example 9) The same operation as in Example 8 was carried out by using 500 g of the ground product of germinated rice obtained by the same operation as in Example 2 to obtain another 720 ml of the present invention product. (Example 10) By the same operation as in Example 3, 2000 g of an extract of white rice was obtained. Starch-degrading enzyme 10 was added to this extract.
g was added and the mixture was allowed to stand at 55 ° C. for 24 hours. Then, it was squeezed with a squeezing machine to obtain 900 ml of the product of the present invention and 1050 g of a residue. (Example 11) The same operation as in Example 10 was carried out using 500 g of the crushed product of germinated rice obtained by the same operation as in Example 2 to obtain another 910 ml of the product of the present invention. (Example 12) 1000 m of the product of the present invention obtained in Example 6
2 g of dry yeast was added to 1 and the mixture was subjected to alcohol fermentation at 20 ° C. for 7 days and then filtered to obtain another 980 g of the product of the present invention. (Example 13) 1000 m of the product of the present invention obtained in Example 6
2g of dry yeast was added to 1, and while blowing air,
Aeration fermentation of yeast was performed at 30 ° C. for 18 hours. Then, it was filtered to obtain another 900 ml of the product of the present invention. (Example 14) 500 ml of the product of the present invention obtained in Example 6
To the above, 1400 ml of 95% ethanol was added and then filtered. The filtrate was concentrated with an evaporator to obtain another 400 ml of the present invention product.

[0029]

EFFECTS OF THE INVENTION As can be seen from the above results, the use of rice or a germinated product of rice makes the skin moist and smooth easily and completely safely, and has the effect of keeping the skin texture and whitening. Thus, a very excellent cosmetic having the effect, the effect of absorbing ultraviolet rays, the effect of preventing aging, and the effect of removing keratin was obtained.

Since rice has been the staple food until now, new production methods and uses have hardly been developed. Furthermore, rice has been the staple food until now, and its safety has been proven. That is, the present invention not only has a very excellent effect as a cosmetic,
We have found that the safety has been well verified, and can be said to be a very meaningful invention that can be used in various cosmetics. In addition, it is extremely significant that the current use of rice is said to be over-produced and that new uses of rice are found and that consumption of rice can be increased by improving the image of rice.

[Brief description of drawings]

FIG. 1 is an absorption spectrum showing a result of measuring ultraviolet absorption of a product of the present invention.

FIG. 2 is a graph showing changes in the water content of the stratum corneum according to the product of the present invention.

FIG. 3 illustrates a micrograph of the back of the hand of a 21 year old female monitor.

FIG. 4 illustrates a micrograph of the back of the hand of a 71 year old female monitor.

FIG. 5: The present invention product 1 on the back of a 71-year-old female monitor
It is what illustrated the micrograph which shows the result of application for a week.

FIG. 6 illustrates a micrograph of the back of the hand of a female monitor in her 40s.

FIG. 7 is a micrograph showing a result of applying the product of the present invention to the back of a hand of a female monitor in her 40s for one week.

Claims (3)

(57) [Claims] 1. A cosmetic product from rice, which comprises or comprises starch hydrolyzate or koji which has been acted on germinated rice water. 2. A cosmetic comprising rice, which is made of germinated rice extracted with water or an organic solvent, or containing the same. 3. A cosmetic product from rice, which comprises, before or during the extraction of germinated rice, a starch-degrading enzyme or koji, or contains the same. .