JP3370571B2 - Disinfectant cleaning agents for medical equipment and disinfecting cleaning methods - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sterilizing detergent for medical equipment used for washing and disinfecting various medical equipment such as artificial dialysis equipment and its peripheral equipment, endoscopes, and disinfection using the same. Regarding the cleaning method.

[0002]

2. Description of the Related Art Artificial dialysis machines are contaminated with body fluids such as blood and its components during use. If left uncontaminated, infection with bacteria and viruses, anaphylaxis due to foreign proteins, etc. will occur. Therefore, it is necessary to remove the attached contaminants by washing and sterilize them after use to eliminate the danger.
Also, contamination of the dialysate supply device and supply line can cause bacterial growth, which can lead to fever in patients due to bacterial infection and endotoxin. In recent years, sodium bicarbonate has been added for pH adjustment. Since dialysate is commonly used, calcium salts such as calcium carbonate are likely to deposit and adhere to the liquid contact parts such as pipes, which may cause trouble such as malfunction of the patient monitoring device. Removal of this dirt is required along with sterilization. In particular, for this calcium salt, although the cause is unknown, sometimes large deposits, which are considered to be calcium carbonate, may adhere in large amounts. Further, in the dialysate supply line, bacterial contamination contaminating the dialysate must be avoided.

Therefore, conventionally, two-step cleaning with an aqueous solution of sodium hypochlorite and an aqueous solution of acetic acid is generally performed in order to remove and sterilize the adhered substances / contaminants in the above-mentioned dialysis apparatus and its peripheral equipment. It is being appreciated. Further, a two-step cleaning method (Japanese Patent Laid-Open No. 8-224299) using an aqueous solution of peracetic acid in place of the aqueous solution of acetic acid has also been proposed. Furthermore, as a disinfectant cleaner that can perform one-step cleaning for the same purpose,
An aqueous solution containing sodium hypochlorite, a sequestering agent, and an anionic surfactant (Japanese Patent Laid-Open No. 4-135555)
No. 9, 7-233396, etc.) and 6 to 8% hydrogen peroxide, 2 to 10% acetic acid and 0.3 to 1% peracetic acid, and a mixture of acetic acid and peracetic acid with respect to hydrogen peroxide. Consisting of an aqueous solution in which the weight ratio of the amounts is less than 1 (Patent No. 259
No. 9204) has been proposed.

On the other hand, also in the endoscope, since it enters the patient's body, a high level of disinfection is required to prevent the risk of infection by bacteria or viruses. According to the "Guidelines for cleaning and disinfection of endoscopes" by the Society of Engineers' Disinfection Committee, "all patients must be considered infected and each must be immersed in 2% glutaraldehyde for 10 minutes". .
Then, in the actual cleaning and disinfecting, after use, first remove external dirt by running water or wiping, then attach all tube injection tool, put cleaning agent inside and brush, wash with water and dehydrate by air supply, A method of injecting 2% or more glutaraldehyde aqueous solution into the inside, further immersing the whole in 2% or more glutaraldehyde aqueous solution for 10 minutes, and finally washing with water to perform dehydration by air supply is adopted.

[0005]

However, the conventional two-step cleaning with the sodium hypochlorite aqueous solution and the acetic acid aqueous solution or the peracetic acid aqueous solution is excellent in sterilizing and disinfecting properties but is poor in the cleaning property, and the adhering components such as fats and oils are deteriorated. The cleaning effect is not sufficient due to its poor removal ability, and there is a problem in that it requires a lot of labor and time because it is operationally complicated to perform the cleaning in two steps. In many cases, there is not enough time to perform the two-step cleaning. In addition, a disinfecting detergent containing sodium hypochlorite, a sequestering agent and an anionic surfactant is excellent in disinfecting effect and removing effect of bodily fluid components, but removal of large and large amount of deposits of calcium salt that occasionally occurs as described above. In addition to insufficient capacity, the decomposition of the sequestering agent with sodium hypochlorite progresses over time, resulting in a decrease in drag. Therefore, the prepared cleaning liquid cannot be stored for a long time.

Further, the above-mentioned proposed aqueous solution containing hydrogen peroxide, acetic acid and peracetic acid, which contains 6% or more of hydrogen peroxide, corresponds to a non-medical deleterious substance and is not only restricted in its distribution. Since the amount of hydrogen peroxide is large, strong irritation occurs when it comes into contact with the skin, and thus there is a problem in safety in handling, and as shown in the test results of Comparative Example 2 described later, calcium salt removing property and bactericidal property are exhibited. However, no satisfactory results were obtained with respect to both protein removability.

On the other hand, the glutaraldehyde used for disinfection of the endoscope has strong side effects and toxicity, so that in addition to the risk of residue, there is a great concern for the health of workers, and it reacts with proteins. Since it has the property of forming a strong coagulation product, there is a problem that if the protein cannot be completely removed by the washing in the previous step, there is a concern that it may remain.

In view of the above situation, the present invention provides a powerful disinfecting cleaning effect by one-step cleaning in disinfecting and cleaning various medical devices such as artificial dialysis machines and peripheral devices thereof, endoscopes and the like. To provide a disinfecting and cleaning means that can easily remove large and large amounts of calcium salts, has excellent storage stability of cleaning agents, has high safety in handling, and has no problem of environmental pollution. It is an object.

[0009]

In order to achieve the above object, the disinfecting and cleaning agent for medical equipment according to the invention of claim 1 is hydrogen peroxide 3.5 to 6%, organic acid 5 to 30%, organic Peracid 0.4-3.4%, and 2-aminoethanesulfonic acid or its salt 0.002-1% as a stabilizer,
It is composed of an aqueous solution having a weight ratio of (organic acid + organic peracid) / hydrogen peroxide of 1 or more.

In the disinfecting and cleaning agent for medical equipment according to claim 1, the organic acid is acetic acid in the invention of claim 2, and in the acetic acid containing the organic acid as a main component and the aqueous solution in the invention of claim 3. 2) and succinic acid having a succinic acid content of 0.1 to 6%.

According to a fourth aspect of the present invention, in the disinfectant cleaner for medical devices according to any of the first to third aspects, the weight ratio of (organic acid + organic peracid) / hydrogen peroxide is 2 or more. There is.

On the other hand, the method for disinfecting and cleaning medical equipment according to a fifth aspect of the present invention is to dilute the disinfectant cleaning agent for medical equipment according to any one of the first to fourth aspects with water 20 to 100 times, It is characterized in that medical equipment is disinfected and washed using this diluted solution.

The medical device to be disinfected and cleaned by the disinfecting and cleaning method of the fifth aspect is a dialysis line of an artificial dialysis device in the invention of the sixth aspect and an endoscope in the invention of the seventh aspect.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION As described above, the disinfectant cleaner for medical equipment of the present invention contains hydrogen peroxide, an organic acid, an organic peracid, and 2-aminoethanesulfonic acid or a salt thereof. is there. Among these ingredients, hydrogen peroxide and organic peracids act as oxidizing agents to denature or destroy the cellular proteins of microorganisms to bring about a bactericidal effect and to oxidize and decompose the toxins produced by microorganisms to render them harmless. There is a characteristic. The organic acid also has the function of dissolving and removing the calcium salt that precipitates in the dialysis line of the artificial dialysis device. And 2-aminoethane sulfonic acid or its salt improves the storage stability of a disinfecting detergent.

In the present invention, the hydrogen peroxide concentration in the disinfecting detergent is 3.5 to 6%. That is, if the concentration of hydrogen peroxide is within this range, it is not equivalent to a non-medical deleterious substance, so it is not restricted in distribution and there is no possibility of causing strong inflammation even if it comes into contact with the skin. There is no problem in the property, and the above-mentioned characteristics due to hydrogen peroxide can be sufficiently exhibited.

The organic peracid acts as an oxidizing agent as described above, but the coexistence of this organic peracid and hydrogen peroxide provides a higher bactericidal effect than in the presence of hydrogen peroxide alone. Thus, such an organic peracid is easily produced by contacting the above hydrogen peroxide with the organic acid in the presence or absence of a catalyst such as a mineral acid. For example, when the organic acid and hydrogen peroxide are brought into contact with each other in the absence of a catalyst at room temperature, the content of the organic peracid reaches a certain value after about 3 to 4 weeks, and the hydrogen peroxide, the organic acid and the organic peracid are brought into contact with each other. An aqueous solution containing is obtained. The concentration of the organic peracid in this hydrogen peroxide-organic acid-organic peracid aqueous solution is 0.4 or more in order to obtain a sufficient bactericidal effect, and the upper limit is 3.4% from the production limit.

The amount of the organic peracid produced is the same when the total amount of hydrogen peroxide and the organic acid is the same, for example, the former / latter weight ratio is about 0.5 and about 2 so,
It's not so different. Considering this point and the point of solubility of calcium by the organic acid, it is advantageous to use the organic acid in an amount larger than that of hydrogen peroxide in order to generate the same amount of the organic peracid. However, the storage stability of the hydrogen peroxide-organic acid-organic peracid aqueous solution tends to decrease as the concentration of the organic acid increases.
The upper limit of the organic acid concentration must be set to 30% in order to maintain the residual ratio of active oxygen after storage for a week near 90%. The lower limit of the organic acid concentration is 5% from the viewpoint of calcium solubility. Therefore, the total amount of the organic acid and the organic peracid should be 1 or more by weight ratio with respect to hydrogen peroxide, and if the weight ratio is less than 1, calcium salt solubility and bactericidal property are obtained. Satisfactory results cannot be obtained on both sides.

As the above-mentioned organic acid, acetic acid, succinic acid, maleic acid, citric acid, malic acid, glycolic acid and the like are preferable because of their high solubility in calcium salts, especially calcium carbonate. These organic acids also have an advantage that they are easy to handle because they are not dangerous and odors do not matter so much. The following table 1 shows that 0.2% concentration of organic acid 1
The amount of dissolved calcium carbonate (CaCO ₃ ) per liter is shown.

[0019]

[Table 1]

On the other hand, the storage stability of the hydrogen peroxide-organic acid-organic peracid aqueous solution shows that when acetic acid is used, the comparison of the above 6 kinds (6 kinds excluding oxalic acid in Table 1) as the organic acid component is shown. Is the best, followed by succinic acid, but not maleic acid, citric acid, malic acid, glycolic acid, etc. In addition, the organic peracid production rate due to contact between hydrogen peroxide and organic acid is highest when the organic acid component is acetic acid, followed by succinic acid. However, succinic acid also has the advantage that it has no odor. Therefore, as the organic acid, acetic acid or succinic acid is preferable in terms of storage stability and organic peracid generation rate,
Since succinic acid has a low solubility and cannot be mixed in a large amount, it is recommended to use acetic acid alone or to use acetic acid and succinic acid as the main components in combination. In this combined system, however, the organic acid concentration in the aqueous solution is 5 to 30%, especially the succinic acid concentration is 0.1 to 6%.
It is good to set it in the range of%.

That is, the disinfecting and cleaning agent for medical equipment according to the present invention comprises hydrogen peroxide of 3.5 to 6%, organic acid of 5 to 30%,
And 0.4 to 3.4% of organic peracid, and is characterized in that the weight ratio of (organic acid + organic peracid) / hydrogen peroxide is 1 or more. Therefore, it is recommended to set the weight ratio of (organic acid + organic peracid) / hydrogen peroxide to 2 or more, particularly in order to improve the bactericidal activity and the solubility of calcium salt. As described above, the organic acid is preferably acetic acid alone or a combination of acetic acid and succinic acid having an aqueous solution concentration of 0.1 to 6%.

In such a disinfecting and cleaning agent composed of hydrogen peroxide-organic acid-organic peracid aqueous solution, it is particularly recommended to add a stabilizer because improvement in storage stability is more important than distribution. It As such stabilizers, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), aminotrimethylenephosphonic acid (A
TMP), dipicolinic acid, phosphoric acid, salts of these, and the like, together with conventionally known stabilizer components, 2-aminoethanesulfonic acid (taurine) and the like have been found by the present inventors to be useful as stabilizer components. Examples thereof include salts thereof, and among them, it has been found that particularly taurine and HEDP and salts such as sodium salts thereof exhibit a high stability improving action even when added in a trace amount.

However, it is not clear whether the commercially available HEDP is due to its own characteristics or impurities contained therein, but it is observed that an insoluble salt is formed with calcium under acidic conditions to cause turbidity. On the other hand, taurine has a characteristic that it does not form an insoluble salt with calcium and has an action of suppressing metal corrosion. Therefore, the disinfecting and cleaning agent of the present invention is configured to contain taurine or a salt thereof such as sodium salt as a stabilizer. Therefore, the addition amount of this taurine or its salt is preferably in the range of 0.002 to 1%, particularly preferably in the range of 0.01 to 0.2%,
If it is too small, the effect of addition will not be sufficiently exerted, and if it is too large, it will be uneconomical.

When such a disinfecting detergent is used by diluting it with water about 20 to 100 times for disinfecting and cleaning medical equipment, it has an excellent sterilizing and disinfecting effect and an effect of removing deposits such as calcium carbonate. It exerts a cleaning action on dirt components such as proteins and oils and fats. There are no particular restrictions on the medical equipment to be cleaned, but it is highly suitable for disinfection and cleaning of dialysis lines of artificial dialysis machines and endoscopes.

That is, in the dialysis line of the artificial dialysis device, as described above, precipitation / adhesion of calcium carbonate derived from calcium salt and sodium bicarbonate in the dialysate,
In addition, waste products containing proteins that migrate to the line during dialysis are prone to stains, and are exposed to the opportunity for bacterial contamination by dilution water and other factors. Not only will it cause malfunction of the dialysis machine. In addition, a dirty dialysis line may lead to infection through dialysis and cause a serious medical accident, and if endotoxin, which is a fragment of bacteria, enters the body through dialysis, it causes allergies and fever. Therefore, the cleaning of the dialysis line is important for the safe implementation and management of artificial dialysis. However, since the disinfecting and cleaning agent of the present invention has the excellent disinfecting and cleaning function described above, the disinfecting and cleaning by the disinfecting cleaning is performed as described above. And very effective in its maintenance.

In addition, in the endoscope, in addition to the difficulty of disinfection and cleaning due to the tubular form, the glutaraldehyde used in the conventional disinfection is toxic and blood adheres to it as described above. There has been a problem that proteins in body fluids such as the above are coagulated to make it difficult to remove. However, according to the disinfecting detergent of the present invention, a good disinfecting and sterilizing effect can be obtained, and since the contained component finally decomposes into carbon dioxide and water, there is no toxicity problem, and moreover, without coagulating the protein, other Exhibits the effect of washing and removing together with the dirt component of. Therefore, the disinfecting detergent of the present invention is extremely effective as an endoscope disinfecting detergent in place of the glutaraldehyde.

The results of various tests conducted on the relationship between the composition difference of the disinfecting detergent and various characteristics and performances are shown below.

[Test 1] Hydrogen peroxide having a concentration shown in Table 2 below and an organic acid were brought into contact with each other at room temperature, and the amount of produced organic peracid (concentration%) after storage for 4 weeks in a dark place at room temperature was examined. The hydrogen peroxide-organic acid-organic peracid aqueous solution obtained after the above contact was stored in a dark place at 36 ° C. for 4 weeks and after 8 weeks, and the residual ratio of active oxygen (%) was measured. The results are shown in Table 2. The amount of organic peracid produced was shown as a value converted to peracetic acid. In addition, the residual ratio of active oxygen is based on 100% of active oxygen derived from the initial hydrogen peroxide at the time of mixed contact of hydrogen peroxide and organic acid, and is derived from both hydrogen peroxide and organic peracid after storage. The amount of active oxygen used was defined as the residual rate. () In the table means omission of measurement.

[0029]

[Table 2]

From the results shown in Table 2, the amount of organic peracid produced by contact between hydrogen peroxide and organic acid is highest when the organic acid component is acetic acid, followed by succinic acid. Also, as the acid concentration increases, the amount of organic peracid produced tends to increase,
It can be seen that an organic peracid concentration of 0.4% or more cannot be obtained except for acetic acid and succinic acid. Then, when the hydrogen peroxide 6% and acetic acid 12% are brought into contact with each other (b) and when the hydrogen peroxide 12% and acetic acid 6% are brought into contact with each other (q),
There is almost no difference in the amount of organic peracid produced. On the other hand, hydrogen peroxide
Storage stability of the organic acid-organic peracid aqueous solution is the best when acetic acid is used as the organic acid component, then succinic acid is good, acetic acid-similar to acetic acid alone in the combined system, It is clear that maleic acid, citric acid, malic acid, glycolic acid, etc. are not good.

[Test 2] The aqueous solutions (a), (c) and (e) of Test 1 and the stabilizers (taurine) shown in Table 3 below were added to the aqueous solutions (c), (e) and (o). = 2-aminoethanesulfonic acid, HEDP =
With respect to the aqueous solution to which 1-hydroxyethylidene-1,1-diphosphonic acid) was added, the residual ratio (%) of active oxygen after storage for 4 weeks and after storage for 12 weeks in the dark at 36 ° C was measured.
The results are shown in Table 3.

[0032]

[Table 3]

From the results shown in Table 3, the storage stability of the disinfecting detergent is remarkably improved by adding a trace amount of taurine or HEDP as a stabilizer, but taurine is more stable than taurine in comparison with HEDP. It is understood that it shows a chemical action.

[Test 3] Hydrogen peroxide 5.2%, acetic acid 16.9%, peracetic acid 1.26
% Taurine in various proportions to an aqueous solution containing
The iron plate was dipped in a diluting solution prepared by diluting these aqueous solutions 50 times with water, and the generation state of rust was examined. As a result, rust was immediately generated in the aqueous solution containing no taurine, but addition of 0.05% showed some rust-inhibiting effect, and addition of 0.1% or more caused rust even after 1 hour or more. No more.
When 5% was added, no rust was observed even after 24 hours, and it was proved that taurine provided a corrosion preventing effect.

[0035]

EXAMPLES Next, examples of the present invention will be specifically described in comparison with comparative examples and reference examples. In Tables 4 to 7 below, “ratio” means a comparative example, “reference” means a reference example, and “actual” means an example.

Examples 1 and 2, Comparative Example 2, Reference Examples 1 to 6 An aqueous solution of hydrogen peroxide having a predetermined concentration and an aqueous solution of acetic acid are mixed,
This mixed solution was stored at room temperature for 4 weeks to prepare a disinfecting and cleaning agent comprising a hydrogen peroxide-acetic acid-peracetic acid aqueous solution containing each component shown in Table 4. In addition, the stabilizer described above was added to the disinfecting detergents of Examples 1 and 2.

Reference Example 7 Hydrogen peroxide aqueous solution, acetic acid aqueous solution and succinic acid aqueous solution were mixed, and hydrogen peroxide-organic acid-organic peracid aqueous solution containing each component shown in Table 4 was prepared in the same manner as in Reference Examples 1-6. Was prepared. The mixing ratio of each component was as follows: hydrogen peroxide 6%, acetic acid 15% and succinic acid 3%.

[0038]

[Table 4]

Examples 1 and 2 above, Comparative Example 2 and Reference Example 1
7 to the disinfecting detergent and the 7% hydrogen peroxide aqueous solution as Comparative Example 1 were diluted 50 times with water, and the diluted aqueous solution was used to dissolve calcium carbonate and remove proteins. (Comparative Example 1 and Examples 1 and 2 are omitted) were tested. The results are shown in Table 5. The test methods are as follows.

[Calcium Carbonate Solubility] 0.1 g of calcium carbonate was added to 1 liter of a 1/50 aqueous solution of a disinfecting detergent, and the mixture was stirred with a magnetic stirrer. The input amount was defined as the dissolution amount.

[Removal of Protein] 10 μl of human serum was dropped on a slide glass and left to dry at room temperature for 2 days as a protein-adhered sample, which was immersed in a 1/50 aqueous solution of a disinfecting detergent at room temperature, The immersion time until the protein was removed was measured. The removal of protein was judged by applying Amido Black 10B solution to the sample and losing the color.

[0042]

[Table 5]

From the results shown in Table 5, the solubility of calcium carbonate in the case of hydrogen peroxide alone (Comparative Example 1) did not show, and the ratio of (organic acid + organic peracid) / hydrogen peroxide was 1 The smaller amount (Comparative Example 2) has insufficient solubility, whereas the disinfecting and cleaning agents of the Examples having the same ratio of 1 or more show good solubility, and particularly the one having the same ratio of 2 or more has high solubility. It turns out that it shows sex. Also in terms of protein removability, the disinfecting detergent of the reference example having a ratio of (organic acid + organic peracid) / hydrogen peroxide of less than 1 (Comparative Example 2) has a higher removal rate than that of Comparative Example 2. It is understood that, when the ratio is 2 or more, the removability is high. From the comparison between Reference Examples 3 and 6 and Example 1 which have almost the same acid concentration, when HEDP is used as a stabilizer (Reference Example 6), the solubility of calcium carbonate decreases, but taurine is also used. It can be seen that when it is used (Example 1), the dissolution amount does not decrease.

[Sterilization test] Next, with respect to the disinfecting detergents of Example 1, Reference Examples 1 to 5, 7 and Comparative Examples 1 and 2, aqueous solutions diluted 50 times and 35 times with water were prepared, respectively. The results of the sterilization test using the diluted aqueous solution are shown in Tables 6 and 7. This test was conducted using Pseudom-onas aeruginosa and Escherichis as test bacteria.
o157, Staphylococcus aureus (MRSA) 31, Bac-illus sub
Using 4 kinds of tilis, 1 ml of bacterial solution (average number of bacteria 108
(/ Piece / ml) in 10 ml of the above diluted aqueous solution for 30 seconds, 5
After contacting each for 10 minutes, 30 minutes, and 60 minutes, 50 μl of each was put on a SCPDL agar plate medium, spread with a conradi stick, and this was cultured for 24 hours, and the number of colonies was counted.

[0045]

[Table 6]

[0046]

[Table 7]

From the results shown in Tables 6 and 7, the disinfecting and cleaning agent of Comparative Example 1 containing only hydrogen peroxide had 1/35 solution and 1/35 solution.
It can be seen that almost no bactericidal activity was observed against 4 kinds of bacteria in both 50 solutions. Then Pseudomonas aeruginosa, Es
cherichia coli.o-157, S-taphylococcus aureus (MRS
With respect to the three kinds of bacteria A) 31, the disinfecting and cleaning agents of Example 1, each of the reference examples and the comparative example 2 were 1/35 liquid and 1/5.
It is clear that no colony was generated by contacting with the 0 liquid for 30 seconds, and all of them showed good bactericidal properties.

For Bacillus su-btilis, the disinfecting and cleaning agents of Example 1 and Reference Examples 2 to 5 and 7 were all 1/3.
Both 5 and 1/50 liquids show excellent bactericidal properties because no colonies are generated by contact for 30 seconds. On the other hand, in the disinfecting and cleaning agent of Comparative Example 2, colonies are observed after contact with the 1/50 liquid for 10 minutes. In addition, in the disinfecting and cleaning agent of Example 1, both the 1/35 solution and the 1/50 solution show colonies when contacted for 5 minutes, but the bacteria can be completely sterilized by contacting for 10 minutes, so Comparative Example 2 Better as a disinfectant cleaner than From these points, the ratio of (organic acid + organic peracid) / hydrogen peroxide in the disinfecting detergent should be 1 or more,
Further, it can be said that it is preferable to set the same ratio to 2 or more.
When disinfecting the dialysis line of an artificial dialysis machine, 10
Being able to complete the sterilization within minutes is a huge advantage in the actual medical field, which is busy and has little time.

[Disinfection of the dialysis line of the artificial dialysis device] 1/50 solution of the disinfecting and cleaning agent of Example 1, Reference Examples 2 to 5, 7 and Comparative Example 2 was used as the disinfecting and cleaning liquid, and the artificial dialysis device DBB-22 was used. (Manufactured by Nikkiso Co., Ltd.), after dialysis, 15 minutes of pre-washing-injection of 15 minutes of disinfecting cleaning solution-overnight storage-30 minutes of pre-washing-20 minutes of replacement of dialysate-dialysis cycle repeated for 3 weeks, calcium carbonate and protein to the line The state of adherence of dirt to the system was observed, and the bacterial count and endotoxin level were examined. In addition, the presence or absence of residue after washing with the disinfecting cleaning liquid was also investigated.

As a result, when the disinfecting detergent of each example was used, no calcium salt was found to adhere, but when the disinfecting detergent of Comparative Example 2 was used, the tube was considered to be calcium carbonate. Adhesion of calcium salts was observed. However, protein-based stains were not found in any of the disinfecting and cleaning agents of Examples and Comparative Example 2. On the other hand, at the end of dialysis, Pseudomonas aeru
Although ginosa and Klebsiella pneumoniae were detected, even when any of the disinfecting detergents of Examples and Comparative Example 2 was used, it was not observed in the sampling after injecting the disinfecting detergent solution and washing with water, and the endotoxin level was 25 to 45 EU. It showed a low value of 1 / l. Also, the active oxygen was 0.5 ppm or less as hydrogen peroxide after 10 minutes of washing with water, and the PH became the same value as the pH of RO (reverse osmosis) water which was the washing water after 15 minutes. For example, it is suggested that the disinfection cleaning liquid can be reliably prevented from remaining. Therefore, it is clear that the dialysis line can be kept extremely clean by using the disinfecting detergent of the embodiment of the present invention.

[Disinfection and Cleaning of Endoscope] After washing the outside of the endoscope used for inspection, all pipe line cleaning tools are attached, water is supplied to each pipe line inside, and pre-cleaning is performed. Carefully removed the water. Then, 1/33 liquid obtained by diluting each of the disinfecting and cleaning agents of Example 1 and Reference Examples 1, 3, and 5 with water was poured into each of the inner pipes from the whole pipe cleaning tool to completely fill the pipes. And then replace the entire endoscope with one
It was dipped in the / 33 liquid and taken out after 10 minutes, and the outside and the inside were washed with water. Sterile water was used for the washing with water after the disinfection and washing, and the collected washing water was examined for a bacterial test by SCPDL agar plate medium and the removability of blood proteins by occult blood reaction. As a result, the bacterial test and occult blood reaction were positive before disinfecting and cleaning, but were negative after disinfecting and cleaning using any of the disinfecting and cleaning agents.

[0052]

According to the invention of claim 1, in the disinfection and cleaning of various medical equipment such as artificial dialysis equipment and its peripheral equipment, endoscopes, etc., a strong disinfection cleaning effect is obtained by one-step cleaning. The obtained disinfecting and cleaning means is capable of easily removing a large amount of a large amount of a calcium salt precipitate, has excellent storage stability of the cleaning agent, has high safety in handling, and has no problem of environmental pollution. It

According to the inventions of claims 2 and 3, as the above-mentioned disinfecting detergent, there is provided one having excellent storage stability and calcium salt removability.

According to the fourth aspect of the present invention, as the above-mentioned disinfecting detergent, one having excellent bactericidal property and calcium salt solubility is provided.

According to the fifth aspect of the present invention, the above disinfecting and cleaning agent can surely and safely sterilize and clean medical equipment.

According to the sixth aspect of the present invention, the above disinfecting and cleaning agent enables efficient and safe sterilization and cleaning of the dialysis line of the artificial dialysis machine.

According to the seventh aspect of the present invention, the disinfecting and cleaning agent described above enables reliable and sterilizing and cleaning of the endoscope particularly efficiently and safely.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification symbol FI A61L 2/16 A61L 2/16 Z A61M 1/14 563 A61M 1/14 563 C11D 7/18 C11D 7/18 7/26 7 / 26 7/34 7/34 7/38 7/38 (56) Reference JP-A-2-193905 (JP, A) JP-A-62-190122 (JP, A) JP-A-4-69235 (JP, A) ) JP 8-19593 (JP, A) JP 8-224299 (JP, A) JP 4-135559 (JP, A) JP 7-233396 (JP, A) JP 6- 99716 (JP, B2) Special table 2-502532 (JP, A) Special table 8-500843 (JP, A) Special table 8-508916 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61L 2/18 A61L 2/16 A61B 1/12 A61M 1/14 563 C11D 7/26 C11D 7/38 C11D 7/18 C11D 7/34 A01N 59/00 A01N 37/16 A01N 37/02

Claims (7)

(57) [Claims] 1. Hydrogen peroxide 3.5 to 6%, organic acid 5 to 3
0%, organic peracids from 0.4 to 3.4%, and as a stabilizer
2-aminoethanesulfonic acid or its salt 0.002-
A disinfecting and cleaning agent for medical devices, which comprises an aqueous solution containing 1% and having a weight ratio of (organic acid + organic peracid) / hydrogen peroxide of 1 or more. 2. The disinfectant cleaner for medical equipment according to claim 1, wherein the organic acid is acetic acid. 3. The content of the organic acid in acetic acid and the aqueous solution is 0.
The disinfectant cleaning agent for medical devices according to claim 1, comprising two components of succinic acid of 1 to 6%. 4. The weight of (organic acid + organic peracid) / hydrogen peroxide
Disinfectant cleaners for medical instruments according to any one of the amount ratio of 2 or more der Ru claims 1-3. 5. The doctor according to any one of claims 1 to 4.
Dilute the disinfectant cleaner for medical equipment 20 to 100 times with water,
Disinfecting and cleaning medical equipment using diluted solution
The method of disinfecting and cleaning medical equipment. 6. The medical device is a dialysis line of an artificial dialysis machine.
A method for disinfecting and cleaning a medical device according to claim 5 . 7. A disinfecting and cleaning method of the medical device according to claim 6, wherein the endoscopic medical devices.