JP3431357B2 - Manufacturing method of adhesive material - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch in the fields of medicines, quasi drugs, cosmetics and the like, and more particularly to a method for producing a patch in which a patch and a heating element or a cooling body are integrated.

[0002]

2. Description of the Related Art As a method for producing this type of patch,
The following exist. First, as shown in FIG.
As a preparation, the strip-shaped sticking portion 31, the polyethylene adhesive sheet 32, and the ventilation adjusting sheet 33 are wound in a roll shape. As shown in FIG. 4, the sticking part 31 is configured by applying an adhesive paste 35 to one surface of a support 34, and further applying a coating sheet 36 on the adhesive paste 35. . The polyethylene adhesive sheet 32 has an adhesive 38 applied to one side of a polyethylene film 37, and the release paper 3 is applied on the adhesive 38.
9 is affixed, and it is comprised. The ventilation adjusting sheet 33 is configured by bonding the ventilation adjusting film 40 and the non-woven fabric 41 together.

The polyethylene adhesive sheet 32 and the ventilation adjusting sheet 33 are supplied from a roll toward the press 45. By the press 45, the peripheral edge portion of the ventilation adjusting sheet 33 is heat-melt-sealed to the polyethylene adhesive sheet 32 to form a bag. And the exothermic agent 42
Is filled in the bag body, and the opening of the bag body is the press 45
Then, the heating element 43 is formed.

The heating element 43 formed as described above
Is on the way to the supply position of the sticking section 31,
The release paper 39 on the side of the polyethylene adhesive sheet 32 is peeled off. Therefore, the heating element 43 reaches the supply position of the sticking portion 31 with the adhesive 38 of the polyethylene adhesive sheet 32 exposed, and the sticking portion 31 supplied from the roll is stuck to the surface of the same adhesive 38. By the same heating element 4
3 and the attachment part 31 are integrated. The strip-shaped integrated product is cut at the end of the heating element 43,
The cut patch 30 is turned upside down by the reversing machine 46, and the inspector M inspects whether the product is good or bad.

[0005]

However, the above-mentioned manufacturing method has the following problems. In order to strengthen the bond between the plaster 35 and the support 34, the plaster 35 was heated to improve the fluidity. Therefore, the highly fluid plaster 35 exudes from the support 34,
The extruded plaster 35 was attached to the surface of the support 34 during the roll forming process of the sticking part 31. Therefore, the plaster 35 attached to the surface of the support 34 was fluffed on the surface of the support 34 by sliding contact with a roller (not shown) due to its adhesive force. As a result, the fluffy support 3
The bonding state between the No. 4 and the heating element 43 was weak, and the patch 30 was easily peeled from between the both 34 and 43 in the used state. In order to solve the above problems, the paste 3 is applied to the support 34.
In order to prolong the time from applying 5 to winding in a roll or to reduce the fluidity of the plaster 35, the plaster 35
The cooling step was added after the application of. In the step of integrating the heating element 43 and the attachment section 31, the release paper 39 attached to the heating element 43 is peeled off and wound into a roll. Therefore, when the winding amount reaches a certain amount, the roll has to be replaced, and it is necessary to stop the production line each time the roll is replaced. The release paper 39 may be broken by the winding tension, and it is necessary to stop the production line and restore the winding state each time. In this way, the productivity of the patch 30 is reduced, including the problems described above and the like.

The present invention has been made in view of the problems existing in the above-mentioned prior art, and an object thereof is to provide a method for manufacturing a patch that can improve productivity. .

[0007]

In order to achieve the above object, in the invention of claim 1, the peripheral edge portion of the sheet is sealed to the film sticking surface of the support having the film stuck to one surface. To form a bag body, a step of filling the bag body with a heating material or a cooling material, and a step of sealing the opening of the bag body filled with the heating material or the cooling material, or a cooling element. A body manufacturing process, a manufacturing process of a sticking part for applying an adhesive plaster to a cover sheet, and the sticking part is pasted with the other face of the support in the heating element or the cooling body with its plastered surface It is a method for manufacturing a patch, which comprises a chemical conversion step.

According to the second aspect of the invention, the temperature of the adhesive paste supplied to the covering sheet is set in the range of 100 ° C. to 180 ° C. in the step of manufacturing the sticking part. According to the invention of claim 3, the coating surface of the sticking part is heated during the process from the manufacturing process of the sticking part to the integration process.

According to the invention of claim 4, the surface temperature of the plaster surface is maintained in the range of 100 to 180 ° C. by the heating. (Operation) In the invention of claim 1 having the above structure, the peripheral edge portion of the sheet is sealed to the film sticking surface of the support to form a bag. The heat generating material or the cooling material is filled in the bag body. Then, the heating element or the cooling element is manufactured by sealing the opening of the bag.

Further, the adhesive sheet is applied to the covering sheet to manufacture the sticking part. Then, the adhesive part is adhered to the other surface of the support in the heating element or the cooling element with its plastered surface, so that both are integrated to obtain an adhesive material.

As described above, it is not necessary to apply the adhesive plaster to the support in advance as a preliminary preparation. In the invention of claim 2, the temperature of the adhesive plaster supplied to the covering sheet is 100 ° C. to 180 ° C. in the manufacturing process of the sticking part.
℃. The adhesive paste supplied at a temperature of less than 100 ° C. lowers the anchoring property to the support, and the adhesive paste supplied at a temperature of more than 180 ° C., for example, has an embossed pattern formed on the coating sheet at a high temperature. Will erase it. However, in the present invention in which the temperature of the adhesive plaster is 100 ° C to 180 ° C,
It is ideal in terms of the balance.

In the third aspect of the invention, the plaster surface of the sticking part is heated during the process from the manufacturing process of the sticking part to the integration process. For example, if the distance between the sticking part and the heat-generating body or cooling body merges in the integration step is long, the surface of the adhesive plaster cools due to outside air to form a film, and the anchoring property to the support deteriorates. To be done. However, this can be prevented by applying heat to the plaster surface in the same step.

In the invention of claim 4, the surface temperature of the plaster surface is maintained in the range of 100 to 180 ° C. by the heating of claim 3. Therefore, the anchoring property of the plaster on the support can be prevented from being deteriorated.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention will be described below. First, the patch 1 obtained by the manufacturing method of the present embodiment will be described. As shown in FIG. 2, the ventilation adjusting sheet 2 as a sheet is configured by laminating a ventilation adjusting film 3 and a non-woven fabric 4. The film-attached support 5 is constructed by attaching a support 6 made of a non-woven fabric and a film 7 together. The surface of the air flow adjusting sheet 2 of the air flow adjusting sheet 2 is polymerized on the film sticking surface of the film sticking support 5, and the peripheral edge portion is welded in an annular shape by heat melting. A heating agent 8 is filled in the inner space formed by the annular welding of the films 3 and 7 to form a heating element 9.

The sticking part 10 is constituted by applying an adhesive paste 12 made of an adhesive substance containing a medicinal component to a covering sheet 11 made of a polyester material. The sticking part 10 is superposed on the side of the support 6 of the film sticking support 5 with its plaster surface. Therefore, when the plaster 12 is inserted into the gap between the supports 6, the two 6 and 12 are joined together, and the heating element 9 and the sticking portion 10
And are integrated. Although not shown in the drawings, in order to prevent the patch 1 from having a high-quality appearance and to prevent the color of the heating element 9 from being transparent, the surface of the cover sheet 11 on which the plaster 12 is applied is prevented. , A diamond pattern is formed by embossing, for example.

The patch 1 having the above-mentioned structure is a pharmaceutical product (for example,
It is used as a transdermal drug, a compound for treating skin diseases), a quasi drug, a cosmetic (eg, a pack), etc. for the purpose of sticking to human skin.

Next, a method of manufacturing the patch 1 will be described. As shown in FIG. 1, the ventilation adjusting sheet 2 described above.
The film-adhering support 5 is in the form of a strip, and is wound and arranged in a roll. The air flow adjusting sheet 2 and the film sticking support 5 are supplied from a roll toward the press 21. In the press 21, the peripheral edge portion of the ventilation adjusting sheet 2 is heat-melt-sealed to the film sticking support 5 to form a bag (2, 5). Then, the exothermic agent 8 is filled in the bags (2, 5), and the bags (2, 5,
The heating element 9 is formed by sealing the opening of 5). The above is the manufacturing process of the heating element 9 in the present embodiment.

Cover sheet 11 wound into a roll
Is arranged on the downstream side of the press 21 in the line, and the covering sheet 11 is supplied toward the traveling area of the heating element 9. The tank 22 consists of a heat melting tank with a pump,
The plaster 12 is accommodated in a dissolved state. The pipe 23 extends from the tank 22 and faces the supply area of the cover sheet 11 by the nozzle 23α at the tip thereof. Then, the plaster 12 supplied from the tank 22 is applied to one surface of the covering sheet 11 via the pipe 23 and the nozzle 23α. The above is the manufacturing process of the sticking part 10 in this embodiment.

As described above, the tank 22 has a heating structure for melting the plaster 12, and the pipe 23 has a heat retaining structure for keeping the temperature of the plaster 12 supplied from the tank 22 at a predetermined value. have. In this embodiment,
The temperature of the plaster 12 supplied to the covering sheet 11 is 100 ° C.
The range is 180 ° C.

That is, as a result of experiments conducted by the present inventor under various conditions, when the temperature of the paste 12 applied to the covering sheet 11 exceeds 180 ° C., the covering sheet 11 is subjected to the high temperature, for example. There was a problem that the embossed pattern was erased as if it were pressed with an iron. Also,
When the temperature of the supply plaster 12 is lower than 100 ° C., there is a problem that the fluidity is lowered and the bond with the support 6 is weakened. That is, the range of 100 ° C. to 180 ° C. is excellent in terms of balancing both problems. Moreover, when this range is set to 110 ° C. to 150 ° C., the balance between the two is further excellent, and within this range, 130 ° C. (± 5 ° C.)
At that time, the anchoring property of the plaster 12 to the support 6 was most improved.

Further, in the present embodiment using the apparatus of FIG. 1, the position where the paste 12 is supplied to the covering sheet 11 and the position where the sticking portion 10 merges with the heating element 9 are slightly separated. ing. Therefore, after the plaster 12 is applied, the support 6
Depending on the line speed, there is a time lag of about several seconds before the transfer to. Therefore, even if the temperature of the plaster 12 applied to the covering sheet 11 is maintained in the range of 100 ° C. to 180 ° C. by the heat retaining function of the pipe 23, the plaster surface (12) of the sticking portion 10 has this temperature. Cool to a few seconds to form a plaster film layer, and plaster 1 on support 6
The anchoring state of 2 becomes unstable.

Therefore, in this embodiment, the heater 24 composed of an electric heater (electricity-heat converter) is provided in the area between the supply position of the paste 12 and the confluence position of the heating element 9 and the sticking portion 10. It is arranged and is opposed to the plaster surface of the sticking section 10. And the same heater 24 heats and maintains the surface temperature of the plaster surface of the sticking part 10 in the range of 100 to 180 degreeC. If the temperature is maintained at the high temperature side (175 ° C. (± 5 ° C.)) in this range, the anchoring state of the plaster 12 onto the support 6 is most improved. However, when the surface temperature exceeded 180 ° C., the embossed pattern was thermally deteriorated.

Now, the sticking part 10 manufactured as described above is supplied to the running area of the heating element 9 in the line. The adhesive part 10 is attached to the surface of the support 6 of the heating element 9 with its plaster surface, so that the adhesive 12 is transferred to the support 6 and integrated with the heating element 9 ( Integration process). The band-shaped integrally processed product is cut by a cutting machine 25 at each end of the heating element 9, and the cut patch 1 is turned upside down by a reversing machine 26 and inspected by an inspector M.

The present embodiment having the above-mentioned structure has the following effects. In the process of supplying the covering sheet 11 wound into a roll toward the heating element 9, the plaster 12 is applied to the covering sheet 11. That is, unlike the prior art, it is not necessary to apply the paste 35 to the support 34 in advance and wind it up in a roll shape, and it is possible to solve various problems of the prior art caused by it. That is, according to this embodiment, the productivity of the patch 1 can be improved. With the tank 22 and the hose 23 having a heating configuration,
The temperature of the plaster 12 supplied toward the covering sheet 11 is set to 1
It was set to 00 ° C to 180 ° C. As described above, by setting the temperature of the plaster 12 supplied to the covering sheet 11 in this range, the anchoring property of the plaster 12 to the support 6 is improved and the adverse effect on the embossed pattern is balanced. Is excellent in. A heater 24 is provided so as to face the sticking part 10 that reaches the integration step, and the plaster surface (12) of the sticking part 10 is heated by the heater 24. Therefore, as described above, it is possible to prevent a film from being formed by cooling the plaster surface (12) and prevent an unstable anchoring state with respect to the support 6. The heater 24 maintains the surface temperature of the plaster 12 of the sticking part 10 in the range of 100 ° C. to 180 ° C. by the heating. In the case where the supply position of the paste 12 to the covering sheet 11 and the confluence position of the sticking portion 10 and the heating element 9 are apart from each other as in the present device, the balance between the two is excellent as described above.

The following embodiments can be carried out without departing from the spirit of the present invention. In the above embodiment, the bag (2, 5) is embodied as the heating element 9 by filling the heating agent 8 therein. However, the cooling body is not limited to this, and may be embodied as a cooling body by filling the bag (2, 5) with a cooling agent.

The technical ideas other than the claims that can be understood from the above embodiment will be described. (1) In the manufacturing process of the said sticking part 10, the temperature of the adhesive paste 12 supplied to the coating sheet 11 is 110 degreeC-1.
The method for producing a patch according to claim 1, wherein the temperature is within the range of 50 ° C.

In this way, it is more excellent in terms of both the anchoring property of the plaster 12 onto the support 6 and the prevention of erasing of the embossed pattern formed on the cover sheet 11. (2) In the manufacturing process of the sticking part 10, the temperature of the adhesive paste 12 supplied to the covering sheet 11 is set to 130 ° C. (±
The method for producing the patch according to claim 1, wherein the temperature is 5 ° C.).

By so doing, it is more excellent in terms of both the anchoring property of the plaster 12 onto the support 6 and the prevention of erasing of the embossed pattern formed on the cover sheet 11. (3) The method for producing a patch according to claim 3, wherein in the integration step, the plaster surface of the patch is maintained at 175 ° C (± 5 ° C).

In this way, the anchoring property of the plaster 12 on the support 6 is most improved. (Definition) -The adhesive material in the above embodiment includes a rubber-based adhesive material, an acrylic-based adhesive material, and the like. Examples of the rubber-based adhesive substance include diene-based polymer compounds, specifically, natural rubber, synthetic rubber, and a mixture thereof. Examples of the synthetic rubber include styrene-isobutylene-styrene block copolymer rubber, styrene-butadiene rubber, polyisoprene rubber, butyl rubber, silicone rubber and the like. As the acrylic adhesive material, n-butyl (meth) acrylate, hexyl (meth) acrylate, 2-ethylbutyl (meth) acrylate, which have been conventionally used,
One or more (meth) acrylate esters such as isooctyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, decyl (meth) acrylate, dodecyl (meth) acrylate, and tridecyl (meth) acrylate;
(Meth) acrylic acid, maleic acid, maleic anhydride, hydroxyethyl acrylate, hydroxypropyl acrylate, acrylamide, which is copolymerizable with the ester
Dimethylacrylamide, aminoethyl methacrylate,
Examples thereof include a functional monomer such as methoxyethyl (meth) acrylate or a copolymer with a vinyl monomer such as acrylonitrile, vinyl acetate and vinyl propionate.

In the above embodiment, examples of the medicinal component include phenolic hydroxyl group-containing compounds and amine compounds. Examples of the phenolic hydroxyl group-containing compound include salicylic acid derivatives, vitamin E and its derivatives, capsaicin, and the like, and amine compounds include ethanolamine-based histamine drugs such as diphenhydramine and ethylenediamine such as chlorophenylamine. The antihistamine drug of the system, lidocaine and the like can be mentioned. Other medicinal ingredients include non-steroidal anti-inflammatory drugs such as indomethacin and cyclophenac sodium, steroidal anti-inflammatory agents such as dexamethasone and betamethasone, and bactericides such as chlorhexidine diglyconate and acrinol.

Examples of the cold-sensing skin irritant drug in the above embodiment include l-menthol, dl-camphor, thymol, d-borneol and the like. -In the above-mentioned embodiment, the warm-sensing skin-irritating drug includes pepper extract, nonyl acid vanillylamide, capsaicin, ginger extract, cantharisin tincture, cantharidin, and the like.

Examples of the exothermic heating element include iron-containing compounds. -A water absorbent resin or the like can be used as the cooling body. -As the material of the covering sheet, polyester-based, polypropylene-based, polyethylene-based, alkylbenzene sulfonic acid-based, polyvinyl chloride-based, metal film-based, etc. may be mentioned. It is preferable from the point.

As the material for the support, a non-woven fabric having excellent morphological stability is preferable, but a film such as polyethylene may be used. The fluid pressure-sensitive adhesive applied to one side of the support has a viscosity that can be easily applied to the surface of the support, for example, natural rubber type, acrylic type, styrene-isoprene block copolymer type And the like, and any type such as an emulsion, a solvent solution, an aqueous solution, or a hot melt type can be used as long as the viscosity becomes low at the time of application. Examples of the compounding substance of the natural rubber adhesive include natural rubber, styrene-butadiene copolymer, zinc white, polyterpene resin, petroleum softener (process oil), antiaging agent, and the like. Examples of the compounding substance of the acrylic pressure-sensitive adhesive include polyethyl acrylate, polybutyl acrylate, polyterpene-based resin, antioxidant, polyisocyanate-based, and the like. Examples of the compounding substance of the styrene-isoprene block copolymer-based pressure-sensitive adhesive include califlex, hydrogenated alicyclic petroleum resin, zinc white, naphthene-based oil, antioxidant, and the like.

[0034]

According to the invention of claim 1 having the above structure, the productivity of the patch can be improved.

According to the second aspect of the present invention, it is ideal in terms of improving the anchoring property of the adhesive plaster to the support and preventing the coating sheet from being adversely affected by high temperature. According to the invention of claim 3, it is possible to prevent the anchoring property of the support from being deteriorated.

According to the invention of claim 4, it is ideal in terms of improving the anchoring property of the adhesive plaster to the support.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing a manufacturing apparatus.

FIG. 2 is a partially enlarged sectional view of a patch.

FIG. 3 is a schematic view showing a conventional manufacturing apparatus.

FIG. 4 is a partially enlarged sectional view of a patch obtained by the same device.

[Explanation of symbols]

1 ... Sticking material, 2 ... Ventilation adjusting sheet as a sheet, 6 ...
Support, 7 ... Film, 8 ... Heating material, 9 ... Heating element, 10
... Sticking part, 11 ... Covering sheet, 12 ... Adhesive plaster.

─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-5-170644 (JP, A) JP-A-7-330588 (JP, A) JP-A-7-284506 (JP, A) (58) Field (Int.Cl. ⁷ , DB name) A61K 9/70 A61F 7/02

Claims (4)

(57) [Claims] 1. A step of sealing a peripheral edge portion of a sheet on a film sticking surface of a support having a film stuck on one surface to form a bag body, and a heat generating material or a cooling material in the bag body. And the step of sealing the opening of the bag filled with the heating material or the cooling material, the manufacturing step of the heating element or the cooling element, and the sticking part for applying the adhesive paste to the covering sheet. A method of manufacturing a patch, comprising: a manufacturing step; and an integration step of bonding the patch part to the other surface of the support in the heating element or the cooling element with its coating surface. 2. The temperature of the adhesive paste supplied to the cover sheet is 100 ° C. to 180 ° C. in the step of manufacturing the sticking part.
The method for producing a patch according to claim 1, wherein the temperature is in the range of ° C. 3. The coating surface of the sticking part is heated during the process from the manufacturing process of the sticking part to the integration process.
Or the method for producing the patch according to 2. 4. The surface temperature of the plaster surface is set to 1 by the heating.
The method for producing a patch according to claim 3, which is maintained in the range of 00 ° C to 180 ° C.