JP3417650B2 - Toothpaste composition - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a dentifrice composition containing alkyldiaminoethylglycine hydrochloride, in which the bactericidal activity of alkyldiaminoethylglycine hydrochloride is kept stable and the coloring of teeth and dentures with alkyldiaminoethylglycine hydrochloride is suppressed. The present invention relates to a dentifrice composition which is excellent in prevention and appearance.

[0002]

2. Description of the Related Art Alkyldiaminoethylglycine hydrochloride (hereinafter abbreviated as AG) is known to be effective in suppressing plaque formation due to its strong bactericidal action, and has been conventionally blended in toothpaste. However, AG has a poor compatibility with commonly used toothpaste components such as silica-based abrasives, foaming agents and binders, and when incorporated into a composition, the bactericidal activity of AG is significantly reduced. . In order to maintain the bactericidal activity of AG in the composition, for example, a dentifrice without a binder is disclosed in JP-A-2-282317, and in order to prevent deactivation by a nonionic surfactant, phenol is used. An oral composition containing a compound of the above-mentioned type is disclosed in JP-A-60-255717. However, as a result of the study by the present inventors, it was found that, when the bactericidal activity of AG is maintained by the above-described technique, the teeth and the denture are colored due to the pigmentation of black tea after the use of toothpaste. Furthermore, in JP-A-60-255717, it was found that when other anionic binders were used in combination, AG was significantly deactivated and its effect was not fully exhibited.

The inventors of the present invention have made extensive studies in order to solve such a situation. As a result, by combining a silica-based abrasive, a specific surfactant, and a polyphosphate salt, the bactericidal activity of AG was stably maintained, and the teeth and artificial teeth were prevented from being colored, and the property stability was also excellent. The inventors have found that a dentifrice composition can be obtained, and completed the present invention.

[0004]

That is, the present invention provides AG
To provide a dentifrice composition containing a silica-based abrasive, a specific polyoxyethylene / polyoxypropylene block copolymer surfactant, and a polyphosphate salt in a dentifrice composition containing .
According to the dentifrice composition of the present invention, reduction of the bactericidal activity of AG is effectively prevented, plaque formation can be suppressed and gingivitis can be prevented very effectively, and tooth and denture coloring due to AG can be prevented. it can.

The blending amount of AG used in the present invention is not particularly limited, but is usually 0.001 to 0.5% by weight based on the whole dentifrice composition from the viewpoint of bactericidal activity and economical efficiency.

As the silica-based abrasive used in the present invention, anhydrous silicic acid, aluminum silicate, zirconium silicate or the like is used, and the compounding amount thereof is usually 5 to 3 with respect to the whole dentifrice composition.
0% by weight is preferred. When the blending amount exceeds 30% by weight,
If the content is less than 5% by weight, the viscosity and the squeeze out of the container become difficult, and the effect of removing stains and stains on teeth such as tobacco tar and black tea stains and artificial teeth is insufficient.

The polyoxyethylene / polyoxypropylene block copolymer surfactant used in the present invention is generally chemically defined by the molecular weight of polyoxypropylene and the weight% of the polyoxyethylene in the molecule. The ethylene / polyoxypropylene block copolymer has a molecular weight of polyoxypropylene of 1400 to 4000 and a proportion of polyoxyethylene in the molecule of 30 to 80% by weight. The blending amount is not particularly limited, but is usually 5 to 11% by weight, and more preferably 7 to 9% by weight, based on the whole dentifrice composition. When the blending amount exceeds 11% by weight, gelation occurs, and interaction with gelation by the silica-based abrasive causes a problem of property stability due to solid-liquid separation. On the other hand, if it is less than 5% by weight, teeth due to AG,
Insufficient prevention of coloration on dentures.

Examples of the polyphosphate used in the present invention include pyrophosphate, tripolyphosphate, hexametaphosphate, and the like, and salts thereof include sodium and potassium. These compounds may be used alone or in combination of two or more. Further, the blending amount thereof is usually 0.2 to 4% by weight, preferably 0.4 to 2% by weight, more preferably 0.8 to 1.2% by weight, based on the whole dentifrice composition. If the concentration is more than 4% by weight, safety problems such as oral mucous membrane peeling will occur on the oral mucous membrane, while if less than 0.2% by weight, AG will not sufficiently prevent coloring of teeth and dentures. .

Furthermore, the dentifrice composition of the present invention is for teeth,
It can be used in any of dentures, and can be made into a dosage form such as toothpaste, powder toothpaste, liquid toothpaste, and pasta agent according to a conventional method, and if necessary, appropriate ingredients such as sorbit, propylene glycol, and glycerin. , Humectants such as polyethylene glycol, essential oils such as peppermint and spearmint, fragrances such as perfume materials such as l-menthol, carvone and anethole, sodium saccharin, stevioside, neohespiridyl hydrochalcone, glycyrrhizin, thaumatin, perillartin, P-methoxycinnamic Sweeteners such as aldehydes, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium alginate, binders such as hydroxyethyl cellulose, and sodium fluoride, sodium monofluorophosphate, dex Ranaze, mutanase, hinokitiol, lysozyme, allantoin, dipotassium glycyrrhizinate, epsilon-aminocaproic acid, tranexamic acid, vitamin E and derivatives thereof, sodium chloride,
Active ingredients such as azulene may be added within a range that does not impair the effects of the present invention.

[0010]

【Example 】

Examples 1 to 7 and Comparative Examples 1 to 9 Toothpastes were prepared according to a conventional method according to the formulations shown in Table 1. The toothpaste thus obtained was measured for its bactericidal activity and colorability by the following measuring methods.

(Bactericidal test) About 1 g of each toothpaste was weighed, suspended in distilled water, and then centrifuged to obtain a supernatant. The AG concentration in the obtained supernatant was 0.0015%,
Diluted with distilled water to 003% and 0.006%. On the other hand, AG is dissolved in distilled water to obtain 0.0015%,
The concentration of 0.003% and 0.006% was used as a standard for measuring the minimum bactericidal concentration (%, hereinafter abbreviated as MBC). 10 ⁸ to 10 ⁹ CFU for 10 ml of each prepared sample
/ Ml Streptococcus mutans bacteria suspension 0.
1 ml was added, and a sterilization reaction was performed at 37 ° C. for 3 minutes in a hot water bath. After the reaction, 1 platinum loop of the sample solution was sampled and polyoxyethylene monooleate 0.5% and lecithin 0.07%
Containing tryptinase soy agar (TSA) on a flat plate and subjected to anaerobic conditions (N ₂ / H ₂ / CO ₂ = 85/10 /
MBC was measured by culturing at 5) for 2 days at 37 ° C. The MBC of the standard AG was 0.003%. The evaluation was performed according to the following criteria. ◯: MBC of the test sample is 0.0015% or 0.0030% Δ: MBC of the test sample is 0.0060% X: MBC of the test sample is greater than 0.0060%

(Coloring Test) A hydroxyapatite disc manufactured by Asahi Optical Co., Ltd. is dipped in a slurry prepared by diluting a toothpaste 4 times with distilled water for 3 minutes and washed with water for 1 minute. Next, the disc is immersed in the black tea extract for 10 minutes and washed with water for 1 minute. This operation is repeated 10 times, and the color difference of the color tone of the disk before and after the test is measured. As a control, distilled water was used instead of the toothpaste slurry. The color difference was measured with a colorimeter. The evaluation was performed according to the following criteria. ◯: Color difference is 10 or less (equivalent to control disc) Δ: Color difference is 10 or more and less than 20 X: Color difference is 20 or more

(Comprehensive Evaluation) The comprehensive evaluation was evaluated according to the following criteria. ◯: Evaluation of bactericidal power is ◯ and evaluation of coloring property is ◯ X: Evaluation of bactericidal power is Δ or X, or evaluation of coloring property is Δ or X. Table 1 shows the results.

[0014]

[Table 1]

As shown in Table 1, in a dentifrice composition containing AG, by combining a silica-based abrasive with a specific polyoxyethylene / polyoxypropylene block copolymer surfactant and polyphosphate, sterilization of AG is performed. The decrease in activity was effectively prevented, and coloring of teeth and dentures by AG was prevented.

[0016]

INDUSTRIAL APPLICABILITY According to the present invention, the reduction of the bactericidal activity of AG is effectively prevented, the formation of plaque and the prevention of gingivitis can be extremely effectively performed, and the coloring of teeth and dentures by AG is performed. It can be prevented.

Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50 CA (STN) REGISTRY (STN)

Claims (5)

(57) [Claims] 1. In a dentifrice composition containing alkyldiaminoethylglycine hydrochloride, the silica-based abrasive and the polyoxypropylene have a molecular weight of 1400 to 4000, and the ratio of polyoxyethylene contained in the molecule is 30 to 40.
Toothpaste composition comprising 80% by weight of a polyoxyethylene polyoxypropylene block copolymer surfactant and a polyphosphate salt 2. The dentifrice composition according to claim 1, wherein the amount of alkyldiaminoethylglycine hydrochloride mixed is 0.001 to 1% by weight based on the total weight of the composition. 3. The dentifrice composition according to claim 1, wherein the amount of the silica-based abrasive compounded is 5 to 30% by weight based on the total weight of the composition. 4. The dentifrice composition according to claim 1, wherein the compounding amount of the polyoxyethylene / polyoxypropylene block copolymer-based surfactant is 5 to 11% by weight of the total composition. 5. The dentifrice composition according to any one of claims 1 to 4, wherein the compounding amount of the polyphosphate salt is 0.2 to 4.0% by weight based on the whole composition.